New research suggests that post-exertional malaise (PEM) in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) varies greatly among individuals and leads to a diminished quality of life. Recently published in the journal Frontiers in Neurology, this is the first publication resulting from the NIH Intramural Study on ME/CFS, which is led by the National Institute of Neurological Disorders and Stroke in collaboration with dozens of investigators from at least eight institutes and centers of the National Institutes of Health, including the National Center for Complementary and Integrative Health.
The current study’s scientists collected data from 43 people with ME/CFS between November 2016 and August 2019. The participants were divided into nine focus groups and were asked about PEM in daily life and after cardiopulmonary exercise testing. While they reported a wide range of symptoms attributed to exertion both in daily life and following a cardiopulmonary exercise test, the researchers noted the presence of three core symptoms: exhaustion, cognitive difficulties, and neuromuscular complaints.
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