DNA methylation markers for endometrial cancer detection in minimally invasive samples: a systematic review - PubMed

DNA methylation markers for endometrial cancer detection in minimally invasive samples: a systematic review - PubMed

DNA methylation markers for endometrial cancer detection in minimally invasive samples: a systematic review

Rianne van den Helder 1 2, Birgit Mm Wever 1, Jip A van Trommel 1, Johannes Cf Ket 3, Maaike Cg Bleeker 1, Renske Dm Steenbergen 1, Nienke E van Trommel 2

Affiliations 

• PMID: 32938224
 
• DOI: 10.2217/epi-2020-0164

Abstract

Aim: DNA methylation testing for endometrial cancer detection in minimally invasive specimens is a promising tool to improve screening and diagnostic procedures. Available literature was systematically reviewed to assess the potential of this approach and define methylation markers deserving further development. Methods: A systematic search up to March 31 2020 was conducted according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. Results: 15 methylation markers with an area under the curve value of ≥ 0.80 for endometrial cancer detection in cytological specimens were selected from nine studies. Conclusion: Detection of methylation markers in cytological samples indicate the feasibility of minimally invasive testing methods, potentially guiding diagnosis and detection of endometrial cancer in high-risk women and in cancer screening programs.

Keywords: DNA methylation; biomarkers; cancer detection; endometrial cancer; minimally invasive.

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