los temas incluídos en cada índice se actualizarán semanalmente... los contenidos están en idioma inglés únicamente y los accesos son múltiples hacia una base de datos de versión beta para cada uno de los capítulos y materias médicas incluídas en las mismas.
Spotlight
Genomic discoveries to clinical applications: Are we reaching an inflection point toward precision medicine?:A New CDC Blog Post from Dr W. Gregory Feero commenting on the 2015 American Society for Human Genetics meeting. Interest in precision medicine will grow as more evidence of health benefits is accumulated over the next decade.
Search more on [precision medicine]
Search more on [precision medicine]
Spotlight
Sabin vaccine reversion in the field: a comprehensive analysis of Sabin-like poliovirus isolates in Nigeria. The global polio eradication effort has completed its twenty-sixth year. Despite success in eliminating wild poliovirus from most of the world, polio persists in populations where logistical, social, and political factors have not allowed for vaccination programs of sustained high quality. One issue of critical importance is eliminating circulating vaccine-derived poliovirus (cVDPV) that have properties indistinguishable from wild poliovirus and can cause paralytic disease. cVDPV emerges due to the genetic instability of the Sabin viruses used in oral polio vaccine (OPV) in populations that have low immunity to poliovirus. However, the dynamics responsible are incompletely understood because it has historically been difficult to gather and interpret data about OPV evolution in regions where cVDPV has occurred. This study is the first to combine whole-genome sequencing of poliovirus isolates collected during routine surveillance with knowledge about polio intra-host dynamics to provide quantitative insight into polio vaccine evolution in the field.
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