Tumor metastasis

Tumor metastasis

Edited by Jian Zhang and Chao-Nan Qian

Every year, more than 8 million people die from cancer worldwide and the majority of them are actually killed by cancer metastasis. Current knowledge of cancer metastasis is limited. Many questions remain unanswered. For example, when and how do cancer cells actually spread from the primary tumor to the sentinel lymph node? How do they further travel to distant organs from the lymph node? What are the driving molecules promoting cancer metastasis? And how do different types of cancer rely on different molecular mechanisms for metastasis? With the help of high through-put technologies plus big data analyses, we are hoping to accelerate our endeavors in unveiling cancer metastasis.

In this thematic series on metastasis, we are excited about new insights into the roles of different genes in controlling metastasis via influencing epithelial-mesenchymal transition, and the involvement of immune cells as well as tumor microenvironment alteration for metastasis. A collection of the 150 most important genes promoting cancer metastasis in this series will also be very useful for future big data analyses.

This series was published in Chinese Journal of Cancer. 

1. Content Type:Editorial

   Cancer metastasis: issues and challenges

   Metastasis is the major cause of treatment failure in cancer patients and of cancer-related deaths. This editorial discusses how cancer metastasis may be better perceived and controlled. Based on big-data anal...

   Authors:Chao-Nan Qian, Yan Mei and Jian Zhang

   Citation:Chinese Journal of Cancer 2017 36:38

   Published on: 3 April 2017

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2. Content Type:Original Article

   Down-regulation of E-cadherin enhances prostate cancer chemoresistance via Notch signaling

   The chemoresistance of prostate cancer (PCa) is invariably associated with the aggressiveness and metastasis of this disease. New emerging evidence indicates that the epithelial-to-mesenchymal transition (EMT)...

   Authors:Wenchu Wang, Lihui Wang, Atsushi Mizokami, Junlin Shi, Chunlin Zou, Jinlu Dai, Evan T. Keller, Yi Lu and Jian Zhang

   Citation:Chinese Journal of Cancer 2017 36:35

   Published on: 29 March 2017

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3. Content Type:Review

   Tumor microenvironment: driving forces and potential therapeutic targets for breast cancer metastasis

   Distant metastasis to specific target organs is responsible for over 90% of breast cancer-related deaths, but the underlying molecular mechanism is unclear. Mounting evidence suggests that the interplay betwee...

   Authors:Hong-Yan Xie, Zhi-Min Shao and Da-Qiang Li

   Citation:Chinese Journal of Cancer 2017 36:36

   Published on: 29 March 2017

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4. Content Type:Review

   Immune mediators in the tumor microenvironment of prostate cancer

   Prostate cancer tissue is composed of both cancer cells and host cells. The milieu of host components that compose the tumor is termed the tumor microenvironment (TME). Host cells can be those derived from the...

   Authors:Jinlu Dai, Yi Lu, Hernan Roca, Jill M. Keller, Jian Zhang, Laurie K. McCauley and Evan T. Keller

   Citation:Chinese Journal of Cancer 2017 36:29

   Published on: 14 March 2017

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5. Content Type:Review

   Corepressor metastasis-associated protein 3 modulates epithelial-to-mesenchymal transition and metastasis

   Worldwide, metastasis is the leading cause of more than 90% of cancer-related deaths. Currently, no specific therapies effectively impede metastasis. Metastatic processes are controlled by complex regulatory n...

   Authors:Liang Du, Zhifeng Ning, Fuxing Liu and Hao Zhang

   Citation:Chinese Journal of Cancer 2017 36:28

   Published on: 9 March 2017

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6. Content Type:Review

   For robust big data analyses: a collection of 150 important pro-metastatic genes

   Metastasis is the greatest contributor to cancer-related death. In the era of precision medicine, it is essential to predict and to prevent the spread of cancer cells to significantly improve patient survival....

   Authors:Yan Mei, Jun-Ping Yang and Chao-Nan Qian

   Citation:Chinese Journal of Cancer 2017 36:16

   Published on: 21 January 2017

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