Acupuncture (PDQ®)–Health Professional Version
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References
- Xia YQ, Zhang D, Yang CX, et al.: An approach to the effect on tumors of acupuncture in combination with radiotherapy or chemotherapy. J Tradit Chin Med 6 (1): 23-6, 1986. [PUBMED Abstract]
- Zhou RX, Huang FL, Jiang SR, et al.: The effect of acupuncture on the phagocytic activity of human leukocytes. J Tradit Chin Med 8 (2): 83-4, 1988. [PUBMED Abstract]
- He CJ, Gong KH, Xu QZ, et al.: Effects of microwave acupuncture on the immunological function of cancer patients. J Tradit Chin Med 7 (1): 9-11, 1987. [PUBMED Abstract]
- Wu B, Zhou RX, Zhou MS: [Effect of acupuncture on interleukin-2 level and NK cell immunoactivity of peripheral blood of malignant tumor patients] Zhongguo Zhong Xi Yi Jie He Za Zhi 14 (9): 537-9, 1994. [PUBMED Abstract]
- Wu B, Zhou RX, Zhou MS: [Effect of acupuncture on immunomodulation in patients with malignant tumors] Zhongguo Zhong Xi Yi Jie He Za Zhi 16 (3): 139-41, 1996. [PUBMED Abstract]
- Wei Z: Clinical observation on therapeutic effect of acupuncture at zusanli for leukopenia. J Tradit Chin Med 18 (2): 94-5, 1998. [PUBMED Abstract]
- Ye F, Chen S, Liu W: Effects of electro-acupuncture on immune function after chemotherapy in 28 cases. J Tradit Chin Med 22 (1): 21-3, 2002. [PUBMED Abstract]
- Niemtzow RC: Integration of complementary disciplines into the oncology clinic. Part I. Acupuncture. Curr Probl Cancer 24 (4): 184-93, 2000 Jul-Aug. [PUBMED Abstract]
- Dang W, Yang J: Clinical study on acupuncture treatment of stomach carcinoma pain. J Tradit Chin Med 18 (1): 31-8, 1998. [PUBMED Abstract]
- Alimi D, Rubino C, Leandri EP, et al.: Analgesic effects of auricular acupuncture for cancer pain. J Pain Symptom Manage 19 (2): 81-2, 2000. [PUBMED Abstract]
- Filshie J, Redman D: Acupuncture and malignant pain problems. Eur J Surg Oncol 11 (4): 389-94, 1985. [PUBMED Abstract]
- Wen HL: Cancer pain treated with acupuncture and electrical stimulation. Mod Med Asia 13 (2): 12-6, 1977.
- Alimi D, Rubino C, Pichard-Léandri E, et al.: Analgesic effect of auricular acupuncture for cancer pain: a randomized, blinded, controlled trial. J Clin Oncol 21 (22): 4120-6, 2003. [PUBMED Abstract]
- Paley CA, Johnson MI, Tashani OA, et al.: Acupuncture for cancer pain in adults. Cochrane Database Syst Rev (10): CD007753, 2015. [PUBMED Abstract]
- Hu C, Zhang H, Wu W, et al.: Acupuncture for Pain Management in Cancer: A Systematic Review and Meta-Analysis. Evid Based Complement Alternat Med 2016: 1720239, 2016. [PUBMED Abstract]
- Deng G, Rusch V, Vickers A, et al.: Randomized controlled trial of a special acupuncture technique for pain after thoracotomy. J Thorac Cardiovasc Surg 136 (6): 1464-9, 2008. [PUBMED Abstract]
- Wong RH, Lee TW, Sihoe AD, et al.: Analgesic effect of electroacupuncture in postthoracotomy pain: a prospective randomized trial. Ann Thorac Surg 81 (6): 2031-6, 2006. [PUBMED Abstract]
- Mehling WE, Jacobs B, Acree M, et al.: Symptom management with massage and acupuncture in postoperative cancer patients: a randomized controlled trial. J Pain Symptom Manage 33 (3): 258-66, 2007. [PUBMED Abstract]
- Pfister DG, Cassileth BR, Deng GE, et al.: Acupuncture for pain and dysfunction after neck dissection: results of a randomized controlled trial. J Clin Oncol 28 (15): 2565-70, 2010. [PUBMED Abstract]
- He JP, Friedrich M, Ertan AK, et al.: Pain-relief and movement improvement by acupuncture after ablation and axillary lymphadenectomy in patients with mammary cancer. Clin Exp Obstet Gynecol 26 (2): 81-4, 1999. [PUBMED Abstract]
- Bao T, Ye X, Skinner J, et al.: The analgesic effect of magnetic acupressure in cancer patients undergoing bone marrow aspiration and biopsy: a randomized, blinded, controlled trial. J Pain Symptom Manage 41 (6): 995-1002, 2011. [PUBMED Abstract]
- Sharifi Rizi M, Shamsalinia A, Ghaffari F, et al.: The effect of acupressure on pain, anxiety, and the physiological indexes of patients with cancer undergoing bone marrow biopsy. Complement Ther Clin Pract 29: 136-141, 2017. [PUBMED Abstract]
- Vickers AJ, Cronin AM, Maschino AC, et al.: Acupuncture for chronic pain: individual patient data meta-analysis. Arch Intern Med 172 (19): 1444-53, 2012. [PUBMED Abstract]
- Chien TJ, Liu CY, Chang YF, et al.: Acupuncture for treating aromatase inhibitor-related arthralgia in breast cancer: a systematic review and meta-analysis. J Altern Complement Med 21 (5): 251-60, 2015. [PUBMED Abstract]
- Bae K, Yoo HS, Lamoury G, et al.: Acupuncture for Aromatase Inhibitor-Induced Arthralgia: A Systematic Review. Integr Cancer Ther 14 (6): 496-502, 2015. [PUBMED Abstract]
- Chen L, Lin CC, Huang TW, et al.: Effect of acupuncture on aromatase inhibitor-induced arthralgia in patients with breast cancer: A meta-analysis of randomized controlled trials. Breast 33: 132-138, 2017. [PUBMED Abstract]
- Crew KD, Capodice JL, Greenlee H, et al.: Randomized, blinded, sham-controlled trial of acupuncture for the management of aromatase inhibitor-associated joint symptoms in women with early-stage breast cancer. J Clin Oncol 28 (7): 1154-60, 2010. [PUBMED Abstract]
- Bao T, Cai L, Giles JT, et al.: A dual-center randomized controlled double blind trial assessing the effect of acupuncture in reducing musculoskeletal symptoms in breast cancer patients taking aromatase inhibitors. Breast Cancer Res Treat 138 (1): 167-74, 2013. [PUBMED Abstract]
- Oh B, Kimble B, Costa DS, et al.: Acupuncture for treatment of arthralgia secondary to aromatase inhibitor therapy in women with early breast cancer: pilot study. Acupunct Med 31 (3): 264-71, 2013. [PUBMED Abstract]
- Mao JJ, Xie SX, Farrar JT, et al.: A randomised trial of electro-acupuncture for arthralgia related to aromatase inhibitor use. Eur J Cancer 50 (2): 267-76, 2014. [PUBMED Abstract]
- Hershman DL, Unger JM, Greenlee H, et al.: Effect of Acupuncture vs Sham Acupuncture or Waitlist Control on Joint Pain Related to Aromatase Inhibitors Among Women With Early-Stage Breast Cancer: A Randomized Clinical Trial. JAMA 320 (2): 167-176, 2018. [PUBMED Abstract]
- Garcia MK, McQuade J, Haddad R, et al.: Systematic review of acupuncture in cancer care: a synthesis of the evidence. J Clin Oncol 31 (7): 952-60, 2013. [PUBMED Abstract]
- Ezzo J, Vickers A, Richardson MA, et al.: Acupuncture-point stimulation for chemotherapy-induced nausea and vomiting. J Clin Oncol 23 (28): 7188-98, 2005. [PUBMED Abstract]
- Dundee JW, Ghaly RG, Fitzpatrick KT, et al.: Acupuncture to prevent cisplatin-associated vomiting. Lancet 1 (8541): 1083, 1987. [PUBMED Abstract]
- Roscoe JA, Morrow GR, Hickok JT, et al.: The efficacy of acupressure and acustimulation wrist bands for the relief of chemotherapy-induced nausea and vomiting. A University of Rochester Cancer Center Community Clinical Oncology Program multicenter study. J Pain Symptom Manage 26 (2): 731-42, 2003. [PUBMED Abstract]
- Vickers AJ: Can acupuncture have specific effects on health? A systematic review of acupuncture antiemesis trials. J R Soc Med 89 (6): 303-11, 1996. [PUBMED Abstract]
- Lee A, Done ML: The use of nonpharmacologic techniques to prevent postoperative nausea and vomiting: a meta-analysis. Anesth Analg 88 (6): 1362-9, 1999. [PUBMED Abstract]
- Park J, Linde K, Manheimer E, et al.: The status and future of acupuncture clinical research. J Altern Complement Med 14 (7): 871-81, 2008. [PUBMED Abstract]
- Ezzo J, Streitberger K, Schneider A: Cochrane systematic reviews examine P6 acupuncture-point stimulation for nausea and vomiting. J Altern Complement Med 12 (5): 489-95, 2006. [PUBMED Abstract]
- Ezzo JM, Richardson MA, Vickers A, et al.: Acupuncture-point stimulation for chemotherapy-induced nausea or vomiting. Cochrane Database Syst Rev (2): CD002285, 2006. [PUBMED Abstract]
- NIH Consensus Conference. Acupuncture. JAMA 280 (17): 1518-24, 1998. [PUBMED Abstract]
- Dundee JW, Ghaly RG, Fitzpatrick KT, et al.: Acupuncture prophylaxis of cancer chemotherapy-induced sickness. J R Soc Med 82 (5): 268-71, 1989. [PUBMED Abstract]
- Dundee JW, McMillan CM: Clinical uses of P6 acupuncture antiemesis. Acupunct Electrother Res 15 (3-4): 211-5, 1990. [PUBMED Abstract]
- Dundee JW, Yang J, McMillan C: Non-invasive stimulation of the P6 (Neiguan) antiemetic acupuncture point in cancer chemotherapy. J R Soc Med 84 (4): 210-2, 1991. [PUBMED Abstract]
- McMillan C, Dundee JW, Abram WP: Enhancement of the antiemetic action of ondansetron by transcutaneous electrical stimulation of the P6 antiemetic point, in patients having highly emetic cytotoxic drugs. Br J Cancer 64 (5): 971-2, 1991. [PUBMED Abstract]
- Shen Y, Liu L, Chiang JS, et al.: Randomized, placebo-controlled trial of K1 acupoint acustimulation to prevent cisplatin-induced or oxaliplatin-induced nausea. Cancer 121 (1): 84-92, 2015. [PUBMED Abstract]
- Xie J, Chen LH, Ning ZY, et al.: Effect of transcutaneous electrical acupoint stimulation combined with palonosetron on chemotherapy-induced nausea and vomiting: a single-blind, randomized, controlled trial. Chin J Cancer 36 (1): 6, 2017. [PUBMED Abstract]
- Eghbali M, Yekaninejad MS, Varaei S, et al.: The effect of auricular acupressure on nausea and vomiting caused by chemotherapy among breast cancer patients. Complement Ther Clin Pract 24: 189-94, 2016. [PUBMED Abstract]
- Dupuis LL, Kelly KM, Krischer JP, et al.: Acupressure bands do not improve chemotherapy-induced nausea control in pediatric patients receiving highly emetogenic chemotherapy: A single-blinded, randomized controlled trial. Cancer 124 (6): 1188-1196, 2018. [PUBMED Abstract]
- Enblom A, Lekander M, Hammar M, et al.: Getting the grip on nonspecific treatment effects: emesis in patients randomized to acupuncture or sham compared to patients receiving standard care. PLoS One 6 (3): e14766, 2011. [PUBMED Abstract]
- Shen J, Wenger N, Glaspy J, et al.: Electroacupuncture for control of myeloablative chemotherapy-induced emesis: A randomized controlled trial. JAMA 284 (21): 2755-61, 2000. [PUBMED Abstract]
- Streitberger K, Friedrich-Rust M, Bardenheuer H, et al.: Effect of acupuncture compared with placebo-acupuncture at P6 as additional antiemetic prophylaxis in high-dose chemotherapy and autologous peripheral blood stem cell transplantation: a randomized controlled single-blind trial. Clin Cancer Res 9 (7): 2538-44, 2003. [PUBMED Abstract]
- You Q, Yu H, Wu D, et al.: Vitamin B6 points PC6 injection during acupuncture can relieve nausea and vomiting in patients with ovarian cancer. Int J Gynecol Cancer 19 (4): 567-71, 2009. [PUBMED Abstract]
- Price H, Lewith G, Williams C: Acupressure as an antiemetic in cancer chemotherapy. Complementary Medical Research 5 (2): 93-4, 1991.
- Molassiotis A, Helin AM, Dabbour R, et al.: The effects of P6 acupressure in the prophylaxis of chemotherapy-related nausea and vomiting in breast cancer patients. Complement Ther Med 15 (1): 3-12, 2007. [PUBMED Abstract]
- Dibble SL, Luce J, Cooper BA, et al.: Acupressure for chemotherapy-induced nausea and vomiting: a randomized clinical trial. Oncol Nurs Forum 34 (4): 813-20, 2007. [PUBMED Abstract]
- Deng G, Vickers A, Yeung S, et al.: Randomized, controlled trial of acupuncture for the treatment of hot flashes in breast cancer patients. J Clin Oncol 25 (35): 5584-90, 2007. [PUBMED Abstract]
- Porzio G, Trapasso T, Martelli S, et al.: Acupuncture in the treatment of menopause-related symptoms in women taking tamoxifen. Tumori 88 (2): 128-30, 2002 Mar-Apr. [PUBMED Abstract]
- Walker EM, Rodriguez AI, Kohn B, et al.: Acupuncture versus venlafaxine for the management of vasomotor symptoms in patients with hormone receptor-positive breast cancer: a randomized controlled trial. J Clin Oncol 28 (4): 634-40, 2010. [PUBMED Abstract]
- Beer TM, Benavides M, Emmons SL, et al.: Acupuncture for hot flashes in patients with prostate cancer. Urology 76 (5): 1182-8, 2010. [PUBMED Abstract]
- Nedstrand E, Wyon Y, Hammar M, et al.: Psychological well-being improves in women with breast cancer after treatment with applied relaxation or electro-acupuncture for vasomotor symptom. J Psychosom Obstet Gynaecol 27 (4): 193-9, 2006. [PUBMED Abstract]
- Frisk J, Spetz AC, Hjertberg H, et al.: Two modes of acupuncture as a treatment for hot flushes in men with prostate cancer--a prospective multicenter study with long-term follow-up. Eur Urol 55 (1): 156-63, 2009. [PUBMED Abstract]
- Ashamalla H, Jiang ML, Guirguis A, et al.: Acupuncture for the alleviation of hot flashes in men treated with androgen ablation therapy. Int J Radiat Oncol Biol Phys 79 (5): 1358-63, 2011. [PUBMED Abstract]
- Hervik J, Mjåland O: Acupuncture for the treatment of hot flashes in breast cancer patients, a randomized, controlled trial. Breast Cancer Res Treat 116 (2): 311-6, 2009. [PUBMED Abstract]
- Frisk J, Carlhäll S, Källström AC, et al.: Long-term follow-up of acupuncture and hormone therapy on hot flushes in women with breast cancer: a prospective, randomized, controlled multicenter trial. Climacteric 11 (2): 166-74, 2008. [PUBMED Abstract]
- Bokmand S, Flyger H: Acupuncture relieves menopausal discomfort in breast cancer patients: a prospective, double blinded, randomized study. Breast 22 (3): 320-3, 2013. [PUBMED Abstract]
- Bao T, Cai L, Snyder C, et al.: Patient-reported outcomes in women with breast cancer enrolled in a dual-center, double-blind, randomized controlled trial assessing the effect of acupuncture in reducing aromatase inhibitor-induced musculoskeletal symptoms. Cancer 120 (3): 381-9, 2014. [PUBMED Abstract]
- Garcia MK, Graham-Getty L, Haddad R, et al.: Systematic review of acupuncture to control hot flashes in cancer patients. Cancer 121 (22): 3948-58, 2015. [PUBMED Abstract]
- Salehi A, Marzban M, Zadeh AR: Acupuncture for treating hot flashes in breast cancer patients: an updated meta-analysis. Support Care Cancer 24 (12): 4895-4899, 2016. [PUBMED Abstract]
- Chen YP, Liu T, Peng YY, et al.: Acupuncture for hot flashes in women with breast cancer: A systematic review. J Cancer Res Ther 12 (2): 535-42, 2016 Apr-Jun. [PUBMED Abstract]
- Mao JJ, Bowman MA, Xie SX, et al.: Electroacupuncture Versus Gabapentin for Hot Flashes Among Breast Cancer Survivors: A Randomized Placebo-Controlled Trial. J Clin Oncol 33 (31): 3615-20, 2015. [PUBMED Abstract]
- Lesi G, Razzini G, Musti MA, et al.: Acupuncture As an Integrative Approach for the Treatment of Hot Flashes in Women With Breast Cancer: A Prospective Multicenter Randomized Controlled Trial (AcCliMaT). J Clin Oncol 34 (15): 1795-802, 2016. [PUBMED Abstract]
- Molassiotis A, Sylt P, Diggins H: The management of cancer-related fatigue after chemotherapy with acupuncture and acupressure: a randomised controlled trial. Complement Ther Med 15 (4): 228-37, 2007. [PUBMED Abstract]
- Cheng CS, Chen LY, Ning ZY, et al.: Acupuncture for cancer-related fatigue in lung cancer patients: a randomized, double blind, placebo-controlled pilot trial. Support Care Cancer 25 (12): 3807-3814, 2017. [PUBMED Abstract]
- Molassiotis A, Bardy J, Finnegan-John J, et al.: Acupuncture for cancer-related fatigue in patients with breast cancer: a pragmatic randomized controlled trial. J Clin Oncol 30 (36): 4470-6, 2012. [PUBMED Abstract]
- Molassiotis A, Bardy J, Finnegan-John J, et al.: A randomized, controlled trial of acupuncture self-needling as maintenance therapy for cancer-related fatigue after therapist-delivered acupuncture. Ann Oncol 24 (6): 1645-52, 2013. [PUBMED Abstract]
- Wells S, Trower C, Hough TA, et al.: Urethral obstruction by seminal coagulum is associated with medetomidine-ketamine anesthesia in male mice on C57BL/6J and mixed genetic backgrounds. J Am Assoc Lab Anim Sci 48 (3): 296-9, 2009. [PUBMED Abstract]
- Deng G, Chan Y, Sjoberg D, et al.: Acupuncture for the treatment of post-chemotherapy chronic fatigue: a randomized, blinded, sham-controlled trial. Support Care Cancer 21 (6): 1735-41, 2013. [PUBMED Abstract]
- Mao JJ, Farrar JT, Bruner D, et al.: Electroacupuncture for fatigue, sleep, and psychological distress in breast cancer patients with aromatase inhibitor-related arthralgia: a randomized trial. Cancer 120 (23): 3744-51, 2014. [PUBMED Abstract]
- Smith C, Carmady B, Thornton C, et al.: The effect of acupuncture on post-cancer fatigue and well-being for women recovering from breast cancer: a pilot randomised controlled trial. Acupunct Med 31 (1): 9-15, 2013. [PUBMED Abstract]
- Mao H, Mao JJ, Guo M, et al.: Effects of infrared laser moxibustion on cancer-related fatigue: A randomized, double-blind, placebo-controlled trial. Cancer 122 (23): 3667-3672, 2016. [PUBMED Abstract]
- Johnston MF, Hays RD, Subramanian SK, et al.: Patient education integrated with acupuncture for relief of cancer-related fatigue randomized controlled feasibility study. BMC Complement Altern Med 11: 49, 2011. [PUBMED Abstract]
- Balk J, Day R, Rosenzweig M, et al.: Pilot, randomized, modified, double-blind, placebo-controlled trial of acupuncture for cancer-related fatigue. J Soc Integr Oncol 7 (1): 4-11, 2009. [PUBMED Abstract]
- Meng Z, Garcia MK, Hu C, et al.: Randomized controlled trial of acupuncture for prevention of radiation-induced xerostomia among patients with nasopharyngeal carcinoma. Cancer 118 (13): 3337-44, 2012. [PUBMED Abstract]
- Braga FP, Lemos Junior CA, Alves FA, et al.: Acupuncture for the prevention of radiation-induced xerostomia in patients with head and neck cancer. Braz Oral Res 25 (2): 180-5, 2011 Mar-Apr. [PUBMED Abstract]
- Simcock R, Fallowfield L, Monson K, et al.: ARIX: a randomised trial of acupuncture v oral care sessions in patients with chronic xerostomia following treatment of head and neck cancer. Ann Oncol 24 (3): 776-83, 2013. [PUBMED Abstract]
- Blom M, Dawidson I, Fernberg JO, et al.: Acupuncture treatment of patients with radiation-induced xerostomia. Eur J Cancer B Oral Oncol 32B (3): 182-90, 1996. [PUBMED Abstract]
- Cho JH, Chung WK, Kang W, et al.: Manual acupuncture improved quality of life in cancer patients with radiation-induced xerostomia. J Altern Complement Med 14 (5): 523-6, 2008. [PUBMED Abstract]
- Meng Z, Kay Garcia M, Hu C, et al.: Sham-controlled, randomised, feasibility trial of acupuncture for prevention of radiation-induced xerostomia among patients with nasopharyngeal carcinoma. Eur J Cancer 48 (11): 1692-9, 2012. [PUBMED Abstract]
- Blom M, Lundeberg T: Long-term follow-up of patients treated with acupuncture for xerostomia and the influence of additional treatment. Oral Dis 6 (1): 15-24, 2000. [PUBMED Abstract]
- Hershman DL, Lacchetti C, Dworkin RH, et al.: Prevention and management of chemotherapy-induced peripheral neuropathy in survivors of adult cancers: American Society of Clinical Oncology clinical practice guideline. J Clin Oncol 32 (18): 1941-67, 2014. [PUBMED Abstract]
- Pachman DR, Barton DL, Watson JC, et al.: Chemotherapy-induced peripheral neuropathy: prevention and treatment. Clin Pharmacol Ther 90 (3): 377-87, 2011. [PUBMED Abstract]
- Mols F, Beijers T, Lemmens V, et al.: Chemotherapy-induced neuropathy and its association with quality of life among 2- to 11-year colorectal cancer survivors: results from the population-based PROFILES registry. J Clin Oncol 31 (21): 2699-707, 2013. [PUBMED Abstract]
- Wong R, Sagar S: Acupuncture treatment for chemotherapy-induced peripheral neuropathy--a case series. Acupunct Med 24 (2): 87-91, 2006. [PUBMED Abstract]
- Schroeder S, Meyer-Hamme G, Epplée S: Acupuncture for chemotherapy-induced peripheral neuropathy (CIPN): a pilot study using neurography. Acupunct Med 30 (1): 4-7, 2012. [PUBMED Abstract]
- Rostock M, Jaroslawski K, Guethlin C, et al.: Chemotherapy-induced peripheral neuropathy in cancer patients: a four-arm randomized trial on the effectiveness of electroacupuncture. Evid Based Complement Alternat Med 2013: 349653, 2013. [PUBMED Abstract]
- Bao T, Seidman AD, Piulson L, et al.: A phase IIA trial of acupuncture to reduce chemotherapy-induced peripheral neuropathy severity during neoadjuvant or adjuvant weekly paclitaxel chemotherapy in breast cancer patients. Eur J Cancer 101: 12-19, 2018. [PUBMED Abstract]
- Bao T, Goloubeva O, Pelser C, et al.: A pilot study of acupuncture in treating bortezomib-induced peripheral neuropathy in patients with multiple myeloma. Integr Cancer Ther 13 (5): 396-404, 2014. [PUBMED Abstract]
- Garcia MK, Cohen L, Guo Y, et al.: Electroacupuncture for thalidomide/bortezomib-induced peripheral neuropathy in multiple myeloma: a feasibility study. J Hematol Oncol 7: 41, 2014. [PUBMED Abstract]
- Han X, Wang L, Shi H, et al.: Acupuncture combined with methylcobalamin for the treatment of chemotherapy-induced peripheral neuropathy in patients with multiple myeloma. BMC Cancer 17 (1): 40, 2017. [PUBMED Abstract]
- Kanakura Y, Niwa K, Kometani K, et al.: Effectiveness of acupuncture and moxibustion treatment for lymphedema following intrapelvic lymph node dissection: a preliminary report. Am J Chin Med 30 (1): 37-43, 2002. [PUBMED Abstract]
- Alem M, Gurgel MS: Acupuncture in the rehabilitation of women after breast cancer surgery--a case series. Acupunct Med 26 (2): 87-93, 2008. [PUBMED Abstract]
- Cassileth BR, Van Zee KJ, Chan Y, et al.: A safety and efficacy pilot study of acupuncture for the treatment of chronic lymphoedema. Acupunct Med 29 (3): 170-2, 2011. [PUBMED Abstract]
- Cassileth BR, Van Zee KJ, Yeung KS, et al.: Acupuncture in the treatment of upper-limb lymphedema: results of a pilot study. Cancer 119 (13): 2455-61, 2013. [PUBMED Abstract]
- de Valois B, Asprey A, Young T: "The Monkey on Your Shoulder": A Qualitative Study of Lymphoedema Patients' Attitudes to and Experiences of Acupuncture and Moxibustion. Evid Based Complement Alternat Med 2016: 4298420, 2016. [PUBMED Abstract]
- Smith CA, Pirotta M, Kilbreath S: A feasibility study to examine the role of acupuncture to reduce symptoms of lymphoedema after breast cancer: a randomised controlled trial. Acupunct Med 32 (5): 387-93, 2014. [PUBMED Abstract]
- Yao C, Xu Y, Chen L, et al.: Effects of warm acupuncture on breast cancer-related chronic lymphedema: a randomized controlled trial. Curr Oncol 23 (1): e27-34, 2016. [PUBMED Abstract]
- Bao T, Iris Zhi W, Vertosick EA, et al.: Acupuncture for breast cancer-related lymphedema: a randomized controlled trial. Breast Cancer Res Treat 170 (1): 77-87, 2018. [PUBMED Abstract]
- Meng ZQ, Garcia MK, Chiang JS, et al.: Electro-acupuncture to prevent prolonged postoperative ileus: a randomized clinical trial. World J Gastroenterol 16 (1): 104-11, 2010. [PUBMED Abstract]
- Deng G, Wong WD, Guillem J, et al.: A phase II, randomized, controlled trial of acupuncture for reduction of Postcolectomy Ileus. Ann Surg Oncol 20 (4): 1164-9, 2013. [PUBMED Abstract]
- Ng SS, Leung WW, Mak TW, et al.: Electroacupuncture reduces duration of postoperative ileus after laparoscopic surgery for colorectal cancer. Gastroenterology 144 (2): 307-313.e1, 2013. [PUBMED Abstract]
- Liu YH, Dong GT, Ye Y, et al.: Effectiveness of Acupuncture for Early Recovery of Bowel Function in Cancer: A Systematic Review and Meta-Analysis. Evid Based Complement Alternat Med 2017: 2504021, 2017. [PUBMED Abstract]
- Feng Y, Wang XY, Li SD, et al.: Clinical research of acupuncture on malignant tumor patients for improving depression and sleep quality. J Tradit Chin Med 31 (3): 199-202, 2011. [PUBMED Abstract]
- Deng G, Giralt S, Chung DJ, et al.: Acupuncture for reduction of symptom burden in multiple myeloma patients undergoing autologous hematopoietic stem cell transplantation: a randomized sham-controlled trial. Support Care Cancer 26 (2): 657-665, 2018. [PUBMED Abstract]
- Johnstone PA, Polston GR, Niemtzow RC, et al.: Integration of acupuncture into the oncology clinic. Palliat Med 16 (3): 235-9, 2002. [PUBMED Abstract]
- Zhang ZH: Effect of acupuncture on 44 cases of radiation rectitis following radiation therapy for carcinoma of the cervix uteri. J Tradit Chin Med 7 (2): 139-40, 1987. [PUBMED Abstract]
- Yao W: Prof. Sheng Canruo's experience in acupuncture treatment of throat diseases with yan si xue. J Tradit Chin Med 20 (2): 122-5, 2000. [PUBMED Abstract]
- Feng RZ: Relief of oesophageal carcinomatous obstruction by acupuncture. J Tradit Chin Med 4 (1): 3-4, 1984. [PUBMED Abstract]
- Ge AX, Ryan ME, Giaccone G, et al.: Acupuncture treatment for persistent hiccups in patients with cancer. J Altern Complement Med 16 (7): 811-6, 2010. [PUBMED Abstract]
- Tong T, Pei C, Chen J, et al.: Efficacy of Acupuncture Therapy for Chemotherapy-Related Cognitive Impairment in Breast Cancer Patients. Med Sci Monit 24: 2919-2927, 2018. [PUBMED Abstract]
- de Valois BA, Young TE, Melsome E: Assessing the feasibility of using acupuncture and moxibustion to improve quality of life for cancer survivors with upper body lymphoedema. Eur J Oncol Nurs 16 (3): 301-9, 2012. [PUBMED Abstract]
Adverse Effects
Serious adverse effects of acupuncture are rare. Reported accidents and infections appear to be related to violations of sterile procedure, negligence of the practitioner, or both.[1,2] A systematic review of case reports on the safety of acupuncture, involving 98 papers published in the English language from 22 countries during the period from 1965 to 1999, found only 202 incidents. The number of incidents appeared to decline as training standards and licensure requirements were enhanced. Among the 118 (60%) reported incidents involving infection, 94 (80%) involved hepatitis, occurring mainly in the late 1970s and early 1980s. Very few hepatitis or other infections associated with acupuncture have been reported since 1988, when widespread use of disposable needles was introduced and national certification requirements for clean-needle techniques were developed and enforced as an acupuncture licensure requirement.[3,4] Because cancer patients who are undergoing chemotherapy or radiation therapy are immunocompromised, precautions must be taken and strict clean-needle techniques must be applied when acupuncture treatment is given.[5]
Minor adverse effects of acupuncture, such as pain at needling sites, hematoma, tiredness, lightheadedness, drowsiness, and localized skin irritation, have been reported.[6-11] These minor adverse effects can be minimized by appropriate patient management, including local pressing and massage at the needling site after treatment.[12,13]
Acupuncture in children has not been studied extensively; however, adverse effects appear to be rare and limited to the same effects as observed in adults.[14-16]. At least one study has shown that there was no increased incidence of adverse events in children with thrombocytopenia or neutropenia.[16]
References
- Lao L: Acupuncture techniques and devices. J Altern Complement Med 2 (1): 23-5, 1996. [PUBMED Abstract]
- MacPherson H: Fatal and adverse events from acupuncture: allegation, evidence, and the implications. J Altern Complement Med 5 (1): 47-56, 1999. [PUBMED Abstract]
- Lao L, Zhang G, Wong RH, et al.: The effect of electroacupuncture as an adjunct on cyclophosphamide-induced emesis in ferrets. Pharmacol Biochem Behav 74 (3): 691-9, 2003. [PUBMED Abstract]
- National Commission for the Certification of Acupuncturists: Clean Needle Technique for Acupuncturists: A Manual: Guidelines and Standards for the Clean & Safe Clinical Practice of Acupuncture. 3rd ed. Washington, DC: National Commission for the Certification of Acupuncturists, 1989.
- Shen J, Wenger N, Glaspy J, et al.: Electroacupuncture for control of myeloablative chemotherapy-induced emesis: A randomized controlled trial. JAMA 284 (21): 2755-61, 2000. [PUBMED Abstract]
- Enblom A, Johnsson A: Type and frequency of side effects during PC6 acupuncture: observations from therapists and patients participating in clinical efficacy trials of acupuncture. Acupunct Med 35 (6): 421-429, 2017. [PUBMED Abstract]
- Brattberg G: Acupuncture treatment: a traffic hazard? Am J Acupunct 14 (3): 265-7, 1986.
- Ernst E, White AR: Prospective studies of the safety of acupuncture: a systematic review. Am J Med 110 (6): 481-5, 2001. [PUBMED Abstract]
- White A, Hayhoe S, Hart A, et al.: Adverse events following acupuncture: prospective survey of 32 000 consultations with doctors and physiotherapists. BMJ 323 (7311): 485-6, 2001. [PUBMED Abstract]
- MacPherson H, Thomas K, Walters S, et al.: The York acupuncture safety study: prospective survey of 34 000 treatments by traditional acupuncturists. BMJ 323 (7311): 486-7, 2001. [PUBMED Abstract]
- Yamashita H, Tsukayama H, Tanno Y, et al.: Adverse events related to acupuncture. JAMA 280 (18): 1563-4, 1998. [PUBMED Abstract]
- Cheng X, ed.: Chinese Acupuncture and Moxibustion. Beijing, China: Foreign Languages Press, 1987.
- O'Connor J, Bensky D, eds.: Acupuncture: A Comprehensive Text. Chicago, Ill: Eastland Press, 1981.
- Jindal V, Ge A, Mansky PJ: Safety and efficacy of acupuncture in children: a review of the evidence. J Pediatr Hematol Oncol 30 (6): 431-42, 2008. [PUBMED Abstract]
- Ladas EJ, Rooney D, Taromina K, et al.: The safety of acupuncture in children and adolescents with cancer therapy-related thrombocytopenia. Support Care Cancer 18 (11): 1487-90, 2010. [PUBMED Abstract]
- Chokshi SK, Ladas EJ, Taromina K, et al.: Predictors of acupuncture use among children and adolescents with cancer. Pediatr Blood Cancer 64 (7): , 2017. [PUBMED Abstract]
Summary of the Evidence for Acupuncture Treatment of Cancer-Related Symptoms
It is noteworthy that almost all reported clinical studies on the effects of acupuncture on cancer or cancer therapy –related symptoms focus on symptom management rather than the disease itself. Investigations into the effects of acupuncture on chemotherapy -induced nausea and vomiting, many of which were randomized and well-controlled, produced the most convincing findings. A number of randomized controlled trials have reported on the effect of acupuncture in alleviating other cancer treatment-associated side effects, with many showing promising evidence supporting the use of acupuncture. Additional phase III clinical trials are ongoing.
Changes to This Summary (04/19/2019)
The PDQ cancer information summaries are reviewed regularly and updated as new information becomes available. This section describes the latest changes made to this summary as of the date above.
Revised Table 3, Clinical Studies of Acupuncture for Aromatase Inhibitor-Induced Musculoskeletal Symptoms, to include results of the Hershman et al. study.
Added text to state that the National Institutes of Health (NIH) Consensus Development Conference held in 1997 reviewed studies that evaluated the safety and efficacy of acupuncture in treating postoperative- and chemotherapy-related nausea and vomiting (N/V) (cited NIH Consensus Conference as reference 41). Also added that studies discussed at the conference reported significantly less N/V compared with the control group (cited 1989 Dundee et al., 1990 Dundee et al., 1991 Dundee et al., and McMillan et al. as references 42, 43, 44, and 45, respectively); the panel stated that there is clear evidence that needle acupuncture treatment is effective for postoperative and chemotherapy N/V.
Revised Table 4, Randomized Controlled Trials of Acupuncture for Nausea and Vomiting from Chemotherapy or Radiation Therapy.
Revised Table 5, Summary of Randomized Controlled Trials of Acupuncture for Hot Flashes in Breast Cancer Patients.
Revised Table 8 to include results of the Yao et al., Bao et al., Tong et al., Deng et al., and Zhang et al. studies.
This summary is written and maintained by the PDQ Integrative, Alternative, and Complementary Therapies Editorial Board, which is editorially independent of NCI. The summary reflects an independent review of the literature and does not represent a policy statement of NCI or NIH. More information about summary policies and the role of the PDQ Editorial Boards in maintaining the PDQ summaries can be found on the About This PDQ Summary and PDQ® - NCI's Comprehensive Cancer Database pages.
About This PDQ Summary
Purpose of This Summary
This PDQ cancer information summary for health professionals provides comprehensive, peer-reviewed, evidence-based information about the use of acupuncture in the treatment of people with cancer. It is intended as a resource to inform and assist clinicians who care for cancer patients. It does not provide formal guidelines or recommendations for making health care decisions.
Reviewers and Updates
This summary is reviewed regularly and updated as necessary by the PDQ Integrative, Alternative, and Complementary Therapies Editorial Board, which is editorially independent of the National Cancer Institute (NCI). The summary reflects an independent review of the literature and does not represent a policy statement of NCI or the National Institutes of Health (NIH).
Board members review recently published articles each month to determine whether an article should:
- be discussed at a meeting,
- be cited with text, or
- replace or update an existing article that is already cited.
Changes to the summaries are made through a consensus process in which Board members evaluate the strength of the evidence in the published articles and determine how the article should be included in the summary.
The lead reviewers for Acupuncture are:
- Ting Bao, MD, DABMA, MS (Memorial Sloan Kettering Cancer Center)
- Jinhui Dou, PhD (Yiling Pharmaceutical, Inc.)
- Weidong Lu, MB, PhD, MPH (Dana-Farber Cancer Institute)
- Patrick J. Mansky, MD (FMH Regional Cancer Therapy Center)
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Levels of Evidence
Some of the reference citations in this summary are accompanied by a level-of-evidence designation. These designations are intended to help readers assess the strength of the evidence supporting the use of specific interventions or approaches. The PDQ Integrative, Alternative, and Complementary Therapies Editorial Board uses a formal evidence ranking system in developing its level-of-evidence designations.
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The preferred citation for this PDQ summary is:
PDQ® Integrative, Alternative, and Complementary Therapies Editorial Board. PDQ Acupuncture. Bethesda, MD: National Cancer Institute. Updated <MM/DD/YYYY>. Available at: https://www.cancer.gov/about-cancer/treatment/cam/hp/acupuncture-pdq. Accessed <MM/DD/YYYY>. [PMID: 26389159]
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