Grape Seed Extract: Science and Safety

Grape Seed Extract: Science and Safety

Background Grapes have been used for health purposes since ancient Greece, but grape seed extract was developed in the 1970s. It contains the antioxidant compound oligomeric proanthocyanidin (OPC). How Much Do We Know? There are a few well-controlled studies of grape seed extract for health conditions. What Have We Learned? Some studies suggest that compounds in grape seed extract may reduce swelling and help with symptoms of chronic venous insufficiency, but the evidence isn’t strong. Grape seed extract may lower systolic blood pressure and heart rate but has no effect on cholesterol. Preliminary studies of grape seed extract for other conditions are under way. What Do We Know About Safety? Grape seed extract is generally well tolerated when taken in moderate amounts. It might be unsafe, though, for people who have a bleeding disorder, take anticoagulants, or will soon have surgery.    Find out more