Article collection: genotoxicity tests

Article collection: Genotoxicity Tests

Here's a collection of highlighted articles recommended by the editors and the publisher. Be sure to bookmark this page, as it will be with new contents. 

This is a non-sponsored collection assembled by the Editor-in-Chief Prof. Masami Yamada, Genes and Environment. 

1. Content Type:Research

   Evaluation of the novel liver micronucleus assay using formalin-fixed tissues

   The repeated-dose liver micronucleus (RDLMN) assay is an effective and important in vivo test for detecting genotoxic compounds, particularly for those that require metabolic activation to show genotoxicity. I...

   Authors:Shuichi Hamada, Miyuki Shigano, Satoru Kawakami, Maya Ueda, Hajime Sui, Katsuya Yamada, Soichiro Hagio, Ayaka Momonami, Akihisa Maeda, Yukari Terashima, Wakako Ohyama, Takeshi Morita and Makoto Hayashi

   Citation:Genes and Environment 2019 41:13

   Published on: 9 May 2019

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2. Content Type:Method

   Standard protocol for the total red blood cell Pig-a assay used in the interlaboratory trial organized by the Mammalian Mutagenicity Study Group of the Japanese Environmental Mutagen Society

   The Pig-a assay, a promising tool for evaluating in vivo genotoxicity, is based on flow cytometric enumeration of red blood cells (RBCs) that are deficient in glycosylphosphatidylinositol anchor protein. Various ...

   Authors:Satsuki Chikura, Takafumi Kimoto, Satoru Itoh, Hisakazu Sanada, Shigeharu Muto and Katsuyoshi Horibata

   Citation:Genes and Environment 2019 41:5

   Published on: 27 February 2019

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3. Content Type:Meeting Report

   Meeting report, ICH M7 relevant workshop: use of (Q)SAR systems and expert judgment

   Use of Quantitative Structure-Activity Relationships ((Q)SAR) prediction tools has been increasing since the International Council for Harmonization of Technical Requirements for Pharmaceuticals for Human Use ...

   Authors:Masayuki Mishima, Tsuneo Hashizume, Yu Haranosono, Yusuke Nagato, Kentaro Takeshita, Junichi Fukuchi and Masamitsu Homma

   Citation:Genes and Environment 2018 40:19

   Published on: 17 September 2018

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4. Content Type:Short Report

   Negative and positive control ranges in the bacterial reverse mutation test: JEMS/BMS collaborative study

   A large-scale study was conducted by multiple laboratories affiliated with the Japanese Environmental Mutagen Society and the Bacterial Mutagenicity Study Group to investigate possible proficiency indicators f...

   Authors:Masayuki Kato, Kei-ichi Sugiyama, Toshiro Fukushima, Yasuyoshi Miura, Takumi Awogi, Shigetomo Hikosaka, Kumiko Kawakami, Madoka Nakajima, Masato Nakamura, Hajime Sui, Kumiko Watanabe and Atsushi Hakura

   Citation:Genes and Environment 2018 40:7

   Published on: 4 April 2018

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5. Content Type:Letter To The Editor

   Evolution of genotoxicity test methods in Japan

   The evolution of methods to assess genotoxicity of test compounds is thought to be one of the important subjects in The Japanese Environmental and Mutagen Society (JEMS). In 1970, the Ministry of Education of...

   Authors:Toshio Sofuni

   Citation:Genes and Environment 2017 39:15

   Published on: 21 February 2017

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6. Content Type:Review

   Transgenic rat models for mutagenesis and carcinogenesis

   Rats are a standard experimental animal for cancer bioassay and toxicological research for chemicals. Although the genetic analyses were behind mice, rats have been more frequently used for toxicological resea...

   Authors:Takehiko Nohmi, Kenichi Masumura and Naomi Toyoda-Hokaiwado

   Citation:Genes and Environment 2017 39:11

   Published on: 1 February 2017

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7. Content Type:Review

   Development and progress for three decades in umu test systems

   Umu test have been widely used to predict the detection and assessment of DNA- damaging chemicals in environmental genotoxicity field for three decades. This test system is more useful wi...

   Authors:Yoshimitsu Oda

   Citation:Genes and Environment 2016 38:24

   Published on: 1 December 2016

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8. Content Type:Review

   The micronucleus test—most widely used in vivo genotoxicity test—

   Genotoxicity is commonly evaluated during the chemical safety assessment together with other toxicological endpoints. The micronucleus test is always included in many genotoxic test guidelines for long time in...

   Authors:Makoto Hayashi

   Citation:Genes and Environment 2016 38:18

   Published on: 1 October 2016

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