Inducible transgene expression in PDX models in vivo identifies KLF4 as a therapeutic target for B-ALL
Clinically relevant methods are not available that prioritize and validate potential therapeutic targets for individual tumors, from the vast amount of tumor descriptive expression data.Biomarker Research 2020 8:46Expression of p52, a non-canonical NF-kappaB transcription factor, is associated with poor ovarian cancer prognosis
The canonical and non-canonical nuclear factor-kappaB (NF-κB) signaling pathways have key roles in cancer, but studies have previously evaluated only the association of canonical transcription factors and ovar...Biomarker Research 2020 8:45Epigenetic based synthetic lethal strategies in human cancers
Over the past decades, it is recognized that loss of DNA damage repair (DDR) pathways is an early and frequent event in tumorigenesis, occurring in 40-50% of many cancer types. The basis of synthetic lethality...Biomarker Research 2020 8:44Advances in RNA cytosine-5 methylation: detection, regulatory mechanisms, biological functions and links to cancer
As an important posttranscriptional modification of RNA, 5-methylcytosine (m5C) has attracted increasing interest recently, with accumulating evidence suggesting the involvement of RNA m5C modification in multipl...Biomarker Research 2020 8:43Redox signaling and Alzheimer’s disease: from pathomechanism insights to biomarker discovery and therapy strategy
Aging and average life expectancy have been increasing at a rapid rate, while there is an exponential risk to suffer from brain-related frailties and neurodegenerative diseases as the population ages. Alzheime...Biomarker Research 2020 8:42
LncRNA SNHG16 as a potential biomarker and therapeutic target in human cancers
Long non-coding RNAs (lncRNAs) represent an important class of RNAs comprising more than 200 nucleotides, which are produced by RNA polymerase II. Although lacking an open reading framework and protein-encodin...Biomarker Research 2020 8:41Recent progress of prognostic biomarkers and risk scoring systems in chronic lymphocytic leukemia
Chronic lymphocytic leukemia (CLL) is the most prevalent adult leukemia with high heterogeneity in the western world. Thus, investigators identified a number of prognostic biomarkers and scoring systems to gui...Biomarker Research 2020 8:40The role of estrogen receptor beta in breast cancer
Breast cancer, a malignant tumor originating from mammary epithelial tissue, is the most common cancer among women worldwide. Challenges facing the diagnosis and treatment of breast cancer necessitate the sear...Biomarker Research 2020 8:39The biological function and clinical significance of SF3B1 mutations in cancer
Spliceosome mutations have become the most interesting mutations detected in human cancer in recent years. The spliceosome, a large, dynamic multimegadalton small nuclear ribonucleoprotein composed of small nu...Biomarker Research 2020 8:38A meta-analysis of potential biomarkers associated with severity of coronavirus disease 2019 (COVID-19)
Prognostic factors for the Coronavirus disease 2019 (COVID1–9) are not well established. This study aimed to summarize the available data on the association between the severity of COVID-19 and common hematolo...Biomarker Research 2020 8:37Secondary donor-derived humanized CD19-modified CAR-T cells induce remission in relapsed/refractory mixed phenotype acute leukemia after allogeneic hematopoietic stem cell transplantation: a case report
Mixed phenotype acute leukemia (MPAL) is a rare leukemia and is regarded as a high-risk entity with a poor prognosis. Induction therapy of an acute lymphoblastic leukemia type or hybrid regimen and hematopoiet...Biomarker Research 2020 8:36Resistance to PD-1/PD-L1 blockade cancer immunotherapy: mechanisms, predictive factors, and future perspectives
PD-1/PD-L1 blockade therapy is a promising cancer treatment strategy, which has revolutionized the treatment landscape of malignancies. Over the last decade, PD-1/PD-L1 blockade therapy has been trialed in a b...Biomarker Research 2020 8:35Predictive biomarkers for cancer immunotherapy with immune checkpoint inhibitors
Although the clinical development of immune checkpoint inhibitors (ICIs) therapy has ushered in a new era of anti-tumor therapy, with sustained responses and significant survival advantages observed in multipl...Biomarker Research 2020 8:34A genetic predictive model for precision treatment of diffuse large B-cell lymphoma with early progression
Early progression after the first-line R-CHOP treatment leads to a very dismal outcome and necessitates alternative treatment for patients with diffuse large B-cell lymphoma (DLBCL). This study aimed to develo...Biomarker Research 2020 8:33Application of pharmacogenetics in oncology
The term “pharmacogenetics” is used to describe the study of variability in drug response due to heredity. It is associated with “gene – drug interactions”. Later on, the term “pharmacogenomics” has been intro...Biomarker Research 2020 8:32Bidirectional interaction between intestinal microbiome and cancer: opportunities for therapeutic interventions
Gut microbiota composition influences the balance between human health and disease. Increasing evidence suggests the involvement of microbial factors in regulating cancer development, progression, and therapeu...Biomarker Research 2020 8:31Development of a highly sensitive method for detection of FLT3D835Y
Acute myeloid leukemia (AML) is a malignant hematological neoplasm of myeloid progenitor cells. Mutations of FLT3 in its tyrosine kinase domain (FLT3-TKD) are found in ~ 8% of patients with AML, with D835Y as ...Biomarker Research 2020 8:30AML risk stratification models utilizing ELN-2017 guidelines and additional prognostic factors: a SWOG report
The recently updated European LeukemiaNet risk stratification guidelines combine cytogenetic abnormalities and genetic mutations to provide the means to triage patients with acute myeloid leukemia for optimal ...Biomarker Research 2020 8:29Role of platelet biomarkers in inflammatory response
Beyond hemostasis, thrombosis and wound healing, it is becoming increasingly clear that platelets play an integral role in inflammatory response and immune regulation. Platelets recognize pathogenic microorgan...Biomarker Research 2020 8:28Plasma circulating tumor DNA assessment reveals KMT2D as a potential poor prognostic factor in extranodal NK/T-cell lymphoma
The early detection of tumors upon initial diagnosis or during routine surveillance is important for improving survival outcomes. Here, we investigated the feasibility and clinical significance of circulating ...Biomarker Research 2020 8:27Inactivating mutations in genes encoding for components of the BAF/PBAF complex and immune-checkpoint inhibitor outcome
Alterations of genes encoding subunits of the BAF/PBAF complexes are among the most frequent gene aberrations in human cancer. Such alterations have been shown to have an impact on tumor microenvironnement and...Biomarker Research 2020 8:26The emerging landscape of circular RNAs in immunity: breakthroughs and challenges
Circular RNAs (circRNAs) are covalently linked RNAs that exhibit individual strand with a closed-loop framework compared with a conserving, steady and abundant linear counterpart. In recent years, as high-thro...Biomarker Research 2020 8:25The emerging roles of N6-methyladenosine RNA methylation in human cancers
N6-methyladenosine (m6A) is the most abundant form of mRNA modification in eukaryotes. It affects various aspects of RNA metabolism, including nuclear export, translation, decay and alternative splicing. In addit...Biomarker Research 2020 8:24Role of DNA repair defects in predicting immunotherapy response
Defect in DNA damage response (DDR) is a common feature of cancer cells, which regulates tumor growth and therapeutic response. Recently, the approval of immune checkpoint blockade (ICB) for tumors with defect...Biomarker Research 2020 8:23Clinical characteristics and prognostic value of the KRAS G12C mutation in Chinese non-small cell lung cancer patients
The KRAS mutation is the second most common genetic variant in Chinese non-small cell lung cancer (NSCLC) patients. At the 2019th World Conference of Lung Cancer, the KRAS G12C-specific inhibitor AMG510 showed pr...Biomarker Research 2020 8:22Roles of HMGB1 in regulating myeloid-derived suppressor cells in the tumor microenvironment
Myeloid-derived suppressor cells (MDSCs) are notable contributors to the immunosuppressive tumor microenvironment (TME) and are closely associated with tumor progression; in addition, MDSCs are present in most...Biomarker Research 2020 8:21Lysyl oxidase expression is associated with inferior outcome and Extramedullary disease of acute myeloid leukemia
Lysyl oxidase (LOX) has been described as necessary for premetastatic niche formation in epithelium-derived malignancies and its expression level therefore correlates with risk of metastatic disease and overal...Biomarker Research 2020 8:20Chimeric antigen receptor T cells targeting PD-L1 suppress tumor growth
Chimeric antigen receptor T cells (CAR-T cells) therapy has been well recognized for treating B cell-derived malignancy. However, the efficacy of CAR-T cells against solid tumors remains dissatisfactory, parti...Biomarker Research 2020 8:19Mechanisms underlying CD19-positive ALL relapse after anti-CD19 CAR T cell therapy and associated strategies
Chimeric antigen receptor (CAR) T cell therapy, especially anti-CD19 CAR T cell therapy, has shown remarkable anticancer activity in patients with relapsed/refractory acute lymphoblastic leukemia, demonstratin...Biomarker Research 2020 8:18Advances in targeted therapy for acute myeloid leukemia
Acute myeloid leukemia (AML) is a clonal malignancy characterized by genetic heterogeneity due to recurrent gene mutations. Treatment with cytotoxic chemotherapy has been the standard of care for more than hal...Biomarker Research 2020 8:17Trends and projections of kidney cancer incidence at the global and national levels, 1990–2030: a Bayesian age-period-cohort modeling study
Identifying the temporal trends of kidney cancer (KC) incidence in both the past and the future at the global and national levels is critical for KC prevention.Biomarker Research 2020 8:16Circulating long non-coding RNA GAS5 (growth arrest-specific transcript 5) as a complement marker for the detection of malignant mesothelioma using liquid biopsies
For the detection of malignant mesothelioma additional markers are needed besides the established panel consisting of calretinin and mesothelin. The aim of this study was the identification and verification of...Biomarker Research 2020 8:15Characterization of novel dual tandem CD19/BCMA chimeric antigen receptor T cells to potentially treat multiple myeloma
Treatment with chimeric antigen receptor (CAR)-engineered T cells directed against the B-cell maturation antigen (BCMA) promoted transient recovery from multiple myeloma (MM). However, the absence of this anti...Biomarker Research 2020 8:14Biomarkers in individualized management of chimeric antigen receptor T cell therapy
The development of chimeric antigen receptor (CAR) T cell immunotherapy has achieved promising results, both in clinical studies and in commercial products for patients with hematologic malignancies. Despite h...Biomarker Research 2020 8:13Successful treatment of acute B lymphoblastic leukemia relapse in the skin and testicle by anti-CD19 CAR-T with IL-6 knocking down: a case report
Extramedullary relapse is an important cause of treatment failure among patients with acute lymphoblastic leukemia (ALL). This type of relapse is commonly observed in the central nervous system, while it is ra...Biomarker Research 2020 8:12Overexpressed immunoglobulin-like transcript (ILT) 4 in lung adenocarcinoma is correlated with immunosuppressive T cell subset infiltration and poor patient outcomes
The poor response to current PD-1/PD-L1 inhibitors in lung cancer patients requires development of novel immunotargets. Immunoglobulin-like transcript (ILT)4 is an immunosuppressive molecule mainly expressed i...Biomarker Research 2020 8:11TBL1XR1 mutation predicts poor outcome in primary testicular diffuse large B-cell lymphoma patients
Primary testicular lymphoma (PTL), often appearing as focal masses in the scrotum and epididymides, is the most frequent testicular tumor in aged men. Although MYD88 and CD79B mutations were the most common ge...Biomarker Research 2020 8:10The predictive value of tumor mutation burden for immune checkpoint inhibitors therapy in non-small cell lung cancer is affected by patients’ age
High tumor mutation burden (TMB), which is associated with increased tumor immunogenicity, has been identified to predict improved response to immune checkpoint inhibitors (ICIs) therapy in non-small cell lung...Biomarker Research 2020 8:9LncRNA profile study reveals a seven-lncRNA signature predicts the prognosis of patients with colorectal cancer
The prognosis of colorectal cancer (CRC) is still challenging to evaluate or predict. Recently, long non-coding RNAs (lncRNAs) have been found to play an important role in tumorigenesis and prognosis, however,...Biomarker Research 2020 8:8The mir-767-105 cluster: a crucial factor related to the poor prognosis of hepatocellular carcinoma
MiRNAs have been widely reported as the therapeutic target for hepatocellular carcinoma (HCC). However, mirna clusters, as the more impressive tumor regulatory factors, have received little attention. By deepl...Biomarker Research 2020 8:7Increased PD-1+Tim-3+ exhausted T cells in bone marrow may influence the clinical outcome of patients with AML
Altered expression of T cell immune inhibitory receptors may result in immunosuppression and associate with the poor prognosis of leukemia patients in which the leukemic bone marrow (BM) microenvironment may c...Biomarker Research 2020 8:6Using toponomics to characterize phenotypic diversity in alveolar macrophages from male mice treated with exogenous SP-A1
We used the Toponome Imaging System (TIS) to identify “patterns of marker expression”, referred to here as combinatorial molecular phenotypes (CMPs) in alveolar macrophages (AM) in response to the innate immun...Biomarker Research 2020 8:5Identification of pAKT as a pharmacodynamic marker for MER kinase in human melanoma G361 cells
The MER signaling pathway represents an attractive therapeutic target for human cancers. Growth arrest–specific protein 6 (GAS6)–induced MER phosphorylation is often unstable and difficult to detect without pe...Biomarker Research 2020 8:4PSCA is a target of chimeric antigen receptor T cells in gastric cancer
Gastric cancer is a deadly malignancy and is a prognostically unfavorable entity with restricted therapeutic strategies available. Prostate stem cell antigen (PSCA) is a glycosylphosphatidylinositol (GPI)-anch...Biomarker Research 2020 8:3Novel immunomodulatory drugs and neo-substrates
Thalidomide, lenalidomide and pomalidomide are immunomodulatory drugs (IMiDs) effective in the treatment of multiple myeloma, myelodysplastic syndrome (MDS) with deletion of chromosome 5q and other hematologic...Biomarker Research 2020 8:2LOX family and ZFPM2 as novel diagnostic biomarkers for malignant pleural mesothelioma
Malignant pleural mesothelioma (MPM) is a rare and aggressive cancer that develops in the pleural and outer layer of tissues surrounding the lungs. MPM is primarily caused by occupational exposure to asbestos ...Biomarker Research 2020 8:1Immune biomarkers in thymic epithelial tumors: expression patterns, prognostic value and comparison of diagnostic tests for PD-L1
Immunotherapy is currently under investigation in B3 Thymoma (TB3) and Thymic Carcinoma (TC). PD-L1 expression has been evaluated on a limited number of patients with selected antibodies. We aimed to analyze c...Biomarker Research 2019 7:28Impact of MET alterations on targeted therapy with EGFR-tyrosine kinase inhibitors for EGFR-mutant lung cancer
EGFR-tyrosine kinase inhibitors (EGFR-TKIs) have achieved remarkable outcomes in the treatment of patients with EGFR-mutant non-small-cell lung cancer, but acquired resistance is still the main factor restrict...Biomarker Research 2019 7:27Clinical significance of stromal ER and PR expression in periampullary adenocarcinoma
Tamoxifen treatment has previously been reported to confer life-prolonging effects in patients with advanced pancreatic cancer, and most evidently so in women. None of these trials did however include biomarke...Biomarker Research 2019 7:26Cancer biomarkers for targeted therapy
Tumor-associated antigens (TAA) or cancer biomarkers are major targets for cancer therapies. Antibody- based agents targeting the cancer biomarkers include monoclonal antibodies (MoAbs), radiolabeled MoAbs, bi...Biomarker Research 2019 7:25
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