Tumor Angiogenesis

Tumor Angiogenesis

Edited by Francesco Pezzella and Chao-Nan Qian

Forming efficient vasculature network, also known as tumor angiogenesis, is a critical hallmark in tumor development. Explorations on its underlying molecular mechanisms have resulted in several novel anti-cancer drugs approved by the Food & Drug Administration (FDA) of the United States. However, the modest survival benefits from anti-angiogenic therapy have forced us to revisit our understanding on tumor angiogenesis. In this special issue of the Chinese Journal of Cancer (CJC), the world leading experts in pathology, molecular biology, pharmacology, and clinical study have contributed their critical thoughts and insightful investigations from different angles to reveal the alternative tumor angiogenesis approaches and potential treatment targets. This special issue is therefore initiating a new era in tumor angiogenesis research, aiming to develop next-generation anti-angiogenic targeted therapy.

This series was published in Chinese Journal of Cancer.

1. Content Type:Review

   Combination therapy in cancer: effects of angiogenesis inhibitors on drug pharmacokinetics and pharmacodynamics

   Validated preclinical studies have provided evidence that anti-vascular endothelial growth factor (VEGF) compounds enhance the activity of subsequent antitumor therapy, but the mechanism of this potentiation i...

   Authors:Ilaria Fuso Nerini, Marta Cesca, Francesca Bizzaro and Raffaella Giavazzi

   Citation:Chinese Journal of Cancer 2016 35:61

   Published on: 29 June 2016

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2. Content Type:Editorial

   Twenty years after: the beautiful hypothesis and the ugly facts

   The limited clinical benefits from current antiangiogenic therapy for cancer patients have triggered some critical thoughts and insightful investigations aiming to further elucidate the relationship between ve...

   Authors:Francesco Pezzella, Kevin Gatter and Chao-Nan Qian

   Citation:Chinese Journal of Cancer 2016 35:22

   Published on: 24 February 2016

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3. Content Type:Review

   Future options of anti-angiogenic cancer therapy

   In human patients, drugs that block tumor vessel growth are widely used to treat a variety of cancer types. Many rigorous phase 3 clinical trials have demonstrated significant survival benefits; however, the a...

   Authors:Yihai Cao

   Citation:Chinese Journal of Cancer 2016 35:21

   Published on: 15 February 2016

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4. Content Type:Original Article

   Why some tumours trigger neovascularisation and others don’t: the story thus far

   Angiogenesis is not essential for tumours to develop and expand, as cancer can also grow in a non-angiogenic fashion, but why this type of growth occurs is unknown. Surprisingly, our data from mRNA transcripti...

   Authors:Omanma Adighibe, Russell D. Leek, Marta Fernandez-Mercado, Jiangting Hu, Cameron Snell, Kevin C. Gatter, Adrian L. Harris and Francesco Pezzella

   Citation:Chinese Journal of Cancer 2016 35:18

   Published on: 12 February 2016

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5. Content Type:Review

   Mechanisms of vascularization in murine models of primary and metastatic tumor growth

   Directed capillary ingrowth has long been considered synonymous with tumor vascularization. However, the vasculature of primary tumors and metastases is not necessarily formed by endothelial cell sprouting; in...

   Authors:Edina Bugyik, Ferenc Renyi-Vamos, Vanessza Szabo, Katalin Dezso, Nora Ecker, Andras Rokusz, Peter Nagy, Balazs Dome and Sandor Paku

   Citation:Chinese Journal of Cancer 2016 35:19

   Published on: 12 February 2016

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6. Content Type:Original Article

   Comparisons of biophysical properties and bioactivities of mono-PEGylated endostatin and an endostatin analog

   Endostatin (ES) is a well-established potent endogenous antiangiogenic factor. An ES variant, called zinc-binding protein-ES (ZBP-ES), is clinically available; however, its use is limited by rapid renal cleara...

   Authors:Shan Wang, Yan Fu and Yongzhang Luo

   Citation:Chinese Journal of Cancer 2016 35:14

   Published on: 20 January 2016

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7. Content Type:Review

   Revisiting tumor angiogenesis: vessel co-option, vessel remodeling, and cancer cell-derived vasculature formation

   Tumor growth and metastasis depend on the establishment of tumor vasculature to provide oxygen, nutrients, and other essential factors. The well-known vascular endothelial growth factor (VEGF) signaling is cru...

   Authors:Chao-Nan Qian, Min-Han Tan, Jun-Ping Yang and Yun Cao

   Citation:Chinese Journal of Cancer 2016 35:10

   Published on: 8 January 2016

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