Universal tumor screening for lynch syndrome: perspectives of patients regarding willingness and informed consent - PubMed

Universal tumor screening for lynch syndrome: perspectives of patients regarding willingness and informed consent - PubMed

Universal tumor screening for lynch syndrome: perspectives of patients regarding willingness and informed consent

Anusree Subramonian 1, Doug Smith 2, Elizabeth Dicks 1, Lesa Dawson 3 4, Mark Borgaonkar 5, Holly Etchegary 1

Affiliations 

• PMID: 32875945
 
• DOI: 10.2217/pme-2020-0026

Free article

Abstract

Aim: Lynch Syndrome is associated with a significant risk of colorectal carcinoma (CRC) and other cancers. Universal tumor screening is a strategy to identify high-risk individuals by testing all CRC tumors for molecular features suggestive of Lynch Syndrome. Patient interest in screening and preferences for consent have been underexplored. Methods: A postal survey was administered to CRC patients in a Canadian province. Results: Most patients (81.4%) were willing to have tumors tested if universal tumor screening were available and were willing to discuss test results with family members and healthcare professionals. The majority (62.6%) preferred informed consent be obtained prior to screening. Conclusion: Patients were supportive of universal screening. They expected consent to be obtained, contrary to current practice across Canada and elsewhere.

Keywords: colorectal cancer; lynch syndrome; patient oriented research; reflex testing; universal tumor screening.

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