Oncogenic functions of the EMT-related transcription factor ZEB1 in breast cancer
Zinc finger E-box binding homeobox 1 (ZEB1, also termed TCF8 and δEF1) is a crucial member of the zinc finger-homeodomain transcription factor family, originally identified as a binding protein of the lens-spe...Journal of Translational Medicine 2020 18:51Gut metabolomics profiling of non-small cell lung cancer (NSCLC) patients under immunotherapy treatment
Despite the efficacy of immune checkpoint inhibitors (ICIs) only the 20–30% of treated patients present long term benefits. The metabolic changes occurring in the gut microbiota metabolome are herein proposed ...Journal of Translational Medicine 2020 18:49Dynamic changes of angiopoietins and endothelial nitric oxide supply during fluid resuscitation for major gyn-oncological surgery: a prospective observation
Despite goal-directed hemodynamic therapy, vascular function may deteriorate during surgery for advanced abdominal tumor masses. Fluid administration has been shown to be associated with distinct changes in se...Journal of Translational Medicine 2020 18:48The prognostic value of a seven-lncRNA signature in patients with esophageal squamous cell carcinoma: a lncRNA expression analysis
Long non-coding RNAs (lncRNAs) have been reported to be prognostic biomarkers in many types of cancer. We aimed to identify a lncRNA signature that can predict the prognosis in patients with esophageal squamou...Journal of Translational Medicine 2020 18:47A clinical-radiomics nomogram for the preoperative prediction of lymph node metastasis in colorectal cancer
Accurate lymph node metastasis (LNM) prediction in colorectal cancer (CRC) patients is of great significance for treatment decision making and prognostic evaluation. We aimed to develop and validate a clinical...Journal of Translational Medicine 2020 18:46Is there a causal link between PTEN deficient tumors and immunosuppressive tumor microenvironment?
The PTEN tumor suppressor is the second most commonly inactivated gene across cancer types. While it’s role in PI3K/AKT and DNA damage pathways are clear, increasing evidences suggest that PTEN may also promote a...Journal of Translational Medicine 2020 18:45Whole transcriptional analysis identifies markers of B, T and plasma cell signaling pathways in the mesenteric adipose tissue associated with Crohn’s disease
Crohn’s disease (CD) is a multifactorial disease characterized by chronic intestinal inflammation. The increased visceral adiposity near the affected intestinal area, of which mesenteric adipose tissue (MAT) i...Journal of Translational Medicine 2020 18:44Improved therapeutics of modified mesenchymal stem cells: an update
Mesenchymal stromal cells (MSCs) have attracted intense interest due to their powerful intrinsic properties of self-regeneration, immunomodulation and multi-potency, as well as being readily available and easy...Journal of Translational Medicine 2020 18:42Bioinformatics-based screening of key genes for transformation of liver cirrhosis to hepatocellular carcinoma
Hepatocellular carcinoma (HCC) is the most common type of liver tumour, and is closely related to liver cirrhosis. Previous studies have focussed on the pathogenesis of liver cirrhosis developing into HCC, but...Journal of Translational Medicine 2020 18:40Safety, tolerability and immunogenicity of V934/V935 hTERT vaccination in cancer patients with selected solid tumors: a phase I study
Human telomerase reverse transcriptase (hTERT) is an antigen that may represent a target for a novel anti-cancer strategy. A pilot, phase I study tested the safety and feasibility of a prime-boost immunization...Journal of Translational Medicine 2020 18:39Bioresorbable scaffold implantation in STEMI patients: 5 years imaging subanalysis of PRAGUE-19 study
Bioresorbable scaffold (BRS) Absorb™ clinical use has been stopped due to higher rate of device thrombosis. Scaffold struts persist longer than 2 years in the vessel wall. Second generation devices are being d...Journal of Translational Medicine 2020 18:33Lycopene and bone: an in vitro investigation and a pilot prospective clinical study
There are several effective therapies for osteoporosis but these agents might cause serious adverse events. Lycopene intake could prevent bone loss, however studies on its effects on bone are scarce. Our aim w...Journal of Translational Medicine 2020 18:43Establishment of the circadian metabolic phenotype strategy in spontaneously hypertensive rats: a dynamic metabolomics study
Circadian rhythms play a fundamental role in the progression of cardiovascular events. Almost all cardiovascular diseases have a circadian misalignment usually characterized by changes in metabolites. This stu...Journal of Translational Medicine 2020 18:38Role of IL-24 in the mucosal remodeling of children with coeliac disease
Recently, involvement of IL-19, IL-20 and IL-24 has been reported in inflammatory diseases associated with tissue remodeling. However, their impact on the pathomechanism of coeliac disease (CD) is still comple...Journal of Translational Medicine 2020 18:36Immunological effects of adjuvants in subsets of antigen presenting cells of cancer patients undergoing chemotherapy
We have previously shown that HCC patients and healthy subjects are equally responsive to a RNAdjuvant®, a novel TLR-7/8/RIG-I agonist based on noncoding RNA developed by CureVac, by an ex vivo evaluation. Howeve...Journal of Translational Medicine 2020 18:34Clinical application of exosomes and circulating microRNAs in the diagnosis of pregnancy complications and foetal abnormalities
During pregnancy in humans, the physiology of the mother and foetus are finely regulated by many factors. Inappropriate regulation can result in pregnancy disorders, such as complications and foetal abnormalit...Journal of Translational Medicine 2020 18:32Prostanoid receptor genes confer poor prognosis in head and neck squamous cell carcinoma via epigenetic inactivation
Chronic inflammation is a risk factor for head and neck squamous cell carcinoma (HNSCC) and other diseases. Prostanoid receptors are clearly involved in the development of many types of cancer. However, their ...Journal of Translational Medicine 2020 18:31Effects of probiotics on type II diabetes mellitus: a meta-analysis
The purpose of the present study was to evaluate the effectiveness of probiotics on type II diabetes mellitus (T2DM).Journal of Translational Medicine 2020 18:30Immune cell phenotyping in low blood volumes for assessment of cardiovascular disease risk, development, and progression: a pilot study
Cardiovascular disease (CVD) is the leading cause of death in the world. Given the role of immune cells in atherosclerosis development and progression, effective methods for characterizing immune cell populati...Journal of Translational Medicine 2020 18:29The capsaicin receptor TRPV1 is the first line defense protecting from acute non damaging heat: a translational approach
Pain is the vital sense preventing tissue damage by harmful noxious stimuli. The capsaicin receptor TRPV1 is activated by noxious temperatures, however, acute heat pain is only marginally affected in mice afte...Journal of Translational Medicine 2020 18:28Correction to: Crystal structure of PKG Iβ holoenzyme reveals a trans‑inhibiting dimer assembly
After publication of abstract S 2‑06 in supplement [1], it was brought to our attention that the second author’s name is spelled incorrectly. Originally the author name has been published as Rajesh Sarma. The ...Journal of Translational Medicine 2020 18:27The original article was published in Journal of Translational Medicine 2019 17:254Correction to: Systemic microvascular rarefaction is correlated with dysfunction of late endothelial progenitor cells in mild hypertension: a substudy of EXCAVATION-CHN1
Upon publication of the original article [1], it was noticed that Jun Tao’s affiliation information is not complete. The full affiliation information for Jun Tao can be found below and in the complete affiliat...Journal of Translational Medicine 2020 18:26The original article was published in Journal of Translational Medicine 2019 17:368Identification of a small mutation panel of coding sequences to predict the efficacy of immunotherapy for lung adenocarcinoma
Immune checkpoint inhibitors are effective in some cases of lung adenocarcinoma (LUAD). Whole-exome sequencing has revealed that the tumour mutation burden (TMB) is associated with clinical benefits among pati...Journal of Translational Medicine 2020 18:25Phase I and registry study of autologous bone marrow concentrate evaluated in PDE5 inhibitor refractory erectile dysfunction
Bone marrow mononuclear cells have been successfully utilized for numerous regenerative purposes. In the current study, patients suffering from erectile dysfunction (ED) unresponsive to phosphodiesterase 5 inh...Journal of Translational Medicine 2020 18:24IL-23 and PSMA-targeted duo-CAR T cells in Prostate Cancer Eradication in a preclinical model
Prostate cancer is one of the most common adult malignancies in men, and nearly all patients with metastatic prostate cancer can develop and receive resistance to primary androgen deprivation therapy (ADT), a ...Journal of Translational Medicine 2020 18:23Body image perception and body composition: assessment of perception inconsistency by a new index
A correct perception of the body image, as defined by comparison with actual anthropometric analyses, is crucial to ensure the best possible nutritional status of each individual. Bioimpedance analysis (BIA) r...Journal of Translational Medicine 2020 18:20Translational research of temporomandibular joint pathology: a preliminary biomarker and fMRI study
The temporomandibular joint (TMJ) is well innervated by braches of the trigeminal nerve. The temporomandibular joint disorders (TMD) can cause neural-inflammation in the peripheral nervous system (PNS) at the ...Journal of Translational Medicine 2020 18:22Transcriptome analysis defines myocardium gene signatures in children with ToF and ASD and reveals disease-specific molecular reprogramming in response to surgery with cardiopulmonary bypass
Tetralogy of Fallot (ToF) and Atrial Septal Defects (ASD) are the most common types of congenital heart diseases and a major cause of childhood morbidity and mortality. Cardiopulmonary bypass (CPB) is used dur...Journal of Translational Medicine 2020 18:21The potential therapeutic effects of the gut microbiome manipulation by synbiotic containing-Lactobacillus plantarum on neuropsychological performance of diabetic rats
The manipulation of gut microbiota as a target has been suggested to reduce the risks for a number of diseases such as type 2 diabetes mellitus (T2DM). Conversely, T2DM is associated with complications such as...Journal of Translational Medicine 2020 18:18Selenium-binding protein 1 transcriptionally activates p21 expression via p53-independent mechanism and its frequent reduction associates with poor prognosis in bladder cancer
Recent studies have shown that selenium-binding protein 1 (SELENBP1) is significantly down-regulated in a variety of solid tumors. Nevertheless, the clinical relevance of SELENBP1 in human bladder cancer has n...Journal of Translational Medicine 2020 18:17Cocaine and amphetamine-regulated transcript prepropeptide gene (CARTPT) polymorphism interacts with Diet Quality Index-International (DQI-I) and Healthy Eating Index (HEI) to affect hypothalamic hormones and cardio-metabolic risk factors among obese individuals
Epidemiologic studies show that cocaine- and amphetamine-regulated transcript prepropeptide (CARTPT) gene polymorphism modifies diet-obesity relationships. However, the interaction between CARTPT gene polymorp...Journal of Translational Medicine 2020 18:16Can prospective systematic reviews of animal studies improve clinical translation?
Systematic reviews are powerful tools with the potential to generate high quality evidence. Their application to animal studies has been instrumental in exposing the poor quality of these studies, as well as a...Journal of Translational Medicine 2020 18:15Perceptions of artificial intelligence in healthcare: findings from a qualitative survey study among actors in France
Artificial intelligence (AI), with its seemingly limitless power, holds the promise to truly revolutionize patient healthcare. However, the discourse carried out in public does not always correlate with the ac...Journal of Translational Medicine 2020 18:14Bevacizumab treatment of meningeal melanoma metastases
Melanoma patients with metastatic growth in the meninges have poor prognosis and few treatment options. Although treatment with BRAF inhibitors or immune checkpoint inhibitors has provided promising results, m...Journal of Translational Medicine 2020 18:13Exosomes overexpressing miR-34c inhibit malignant behavior and reverse the radioresistance of nasopharyngeal carcinoma
Malignant behavior and radioresistance, which severely limits the efficacy of radiation therapy (RT) in nasopharyngeal carcinoma (NPC), are associated with tumor progression and poor prognosis. Mesenchymal ste...Journal of Translational Medicine 2020 18:12Malignant transformation of oral leukoplakia is associated with macrophage polarization
Most oral squamous cell carcinomas (OSCC) occur on the basis of oral leukoplakias (OLP). The histologic degree of dysplasia is insufficient for the prediction of OLP malignant transformation. Immunologic param...Journal of Translational Medicine 2020 18:11Multi-omic serum biomarkers for prognosis of disease progression in prostate cancer
Predicting the clinical course of prostate cancer is challenging due to the wide biological spectrum of the disease. The objective of our study was to identify prostate cancer prognostic markers in patients ‘s...Journal of Translational Medicine 2020 18:10Phosphatidylcholine PC ae C44:6 in cerebrospinal fluid is a sensitive biomarker for bacterial meningitis
The timely diagnosis of bacterial meningitis is of utmost importance due to the need to institute antibiotic treatment as early as possible. Moreover, the differentiation from other causes of meningitis/enceph...Journal of Translational Medicine 2020 18:9Systematic review of randomized controlled trials for chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME)
Although medical requirements are urgent, no effective intervention has been proven for chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME). To facilitate the development of new therapeutics, we system...Journal of Translational Medicine 2020 18:7Assessing and measuring financial sustainability model of the Spanish HIV HGM BioBank
The Spanish HIV HGM BioBank is of great relevance for basic and clinical investigation, and for those groups trying to establish large networks focused on investigation on specific clinical problems. The colle...Journal of Translational Medicine 2020 18:6Reduced heart rate variability predicts fatigue severity in individuals with chronic fatigue syndrome/myalgic encephalomyelitis
Heart rate variability (HRV) is an objective, non-invasive tool to assessing autonomic dysfunction in chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME). People with CFS/ME tend to have lower HRV; how...Journal of Translational Medicine 2020 18:4
domingo, 9 de febrero de 2020
Journal of Translational Medicine | Articles
Journal of Translational Medicine | Articles
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