Recommendations for Pregnancy in Rare Inherited Anemias - PubMed

Recommendations for Pregnancy in Rare Inherited Anemias - PubMed

Recommendations for Pregnancy in Rare Inherited Anemias

Ali T Taher 1, Achille Iolascon 2 3, Charbel F Matar 1, Rayan Bou-Fakhredin 1, Lucia de Franceschi 4, Maria Domenica Cappellini 5, Wilma Barcellini 6, Roberta Russo 2 3, Immacolata Andolfo 2 3, Paul Tyan 7, Beatrice Gulbis 8, Yesim Aydinok 9, Nicholas P Anagnou 10, Gabriela Amstad Bencaiova 11, Hannah Tamary 12, Patricia Aguilar Martinez 13, Gianluca Forni 14, Raffaele Vindigni 15

Affiliations 

• PMID: 32885142
 
• PMCID: PMC7437563
 
• DOI: 10.1097/HS9.0000000000000446

Free PMC article

Abstract

Rare inherited anemias are a subset of anemias caused by a genetic defect along one of the several stages of erythropoiesis or in different cellular components that affect red blood cell integrity, and thus its lifespan. Due to their low prevalence, several complications on growth and development, and multi-organ system damage are not yet well defined. Moreover, during the last decade there has been a lack of proper understanding of the impact of rare anemias on maternal and fetal outcomes. In addition, there are no clear-cut guidelines outlining the pathophysiological trends and management options unique to this special population. Here, we present on behalf of the European Hematology Association, evidence- and consensus-based guidelines, established by an international group of experts in different fields, including hematologists, gynecologists, general practitioners, medical geneticists, and experts in rare inherited anemias from various European countries for standardized and appropriate choice of therapeutic interventions for the management of pregnancy in rare inherited anemias, including Diamond-Blackfan Anemia, Congenital Dyserythropoietic Anemias, Thalassemia, Sickle Cell Disease, Enzyme deficiency and Red cell membrane disorders.

Copyright © 2020 the Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the European Hematology Association.

Conflict of interest statement

The authors have no conflicts of interest to disclose.

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