Journal of Translational Medicine | Pain, Critical Care and Anesthesia

Journal of Translational Medicine | Pain, Critical Care and Anesthesia

Pain, Critical Care and Anesthesia

Section edited by Yasin S. Al Makadma

Pain, Critical Care and Anesthesia section encompasses three major fields that are often tightly inter-related both historically and in everyday practice. A systematic Translational Medical approach may be our best route towards analysing common links and complete some of our limited understanding of common clinical pictures. Our section will also contribute in the understanding of mechanistic aspect of different anaesthetic agents and molecules and attempt to deepen the insight in the role of pharmacogenetics.

For that to happen, this section welcomes a very wide range of original research and review articles in related areas.

1. Content Type:Research

   Fibroblast growth factor 23, endothelium biomarkers and acute kidney injury in critically-ill patients

   Fibroblast growth factor 23 (FGF23) and endothelium-related biomarkers have been related to AKI in critically-ill patients. Also, FGF23 is associated with endothelial dysfunction. In this study, we investigate...

   Authors:Fernanda Macedo de Oliveira Neves, Camila Barbosa Araújo, Daniele Ferreira de Freitas, Bianca Fernandes Távora Arruda, Leonardo José Monteiro de Macêdo Filho, Vivian Brito Salles, Gdayllon Cavalcante Meneses, Alice Maria Costa Martins and Alexandre Braga Libório

   Citation:Journal of Translational Medicine 2019 17:121

   Published on: 11 April 2019

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2. Content Type:Research

   Exosome microRNA signatures in patients with complex regional pain syndrome undergoing plasma exchange

   Therapeutic plasma exchange (PE) or plasmapheresis is an extracorporeal procedure employed to treat immunological disorders. Exosomes, nanosized vesicles of endosomal origin, mediate intercellular communicatio...

   Authors:Sujay Ramanathan, Sabrina R. Douglas, Guillermo M. Alexander, Botros B. Shenoda, James E. Barrett, Enrique Aradillas, Ahmet Sacan and Seena K. Ajit

   Citation:Journal of Translational Medicine 2019 17:81

   Published on: 14 March 2019

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3. Content Type:Research

   Early and dynamic alterations of Th2/Th1 in previously immunocompetent patients with community-acquired severe sepsis: a prospective observational study

   T helper (Th) cells regulate sepsis processes, including primary pathogen clear and secondary pathogen defence. The objectives of this study were to determine the early and dynamic alterations of Th1 and Th2 p...

   Authors:Ming Xue, Jianfeng Xie, Ling Liu, Yingzi Huang, Fengmei Guo, Jingyuan Xu, Yi Yang and Haibo Qiu

   Citation:Journal of Translational Medicine 2019 17:57

   Published on: 27 February 2019

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4. Content Type:Research

   Saliva molecular inflammatory profiling in female migraine patients responsive to adjunctive cervical non-invasive vagus nerve stimulation: the MOXY Study

   Rising evidence indicate that oxytocin and IL-1β impact trigemino-nociceptive signaling. Current perspectives on migraine physiopathology emphasize a cytokine bias towards a pro-inflammatory status. The anti-n...

   Authors:Azize Boström, Dirk Scheele, Birgit Stoffel-Wagner, Frigga Hönig, Shafqat R. Chaudhry, Sajjad Muhammad, Rene Hurlemann, Joachim K. Krauss, Ilana S. Lendvai, Krishnan V. Chakravarthy and Thomas M. Kinfe

   Citation:Journal of Translational Medicine 2019 17:53

   Published on: 22 February 2019

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5. Content Type:Research

   Dexmedetomidine expands monocytic myeloid-derived suppressor cells and promotes tumour metastasis after lung cancer surgery

   Dexmedetomidine (DEX) has been reported to promote tumour metastases. However the underlying mechanisms remain unclear. The purpose of this study was to investigate whether DEX promotes tumour metastasis by in...

   Authors:Xiaosan Su, Yaodong Fan, Liu Yang, Jie Huang, Fei Qiao, Yu Fang and Jun Wang

   Citation:Journal of Translational Medicine 2018 16:347

   Published on: 11 December 2018

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6. Content Type:Research

   Early goal-directed and lactate-guided therapy in adult patients with severe sepsis and septic shock: a meta-analysis of randomized controlled trials

   The ProCESS, ARISE, and ProMISe trials have failed to show that early goal-directed therapy (EGDT) reduces mortality in patients with severe sepsis and septic shock. Although lactate-guided therapy (LGT) has b...

   Authors:Xian-Fei Ding, Zi-Yue Yang, Zhen-Tao Xu, Li-Feng Li, Bo Yuan, Li-Na Guo, Le-Xin Wang, Xi Zhu and Tong-Wen Sun

   Citation:Journal of Translational Medicine 2018 16:331

   Published on: 29 November 2018

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7. Content Type:Research

   Lactobacillus salivarius reverse antibiotic-induced lung defense impairment in a ventilator model

   Widespread use of antibiotics in the intensive care unit is a potential cause of the emergence of hospital-acquired pneumonia. This study determined whether Lactobacillus salivarius feeding could reverse antibiot...

   Authors:Tzyy-Bin Tsay, Ming-Chieh Yang, Wan-Hsuan Chang, Pei-Hsuan Chen and Lee-Wei Chen

   Citation:Journal of Translational Medicine 2018 16:225

   Published on: 13 August 2018

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8. Content Type:Research

   Dexmedetomidine attenuates spinal cord ischemia–reperfusion injury through both anti-inflammation and anti-apoptosis mechanisms in rabbits

   Dexmedetomidine (Dex) can improve neuronal viability and protect the spinal cord from ischemia–reperfusion (I/R) injury, but the underlying mechanisms are not fully understood. This study investigated the effe...

   Authors:Zhixiang Sun, Tianyun Zhao, Shaojun Lv, Ying Gao, Joe Masters and Hao Weng

   Citation:Journal of Translational Medicine 2018 16:209

   Published on: 21 July 2018

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9. Content Type:Research

   Acquired immunological imbalance after surgery with cardiopulmonary bypass due to epigenetic over-activation of PU.1/M-CSF

   It has been shown that severe insult to the immune system may trigger prolonged macrophage characteristics associated with excessive release of monocyte colony stimulating factor (M-CSF). However, it is unclea...

   Authors:Krzysztof Laudanski, Mateusz Zawadka, Jacek Polosak, Jaymin Modi, Matthew DiMeglio, Jacob Gutsche, Wilson Y. Szeto and Monika Puzianowska-Kuznicka

   Citation:Journal of Translational Medicine 2018 16:143

   Published on: 25 May 2018

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10. Content Type:Research

    Dexmedetomidine attenuates lung apoptosis induced by renal ischemia–reperfusion injury through α2AR/PI3K/Akt pathway

    Acute lung injury caused by renal ischemia–reperfusion is one of the leading causes of acute kidney injury-related death. Dexmedetomidine, an α2-adrenergic agonist sedative, has been found to have protective effe...

    Authors:Juanjuan Li, Qian Chen, Xinhai He, Azeem Alam, Jiaolin Ning, Bin Yi, Kaizhi Lu and Jianteng Gu

    Citation:Journal of Translational Medicine 2018 16:78

    Published on: 23 March 2018

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11. Content Type:Research

    R-100 improves pulmonary function and systemic fluid balance in sheep with combined smoke-inhalation injury and Pseudomonas aeruginosa sepsis

    Septic shock is a major cause of death in intensive care units around the world . The aim of the study was to investigate whether the novel drug R-100 (a superoxide degradation catalyst and nitric oxide donor)...

    Authors:Hiroshi Ito, Erik Malgerud, Sven Asmussen, Ernesto Lopez, Andrew L. Salzman and Perenlei Enkhbaatar

    Citation:Journal of Translational Medicine 2017 15:266

    Published on: 28 December 2017

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12. Content Type:Protocol

    Inorganic nitrate as a treatment for acute heart failure: a protocol for a single center, randomized, double-blind, placebo-controlled pilot and feasibility study

    Acute heart failure (AHF) is a frequent reason for hospitalization worldwide and effective treatment options are limited. It is known that AHF is a condition characterized by impaired vasorelaxation, together ...

    Authors:Roman Falls, Michael Seman, Sabine Braat, Joshua Sortino, Jason D. Allen and Christopher J. Neil

    Citation:Journal of Translational Medicine 2017 15:172

    Published on: 8 August 2017

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13. Content Type:Research

    Temperature variability in the day–night cycle is associated with further intracranial pressure during therapeutic hypothermia

    To assess whether circadian patterns of temperature correlate with further values of intracranial pressure (ICP) in severe brain injury treated with hypothermia.

    Authors:Adriano Barreto Nogueira, Eva Annen, Oliver Boss, Faraneh Farokhzad, Christopher Sikorski and Emanuela Keller

    Citation:Journal of Translational Medicine 2017 15:170

    Published on: 3 August 2017

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14. Content Type:Research

    MicroRNA-223 demonstrated experimentally in exosome-like vesicles is associated with decreased risk of persistent pain after lumbar disc herniation

    Previous findings have demonstrated that lumbar radicular pain after disc herniation may be associated with up-regulation of inflammatory mediators. In the present study we examined the possible role of extrac...

    Authors:Aurora Moen, Daniel Jacobsen, Santosh Phuyal, Anna Legfeldt, Fred Haugen, Cecilie Røe and Johannes Gjerstad

    Citation:Journal of Translational Medicine 2017 15:89

    Published on: 1 May 2017

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15. Content Type:Review

    The role of vitamin C in the treatment of pain: new insights

    The vitamin C deficiency disease scurvy is characterised by musculoskeletal pain and recent epidemiological evidence has indicated an association between suboptimal vitamin C status and spinal pain. Furthermor...

    Authors:Anitra C. Carr and Cate McCall

    Citation:Journal of Translational Medicine 2017 15:77

    Published on: 14 April 2017

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16. Content Type:Research

    Inhibitory effects of serum from sepsis patients on epithelial cell migration in vitro: a case control study

    Sepsis delays wound re-epithelialization. In this study we explored the effect of human sepsis sera as well as the effects of cytokines, growth factors and exosomes of sepsis sera treated normal fibroblasts (N...

    Authors:Henna Jaurila, Vesa Koivukangas, Marjo Koskela, Fiia Gäddnäs, Sirpa Salo, Johanna Korvala, Maija Risteli, Toni Karhu, Karl-Heinz Herzig, Tuula Salo and Tero I. Ala-Kokko

    Citation:Journal of Translational Medicine 2017 15:11

    Published on: 13 January 2017

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17. Content Type:Research

    Does therapeutic hypothermia during extracorporeal cardiopulmonary resuscitation preserve cardiac function?

    Extracorporeal cardiopulmonary resuscitation (E-CPR) is increasingly used as a rescue method in the management of cardiac arrest and provides the opportunity to rapidly induce therapeutic hypothermia. The surv...

    Authors:Harald A. Bergan, Per S. Halvorsen, Helge Skulstad, Erik Fosse and Jan F. Bugge

    Citation:Journal of Translational Medicine 2016 14:345

    Published on: 20 December 2016

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18. Content Type:Research

    AQP5-1364A/C polymorphism and the AQP5 expression influence sepsis survival and immune cell migration: a prospective laboratory and patient study

    The C-allele of the aquaporin (AQP5) -1364A/C polymorphism is associated with decreased AQP5 expression but increased 30-day survival in patients with severe sepsis. AQP5 expression might affect survival via a...

    Authors:Katharina Rump, Matthias Unterberg, Lars Bergmann, Agnes Bankfalvi, Anil Menon, Simon Schäfer, André Scherag, Zainab Bazzi, Winfried Siffert, Jürgen Peters and Michael Adamzik

    Citation:Journal of Translational Medicine 2016 14:321

    Published on: 21 November 2016

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19. Content Type:Research

    Changes in ceftriaxone pharmacokinetics/pharmacodynamics during the early phase of sepsis: a prospective, experimental study in the rat

    Sepsis is characterized by the loss of the perm-selectivity properties of the glomerular filtration barrier (GFB) with consequent albuminuria. We examined whether the pharmacokinetics–pharmacodynamics (PK/PD) ...

    Authors:Valentina Selmi, Beatrice Loriga, Luca Vitali, Martina Carlucci, Alessandro Di Filippo, Giulio Carta, Eleonora Sgambati, Lorenzo Tofani, Angelo Raffaele De Gaudio, Andrea Novelli and Chiara Adembri

    Citation:Journal of Translational Medicine 2016 14:316

    Published on: 15 November 2016

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20. Content Type:Research

    Soluble programmed cell death receptor-1 (sPD-1): a potential biomarker with anti-inflammatory properties in human and experimental acute respiratory distress syndrome (ARDS)

    Acute respiratory distress syndrome (ARDS) remains a common organ dysfunction in the critically ill patient. Mechanisms for its development have focused on immune mediated causes, aspects of our understanding ...

    Authors:Sean F. Monaghan, Chun-Shiang Chung, Yaping Chen, Joanne Lomas-Neira, William G. Fairbrother, Daithi S. Heffernan, William G. Cioffi and Alfred Ayala

    Citation:Journal of Translational Medicine 2016 14:312

    Published on: 11 November 2016

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21. Content Type:Research

    Effect of helium pre- or postconditioning on signal transduction kinases in patients undergoing coronary artery bypass graft surgery

    The noble gas helium induces pre- and postconditioning in animals and humans. Volatile anesthetics induce cardioprotection in humans undergoing coronary artery bypass graft (CABG) surgery. We hypothesized that...

    Authors:Kirsten F. Smit, Daniel Brevoord, Stefan De Hert, Bas A. de Mol, Raphaela P. Kerindongo, Susan van Dieren, Wolfgang S. Schlack, Markus W. Hollmann, Nina C. Weber and Benedikt Preckel

    Citation:Journal of Translational Medicine 2016 14:294

    Published on: 14 October 2016

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22. Content Type:Research

    Microcirculatory blood flow during cardiac arrest and cardiopulmonary resuscitation does not correlate with global hemodynamics: an experimental study

    Current research highlights the role of microcirculatory disorders in post-cardiac arrest patients. Affected microcirculation shows not only dissociation from systemic hemodynamics but also strong connection t...

    Authors:Petra Krupičková, Mikuláš Mlček, Michal Huptych, Zuzana Mormanová, Tomáš Bouček, Tomáš Belza, Stanislav Lacko, Miloš Černý, Petr Neužil, Otomar Kittnar, Aleš Linhart and Jan Bělohlávek

    Citation:Journal of Translational Medicine 2016 14:163

    Published on: 8 June 2016

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23. Content Type:Review

    Early life programming of pain: focus on neuroimmune to endocrine communication

    Chronic pain constitutes a challenge for the scientific community and a significant economic and social cost for modern societies. Given the failure of current drugs to effectively treat chronic pain, which ar...

    Authors:I. Zouikr, M. D. Bartholomeusz and D. M. Hodgson

    Citation:Journal of Translational Medicine 2016 14:123

    Published on: 6 May 2016

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24. Content Type:Research

    Hsa-miR-34a mediated repression of corticotrophin releasing hormone receptor 1 regulates pro-opiomelanocortin expression in patients with complex regional pain syndrome

    Ketamine provides relief for a subset of patients with complex regional pain syndrome (CRPS). The poor responders had a lower body mass index (BMI) relative to responders. Regulation of proopiomelanocortin (PO...

    Authors:Botros B. Shenoda, Guillermo M. Alexander and Seena K. Ajit

    Citation:Journal of Translational Medicine 2016 14:64

    Published on: 3 March 2016

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25. Content Type:Research

    Adverse effects of hydroxyethyl starch (HES 130/0.4) on intestinal barrier integrity and metabolic function are abrogated by supplementation with Albumin

    Volume resuscitation with hydroxyethyl starch (HES) is controversially discussed and we recently showed that HES perfusion impairs endothelial and epithelial intestinal barrier integrity. Here we investigated ...

    Authors:Yuk Lung Wong, Ingmar Lautenschläger, Karina Zitta, Christin Schildhauer, Kerstin Parczany, Christoph Röcken, Markus Steinfath, Norbert Weiler and Martin Albrecht

    Citation:Journal of Translational Medicine 2016 14:60

    Published on: 27 February 2016

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26. Content Type:Review

    Stem/progenitor cells in endogenous repairing responses: new toolbox for the treatment of acute lung injury

    The repair of organs and tissues has stepped into a prospective era of regenerative medicine. However, basic research and clinical practice in the lung regeneration remains crawling. Owing to the complicated t...

    Authors:Ce Yang, Jianxin Jiang, Xuetao Yang, Haiyan Wang and Juan Du

    Citation:Journal of Translational Medicine 2016 14:47

    Published on: 11 February 2016

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27. Content Type:Research

    Effectiveness of pure argon for renal transplant preservation in a preclinical pig model of heterotopic autotransplantation

    In kidney transplantation, the conditions of organ preservation following removal influence function recovery. Current static preservation procedures are generally based on immersion in a cold-storage solution...

    Authors:Alice Faure, Laurie Bruzzese, Jean-Guillaume Steinberg, Yves Jammes, Julia Torrents, Stephane V. Berdah, Emmanuelle Garnier, Tristan Legris, Anderson Loundou, Matthieu Chalopin, Guy Magalon, Regis Guieu, Emmanuel Fenouillet and Eric Lechevallier

    Citation:Journal of Translational Medicine 2016 14:40

    Published on: 4 February 2016

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28. Content Type:Research

    Induction of heme oxygenase-1 by hemin protects lung against orthotopic autologous liver transplantation-induced acute lung injury in rats

    Post-liver transplantation acute lung injury (ALI) severely affects patients’ survival, whereas the mechanism is unclear and effective therapy is lacking. The authors postulated that reperfusion-induced increa...

    Authors:Xinjin Chi, Na Guo, Weifeng Yao, Yi Jin, Wanling Gao, Jun Cai and Ziqing Hei

    Citation:Journal of Translational Medicine 2016 14:35

    Published on: 2 February 2016

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29. Content Type:Commentary

    Individualized real-time clinical decision support to monitor cardiac loading during venoarterial ECMO

    Veno-arterial extracoporeal membrane oxygenation (VA ECMO) is increasingly used for acute and refractory cardiogenic shock. Yet, in clinical practice, monitoring of cardiac loading conditions during VA ECMO ca...

    Authors:Michael Broomé and Dirk W. Donker

    Citation:Journal of Translational Medicine 2016 14:4

    Published on: 6 January 2016

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30. Content Type:Research

    Nerve detection with optical spectroscopy for regional anesthesia procedures

    Regional anesthesia has several advantages over general anesthesia but requires accurate needle placement to be effective. To achieve accurate placement, a needle equipped with optical fibers that allows tiss...

    Authors:Benno H. W. Hendriks, Andrea J. R. Balthasar, Gerald W. Lucassen, Marjolein van der Voort, Manfred Mueller, Vishnu V. Pully, Torre M. Bydlon, Christian Reich, Arnold T. M. H. van Keersop, Jeroen Kortsmit, Gerrit C. Langhout and Geert-Jan van Geffen

    Citation:Journal of Translational Medicine 2015 13:380

    Published on: 15 December 2015

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31. Content Type:Research

    Mother root of Aconitum carmichaelii Debeaux exerts antinociceptive effect in Complete Freund’s Adjuvant-induced mice: roles of dynorphin/kappa-opioid system and transient receptor potential vanilloid type-1 ion channel

    Processed Chuanwu (PCW), the mother root of Aconitum carmichaelii Debeaux, has been widely used as a classic Traditional Chinese Medicine for pain relieve for over two millennia clinic...

    Authors:Chao Wang, Danni Sun, Chunfang Liu, Chunyan Zhu, Xianghong Jing, Shuping Chen, Cuiling Liu, Kai Zhi, Tengfei Xu, Hui Wang, Junling Liu, Ying Xu, Zhiqiang Liu and Na Lin

    Citation:Journal of Translational Medicine 2015 13:284

    Published on: 30 August 2015

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32. Content Type:Research

    Beneficial effects of levobupivacaine regional anaesthesia on postoperative opioid induced hyperalgesia in diabetic mice

    Diabetic neuropathy is one of the most common complications of diabetes and causes various problems in daily life. The aim of this study was to assess the effect of regional anaesthesia on post surgery opioid ...

    Authors:Anne Gomez-Brouchet, Nelly Blaes, Lionel Mouledous, Olivier Fourcade, Ivan Tack, Bernard Francès, Jean-Pierre Girolami and Vincent Minville

    Citation:Journal of Translational Medicine 2015 13:208

    Published on: 2 July 2015

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33. Content Type:Research

    Dexmedetomidine ameliorates acute lung injury following orthotopic autologous liver transplantation in rats probably by inhibiting Toll-like receptor 4–nuclear factor kappa B signaling

    To investigate whether pretreatment with dexmedetomidine (Dex) has a protective effect against acute lung injury (ALI) in an orthotopic autologous liver transplantation (OALT) rat model and to explore the mech...

    Authors:Xinjin Chi, Xiaoxia Wei, Wanling Gao, Jianqiang Guan, Xiaofan Yu, Yiheng Wang, Xi Li and Jun Cai

    Citation:Journal of Translational Medicine 2015 13:190

    Published on: 13 June 2015

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34. Content Type:Research

    Effects of hydrogen-rich saline on early acute kidney injury in severely burned rats by suppressing oxidative stress induced apoptosis and inflammation

    Early acute kidney injury (AKI) in severely burned patients predicts a high mortality that is multi-factorial. Hydrogen has been reported to alleviate organ injury via selective quenching of reactive oxygen sp...

    Authors:Song-Xue Guo, Quan Fang, Chuan-Gang You, Yun-Yun Jin, Xin-Gang Wang, Xin-Lei Hu and Chun-Mao Han

    Citation:Journal of Translational Medicine 2015 13:183

    Published on: 6 June 2015

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35. Content Type:Research

    Electroacupuncture stimulation at sub-specific acupoint and non-acupoint induced distinct brain glucose metabolism change in migraineurs: a PET-CT study

    Acupuncture has analgesic effect to most pain conditions. Many neuroimaging studies were conducted to explore acupoint specificity in pain and other condition, but till now there is still discrepancy. Based on...

    Authors:Mingxiao Yang, Jie Yang, Fang Zeng, Peng Liu, Zhenhong Lai, Shufang Deng, Li Fang, Wenzhong Song, Hongjun Xie and Fanrong Liang

    Citation:Journal of Translational Medicine 2014 12:351

    Published on: 12 December 2014

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36. Content Type:Editorial

    Pain, Critical Care and Anesthesia section

    No abstract

    Authors:Yasin Said AlMakadma

    Citation:Journal of Translational Medicine 2014 12:268

    Published on: 8 October 2014

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