The novel function of tumor protein D54 in regulating pyruvate dehydrogenase and metformin cytotoxicity in breast cancer | Cancer & Metabolism | Full Text

The novel function of tumor protein D54 in regulating pyruvate dehydrogenase and metformin cytotoxicity in breast cancer | Cancer & Metabolism | Full Text

2019 Article Collection: Breast Cancer and Metabolism

The biology of tumor cells in breast cancer is complex and relatively unexplored. Cancer & Metabolism is excited to present the following article highlights that identify novel biomarkers and metabolic profiles of different breast cancer subtypes.

- Metabolic profiling of triple-negative breast cancer cells reveals metabolic vulnerabilities

- Metabolomics of oncogene-specific metabolic reprogramming during breast cancer

- Beta-hydroxybutyrate (3-OHB) can influence the energetic phenotype of breast cancer cells, but does not impact their proliferation and the response to chemotherapy or radiation

- Activation of pro-survival metabolic networks by 1,25(OH)2D3 does not hamper the sensitivity of breast cancer cells to chemotherapeutics

- The novel function of tumor protein D54 in regulating pyruvate dehydrogenase and metformin cytotoxicity in breast cancer