Cystic Fibrosis News Today Weekly Digest

Cystic Fibrosis Weekly Update Contents: CF Foundation Awards Eloxx $1.61M for Phase 2 Trials in People with Nonsense Mutations I Want to Break Up with My CF Clinic Kalydeco’s Efficacy Tied to Phosphorylation Levels of CFTR Protein, Study Suggests CF Foundation Awards Eloxx $1.61M for Phase 2 Trials in People with Nonsense Mutations Sep 25, 2019 07:00 am | Joana Carvalho, MSc The Cystic Fibrosis Foundation (CFF) is giving Eloxx Pharmaceuticals up to $1.61 million to support its planned Phase 2 clinical trial program assessing the safety, tolerability, and chemical properties of ELX-02, Eloxx’s lead investigational compound to treat cystic fibrosis (CF) caused by nonsense, or stop, mutations. The program is set to include two open-label, dose escalation, Phase […] The post CF Foundation Awards Eloxx $1.61M for Phase 2 Trials in People with Nonsense Mutations appeared first on Cystic Fibrosis News Today. Read More I Want to Break Up with My CF Clinic Sep 24, 2019 03:00 pm | Bailey Vincent I might break up with my CF clinic. It’s not them, it’s me. They are doing a good job. My CF doctor is fine. My nurses, dietitian, and support staff are really cool. And everything is basically OK. They’re nice people. It’s fine. The problem is, I’m not sure what the clinic is really doing […] The post I Want to Break Up with My CF Clinic appeared first on Cystic Fibrosis News Today. Read More Kalydeco’s Efficacy Tied to Phosphorylation Levels of CFTR Protein, Study Suggests Sep 24, 2019 07:00 am | Patricia Inacio, PhD CFTR channel activity is controlled by a molecular process known as phosphorylation. Now, a study suggests that the levels of phosphorylation affect how well Kalydeco works in people with certain mutations in the CFTR gene. The study “VX-770-mediated potentiation of numerous human CFTR disease mutants is influenced by phosphorylation level” was published in the journal Nature Scientific Reports. […] The post Kalydeco’s Efficacy Tied to Phosphorylation Levels of CFTR Protein, Study Suggests appeared first on Cystic Fibrosis News Today. Read More Recent News The Benefits and Perils of Social Media Physical Activity Levels in CF Should Be Objectively Researched, Review Says LCI Is Sensitive Lung Function Parameter in Patients with Mild CF, Study Says 1st Biosimilar of Dornase Alfa Inhalation Solution for CF Approved in Russia, Companies Announce Progress for Cystic Fibrosis [INFOGRAPHIC]