Tumor talks: exosomes at center stage

Tumor talks: exosomes at center stage

Edited by Dr Tse-Hua Tan

A thematic series in Journal of Biomedical Science.

Tumor-derived exosomes emerge as critical mediators in tumorigenesis and malignant tumor progression through reprograming and communicating with the tumor microenvironments in nearby and/or distant organs. The nature of tumor-derived exosomes, including versatile selectivity of dynamic biological contents, abundant existence in blood, specific targeting and uptake by cells, are regarded as promising diagnostic/prognostic biomarkers, therapeutic targets, and drug delivery systems. At present, numerous studies have shed light on the basis of exosome biology and pave the way for clinical applications of tumor-derived exosomes. This series is dedicated to review current and future directions of tumor exosomal research and its potential applications, which build the fundamentals for precision medicine of cancer management.

1. Content Type:Review

   Basics and applications of tumor-derived extracellular vesicles

   Extracellular vesicle (EV)-mediated intercellular communication acts as a critical culprit in cancer development. The selective packaging of oncogenic molecules renders tumor-derived EVs capable of altering th...

   Authors:Yu-Ling Tai, Pei-Yu Chu, Bao-Hong Lee, Ko-Chien Chen, Chia-Yu Yang, Wen-Hung Kuo and Tang-Long Shen

   Citation:Journal of Biomedical Science 2019 26:35

   Published on: 11 May 2019

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2. Content Type:Review

   Toward characterizing extracellular vesicles at a single-particle level

   Extracellular vesicles (EVs) are cell-derived membrane-bound vesicles that serve a means of cell-cell communication. Studying EVs at a single-particle level is important because EVs are inherently heterogeneou...

   Authors:Chun-yi Chiang and Chihchen Chen

   Citation:Journal of Biomedical Science 2019 26:9

   Published on: 15 January 2019

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3. Content Type:Review

   Cross-talk between cancer cells and their neighbors via miRNA in extracellular vesicles: an emerging player in cancer metastasis

   Cancer metastasis is the major cause of mortality in cancer cases and is responsible for cancer deaths. It is known that cancer cells communicate with surrounding microenvironmental cells, such as fibroblast c...

   Authors:Akiko Kogure, Nobuyoshi Kosaka and Takahiro Ochiya

   Citation:Journal of Biomedical Science 2019 26:7

   Published on: 12 January 2019

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4. Content Type:Review

   Imaging extracellular vesicles: current and emerging methods

   Extracellular vesicles (EVs) are lipid bilayer-enclosed nanoparticles released by cells. They range from 30 nm to several micrometers in diameter, and ferry biological cargos such as proteins, lipids, RNAs and...

   Authors:Steven Ting-Yu Chuo, Jasper Che-Yung Chien and Charles Pin-Kuang Lai

   Citation:Journal of Biomedical Science 2018 25:91

   Published on: 24 December 2018

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