Involvement of supralemniscal nucleus (B9) 5-HT neuronal system in nociceptive processing: a fiber photometry study
Nociception is important perception that has harmful influence on daily life of humans. As to main pain management system, some descending pathways are called descending antinociceptive systems (DAS). As main ...Molecular Brain 2020 13:14Double deletion of the active zone proteins CAST/ELKS in the mouse forebrain causes high mortality of newborn pups
Presynaptic active zone cytomatrix proteins are essential elements of neurotransmitter release machinery that govern neural transmission. Among active zone proteins, cytomatrix at the active zone-associated st...Molecular Brain 2020 13:13TRPC1 mediates slow excitatory synaptic transmission in hippocampal oriens/alveus interneurons
Hippocampal GABAergic interneurons play key roles in regulating principal cell activity and plasticity. Interneurons located in stratum oriens/alveus (O/A INs) receive excitatory inputs from CA1 pyramidal cells a...Molecular Brain 2020 13:12Epitranscriptomic profiling of N6-methyladenosine-related RNA methylation in rat cerebral cortex following traumatic brain injury
N6-methyladenosine (m6A) is the most prevalent post-transcriptional modification of eukaryotic mRNA. It has been reported that there is a stimulus-dependent regulation of m6A in the mammalian central nervous s...Molecular Brain 2020 13:11Core transcriptional regulatory circuits in prion diseases
Complex diseases involve dynamic perturbations of pathophysiological processes during disease progression. Transcriptional programs underlying such perturbations are unknown in many diseases. Here, we present ...Molecular Brain 2020 13:10Immunogold labeling of synaptic vesicle proteins in developing hippocampal neurons
Synaptic vesicles (SV) contain high concentrations of specific proteins. How these proteins are transported from soma to synapses, and how they become concentrated at SV clusters at presynaptic terminals were ...Molecular Brain 2020 13:9ALS-linked TDP-43M337V knock-in mice exhibit splicing deregulation without neurodegeneration
Abnormal accumulation of TAR DNA-binding protein 43 (TDP-43), a DNA/RNA binding protein, is a pathological signature of amyotrophic lateral sclerosis (ALS). Missense mutations in the TARDBP gene are also found in...Molecular Brain 2020 13:8Pcdhβ deficiency affects hippocampal CA1 ensemble activity and contextual fear discrimination
Clustered protocadherins (Pcdhs), a large group of adhesion molecules, are important for axonal projections and dendritic spread, but little is known about how they influence neuronal activity. The Pcdhβ clust...Molecular Brain 2020 13:7Delayed expression of activity-dependent gating switch in synaptic AMPARs at a central synapse
Developing central synapses exhibit robust plasticity and undergo experience-dependent remodeling. Evidently, synapses in sensory systems such as auditory brainstem circuits mature rapidly to achieve high-fide...Molecular Brain 2020 13:6High-brightness anterograde transneuronal HSV1 H129 tracer modified using a Trojan horse-like strategy
Neurotropic viral transsynaptic tracing is an increasingly powerful technique for dissecting the structure and function of neural circuits. Herpes simplex virus type 1 strain H129 has been widely used as an an...Molecular Brain 2020 13:5Reduced chronic restraint stress in mice overexpressing hyperactive proteasomes in the forebrain
While chronic restraint stress (CRS) results in depression-like behaviors possibly through oxidative stress in the brain, its molecular etiology and the development of therapeutic strategies remain elusive. Si...Molecular Brain 2020 13:4A microRNA signature of toxic extrasynaptic N-methyl-D-aspartate (NMDA) receptor signaling
The cellular consequences of N-Methyl-D-Aspartate receptor (NMDAR) stimulation depend on the receptors’ subcellular localization. Synaptic NMDARs promote plasticity and survival whereas extrasynaptic NMDARs me...Molecular Brain 2020 13:3The small GTPase ARF6 regulates GABAergic synapse development
ADP ribosylation factors (ARFs) are a family of small GTPases composed of six members (ARF1–6) that control various cellular functions, including membrane trafficking and actin cytoskeletal rearrangement, in e...Molecular Brain 2020 13:2An RNAi screen for secreted factors and cell-surface players in coordinating neuron and glia development in Drosophila
The establishment of the functional nervous system requires coordinated development of neurons and glia in the embryo. Our understanding of underlying molecular and cellular mechanisms, however, remains limite...Molecular Brain 2020 13:1Transcriptional activation of USP16 gene expression by NFκB signaling
Ubiquitin Specific Peptidase 16 (USP16) has been reported to contribute to somatic stem-cell defects in Down syndrome. However, how this gene being regulated is largely unknown. To study the mechanism underlyingMolecular Brain 2019 12:120The acute transcriptome response of the midbrain/diencephalon to injury in the adult mummichog (Fundulus heteroclitus)
Adult fish produce new cells throughout their central nervous system during the course of their lives and maintain a tremendous capacity to repair damaged neural tissue. Much of the focus on understanding brai...Molecular Brain 2019 12:119Proteomic profiling of the neurons in mice with depressive-like behavior induced by corticosterone and the regulation of berberine: pivotal sites of oxidative phosphorylation
Chronic corticosterone (CORT) stress is an anxiety and depression inducing factor that involves the dysfunction of glucocorticoid receptor (GR), brain-derived neurotrophic factor (BDNF), and neuronal plasticit...Molecular Brain 2019 12:118TNF-α mediated upregulation of NaV1.7 currents in rat dorsal root ganglion neurons is independent of CRMP2 SUMOylation
Clinical and preclinical studies have shown that patients with Diabetic Neuropathy Pain (DNP) present with increased tumor necrosis factor alpha (TNF-α) serum concentration, whereas studies with diabetic anima...Molecular Brain 2019 12:117Plasma membrane localization of MLC1 regulates cellular morphology and motility
Megalencephalic leukoencephalopathy with subcortical cysts (MLC) is a rare form of infantile-onset leukodystrophy. The disorder is caused primarily by mutations of MLC1 that leads to a series of phenotypic outcom...Molecular Brain 2019 12:116Biological characteristics of transcription factor RelB in different immune cell types: implications for the treatment of multiple sclerosis
Transcription factor RelB is a member of the nuclear factror-kappa B (NF-κB) family, which plays a crucial role in mediating immune responses. Plenty of studies have demonstrated that RelB actively contributes...Molecular Brain 2019 12:115Anxiolytic effects of the flavonoid luteolin in a mouse model of acute colitis
Anxiety related disorders commonly occur in association with major depressive disorder (MDD) in individuals suffering from peripheral inflammation, with a higher prevalence among IBS patients. We have previous...Molecular Brain 2019 12:114Cell-specific expression of Epac2 in the subventricular and subgranular zones
cAMP signal transduction cascade activation is important in regulating neurogenesis in adult rodents by increasing the proliferation of newborn cells. Although the ventricular-subventricular zone (V-SVZ) and s...Molecular Brain 2019 12:113Excitotoxic glutamate causes neuronal insulin resistance by inhibiting insulin receptor/Akt/mTOR pathway
An impaired biological response to insulin in the brain, known as central insulin resistance, was identified during stroke and traumatic brain injury, for which glutamate excitotoxicity is a common pathogenic ...Molecular Brain 2019 12:112Moderate maternal separation mitigates the altered synaptic transmission and neuronal activation in amygdala by chronic stress in adult mice
Exposure to moderate level of stress during the perinatal period helps the organisms to cope well with stressful events in their later life, an effect known as stress inoculation. Amygdala is one of the kernel...Molecular Brain 2019 12:111Systematic analysis of expression signatures of neuronal subpopulations in the VTA
Gene expression profiling across various brain areas at the single-cell resolution enables the identification of molecular markers of neuronal subpopulations and comprehensive characterization of their functio...Molecular Brain 2019 12:110The atypical cadherin flamingo determines the competence of neurons for activity-dependent fine-scale topography
The topographic projection of afferent terminals into two-dimensional maps is essential for sensory systems to encode the locations of sensory stimuli. In vertebrates, guidance cues are critical for establishi...Molecular Brain 2019 12:109Expression of progenitor cell/immature neuron markers does not present definitive evidence for adult neurogenesis
It is agreed upon that adult hippocampal neurogenesis (AHN) occurs in the dentate gyrus (DG) in rodents. However, the existence of AHN in humans, particularly in elderly individuals, remains to be determined. ...Molecular Brain 2019 12:108Peripheral blood metabolome predicts mood change-related activity in mouse model of bipolar disorder
Bipolar disorder is a major mental illness characterized by severe swings in mood and activity levels which occur with variable amplitude and frequency. Attempts have been made to identify mood states and biol...Molecular Brain 2019 12:107Zinc transporters in Alzheimer’s disease
Alzheimer’s disease (AD) is the most devastating neurodegenerative disorder. Due to the increase in population and longevity, incidence will triple by the middle of the twenty-first century. So far, no treatme...Molecular Brain 2019 12:106Analgesic effects of optogenetic inhibition of basolateral amygdala inputs into the prefrontal cortex in nerve injured female mice
Peripheral nerve injury can lead to remodeling of brain circuits, and this can cause chronification of pain. We have recently reported that male mice subjected to spared injury of the sciatic nerve undergo cha...Molecular Brain 2019 12:105Restoring Wnt/β-catenin signaling is a promising therapeutic strategy for Alzheimer’s disease
Alzheimer’s disease (AD) is an aging-related neurological disorder characterized by synaptic loss and dementia. Wnt/β-catenin signaling is an essential signal transduction pathway that regulates numerous cellu...Molecular Brain 2019 12:104RT2 PCR array screening reveals distinct perturbations in DNA damage response signaling in FUS-associated motor neuron disease
Amyotrophic lateral sclerosis (ALS) is a degenerative motor neuron disease that has been linked to defective DNA repair. Many familial ALS patients harbor autosomal dominant mutations in the gene encoding the ...Molecular Brain 2019 12:103Silencing of microRNA-146a alleviates the neural damage in temporal lobe epilepsy by down-regulating Notch-1
This study aimed to evaluate the specific regulatory roles of microRNA-146a (miRNA-146a) in temporal lobe epilepsy (TLE) and explore the related regulatory mechanisms. A rat model of TLE was established by int...Molecular Brain 2019 12:102Matrix metalloproteinase 7 promoted Schwann cell migration and myelination after rat sciatic nerve injury
Schwann cells experience de-differentiation, proliferation, migration, re-differentiation and myelination, and participate in the repair and regeneration of injured peripheral nerves. Our previous sequencing a...Molecular Brain 2019 12:101Autophagic and endo-lysosomal dysfunction in neurodegenerative disease
Due to their post-mitotic state, metabolic demands and often large polarised morphology, the function and survival of neurons is dependent on an efficient cellular waste clearance system both for generation of...Molecular Brain 2019 12:100Identification of stress resilience module by weighted gene co-expression network analysis in Fkbp5-deficient mice
FKBP5 encodes the FK506 binding protein 5, a glucocorticoid receptor (GR) binding protein known to play an important role in the physiological stress response. However, results from previous studies examining the...Molecular Brain 2019 12:99Differential regulation of Cav2.2 channel exon 37 variants by alternatively spliced μ-opioid receptors
We have examined the regulation of mutually exclusive Cav2.2 exon 37a and b variants by the mouse μ-opioid receptor (mMOR) C-terminal splice variants 1, 1C and 1O in tsA-201 cells. Electrophysiological analyse...Molecular Brain 2019 12:98Postsynaptic density protein 95 (PSD-95) is transported by KIF5 to dendritic regions
Postsynaptic density protein 95 (PSD-95) is a pivotal postsynaptic scaffolding protein in excitatory neurons. Although the transport and regulation of PSD-95 in synaptic regions is well understood, dendritic t...Molecular Brain 2019 12:97The impact of RASopathy-associated mutations on CNS development in mice and humans
The RAS signaling pathway is involved in the regulation of developmental processes, including cell growth, proliferation, and differentiation, in the central nervous system (CNS). Germline mutations in the RAS...Molecular Brain 2019 12:96Autism-like behaviors in male mice with a Pcdh19 deletion
Mutations in protocadherin 19 (PCDH19), which is on the X-chromosome, cause the brain disease Epilepsy in Females with Mental Retardation (EFMR). EFMR is also often associated with autism-like symptoms. In mice a...Molecular Brain 2019 12:95Behavioral analysis in mice deficient for GAREM2 (Grb2-associated regulator of Erk/MAPK subtype2) that is a subtype of highly expressing in the brain
Grb2-associated regulator of Erk/MAPK (GAREM), is an adaptor protein related to the several cell growth factor receptor-signaling. The GAREM family has two subtypes, GAREM1 and GAREM2, both encoded in the huma...Molecular Brain 2019 12:94Phosphorylation sites of microtubule-associated protein 1B (MAP 1B) are involved in axon growth and regeneration
The growth cone is a specialized structure that forms at the tip of extending axons in developing and regenerating neurons. This structure is essential for accurate synaptogenesis at developmental stages, and ...Molecular Brain 2019 12:93Pathophysiology of and therapeutic options for a GABRA1 variant linked to epileptic encephalopathy
We report the identification of a de novo GABRA1 (R214C) variant in a child with epileptic encephalopathy (EE), describe its functional characterization and pathophysiology, and evaluate its potential therapeutic...Molecular Brain 2019 12:92Dysregulation of neuron differentiation in an autistic savant with exceptional memory
Autism spectrum disorder (ASD) is a heterogeneous group of complex neurodevelopmental disorders without a unique or definite underlying pathogenesis. Although savant syndrome is common in ASD, few models are a...Molecular Brain 2019 12:91Novel nose poke-based temporal discrimination tasks with concurrent in vivo calcium imaging in freely moving mice
The hippocampus has been known to process temporal information as part of memory formation. While time cells have been observed in the hippocampus and medial entorhinal cortex, a number of the behavioral tasks...Molecular Brain 2019 12:90Peripheral nerve injury-induced alterations in VTA neuron firing properties
The ventral tegmental area (VTA) is one of the main brain regions harboring dopaminergic (DA) neurons, and plays important roles in reinforcement and motivation. Recent studies have indicated that DA neurons n...Molecular Brain 2019 12:89Hyperpolarized [1-13C]lactate flux increased in the hippocampal region in diabetic mice
Increasing evidence suggests there is a relationship between cognitive impairment and metabolic dysfunction. Diabetes is a chronic disease, and metabolic factors affecting brain metabolisms, such as serum gluc...Molecular Brain 2019 12:88
domingo, 9 de febrero de 2020
Molecular Brain | Articles
Molecular Brain | Articles
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