Plasticity Hums With Protein Synthesis on Both Sides of Synapse
17 May 2019
Scientists know that synaptic plasticity requires local protein production from translation of mRNAs in postsynaptic dendrites. However, local synthesis had not been clearly demonstrated on the other, presynaptic side in mature axons. A new study claims that on-the-spot translation on both sides of the synapse fine-tunes the synaptic proteome, and contributes to synaptic plasticity. In the May 17 Science, Erin Schuman, Max Planck Institute for Brain Research, Frankfurt, Germany, and colleagues publish evidence of ongoing, active protein synthesis in both pre- and postsynaptic compartments of neurons from mouse brain. Different types of synaptic plasticity stimulated protein synthesis on one or both sides of the synapse, and did so in distinct ways.
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