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Mysterious factors in the blood are known to trigger aging in the brain. Though researchers have yet to discover the identities of all these aging agents, they have pegged a protein that lets them do their dirty work. On May 13 in Nature Medicine, researchers led by Tony Wyss-Coray at Stanford University in Palo Alto, California, reported that vascular adhesion molecule 1 (VCAM1) expression on the endothelial cells that line the blood-brain barrier is required for systemic factors to accelerate aging in the mouse brain. Blocking VCAM1 not only countered classic signs of brain aging such as microglial activation and waning neurogenesis, it also bestowed old mice with the memory of murine whippersnappers.
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