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It is often thought that roles in immune defense are confined to our white blood cells. However, the phagocytes, leukocytes, and macrophages, which circulate in our bloodstreams, are not the only cells playing defensive roles. What is often overlooked is the potential of red blood cells to defend from pathogenic invaders; notably the species of Plasmodium parasites that cause the blood-borne disease Malaria. | |
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In recent years, a selection of single-cell isolation techniques, such as: compartmentalization, micromanipulation, dilution, microfluidics, and flow cytometry, have been developed. | |
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One of the important cells involved in the immune response is the T follicular helper (Tfh) cell. These are important in the normal process of antibody production following immunization, for instance. However, they are also abnormally increased in number in patients with autoimmune disease, such as systemic lupus erythematosus. | |
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For years, scientists have explored ways to alter the cells of microorganisms in efforts to improve how a wide range of products are made - including medicines, fuels, and even beer. By tapping into the world of metabolic engineering, researchers have also developed techniques to create "smart" bacteria capable of carrying out a multitude of functions that impact processes involved in drug delivery, digestion, and even water decontamination. | |
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When immune cells detect harmful pathogens or cancer, they mobilize and coordinate a competent defense response. To do this effectively immune cells must communicate in a way that is tailored to the pathogenic insult. Consequently, the body's response to various health challenges depends on successful coordination among the cells of the immune system. | |
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A new report highlights the latest advances in cell-based therapies for the treatment of disorders of the musculoskeletal system, such as arthritis and osteoporosis, and it identifies key unanswered questions that should be addressed through ongoing research. | |
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