Sensory systems
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Altered activity in the nucleus raphe magnus underlies cortical hyperexcitability and facilitates trigeminal nociception in a rat model of medication overuse headache
The pathogenesis of medication overuse headache (MOH) involves hyperexcitability of cortical and trigeminal neurons. Derangement of the brainstem modulating system, especially raphe nuclei may contribute to th...BMC Neuroscience 2019 20:54Preferential activation of small cutaneous fibers through small pin electrode also depends on the shape of a long duration electrical current
Electrical stimulation is widely used in experimental pain research but it lacks selectivity towards small nociceptive fibers. When using standard surface patch electrodes and rectangular pulses, large fibers ...BMC Neuroscience 2019 20:48Altered excitability of small cutaneous nerve fibers during cooling assessed with the perception threshold tracking technique
There is a need for new approaches to increase the knowledge of the membrane excitability of small nerve fibers both in healthy subjects, as well as during pathological conditions. Our research group has previ...BMC Neuroscience 2019 20:47Post-surgical inhibition of phosphatidylinositol 3-kinase attenuates the plantar incision-induced postoperative pain behavior via spinal Akt activation in male mice
Postoperative pain (POP) is a severe acute pain encountered in patients suffering from an operation, and is less than adequately controlled by the currently available analgesics. Phosphatidylinositol 3-kinase ...BMC Neuroscience 2019 20:36Live calcium imaging of Aedes aegypti neuronal tissues reveals differential importance of chemosensory systems for life-history-specific foraging strategies
The mosquito Aedes aegypti has a wide variety of sensory pathways that have supported its success as a species as well as a highly competent vector of numerous debilitating infectious pathogens. Investigations in...BMC Neuroscience 2019 20:27Neuro-genetic plasticity of Caenorhabditis elegans behavioral thermal tolerance
Animal responses to thermal stimuli involve intricate contributions of genetics, neurobiology and physiology, with temperature variation providing a pervasive environmental factor for natural selection. Therma...BMC Neuroscience 2019 20:26Subclinical lipopolysaccharide from Salmonella Enteritidis induces neuropeptide dysregulation in the spinal cord and the dorsal root ganglia
Despite increasing evidence that lipopolysaccharide (LPS) affects the biological active substances of dorsal root ganglia (DRG) we have limited knowledge of the influence of a single low dose of LPS, which doe...BMC Neuroscience 2019 20:18Involvement of brain-derived neurotrophic factor (BDNF) in chronic intermittent stress-induced enhanced mechanical allodynia in a rat model of burn pain
Reports show that stressful events before injury exacerbates post-injury pain. The mechanism underlying stress-induced heightened thermal pain is unclear. Here, we examined the effects of chronic intermittent ...BMC Neuroscience 2019 20:17Possible involvement of peripheral TRP channels in the hydrogen sulfide-induced hyperalgesia in diabetic rats
Peripheral diabetic neuropathy can be painful and its symptoms include hyperalgesia, allodynia and spontaneous pain. Hydrogen sulfide (H2S) is involved in diabetes-induced hyperalgesia and allodynia. However, the...BMC Neuroscience 2019 20:1Glycine receptors expression in rat spinal cord and dorsal root ganglion in prostaglandin E2 intrathecal injection models
Glycine receptors (GlyRs) are involved in the development of spinal pain sensitization. The GlyRα3 subunit has recently emerged as a key factor in inflammatory pain pathways in the spinal cord dorsal horn (DH)...BMC Neuroscience 2018 19:72Cochlear morphology in the developing inner ear of the porcine model of spontaneous deafness
Auditory function and cochlear morphology have previously been described in a porcine model with spontaneous WS2-like phenotype. In the present study, cochlear histopathology was further investigated in the in...BMC Neuroscience 2018 19:28Activity-dependent formation of a vesicular inhibitory amino acid transporter gradient in the superior olivary complex of NMRI mice
In the mammalian superior olivary complex (SOC), synaptic inhibition contributes to the processing of binaural sound cues important for sound localization. Previous analyses demonstrated a tonotopic gradient f...BMC Neuroscience 2017 18:75Effectiveness of conservative interventions for sickness and pain behaviors induced by a high repetition high force upper extremity task
Systemic inflammation is known to induce sickness behaviors, including decreased social interaction and pain. We have reported increased serum inflammatory cytokines in a rat model of repetitive strain injury ...BMC Neuroscience 2017 18:36Spectral-temporal EEG dynamics of speech discrimination processing in infants during sleep
Oddball paradigms are frequently used to study auditory discrimination by comparing event-related potential (ERP) responses from a standard, high probability sound and to a deviant, low probability sound. Prev...BMC Neuroscience 2017 18:34Upregulation of the endothelin A (ETA) receptor and its association with neurodegeneration in a rodent model of glaucoma
Primary open angle glaucoma is a heterogeneous group of optic neuropathies that results in optic nerve degeneration and a loss of retinal ganglion cells (RGCs) ultimately causing blindness if allowed to progre...BMC Neuroscience 2017 18:27Quantitative analysis of axon collaterals of single pyramidal cells of the anterior piriform cortex of the guinea pig
The role of the piriform cortex (PC) in olfactory information processing remains largely unknown. The anterior part of the piriform cortex (APC) has been the focus of cortical-level studies of olfactory codin...BMC Neuroscience 2017 18:25Evoked potentials and behavioral performance during different states of brain arousal
Previous studies compared evoked potentials (EPs) between several sleep stages but only one uniform wake state. However, using electroencephalography (EEG), several arousal states can be distinguished before s...BMC Neuroscience 2017 18:21Why does a cooled object feel heavier? Psychophysical investigations into the Weber’s Phenomenon
It has long been known that a concomitantly cooled stimulus is perceived as heavier than the same object at a neutral temperature—termed Weber’s Phenomenon (WP). In the current study, we re-examined this phenomen...BMC Neuroscience 2017 18:4Neural hyperactivity in the amygdala induced by chronic treatment of rats with analgesics may elucidate the mechanisms underlying psychiatric comorbidities associated with medication-overuse headache
Patients with medication-overuse headache suffer not only from chronic headache, but often from psychiatric comorbidities, such as anxiety and depression. The mechanisms underlying these comorbidities are uncl...BMC Neuroscience 2017 18:1Simultaneous acoustic stimulation of human primary and secondary somatosensory cortices using transcranial focused ultrasound
Transcranial focused ultrasound (FUS) is gaining momentum as a novel non-invasive brain stimulation method, with promising potential for superior spatial resolution and depth penetration compared to transcrani...BMC Neuroscience 2016 17:68Identification of environmental stressors and validation of light preference as a measure of anxiety in larval zebrafish
Larval zebrafish, with a simple and transparent vertebrate brain composed of ~100 K neurons, is well suited for deciphering entire neural circuit activity underlying behavior. Moreover, their small body size (...BMC Neuroscience 2016 17:63Hysteretic behavior of bladder afferent neurons in response to changes in bladder pressure
Mechanosensitive afferents innervating the bladder increase their firing rate as the bladder fills and pressure rises. However, the relationship between afferent firing rates and intravesical pressure is not a...BMC Neuroscience 2016 17:57Measuring eye states in functional MRI
In many functional magnetic resonance imaging (fMRI) studies, experimental design often depends on the eye state (i.e., whether the participants had their eyes open or closed). Closed eyes during an fMRI is th...BMC Neuroscience 2016 17:48Effects of hypothermically reduced plantar skin inputs on anticipatory and compensatory balance responses
Anticipatory and compensatory balance responses are used by the central nervous system (CNS) to preserve balance, hence they significantly contribute to the understanding of physiological mechanisms of postura...BMC Neuroscience 2016 17:41The preventive effect of resiniferatoxin on the development of cold hypersensitivity induced by spinal nerve ligation: involvement of TRPM8
Resiniferatoxin (RTX) is a potent analog of capsaicin and activates transient receptor potential (TRP) vanilloid type (TRPV) 1. In the current study, we investigated the preventive effect of perineural RTX on ...BMC Neuroscience 2016 17:38Neuroprotective effect of activated 5′-adenosine monophosphate-activated protein kinase on cone system function during retinal inflammation
Retinal inflammation can cause retinal neural disorders. In particular, functional disorder in the cone photoreceptor system influences visual acuity. However, the underlying mechanism is not yet fully underst...BMC Neuroscience 2016 17:32Multimodal interaction in the insect brain
The magnitude of multimodal enhancement in the brain is believed to depend on the stimulus intensity and timing. Such an effect has been found in many species, but has not been previously investigated in insects.BMC Neuroscience 2016 17:29Driving steady-state visual evoked potentials at arbitrary frequencies using temporal interpolation of stimulus presentation
Steady-state visual evoked potentials have been utilized widely in basic and applied research in recent years. These oscillatory responses of the visual cortex are elicited by flickering stimuli. They have th...BMC Neuroscience 2015 16:95Intracellular chloride concentration of the mouse vomeronasal neuron
The vomeronasal organ (VNO) is specialized in detecting pheromone and heterospecific cues in the environment. Recent studies demonstrate the involvement of multiple ion channels in VNO signal transduction, inc...BMC Neuroscience 2015 16:90Emotional words facilitate lexical but not early visual processing
Emotional scenes and faces have shown to capture and bind visual resources at early sensory processing stages, i.e. in early visual cortex. However, emotional words have led to mixed results. In the current st...BMC Neuroscience 2015 16:89Estimating the location and size of retinal injections from orthogonal images of an intact retina
To study the mapping from the retina to the brain, typically a small region of the retina is injected with a dye, which then propagates to the retina’s target structures. To determine the location of the inje...BMC Neuroscience 2015 16:80Adaptation of cortical activity to sustained pressure stimulation on the fingertip
Tactile adaptation is a phenomenon of the sensory system that results in temporal desensitization after an exposure to sustained or repetitive tactile stimuli. Previous studies reported psychophysical and phys...BMC Neuroscience 2015 16:71The effects of preferential A- and C-fibre blocks and T-type calcium channel antagonist on detection of low-force monofilaments in healthy human participants
A myriad of studies have argued that tactile sensibility is underpinned exclusively by large myelinated mechanoreceptors. However, the functional significance of their slow-conducting counterparts, termed C-lo...BMC Neuroscience 2015 16:52Effects of mouse utricle stromal tissues on hair cell induction from induced pluripotent stem cells
Hair cells are important for maintaining our sense of hearing and balance. However, they are difficult to regenerate in mammals once they are lost. Clarification of the molecular mechanisms underlying inner ea...BMC Neuroscience 2014 15:121Therapeutic potential of a gamma-secretase inhibitor for hearing restoration in a guinea pig model with noise-induced hearing loss
Notch signaling plays a crucial role in the fate determination of cochlear progenitor cells, hair cells, and supporting cells in the developing cochlea. Recent studies have demonstrated the temporal activation...BMC Neuroscience 2014 15:66Intra- and inter-hemispheric effective connectivity in the human somatosensory cortex during pressure stimulation
Slow-adapting type I (SA-I) afferents deliver sensory signals to the somatosensory cortex during low-frequency (or static) mechanical stimulation. It has been reported that the somatosensory projection from SA...BMC Neuroscience 2014 15:43ROS-mediated activation of Drosophila larval nociceptor neurons by UVC irradiation
The complex Drosophila larval peripheral nervous system, capable of monitoring sensory input from the external environment, includes a family of multiple dendritic (md) neurons with extensive dendritic arbors til...BMC Neuroscience 2014 15:14Skn-1a/Pou2f3 is required for the generation of Trpm5-expressing microvillous cells in the mouse main olfactory epithelium
The main olfactory epithelium (MOE) in mammals is a specialized organ to detect odorous molecules in the external environment. The MOE consists of four types of cells: olfactory sensory neurons, supporting cel...BMC Neuroscience 2014 15:13The Caenorhabditis elegans interneuron ALA is (also) a high-threshold mechanosensor
To survive dynamic environments, it is essential for all animals to appropriately modulate their behavior in response to various stimulus intensities. For instance, the nematode Caenorhabditis elegans suppresses ...BMC Neuroscience 2013 14:156Plasticity in neuromagnetic cortical responses suggests enhanced auditory object representation
Auditory perceptual learning persistently modifies neural networks in the central nervous system. Central auditory processing comprises a hierarchy of sound analysis and integration, which transforms an acoust...BMC Neuroscience 2013 14:151Perceptual organization of auditory streaming-task relies on neural entrainment of the stimulus-presentation rate: MEG evidence
Humans are able to extract regularities from complex auditory scenes in order to form perceptually meaningful elements. It has been shown previously that this process depends critically on both the temporal in...BMC Neuroscience 2013 14:120Activation of peripheral nerve fibers by electrical stimulation in the sole of the foot
Human nociceptive withdrawal reflexes (NWR) can be evoked by electrical stimulation applied to the sole of the foot. However, elicitation of NWRs is highly site dependent, and NWRs are especially difficult to ...BMC Neuroscience 2013 14:116Probabilistic model for individual assessment of central hyperexcitability using the nociceptive withdrawal reflex: a biomarker for chronic low back and neck pain
The nociceptive withdrawal reflex (NWR) has been proven to be a valuable tool in the objective assessment of central hyperexcitability in the nociceptive system at spinal level that is present in some chronic ...BMC Neuroscience 2013 14:110Temporal vocal features suggest different call-pattern generating mechanisms in mice and bats
Mice produce ultrasonic vocalizations in various inter-individual encounters and with high call rates. However, it is so far virtually unknown how these vocal patterns are generated. On the one hand, these voc...BMC Neuroscience 2013 14:99Nitric oxide modulates the hyperalgesic response to mechanical noxious stimuli in sleep-deprived rats
Sleep restriction alters pain perception in animals and humans, and many studies have indicated that paradoxical sleep deprivation (PSD) promotes hyperalgesia. The hyperalgesia observed after mechanical nocice...BMC Neuroscience 2013 14:92Continuous theta-burst stimulation modulates tactile synchronization
Temporal order judgement (TOJ) is the ability to detect the order of occurrence of two sequentially delivered stimuli. Previous research has shown that TOJ in the presence of synchronized periodic conditioning...BMC Neuroscience 2013 14:89P-Rex2, a Rac-guanine nucleotide exchange factor, is expressed selectively in ribbon synaptic terminals of the mouse retina
Phosphatidylinositol (3,4,5)-trisphosphate-dependent Rac Exchanger 2 (P-Rex2) is a guanine nucleotide exchange factor (GEF) that specifically activates Rac GTPases, important regulators of actin cytoskeleton r...BMC Neuroscience 2013 14:70Behavioral response of Caenorhabditis elegansto localized thermal stimuli
Nociception evokes a rapid withdrawal behavior designed to protect the animal from potential danger. C. elegans performs a reflexive reversal or forward locomotory response when presented with noxious stimuli at ...BMC Neuroscience 2013 14:66Basal forebrain activation controls contrast sensitivity in primary visual cortex
The basal forebrain (BF) regulates cortical activity by the action of cholinergic projections to the cortex. At the same time, it also sends substantial GABAergic projections to both cortex and thalamus, whose...BMC Neuroscience 2013 14:55Glomerular input patterns in the mouse olfactory bulb evoked by retronasal odor stimuli
Odorant stimuli can access the olfactory epithelium either orthonasally, by inhalation through the external nares, or retronasally by reverse airflow from the oral cavity. There is evidence that odors perceive...BMC Neuroscience 2013 14:45
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