Practical Considerations and Challenges for Germline Genetic Testing in Patients With Prostate Cancer: Recommendations From the Germline Genetics Working Group of the PCCTC - PubMed

Practical Considerations and Challenges for Germline Genetic Testing in Patients With Prostate Cancer: Recommendations From the Germline Genetics Working Group of the PCCTC - PubMed

Practical Considerations and Challenges for Germline Genetic Testing in Patients With Prostate Cancer: Recommendations From the Germline Genetics Working Group of the PCCTC

Brittany M Szymaniak 1, Lauren A Facchini 2, Veda N Giri 3, Emmanuel S Antonarakis 4, Tomasz M Beer 5, Maria I Carlo 6, Daniel C Danila 6, Mallika Dhawan 7, Daniel George 8, Julie N Graff 9, Shilpa Gupta 10, Elisabeth Heath 11, Celestia S Higano 12, Glenn Liu 13, Ana M Molina 14, Channing J Paller 4, Akash Patnaik 15, Daniel P Petrylak 16, Zachery Reichert 17, Matthew B Rettig 18, Charles J Ryan 10, Mary-Ellen Taplin 19, Jake Vinson 20, Young E Whang 21, Alicia K Morgans 22, Heather H Cheng 12, Rana R McKay 23

Affiliations 

• PMID: 32986533
 
• DOI: 10.1200/OP.20.00431

Abstract

Germline genetic testing is now routinely recommended for patients with prostate cancer (PCa) because of expanded guidelines and options for targeted treatments. However, integrating genetic testing into oncology and urology clinical workflows remains a challenge because of the increased number of patients with PCa requiring testing and the limited access to genetics providers. This suggests a critical unmet need for genetic services outside of historical models. This review addresses current guidelines, considerations, and challenges for PCa genetic testing and offers a practical guide for genetic counseling and testing delivery, with solutions to help address potential barriers and challenges for both providers and patients. As genetic and genomic testing become integral to PCa care, developing standardized systems for implementation in the clinic is essential for delivering precision oncology to patients with PCa and realizing the full scope and impact of genetic testing.