Coronavirus [NEW TOPIC PAGE]

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 Coronavirus

SARS-CoV-2 Nasopharyngeal Swab Testing—False-Negative Results From a Pervasive Anatomical Misconception
TS Higgins et al, JAMA Oto Laryngo, September 17, 2020

A qualitative real-time polymerase chain reaction of nasopharyngeal secretions is the criterion standard for identifying respiratory viruses, including severe acute respiratory syndrome coronavirus SARS-CoV-2).However, major concerns have been raised regarding the rates of false-negative results in community testing locations.

Severe COVID-19 Infections—Knowledge Gained and Remaining Questions
LDJ Bos et al, JAMA Internal Medicine, September 18, 2020

Despite rapid progress, much remains to be learned about severe COVID-19. For example, the pathophysiological pathways in COVID-19 that result in ARDS and how these relate to the classical understanding of ARDS are uncertain.

Predictors of characteristics associated with negative SARS-CoV-2 PCR test despite proven disease and association with treatment and outcomes. The COVID-19 RT-PCR Study.
JB Lascarou et al, MEDRXIV, September 15, 2020

Leveraging pathogen sequence and contact tracing data to enhance vaccine trials in emerging epidemics
R Kahn et al, MEDRXIV, September 16, 2020

Clinical course and potential predictive factors for pneumonia of adult patients with Coronavirus Disease 2019 (COVID-19): a retrospective observational analysis of 193 confirmed cases in Thailand
WA Pongpirul et al, MEDRXIV, September 16, 2020

Internet search patterns reveal clinical course of COVID-19 disease progression and pandemic spread across 32 countries
T Lu et al, MEDRXIV, September 16, 2020

Genomic epidemiology of a densely sampled COVID19 outbreak in China
L Geidelberg et al, MEDRXIV, September 16, 2020

Comparison of media and standards for SARS-CoV-2 RT-qPCR without prior RNA preparation
KB Ragan et al, MEDRXIV, September 17, 2020

Estimating Risk of Mechanical Ventilation and Mortality Among Adult COVID-19 patients Admitted to Mass General Brigham: The VICE and DICE Scores
CJ Nicholson et al, MEDRXIV, September 17, 2020

Optimizing direct RT-LAMP to detect transmissible SARS-CoV-2 from primary nasopharyngeal swab and saliva patient samples
DM Dudley et al, MEDRXIV, September 17, 2020

Quantifying SARS-CoV-2 infection risk within the Google/Apple exposure notification framework to inform quarantine recommendations
AM Wilson et al, MEDRXIV, September 14, 2020