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lunes, 1 de julio de 2019

Genomics | Medical News | Medical Articles | Genomics |

	July 1, 2019
	Genomics
	The latest genomics news from AZoNetwork

AdvancementsDisrupting ChIP Assay Technology

Complex sequencing data can be obtained from ChIP-seq of significantly lower amounts of starting material. The high yield of DNA allows NGS sequencing from a single IP from as little as 1000 cells without any need for sample pooling. Higher input DNA improves NGS library complexity

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			What is Comparative Genomics? Comparative genomics is a field of biology where the genome of different species are compared to each other to understand evolutionary and molecular differences between species. The development of low cost, next-generation sequencing has enabled the analysis of a plethora of related genomes using comparitive genomics. This article aims to describe the techniques used in comparative genomics and their advantages/disadvantages.

			Scientists successfully carry out gene editing in vivo Breakthrough research led by Amy Wagers at Harvard University has found that gene-editing cargo can be delivered directly to stem cells while they are in their complex native environment, rather than in a petri dish.

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	Regulatory Mechanisms Involved in Gene Expression Gene expression can be regulated by various cellular processes with the aim to control the amount and nature of the expressed genes. This article aims to describe the regulatory mechanisms that control gene expression in both eukaryotes and prokaryotes.

	Deletion Mapping Explained Deletion mapping allows geneticists to answer several questions about a specific gene. It can determine where a deleted region of a gene is located, whether this deletion affects only the area in which the gene deletion occurs, and whether this can be rectified by way of recombination.

	Understanding Synthetic Epigenetics Synthetic epigenetics is an upcoming field of biology that involves modifying existing epigenetic pathways by constructing artificial and specific pathways. Synthetic epigenetics, therefore, provides the tools for dissecting epigenetic signaling information and has the potential to explore so far unapproachable domains in both basic and clinical research.

	Telomere shortening in adulthood is not caused by smoking, say researchers Researchers have surprised the medical world with a study concluding that smoking does not shorten telomeres. The study suggests that telomere length in adults should be regarded as a static biomarker that does not significantly change during adult life.

	Combination of biological markers and genetic changes can predict radiation sensitivity Latest results from a project to discover what makes a cancer patient more likely to suffer adverse side-effects after radiotherapy have shown that a combination of biological markers and certain genetic changes can predict radiation sensitivity.

	A Guide to Understanding Gene Expression Being able to analyze gene expression patterns is essential for understanding protein function, biological pathways and cellular responses to external and internal stimuli. This article aims to provide a brief overview of the processes that underpin gene expression and the techniques that can be used to quantify the expression of specific genes.