HIV Suppression Using Adenovirus-Mediated Gene Therapy
Research on therapies against the Human Immunodeficiency Virus (HIV) has repeatedly demonstrated the potential of broadly neutralizing antibodies (bn-Abs) as successful therapeutic agents. Injection of such antibodies leads to a decrease in viral concentrations in blood. However, repeated injections are necessary to prevent the recovery of the virus.
In this case study, researchers from the United States of America carried out a proof-of-concept experiment which showed that gene therapy could be used to stimulate bn-Abs long-term in monkeys. However, while this caused the viral load in the blood to drop significantly, so did the levels of antibodies, as they were being cleared by the immune system.
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