viernes, 9 de octubre de 2020

Journal of Experimental & Clinical Cancer Research | Articles

Journal of Experimental & Clinical Cancer Research | Articles

  • New Content Item
  • Owned by the Association for International Promotion & Study in Tumors (APSIT)
  • Regina Elena NCI
  • Official journal of the Regina Elena National Cancer Institute, Scientific Director Gennaro Ciliberto, Rome, Italy

  1. The survival rate is poor in breast cancer patients with brain metastases. Thus, new concepts for therapeutic approaches are required. During metastasis, the cytoskeleton of cancer cells is highly dynamic and ...
    Authors:Julia Arnold, Juliana Schattschneider, Christine Blechner, Christoph Krisp, Hartmut Schlüter, Michaela Schweizer, Marcus Nalaskowski, Leticia Oliveira-Ferrer and Sabine Windhorst
    Citation:Journal of Experimental & Clinical Cancer Research 2020 39:205
    Content type:Research
     
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  2. Tumor angiogenesis is necessary for the continued survival and development of tumor cells, and plays an important role in their growth, invasion, and metastasis. The tumor microenvironment—composed of tumor ce...
    Authors:Xianjie Jiang, Jie Wang, Xiangying Deng, Fang Xiong, Shanshan Zhang, Zhaojian Gong, Xiayu Li, Ke Cao, Hao Deng, Yi He, Qianjin Liao, Bo Xiang, Ming Zhou, Can Guo, Zhaoyang Zeng, Guiyuan Li…
    Citation:Journal of Experimental & Clinical Cancer Research 2020 39:204
    Content type:Review
     
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  3. N6-Methyladenosine (m6A) modification has been implicated in multiple processes for colon cancer development. IGF2BP3 was a newly reported m6A reader, whereas its role in colon cancer remains unclear.
    Authors:Zhou Yang, Tingfeng Wang, Dejun Wu, Zhijun Min, Jingyun Tan and Bo Yu
    Citation:Journal of Experimental & Clinical Cancer Research 2020 39:203
    Content type:Research
     
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  4. Globally, colorectal cancer (CRC) affects more than 1 million people each year. In addition to non-modifiable and other environmental risk factors, Fusobacterium nucleatum infection has been linked to CRC recentl...
    Authors:Pin Guo, Zibin Tian, Xinjuan Kong, Lin Yang, Xinzhi Shan, Bingzi Dong, Xueli Ding, Xue Jing, Chen Jiang, Na Jiang and Yanan Yu
    Citation:Journal of Experimental & Clinical Cancer Research 2020 39:202
    Content type:Research
     
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  5. Although cisplatin-based chemotherapy represents the standard regimen for osteosarcoma (OS), OS patients often exhibit treatment failure and poor prognosis due to chemoresistance to cisplatin. Emerging researc...
    Authors:Dong Yang, Tianyang Xu, Lin Fan, Kaiyuan Liu and Guodong Li
    Citation:Journal of Experimental & Clinical Cancer Research 2020 39:201
    Content type:Research
     
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  6. SARS-coronavirus-2 enters host cells through binding of the Spike protein to ACE2 receptor and subsequent S priming by the TMPRSS2 protease. We aim to assess differences in both ACE2 and TMPRSS2 expression in ...
    Authors:Andrea Sacconi, Sara Donzelli, Claudio Pulito, Stefano Ferrero, Francesca Spinella, Aldo Morrone, Marta Rigoni, Fulvia Pimpinelli, Fabrizio Ensoli, Giuseppe Sanguineti, Raul Pellini, Nishant Agrawal, Evgeny Izumchenko, Gennaro Ciliberto, Aldo Giannì, Paola Muti…
    Citation:Journal of Experimental & Clinical Cancer Research 2020 39:200
    Content type:Research
     
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  7. An amendment to this paper has been published and can be accessed via the original article.
    Authors:Xun Wang, Zhenlong Yu, Chao Wang, Wei Cheng, Xiangge Tian, Xiaokui Huo, Yan Wang, Chengpeng Sun, Lei Feng, Jinshan Xing, Yulong Lan, Dongdong Sun, Qingjuan Hou, Baojing Zhang, Xiaochi Ma and Bo Zhang
    Citation:Journal of Experimental & Clinical Cancer Research 2020 39:199
    Content type:Correction
     
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    The original article was published in Journal of Experimental & Clinical Cancer Research 2017 36:93

  8. Advanced colorectal adenocarcinoma (CRAC), featured by distinctive histopathological appearance, distant organ metastasis, acquired chemoresistance, and tumorigenic stemness is a group of heterogeneous cancers...
    Authors:Hang-Ping Yao, Xiang-Min Tong, Rachel Hudson and Ming-Hai Wang
    Citation:Journal of Experimental & Clinical Cancer Research 2020 39:198
    Content type:Review
     
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  9. Autophagy is an intracellular process through which intracellular components are recycled in response to nutrient or growth factor deficiency to maintain homeostasis. We identified the peptide autophagy-relate...
    Authors:Yang Yang, Qi Wang, Dongjian Song, Ruirui Zen, Lei Zhang, Yingjun Wang, Heying Yang, Da Zhang, Jia Jia, Jiao Zhang and Jiaxiang Wang
    Citation:Journal of Experimental & Clinical Cancer Research 2020 39:197
    Content type:Research
     
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  10. Glioblastoma is the most common primary malignant intracranial tumor with poor clinical prognosis in adults. Accumulating evidence indicates that long non-coding RNAs (lncRNAs) function as important regulators...
    Authors:Xiaoming Zhang, Wanxiang Niu, Maolin Mu, Shanshan Hu and Chaoshi Niu
    Citation:Journal of Experimental & Clinical Cancer Research 2020 39:196
    Content type:Research
     
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  11. Despite reported advances, acquired resistance to tyrosine kinase inhibitors still represents a serious problem in successful cancer treatment. Among this class of drugs, ponatinib (PON) has been shown to have...
    Authors:Diana Corallo, Fabio Pastorino, Marcella Pantile, Elena Mariotto, Federico Caicci, Giampietro Viola, Mirco Ponzoni, Gian Paolo Tonini and Sanja Aveic
    Citation:Journal of Experimental & Clinical Cancer Research 2020 39:195
    Content type:Research
     
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  12. Nuclear casein kinase and cyclin-dependent kinase substrate (NUCKS), a novel gene first reported in 2001, is a member of the high mobility group (HMG) family. Although very little is known regarding the biolog...
    Authors:Erhu Zhao, Liying Feng, Longchang Bai and Hongjuan Cui
    Citation:Journal of Experimental & Clinical Cancer Research 2020 39:194
    Content type:Research
     
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  13. Angiogenesis, a basic requirement for tumor cell survival, is considered to be a malignant characteristic of small cell lung cancer (SCLC) and is closely related to the poor outcomes of SCLC patients. miR-141 ...
    Authors:Shuangshuang Mao, Zhiliang Lu, Sufei Zheng, Hao Zhang, Guochao Zhang, Feng Wang, Jianbing Huang, Yuanyuan Lei, Xinfeng Wang, Chengming Liu, Nan Sun and Jie He
    Citation:Journal of Experimental & Clinical Cancer Research 2020 39:193
    Content type:Research
     
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  14. The chemical modification of RNA is a newly discovered epigenetic regulation mechanism in cells and plays a crucial role in a variety of biological processes. N6-methyladenine (m6A) mRNA modification is the mo...
    Authors:Yuhao Zhang, Xiuchao Geng, Qiang Li, Jianglong Xu, Yanli Tan, Menglin Xiao, Jia Song, Fulin Liu, Chuan Fang and Hong Wang
    Citation:Journal of Experimental & Clinical Cancer Research 2020 39:192
    Content type:Review
     
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  15. Tumor-associated macrophages (TAMs) and tumor cells are important components of the tumor microenvironment. M2 polarization of TAMs, which is a major actor in breast cancer malignancy and metastasis, can be in...
    Authors:Sifeng Tao, Qiang Chen, Chen Lin and Haiying Dong
    Citation:Journal of Experimental & Clinical Cancer Research 2020 39:191
    Content type:Research
     
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  16. Insulin-like growth factor 2 (IGF2) messenger RNA binding protein 3 (IMP3) has been testified to be overexpressed in prostate cancer and strongly related to patients’ poor prognosis. However, the functions of ...
    Authors:Xiang Zhang, Dawei Wang, Boke Liu, Xingwei Jin, Xianjin Wang, Junwei Pan, Weichao Tu and Yuan Shao
    Citation:Journal of Experimental & Clinical Cancer Research 2020 39:190
    Content type:Research
     
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  17. Exploitation of the protein degradation machinery as a therapeutic strategy to degrade oncogenic proteins is experiencing revolutionary advances with the development of proteolysis targeting chimeras (PROTACs)...
    Authors:Alberto Ocaña and Atanasio Pandiella
    Citation:Journal of Experimental & Clinical Cancer Research 2020 39:189
    Content type:Review
     
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  18. Recently, the focus of enhancing tumor radiosensitivity has shifted from chemotherapeutics to targeted therapies. Cyclin-dependent kinase 4 and 6 (CDK4/6) inhibitors are a novel class of selective cell cycle t...
    Authors:Yilan Yang, Jurui Luo, Xingxing Chen, Zhaozhi Yang, Xin Mei, Jinli Ma, Zhen Zhang, Xiaomao Guo and Xiaoli Yu
    Citation:Journal of Experimental & Clinical Cancer Research 2020 39:188
    Content type:Review
     
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  19. Natural antisense transcripts (NATs), which are transcribed from opposite strands of DNA with partial or complete overlap, affect multiple stages of gene expression, from epigenetic to post-translational modif...
    Authors:Shanshan Zhao, Xue Zhang, Shuo Chen and Song Zhang
    Citation:Journal of Experimental & Clinical Cancer Research 2020 39:187
    Content type:Review
     
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  20. Bladder cancer (BC) is a common genitourinary malignancy worldwide. Circular RNAs (circRNAs) participate in cancer development, including BC; thus, the roles of circRNAs in this process have attracted signific...
    Authors:Mingming Jin, Shengjie Lu, Yue Wu, Chen Yang, Chunzi Shi, Yanqiu Wang and Gang Huang
    Citation:Journal of Experimental & Clinical Cancer Research 2020 39:186
    Content type:Research
     
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  21. Molecular oxygen (O2) is a universal electron acceptor that is eventually synthesized into ATP in the mitochondrial respiratory chain of all metazoans. Therefore, hypoxia biology has become an organizational prin...
    Authors:Mingyao Huang, Liang Yang, Xueqiang Peng, Shibo Wei, Qing Fan, Shuo Yang, Xinyu Li, Bowen Li, Hongyuan Jin, Bo Wu, Jingang Liu and Hangyu Li
    Citation:Journal of Experimental & Clinical Cancer Research 2020 39:185
    Content type:Review
     
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  22. The activator protein-1 (AP-1) family of transcription factors modulate a diverse range of cellular signalling pathways into outputs which can be oncogenic or anti-oncogenic. The transcription of relevant gene...
    Authors:Andrew Brennan, James T. Leech, Neil M. Kad and Jody M. Mason
    Citation:Journal of Experimental & Clinical Cancer Research 2020 39:184
    Content type:Review
     
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  23. NEK2, a serine/threonine kinase involved in mitosis, has been found to function in chromosome instability, tumor progression and metastasis, but its role in cervical cancer radioresistance remains unknown.
    Authors:Tie Xu, Yulan Zeng, Linli Shi, Qin Yang, Yeshan Chen, Gang Wu, Guiling Li and Shuangbing Xu
    Citation:Journal of Experimental & Clinical Cancer Research 2020 39:183
    Content type:Research
     
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  24. Glioma is the most common and lethal primary brain tumor in adults, and angiogenesis is one of the key factors contributing to its proliferation, aggressiveness, and malignant transformation. However, the disc...
    Authors:Yang Jiang, Jinpeng Zhou, Junshuang Zhao, Haiying Zhang, Long Li, Hao Li, Lian Chen, Jiangfeng Hu, Wei Zheng and Zhitao Jing
    Citation:Journal of Experimental & Clinical Cancer Research 2020 39:182
    Content type:Research
     
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  25. Nicotine, an active ingredient in tobacco, can promote epithelial-to-mesenchymal transition (EMT) processes that enhance the aggressiveness of a number of human cancers. In the present study, we investigated w...
    Authors:Qiwen Ben, Wei An, Yunwei Sun, Aihua Qian, Jun Liu, Duowu Zou and Yaozong Yuan
    Citation:Journal of Experimental & Clinical Cancer Research 2020 39:181
    Content type:Research
     
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  26. Triple-negative breast cancer (TNBC) is a uniquely aggressive cancer with high rates of relapse due to resistance to chemotherapy. TNBC expresses higher levels of programmed cell death-ligand 1 (PD-L1) compare...
    Authors:Simona Camorani, Margherita Passariello, Lisa Agnello, Silvia Esposito, Francesca Collina, Monica Cantile, Maurizio Di Bonito, Ilya V. Ulasov, Monica Fedele, Antonella Zannetti, Claudia De Lorenzo and Laura Cerchia
    Citation:Journal of Experimental & Clinical Cancer Research 2020 39:180
    Content type:Research
     
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  27. Accumulating evidence demonstrates the essential role of long non-coding RNA (lncRNA) in various types of cancers, including pancreatic cancer. However, the functions and regulation mechanism of lncRNA PMSB8-A...
    Authors:Hao Zhang, Changhao Zhu, Zhiwei He, Shiyu Chen, Lin Li and Chengyi Sun
    Citation:Journal of Experimental & Clinical Cancer Research 2020 39:179
    Content type:Research
     
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  28. Osteosarcoma (OS) is the most common primary bone malignancy and responsible for considerable morbidity and mortality due to its high rates of pulmonary metastasis. Although neoadjuvant chemotherapy has improv...
    Authors:Juncheng Cui, Dylan Dean, Francis J. Hornicek, Zhiwei Chen and Zhenfeng Duan
    Citation:Journal of Experimental & Clinical Cancer Research 2020 39:178
    Content type:Review
     
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  29. A pronounced polarization of healthcare resources and workforce towards the prevention of the rapid spread of SARS-CoV-2 occurred at the expenses of the majority of chronic diseases and cancer, thus jeopardizi...
    Authors:Assunta De Luca, Francesco Ripa di Meana, Branka Vujovic, Aldo Morrone, Chiara Degirolamo, Gennaro Ciliberto and Tiziana Lavalle
    Citation:Journal of Experimental & Clinical Cancer Research 2020 39:177
    Content type:Commentary
     
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  30. Exosomes are emerging as important mediators of the cross-talk between tumor cells and the microenvironment. The communication between tumor-derived exosomes and macrophages has a critical role in facilitating...
    Authors:Manman Liang, Xingwu Chen, Lijing Wang, Lilong Qin, Hanli Wang, Zhengui Sun, Wenying Zhao and Biao Geng
    Citation:Journal of Experimental & Clinical Cancer Research 2020 39:176
    Content type:Research
     
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  31. Overexpression of eukaryotic translation initiation factor 3H (EIF3H) predicts cancer progression and poor prognosis, but the mechanism underlying EIF3H as an oncogene remains unclear in esophageal squamous ce...
    Authors:Xiaobin Guo, Rui Zhu, Aiping Luo, Honghong Zhou, Fang Ding, Hongxin Yang and Zhihua Liu
    Citation:Journal of Experimental & Clinical Cancer Research 2020 39:175
    Content type:Research
     
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  32. Inhibition of p38 MAPK signalling leads to glioblastoma multiform (GBM) tumourigenesis. Nevertheless, the molecular mechanism that induces p38 MAPK signalling pathway silencing during GBM genesis has yet to be...
    Authors:Yang Xu, Qian Sun, Fan’en Yuan, Huimin Dong, Huikai Zhang, Rongxin Geng, Yangzhi Qi, Xiaoxing Xiong, Qianxue Chen and Baohui Liu
    Citation:Journal of Experimental & Clinical Cancer Research 2020 39:174
    Content type:Research
     
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  33. A number of novel anticancer drugs have been developed in recent years. However, the mortality of cancer patients remains high because of the emergence of drug resistance. It was reported that drug resistance ...
    Authors:Cheng Yang, Jiayu Zhang, Yukui Ma, Chunfu Wu, Wei Cui and Lihui Wang
    Citation:Journal of Experimental & Clinical Cancer Research 2020 39:173
    Content type:Review
     
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  34. Lysine succinylation is an emerging posttranslational modification that has garnered increased attention recently, but its role in gastric cancer (GC) remains underexplored.
    Authors:Xiang Li, Chen Zhang, Ting Zhao, Zhongping Su, Mengjing Li, Jiancheng Hu, Jianfei Wen, Jiajia Shen, Chao Wang, Jinshun Pan, Xianmin Mu, Tao Ling, Yingchang Li, Hao Wen, Xiaoren Zhang and Qiang You
    Citation:Journal of Experimental & Clinical Cancer Research 2020 39:172
    Content type:Research
     
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  35. The Covid-19 pandemic has challenged hard the national health systems worldwide. According to the national policy issued in March 2020 in response to the evolving Covid-19 pandemic, several hospitals were re-c...
    Authors:Fabio Pelle, Sonia Cappelli, Franco Graziano, Loredana Piarulli, Flavia Cavicchi, Domenico Magagnano, Assunta De Luca, Roy De Vita, Marcello Pozzi, Maurizio Costantini, Antonio Varanese, Massimo Panimolle, Pietro Paolo Gullo, Maddalena Barba, Patrizia Vici, Enrico Vizza…
    Citation:Journal of Experimental & Clinical Cancer Research 2020 39:171
    Content type:Commentary
     
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  36. The platinum-based chemotherapy is the first-line regimen for the treatment of Non-small cell lung cancer (NSCLC). However, the therapeutic efficiency is largely limited by tenacious chemo-insensitivity that r...
    Authors:Boshi Wang, Tiantian Jing, Weilin Jin, Jinnan Chen, Chengsi Wu, Mingrong Wang and Yizhen Liu
    Citation:Journal of Experimental & Clinical Cancer Research 2020 39:170
    Content type:Research
     
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  38. cAMP responsive element binding protein 5 (CREB5) is a transcriptional activator in eukaryotic cells that can regulate gene expression. Previously, we found that CREB5 was involved in the occurrence and develo...
    Authors:Shuyang Wang, Junfeng Qiu, Lei Liu, Cailin Su, Lu Qi, Chengmei Huang, Xiaoning Chen, Yaxin Zhang, Yaping Ye, Yanqing Ding, Li Liang and Wenting Liao
    Citation:Journal of Experimental & Clinical Cancer Research 2020 39:168
    Content type:Research
     
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  39. An amendment to this paper has been published and can be accessed via the original article.
    Authors:Weiwei Sheng, Xiaoyang Shi, Yiheng Lin, Jingtong Tang, Chao Jia, Rongxian Cao, Jian Sun, Guosen Wang, Lei Zhou and Ming Dong
    Citation:Journal of Experimental & Clinical Cancer Research 2020 39:167
    Content type:Correction
     
    Published on: 
    The original article was published in Journal of Experimental & Clinical Cancer Research 2020 39:16

  40. Nasopharyngeal carcinoma (NPC) is an epithelial cancer emerging from the lining of nasopharyngeal mucosa, with extremely frequent occurrence in east and southeast Asia. For the purpose of exploring roles of th...
    Authors:Xiang Qing, Guo-lin Tan, Huo-wang Liu, Wei Li, Jin-gang Ai, Shan-shan Xiong, Meng-qing Yang and Tian-sheng Wang
    Citation:Journal of Experimental & Clinical Cancer Research 2020 39:166
    Content type:Research
     
    Published on: 

  41. An amendment to this paper has been published and can be accessed via the original article.
    Authors:Qiaoge Zhang, Ge Song, Lili Yao, Yankun Liu, Min Liu, Shengping Li and Hua Tang
    Citation:Journal of Experimental & Clinical Cancer Research 2020 39:165
    Content type:Correction
     
    Published on: 
    The original article was published in Journal of Experimental & Clinical Cancer Research 2018 37:14

  42. An amendment to this paper has been published and can be accessed via the original article.
    Authors:Zichao Li, Luying Zhang, Mingquan Gao, Mei Han, Kaili Liu, Zhuang Zhang, Zhi Gong, Lifei Xing, Xianzhou Shi, Kui Lu and Hui Gao
    Citation:Journal of Experimental & Clinical Cancer Research 2020 39:164
    Content type:Retraction Note
     
    Published on: 
    The original article was published in Journal of Experimental & Clinical Cancer Research 2019 38:8
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