Proteomics of Single Mouse Brain Slices
Mouse brain slices are widely used in neurological research. Scientists have long been interested in using these samples to understand proteome changes in response to neuroactive compounds. However, the protein extraction yield from brain slices is usually too low for protein analysis.
In this case study, researchers demonstrated a two-phase extraction method that allows brain slice protein analysis by nano liquid chromatography coupled to ion mobility mass spectrometry (nanoLC-MS), with particular emphasis on membrane proteins.
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