NONO promotes hepatocellular carcinoma progression by enhancing fatty acids biosynthesis through interacting with ACLY mRNA
Dysregulation of fatty acid (FA) metabolism is involved in hepatocellular carcinoma (HCC) development. Non-POU domain-containing octamer binding protein (NONO), known as the component of nuclear paraspeckles, ...Cancer Cell International 2020 20:425LncRNA SNHG6 enhances the radioresistance and promotes the growth of cervical cancer cells by sponging miR-485-3p
Cervical cancer (CC) is the one of most common malignant gynecological tumors, which is characterized with the high mortality and recurrence rate. Previous studies have elucidated the oncogenic role of small n...Cancer Cell International 2020 20:424Correction to: The m6A eraser FTO facilitates proliferation and migration of human cervical cancer cells
An amendment to this paper has been published and can be accessed via the original article.Cancer Cell International 2020 20:423The original article was published in Cancer Cell International 2019 19:321A novel role of Krüppel-like factor 8 as an apoptosis repressor in hepatocellular carcinoma
Krüppel-like factor 8 (KLF8), a cancer-promoting factor that regulates critical gene transcription and cellular cancer-related events, has been implicated in tumor development and progression. However, the fun...Cancer Cell International 2020 20:422Cost-effectiveness and accuracy of cervical cancer screening with a high-risk HPV genotyping assay vs a nongenotyping assay in China: an observational cohort study
New screening techniques may affect the optimal approaches for the prevention of cervical cancer. We evaluated the cost-effectiveness and accuracy of alternative screening strategies to provide evidence for ce...Cancer Cell International 2020 20:421Hexokinase inhibition using D-Mannoheptulose enhances oncolytic newcastle disease virus-mediated killing of breast cancer cells
Most cancer cells exhibit increased glycolysis and use this metabolic pathway cell growth and proliferation. Targeting cancer cells’ metabolism is a promising strategy in inhibiting cancer cell progression. We...Cancer Cell International 2020 20:420Identification of potential biomarkers and candidate small molecule drugs in glioblastoma
Glioblastoma (GBM) is a common and aggressive primary brain tumor, and the prognosis for GBM patients remains poor. This study aimed to identify the key genes associated with the development of GBM and provide...Cancer Cell International 2020 20:419Down-regulation of TRIB3 inhibits the progression of ovarian cancer via MEK/ERK signaling pathway
Tribbles pseudokinase 3 (TRIB3) protein is a pseudokinase which plays an important role in cellular stress, metabolism, and tumor progression. However, the expression and function of TRIB3 in ovarian cancer is...Cancer Cell International 2020 20:418Development of syngeneic murine cell lines for use in immunocompetent orthotopic lung cancer models
Immunocompetent animal models are required to study tumor-host interactions, immunotherapy, and immunotherapeutic combinations, however the currently available immunocompetent lung cancer models have substanti...Cancer Cell International 2020 20:417MiR-145-5p suppresses the proliferation, migration and invasion of gastric cancer epithelial cells via the ANGPT2/NOD_LIKE_RECEPTOR axis
This study aimed to investigate the relationship among miR-145-5p, ANGPT2 and the NOD_LIKE_RECEPTOR pathway, thereby revealing the molecular mechanism of these three factors underlying the proliferation, migratio...Cancer Cell International 2020 20:416LncRNA TTN-AS1 promotes the progression of oral squamous cell carcinoma via miR-411-3p/NFAT5 axis
Oral squamous cell carcinoma (OSCC) is a common kind of squamous cell carcinoma of the head and neck, which is a threat to public health. Long noncoding RNAs (lncRNAs) are associated with the development of va...Cancer Cell International 2020 20:415Long noncoding RNA MIR99AHG promotes gastric cancer progression by inducing EMT and inhibiting apoptosis via miR577/FOXP1 axis
Long non-coding RNAs (lncRNAs) play a vital role in the genesis and development of human cancer. LncRNA MIR99AHG has been reported to be upregulated in acute myeloid leukemia (AML); however, its function in ga...Cancer Cell International 2020 20:414MicroRNA-214-3p inhibits the stem-like properties of lung squamous cell cancer by targeting YAP1
Emerging evidence reveals that microRNAs (miRNAs) play a crucial role in tumor progression, but the underlying mechanism of microRNAs in lung squamous cell cancer (LSCC) remains unclear.Cancer Cell International 2020 20:413CircRNA hsa_circRNA_0001776 inhibits proliferation and promotes apoptosis in endometrial cancer via downregulating LRIG2 by sponging miR-182
Endometrial cancer (EC) is a common malignancy of the female reproductive system. Circular RNAs (circRNAs) were demonstrated to exert critical roles in cancers, including EC. This study aimed to investigate th...Cancer Cell International 2020 20:412Long non-coding RNA LBX2-AS1 enhances glioma proliferation through downregulating microRNA-491-5p
Dysregulation of lncRNAs is frequent in glioma and has emerged as an important mechanism involved in tumorigenesis. Previous analysis of Chinese Glioma Genome Atlas (CGGA) database indicated that LBX2-AS1 expr...Cancer Cell International 2020 20:411Correction to: Gamma synuclein is a novel nicotine responsive protein in oral cancer malignancy
An amendment to this paper has been published and can be accessed via the original article.Cancer Cell International 2020 20:410The original article was published in Cancer Cell International 2020 20:300Clinical implication of prognostic and predictive biomarkers for castration-resistant prostate cancer: a systematic review
Diagnosis of metastatic castrate resistant prostate cancer (mCRPC) with current biomarkers is difficult and often results in unnecessary invasive procedures as well as over-diagnosis and over-treatment. There ...Cancer Cell International 2020 20:409Comprehensive analysis of key genes associated with ceRNA networks in nasopharyngeal carcinoma based on bioinformatics analysis
Nasopharyngeal carcinoma (NPC) is an epithelial malignancy with high morbidity rates in the east and southeast Asia. The molecular mechanisms of NPC remain largely unknown. We explored the pathogenesis, potent...Cancer Cell International 2020 20:408Circ_0000140 restrains the proliferation, metastasis and glycolysis metabolism of oral squamous cell carcinoma through upregulating CDC73 via sponging miR-182-5p
Oral squamous cell carcinoma (OSCC) is a more common cancer in the world. Emerging evidence suggests that circular RNAs (circRNAs) participate in the progression of OSCC. However, the role of circ_0000140 in O...Cancer Cell International 2020 20:407High CENPM mRNA expression and its prognostic significance in hepatocellular carcinoma: a study based on data mining
Hepatocellular carcinoma (HCC) is a high mortality disease, the fifth most general cancer worldwide, and the second leading to cancer-related deaths, with more than 500,000 new patients diagnosed each year. Fi...Cancer Cell International 2020 20:406Cryptotanshinone chemosensitivity potentiation by TW-37 in human oral cancer cell lines by targeting STAT3–Mcl-1 signaling
Despite being one of the leading cancer types in the world, the diagnosis of oral cancer and its suitable therapeutic options remain limited. This study aims to investigate the single and chemosensitizing effe...Cancer Cell International 2020 20:405Circular RNA circ_0000517 regulates hepatocellular carcinoma development via miR-326/IGF1R axis
Circular RNAs (circRNAs) play vital roles in hepatocellular carcinoma development. However, the role and mechanism of circRNA hsa_circ_0000517 (circ_0000517) in hepatocellular carcinoma development were largel...Cancer Cell International 2020 20:404Epigenetic silencing of long non-coding RNA BM742401 in multiple myeloma: impact on prognosis and myeloma dissemination
Long non-coding RNA (lncRNA) BM742401 is a tumor suppressor in gastric cancer and chronic lymphocytic leukemia. As the promoter and coding region of BM742401 are fully embedded in a CpG island, we hypothesized th...Cancer Cell International 2020 20:403A robust 11-genes prognostic model can predict overall survival in bladder cancer patients based on five cohorts
Bladder cancer is the tenth most common cancer globally, but existing biomarkers and prognostic models are limited.Cancer Cell International 2020 20:402Epstein–Barr virus infection and genome polymorphisms on gastric remnant carcinoma: a meta-analysis
Previous studies reported that Epstein–Barr virus (EBV) may play a causal role in the pathogenesis of gastric remnant carcinoma (GRC). However, there was still some controversy.Cancer Cell International 2020 20:401CircZFR functions as a sponge of miR-578 to promote breast cancer progression by regulating HIF1A expression
Breast cancer (BC) is the most common malignancy among women. Emerging studies have demonstrated that circular RNA (circRNA) zinc finger RNA binding protein (circZFR) serves as a crucial regulator in many huma...Cancer Cell International 2020 20:400Mitochondrion-mediated iron accumulation promotes carcinogenesis and Warburg effect through reactive oxygen species in osteosarcoma
Iron metabolism disorder is closely associated with several malignant tumors, however the mechanisms underlying iron and the carcinogenesis in osteosarcoma are not yet well understood.Cancer Cell International 2020 20:399p33ING1b regulates acetylation of p53 in oral squamous cell carcinoma via SIR2
Oral squamous cell carcinoma (OSCC), a form of head and neck squamous cell carcinoma (HNSCC) has a poor 5-year survival rate. OSCC patients are often treated with cisplatin but resistance to chemotherapy is of...Cancer Cell International 2020 20:398Correction to: Identification of prognosis-related genes and construction of multi-regulatory networks in pancreatic cancer microenvironment by bioinformatics analysis
An amendment to this paper has been published and can be accessed via the original article.Cancer Cell International 2020 20:397The original article was published in Cancer Cell International 2020 20:341TNFAIP8 variants as potential epidemiological and predictive biomarkers in ovarian cancer
This research aimed to investigate the association between tumor necrosis factor-a-induced protein 8 (TNFAIP8) polymorphisms and ovarian cancer (OC) susceptibility.Cancer Cell International 2020 20:396miR-502-5p affects gastric cancer progression by targeting PD-L1
Studies have shown that miR-502-5p functions as a tumor suppressor and is associated with tumor growth and metastasis. This study intends to uncover the potential mechanism of miR-502-5p functioning as a tumor...Cancer Cell International 2020 20:395LncRNA KCNQ1OT1 sponges miR-15a to promote immune evasion and malignant progression of prostate cancer via up-regulating PD-L1
We focused on the KCNQ1OT1/miR-15a/PD-L1 axis and explored its significance in regulating immune evasion and malignant behaviors of prostate cancer (PC) cells.Cancer Cell International 2020 20:394Analyzing the lncRNA, miRNA, and mRNA-associated ceRNA networks to reveal potential prognostic biomarkers for glioblastoma multiforme
Glioblastoma multiforme (GBM) is the most seriously brain tumor with extremely poor prognosis. Recent research has demonstrated that competitive endogenous RNA (ceRNA) network which long noncoding RNAs (lncRNA...Cancer Cell International 2020 20:393Clinical value and potential mechanisms of COL8A1 upregulation in breast cancer: a comprehensive analysis
The situation faced by breast cancer patients, especially those with triple-negative breast cancer, is still grave. More effective therapeutic targets are needed to optimize the clinical management of breast c...Cancer Cell International 2020 20:392CircHIPK3/miR-876-5p/PIK3R1 axis regulates regulation proliferation, migration, invasion, and glutaminolysis in gastric cancer cells
Circular RNAs (circRNAs) are a new group of non-coding RNAs that play vital roles in cancer occurrence, including gastric cancer (GC). Nevertheless, the role and underlying regulatory mechanisms of circHIPK3 i...Cancer Cell International 2020 20:391FOXA1-induced circOSBPL10 potentiates cervical cancer cell proliferation and migration through miR-1179/UBE2Q1 axis
Recently, extensive evidence has clarified the crucial role of circular RNAs (circRNAs) as a pro-tumor or anti-cancer participant in human malignancies. A new circRNA derived from oxysterol binding protein lik...Cancer Cell International 2020 20:389
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