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Genomics|Features|Inflammatory Bowel Disease

Inflammatory Bowel Disease

Inflammatory Bowel Disease: Recent Genomic Insights - March 9, 2015

Epidemiology and risk factors for IBD.
Ananthakrishnan Ashwin N et al. Nat Rev Gastroenterol Hepatol 2015 Mar 3.

Deep resequencing of 131 Crohn's disease associated genes in pooled DNA confirmed three reported variants and identified eight novel variants.
Hong Sung Noh et al. Gut 2015 Mar 2.

Laboratory markers in ulcerative colitis: Current insights and future advances.
Cioffi Michele et al. World J Gastrointest Pathophysiol 2015 Feb 15. (1) 13-22

Pooled sequencing of 531 genes in inflammatory bowel disease identifies an associated rare variant in BTNL2 and implicates other immune related genes.
Prescott Natalie J et al. PLoS Genet. 2015 Feb (2) e1004955

Fecal microbial transplant effect on clinical outcomes and fecal microbiome in active Crohn's disease.
Suskind David L et al. Inflamm. Bowel Dis. 2015 Mar (3) 556-63

High-density mapping of the MHC identifies a shared role for HLA-DRB1*01:03 in inflammatory bowel diseases and heterozygous advantage in ulcerative colitis.
Goyette Philippe et al. Nat. Genet. 2015 Feb (2) 172-9

Inflammatory Bowel Disease: Genomics and the Microbiome - January 23, 2015

CDC Information: In the United States, it is currently estimated that about 1 –1.3 million people suffer from IBD.  The cause of IBD is unknown, and until we understand more, prevention or a cure will not be possible

Recent Reviews and Insights

Therapeutic manipulation of the microbiome in IBD: Current results and future approaches.
Hansen JJ, et al. Curr Treat Options Gastroenterol. 2015 Jan 18

The gut microbiota and inflammatory noncommunicable diseases:  Associations and potentials for gut microbiota therapies.
West et al. J Allergy Clin Immunol. 2015 Jan;135(1):3-13.

The involvement of gut microbiota in inflammatory bowel disease pathogenesis: Potential for therapy.
Cammarota G, et al. Pharmacol Ther. 2015 Jan 3.

The role and utility of faecal markers in inflammatory bowel disease.
Lehmann FS, et al. Therap Adv Gastroenterol. 2015 Jan;8(1):23-36.

The emerging role of miRNAs in inflammatory bowel disease: a review.
Chapman CG, et al. Therap Adv Gastroenterol. 2015 Jan;8(1):4-22.

The genetics of Crohn's disease and ulcerative colitis - status quo and beyond.
Ellinghaus D, et al. Scand J Gastroenterol. 2015 Jan;50(1):13-23.

Complex host genetics influence the microbiome in inflammatory bowel disease.
Knights D, et al. Genome Med. 2014 Dec 2;6(12):107

High-density mapping of the MHC identifies a shared role for HLA-DRB1*01:03 in inflammatory bowel diseases and heterozygous advantage in ulcerative colitis.
Goyette P,et al. Nat Genet. 2015 Jan 5. doi: 10.1038/ng.3176.

Identification of risk loci for Crohn's disease phenotypes using a genome-wide association study.
Alonso A, et al. Gastroenterology. 2014 Dec 31

Down the line from genome-wide association studies in inflammatory bowel disease: the resulting clinical benefits and the outlook for the future.
Spekhorst LM, et al. Expert Rev Clin Immunol. 2015 Jan;11(1):33-44

Disease-specific alterations in the enteric virome in inflammatory bowel disease
Jason M. Norman et al. Cell, January 22, 2015

Inflammatory Bowel Disease: Genomics & Public Health

CDC information: What is Inflammatory Bowel Disease (IBD)?  The greatest relative risk of IBD disease is found among first-degree relatives, suggesting a strong genetic component.

Patient page: Inflammatory bowel disease- Crohn disease and ulcerative colitis are the 2 major types of IBD
Jill Jin JAMA May 21, 2014 

The microbiome in inflammatory bowel disease: Current status and the future ahead.
AD Kostic, et al. Gastroenterology, May 2014

Crohn disease: 82 genomewide association studies have reported on genetic factors in Crohn disease, check out the HuGE Navigator 

Ulcerative colitis: 28 genomewide association studies have reported on genetic factors, check out the HuGE Navigator
The most commonly reported genes are NOD2/CARD15 and IL23R

Host–microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
Luke Jostins et al. Nature (2012)