The microbiota–gut–brain axis

The microbiota–gut–brain axis

Our understanding of the complex and bidirectional signalling relationship between the gastrointestinal tract and the brain is evolving quickly. This relationship, dubbed the microbiota-gut-brain axis, is thought to be involved in many aspects of homeostasis in addition to the pathogenesis of a several diseases, ranging from neurological and degenerative conditions to autoimmune diseases. 

This cross-journal collection brings together both human and animal studies covering all aspects of the microbiota-gut-brain axis’ role in health and disease, as well as its therapeutic potential. The participating journals, spanning both neuroscience and microbiology, are listed below.

Submissions should be formatted according to individual journal guidelines. Please indicate clearly in the cover letter that the manuscript is to be considered for this collection. 

All manuscripts will undergo standard peer review, and must be submitted through the relevant journal's online submission system by 31st December 2019.

Pre-submission enquiries are welcome.

1. Content Type:Research

   Gut microbiota from NLRP3-deficient mice ameliorates depressive-like behaviors by regulating astrocyte dysfunction via circHIPK2

   Inflammasomes have been found to interact with the gut microbiota, and this effect is associated with depression, but the mechanisms underlying this interaction have not been elucidated in detail.

   Authors:Yuan Zhang, Rongrong Huang, Mengjing Cheng, Lirui Wang, Jie Chao, Junxu Li, Peng Zheng, Peng Xie, Zhijun Zhang and Honghong Yao

   Citation:Microbiome 2019 7:116

   Published on: 22 August 2019

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2. Content Type:Review

   Antibiotics, gut microbiota, and Alzheimer’s disease

   Alzheimer’s disease (AD) is a neurodegenerative disease whose various pathophysiological aspects are still being investigated. Recently, it has been hypothesized that AD may be associated with a dysbiosis of m...

   Authors:Francesco Angelucci, Katerina Cechova, Jana Amlerova and Jakub Hort

   Citation:Journal of Neuroinflammation 2019 16:108

   Published on: 22 May 2019

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3. Content Type:Research

   Evidence for an association of gut microbial Clostridia with brain functional connectivity and gastrointestinal sensorimotor function in patients with irritable bowel syndrome, based on tripartite network analysis

   Evidence from preclinical and clinical studies suggests that interactions among the brain, gut, and microbiota may affect the pathophysiology of irritable bowel syndrome (IBS). As disruptions in central and pe...

   Authors:Jennifer S. Labus, Vadim Osadchiy, Elaine Y. Hsiao, Julien Tap, Muriel Derrien, Arpana Gupta, Kirsten Tillisch, Boris Le Nevé, Cecilia Grinsvall, Maria Ljungberg, Lena Öhman, Hans Törnblom, Magnus Simren and Emeran A. Mayer

   Citation:Microbiome 2019 7:45

   Published on: 21 March 2019

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4. Content Type:Review

   Impact of microbiota on central nervous system and neurological diseases: the gut-brain axis

   Development of central nervous system (CNS) is regulated by both intrinsic and peripheral signals. Previous studies have suggested that environmental factors affect neurological activities under both physiolog...

   Authors:Qianquan Ma, Changsheng Xing, Wenyong Long, Helen Y. Wang, Qing Liu and Rong-Fu Wang

   Citation:Journal of Neuroinflammation 2019 16:53

   Published on: 1 March 2019

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5. Content Type:Research

   The gut microbiota-derived metabolite trimethylamine N-oxide is elevated in Alzheimer’s disease

   Trimethylamine N-oxide (TMAO), a small molecule produced by the metaorganismal metabolism of dietary choline, has been implicated in human disease pathogenesis, including known risk factors for Alzheimer’s diseas...

   Authors:Nicholas M. Vogt, Kymberleigh A. Romano, Burcu F. Darst, Corinne D. Engelman, Sterling C. Johnson, Cynthia M. Carlsson, Sanjay Asthana, Kaj Blennow, Henrik Zetterberg, Barbara B. Bendlin and Federico E. Rey

   Citation:Alzheimer's Research & Therapy 2018 10:124

   Published on: 22 December 2018

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6. Content Type:Review

   Antibiotic resistance, the 3As and the road ahead

   Antibiotic resistance is by far one of the most important health threats of our time. Only a global concerted effort of several disciplines based on the One-Health concept will help in slowing down this proces...

   Authors:Esther-Maria Antão, Szilvia Vincze, Regina Hanke, Lukas Klimmek, Katarzyna Suchecka, Antina Lübke-Becker and Lothar H. Wieler

   Citation:Gut Pathogens 2018 10:52

   Published on: 22 December 2018

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7. Content Type:Review

   Bidirectional gut-brain-microbiota axis as a potential link between inflammatory bowel disease and ischemic stroke

   Emerging evidence suggests that gut-brain-microbiota axis (GBMAx) may play a pivotal role linking gastrointestinal and neuronal disease. In this review, we summarize the latest advances in studies of GBMAx in ...

   Authors:Liang Zhao, Qiutang Xiong, Creed M. Stary, Omer Kamal Mahgoub, Yingze Ye, Lijuan Gu, Xiaoxing Xiong and Shengmei Zhu

   Citation:Journal of Neuroinflammation 2018 15:339

   Published on: 11 December 2018

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8. Content Type:Research

   The valproic acid rat model of autism presents with gut bacterial dysbiosis similar to that in human autism

   Gut microbiota has the capacity to impact the regular function of the brain, which can in turn affect the composition of microbiota. Autism spectrum disorder (ASD) patients suffer from gastrointestinal problem...

   Authors:Fang Liu, Kayla Horton-Sparks, Vanessa Hull, Robert W. Li and Verónica Martínez-Cerdeño

   Citation:Molecular Autism 2018 9:61

   Published on: 10 December 2018

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