Journal of Translational Medicine | Cardiovascular, metabolic and Lipoprotein translation

Journal of Translational Medicine

Cardiovascular, metabolic and Lipoprotein translation

Section edited by Nehal N. Mehta

This section aims to speed mechanistic understanding, development of novel diagnostics and potential therapeutic targets within cardiovascular, metabolic diseases and lipoprotein diseases. The section is open to experiments involving cellular models, animal models, observational studies and clinical trials that are distinguished for their novelty in approach, design or indication, timeliness, and unique ability to translate laboratory concepts from the bench to the bedside.

Highest priority will be given to those manuscripts which are specifically focused on cardiovascular, metabolic and lipid disorders which enrich understanding of disease mechanism, novel therapeutics and state-of-the-art scientific technique.

Featured articles

Transforming growth factor-beta 1 produced by vascular smooth muscle cells predicts fibrosis in the gastrocnemius of patients with peripheral artery disease
Duy M. Ha, et al

Combining patient proteomics and in vitro cardiomyocyte phenotype testing to identify potential mediators of heart failure with preserved ejection fraction
Roseanne Raphael, et al

Chronic, not acute, skin-specific inflammation promotes thrombosis in psoriasis murine models.
Jackelyn B. Golden, et al

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Content Type:Research
FNDC5 attenuates obesity-induced cardiac hypertrophy by inactivating JAK2/STAT3-associated inflammation and oxidative stress
Chronic low-grade inflammation and oxidative stress play important roles in the development of obesity-induced cardiac hypertrophy. Here, we investigated the role of Fibronectin type III domain containing 5 (F...
Authors:Zhi Geng, Wen-Yong Fan, Bing Zhou, Chao Ye, Ying Tong, Ye-Bo Zhou and Xiao-Qing Xiong
Citation:Journal of Translational Medicine 2019 17:107
Published on: 2 April 2019
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Content Type:Research
Overexpression of scavenger receptor and infiltration of macrophage in epicardial adipose tissue of patients with ischemic heart disease and diabetes
Oxidized low-density lipoproteins and scavenger receptors (SRs) play an important role in the formation and development of atherosclerotic plaques. However, little is known about their presence in epicardial a...
Authors:Concepción Santiago-Fernández, Luis M. Pérez-Belmonte, Mercedes Millán-Gómez, Inmaculada Moreno-Santos, Fernando Carrasco-Chinchilla, Amalio Ruiz-Salas, Luis Morcillo-Hidalgo, José M. Melero, Lourdes Garrido-Sánchez and Manuel Jiménez-Navarro
Citation:Journal of Translational Medicine 2019 17:95
Published on: 20 March 2019
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Content Type:Research
Hyperoxia-induced lung structure–function relation, vessel rarefaction, and cardiac hypertrophy in an infant rat model
Hyperoxia-induced bronchopulmonary dysplasia (BPD) models are essential for better understanding and impacting on long-term pulmonary, cardiovascular, and neurological sequelae of this chronic disease. Only fe...
Authors:Francesco Greco, Susanne Wiegert, Philipp Baumann, Sven Wellmann, Giovanni Pellegrini and Vincenzo Cannizzaro
Citation:Journal of Translational Medicine 2019 17:91
Published on: 18 March 2019
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Content Type:Research
Serum protein signature of coronary artery disease in type 2 diabetes mellitus
Coronary artery disease (CAD) is the leading cause of morbidity and mortality in patients with type 2 diabetes mellitus (T2DM). The purpose of the present study was to discriminate the Indian CAD patients with...
Authors:Ramu Adela, Podduturu Naveen Chander Reddy, Tarini Shankar Ghosh, Suruchi Aggarwal, Amit Kumar Yadav, Bhabatosh Das and Sanjay K. Banerjee
Citation:Journal of Translational Medicine 2019 17:17
Published on: 24 January 2019
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Content Type:Research
Circulating miR-3659 may be a potential biomarker of dyslipidemia in patients with obesity
The present study attempted to identify potential key genes and miRNAs of dyslipidemia in obese, and to investigate the possible mechanisms associated with them.
Authors:Liu Miao, Rui-Xing Yin, Shang-Ling Pan, Shuo Yang, De-Zhai Yang and Wei-Xiong Lin
Citation:Journal of Translational Medicine 2019 17:25
Published on: 14 January 2019
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Content Type:Research
Regeneration of a neoartery through a completely autologous acellular conduit in a minipig model: a pilot study
Vascular grafts are widely used as a treatment in coronary artery bypass surgery, hemodialysis, peripheral arterial bypass and congenital heart disease. Various types of synthetic and natural materials were ex...
Authors:Tao Wang, Nianguo Dong, Huimin Yan, Sze Yue Wong, Wen Zhao, Kang Xu, Dong Wang, Song Li and Xuefeng Qiu
Citation:Journal of Translational Medicine 2019 17:24
Published on: 11 January 2019
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Content Type:Research
MicroRNA-regulated pathways of flow-stimulated angiogenesis and vascular remodeling in vivo
Vascular shear stress promotes endothelial cell sprouting in vitro. The impact of hemodynamic forces on microRNA (miRNA) and gene expression within growing vascular networks in vivo, however, remain poorly inv...
Authors:Dominic Henn, Masood Abu-Halima, Dominik Wermke, Florian Falkner, Benjamin Thomas, Christoph Köpple, Nicole Ludwig, Matthias Schulte, Marc A. Brockmann, Yoo-Jin Kim, Justin M. Sacks, Ulrich Kneser, Andreas Keller, Eckart Meese and Volker J. Schmidt
Citation:Journal of Translational Medicine 2019 17:22
Published on: 11 January 2019
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Content Type:Research
Characteristics of T cell receptor repertoires of patients with acute myocardial infarction through high-throughput sequencing
T cells are key regulators of immunity and one of the cells recruited in atherosclerosis and participated in various stages of the development of atherosclerosis. Characterizing T-cell receptor (TCR) repertoir...
Authors:Zhixiong Zhong, Heming Wu, Qifeng Zhang, Wei Zhong and Pingsen Zhao
Citation:Journal of Translational Medicine 2019 17:21
Published on: 11 January 2019
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Content Type:Research
Pro-atherosclerotic disturbed flow disrupts caveolin-1 expression, localization, and function via glycocalyx degradation
Endothelial-dependent atherosclerosis develops in a non-random pattern in regions of vessel bending and bifurcations, where blood flow exhibits disturbed flow (DF) patterns. In contrast, uniform flow (UF), nor...
Authors:Ian C. Harding, Ronodeep Mitra, Solomon A. Mensah, Ira M. Herman and Eno E. Ebong
Citation:Journal of Translational Medicine 2018 16:364
Published on: 18 December 2018
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Content Type:Review
Diverse roles of macrophage polarization in aortic aneurysm: destruction and repair
Aortic aneurysm (AA) is defined as an enlargement of the aorta greater than 1.5 times its normal size. Early diagnosis of AA is challenging and mortality of AA is high. Curative pharmacological treatments for ...
Authors:Zhao Cheng, Yang-zhao Zhou, Yin Wu, Qi-ying Wu, Xiao-bo Liao, Xian-ming Fu and Xin-min Zhou
Citation:Journal of Translational Medicine 2018 16:354
Published on: 13 December 2018
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Content Type:Research
Integrin ανβ5 in vitro inhibition limits pro-fibrotic response in cardiac fibroblasts of spontaneously hypertensive rats
To date the TGF-β1 activation mediated by integrin ανβ5 during fibrosis is well-known. This process has been shown also in the heart, where cardiac fibroblasts (CF) differentiate into α-smooth muscle actin (α-...
Authors:Gianluca Lorenzo Perrucci, Veronica Antonietta Barbagallo, Maria Corlianò, Delfina Tosi, Rosaria Santoro, Patrizia Nigro, Paolo Poggio, Gaetano Bulfamante, Federico Lombardi and Giulio Pompilio
Citation:Journal of Translational Medicine 2018 16:352
Published on: 12 December 2018
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Content Type:Research
Application of expanded genetic analysis in the diagnosis of familial hypercholesterolemia in patients with very early-onset coronary artery disease
Patients with monogenic familial hypercholesterolemia (FH) have high risk for coronary artery disease (CAD). A recent FH Expert Panel suggested that FH was underdiagnosed and undertreated which needs early dia...
Authors:Ye-Xuan Cao, Na-Qiong Wu, Di Sun, Hui-Hui Liu, Jing-Lu Jin, Sha Li, Yuan-Lin Guo, Cheng-Gang Zhu, Ying Gao, Qiu-Ting Dong, Geng Liu, Qian Dong and Jian-Jun Li
Citation:Journal of Translational Medicine 2018 16:345
Published on: 10 December 2018
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Content Type:Research
Associations of immunological factors with metabolic syndrome and its characteristic elements in Chinese centenarians
Metabolic syndrome (MetS) has an increased prevalence (approximately 20–25% of the adult population) all over the world. Immunological function is significantly associated with the development of MetS, and Met...
Authors:Shihui Fu, Yao Yao, Faqin Lv, Fu Zhang, Yali Zhao and Fuxin Luan
Citation:Journal of Translational Medicine 2018 16:315
Published on: 19 November 2018
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Content Type:Research
Sirtuin 3 deficiency aggravates contrast-induced acute kidney injury
Sirtuin 3 (Sirt3) is a key regulator of energy metabolism and oxidative stress. To investigate the role of Sirt3 in contrast-induced acute kidney injury (CIAKI), we established the model both in vivo and in vi...
Authors:Qinghai Zhang, Xun Liu, Na li, Jihong Zhang, Jianmin Yang and Peili Bu
Citation:Journal of Translational Medicine 2018 16:313
Published on: 16 November 2018
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Content Type:Research
Association of serum angiopoietin-2 with malnutrition, inflammation, atherosclerosis and valvular calcification syndrome and outcome in peritoneal dialysis patients: a prospective cohort study
To examine serum angiopoietin-2 (Angpt-2) in relation to malnutrition, inflammation, atherosclerosis and cardiac valvular calcification, so-called MIAC syndrome and its predictive role in outcomes of peritonea...
Authors:Xiaoxiao Yang, He Zhang, Yuanyuan Shi, Zanzhe Yu, Hao Yan, Zhaohui Ni, Jiaqi Qian and Wei Fang
Citation:Journal of Translational Medicine 2018 16:312
Published on: 16 November 2018
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Content Type:Commentary
High density lipoprotein cholesterol and proteome in SR-B1 KO mice: lost in precipitation
Scavenger receptor class B type 1 (SR-B1) plays an essential role in high density lipoprotein (HDL) metabolism. SR-B1 deficient (SR-B1 KO) mice are prone to atherosclerosis and exhibit abnormally large, choles...
Authors:Susana Contreras-Duarte, Nicolás Santander, Ruth Birner-Gruenberger, Christian Wadsack, Attilio Rigotti and Dolores Busso
Citation:Journal of Translational Medicine 2018 16:309
Published on: 12 November 2018
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Content Type:Research
Galectin-3 predicts response and outcomes after cardiac resynchronization therapy
Cardiac resynchronization therapy (CRT) reduces symptoms, morbidity and mortality in chronic heart failure patients with wide QRS complexes. However, approximately one third of CRT patients are non-responders....
Authors:Clémentine Andre, Eric Piver, Romain Perault, Arnaud Bisson, Julien Pucheux, Emmanuelle Vermes, Bertrand Pierre, Laurent Fauchier, Dominique Babuty and Nicolas Clementy
Citation:Journal of Translational Medicine 2018 16:299
Published on: 3 November 2018
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Content Type:Research
An increase in myocardial 18-fluorodeoxyglucose uptake is associated with left ventricular ejection fraction decline in Hodgkin lymphoma patients treated with anthracycline
Doxorubicin (DOX)-based chemotherapy for Hodgkin lymphoma (HL) yields excellent disease-free survival, but poses a substantial risk of subsequent left ventricular (LV) dysfunction and heart failure, typically ...
Authors:Matteo Sarocchi, Matteo Bauckneht, Eleonora Arboscello, Selene Capitanio, Cecilia Marini, Silvia Morbelli, Maurizio Miglino, Angela Giovanna Congiu, Giorgio Ghigliotti, Manrico Balbi, Claudio Brunelli, Gianmario Sambuceti, Pietro Ameri and Paolo Spallarossa
Citation:Journal of Translational Medicine 2018 16:295
Published on: 25 October 2018
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Content Type:Research
A loss-of-function mutation p.T52S in RIPPLY3 is a potential predisposing genetic risk factor for Chinese Han conotruncal heart defect patients without the 22q11.2 deletion/duplication
Conotruncal heart defect (CTD) is a complex congenital heart disease with a complex and poorly understood etiology. The transcriptional corepressor RIPPLY3 plays a pivotal role in heart development as a negati...
Authors:Nanchao Hong, Erge Zhang, Qingjie Wang, Xiaoqing Zhang, Fen Li, Qihua Fu, Rang Xu, Yu Yu, Sun Chen, Yuejuan Xu and Kun Sun
Citation:Journal of Translational Medicine 2018 16:260
Published on: 21 September 2018
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Content Type:Research
Molecular analysis of inherited cardiomyopathy using next generation semiconductor sequencing technologies
Cardiomyopathies are the most common clinical and genetic heterogeneity cardiac diseases, and genetic contribution in particular plays a major role in patients with primary cardiomyopathies. The aim of this st...
Authors:Chaoxia Lu, Wei Wu, Fang Liu, Kunqi Yang, Jiacheng Li, Yaping Liu, Rongrong Wang, Nuo Si, Peng Gao, Yongtai Liu, Shuyang Zhang and Xue Zhang
Citation:Journal of Translational Medicine 2018 16:241
Published on: 30 August 2018
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Content Type:Research
Acute effects of different resistance training loads on cardiac autonomic modulation in hypertensive postmenopausal women
Individuals with arterial hypertension often have an autonomic nervous system (ANS) imbalance with predominance of sympathetic ANS. This predominance can lead to injury of several organs affecting its function...
Authors:Arthur F. Vale, Juliana A. Carneiro, Paulo C. V. Jardim, Thiago V. Jardim, James Steele, James P. Fisher and Paulo Gentil
Citation:Journal of Translational Medicine 2018 16:240
Published on: 30 August 2018
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Content Type:Research
Blood pressure components and incident cardiovascular disease and mortality events among Iranian adults with chronic kidney disease during over a decade long follow-up: a prospective cohort study
To explore the association between systolic and diastolic blood pressure (SBP and DBP respectively) and pulse pressure (PP) with cardiovascular disease (CVD) and mortality events among Iranian patients with pr...
Authors:Ashkan Hashemi, Sormeh Nourbakhsh, Samaneh Asgari, Mohammadhassan Mirbolouk, Fereidoun Azizi and Farzad Hadaegh
Citation:Journal of Translational Medicine 2018 16:230
Published on: 15 August 2018
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Content Type:Research
YKL-40 is highly expressed in the epicardial adipose tissue of patients with atrial fibrillation and associated with atrial fibrosis
YKL-40 (CHI3L1) is a novel biomarker for inflammation, tissue remodeling, and fibrosis, as well as cardiovascular diseases. We investigated the association between YKL-40 expression in epicardial adipose tissue (...
Authors:Qing Wang, Hua Shen, Jie Min, Yang Gao, Kai Liu, Wang Xi, Jie Yang, Liang Yin, Jibin Xu, Jian Xiao and Zhinong Wang
Citation:Journal of Translational Medicine 2018 16:229
Published on: 15 August 2018
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Content Type:Research
MRI of atherosclerosis and fatty liver disease in cholesterol fed rabbits
The globally rising obesity epidemic is associated with a broad spectrum of diseases including atherosclerosis and non-alcoholic fatty liver (NAFL) disease. In the past, research focused on the vasculature or ...
Authors:Erik Taylor, Nasi Huang, Jacob Bodde, Andrew Ellison, Ronald Killiany, Markus Michael Bachschmid and James Hamilton
Citation:Journal of Translational Medicine 2018 16:215
Published on: 1 August 2018
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Content Type:Research
MiR-1-3p that correlates with left ventricular function of HCM can serve as a potential target and differentiate HCM from DCM
MicroRNAs (miRNAs) are non-coding RNAs that function as regulators of gene expression and thereby contribute to the complex disease phenotypes. Hypertrophic cardiomyopathy (HCM) and Dilated cardiomyopathy (DCM...
Authors:Mengmeng Li, Xiao Chen, Liang Chen, Kai Chen, Jianye Zhou and Jiangping Song
Citation:Journal of Translational Medicine 2018 16:161
Published on: 9 June 2018
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Content Type:Research
Protein markers of dysfunctional HDL in scavenger receptor class B type I deficient mice
Scavenger receptor class B type I (SR-BI) plays a key role in high density lipoproteins (HDL) metabolism. SR-BI deficiency in mice results in enhanced susceptibility to atherosclerosis with abnormal large, cho...
Authors:Jia Cao, Yanyong Xu, Feifei Li, Liang Shang, Daping Fan and Hong Yu
Citation:Journal of Translational Medicine 2018 16:155
Published on: 7 June 2018
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Content Type:Research
Selective pharmacological inhibition of DDR1 prevents experimentally-induced glomerulonephritis in prevention and therapeutic regime
Discoidin domain receptor 1 (DDR1) is a collagen-activated receptor tyrosine kinase extensively implicated in diseases such as cancer, atherosclerosis and fibrosis. Multiple preclinical studies, performed usin...
Authors:Solange Moll, Yukari Yasui, Ahmed Abed, Takeshi Murata, Hideaki Shimada, Akira Maeda, Naoshi Fukushima, Masakazu Kanamori, Sabine Uhles, Laura Badi, Thomas Cagarelli, Ivan Formentini, Faye Drawnel, Guy Georges, Tobias Bergauer, Rodolfo Gasser…
Citation:Journal of Translational Medicine 2018 16:148
Published on: 1 June 2018
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Content Type:Research
Evidence for a hyper-reductive redox in a sub-set of heart failure patients
Oxidative stress has been linked to heart failure (HF) in humans. Antioxidant-based treatments are often ineffective. Therefore, we hypothesize that some of the HF patients might have a reductive stress (RS) c...
Authors:Thiagarajan Sairam, Amit N. Patel, Meenu Subrahmanian, Rajendiran Gopalan, Steven M. Pogwizd, Sudha Ramalingam, Ramalingam Sankaran and Namakkal Soorapan Rajasekaran
Citation:Journal of Translational Medicine 2018 16:130
Published on: 18 May 2018
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Content Type:Review
The role of HIV Tat protein in HIV-related cardiovascular diseases
The human immunodeficiency virus (HIV) is a major global public health issue. HIV-related cardiovascular disease remains a leading cause of morbidity and mortality in HIV positive patients. HIV Tat is a regula...
Authors:Yanan Jiang, Lu Chai, Moyondafoluwa Blessing Fasae and Yunlong Bai
Citation:Journal of Translational Medicine 2018 16:121
Published on: 8 May 2018
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Content Type:Research
The release of cardioprotective humoral factors after remote ischemic preconditioning in humans is age- and sex-dependent
Preclinical and proof-of-concept studies suggest a cardioprotective effect of remote ischemic preconditioning (RIPC). However, two major clinical trials (ERICCA and RIPHeart) failed to show cardioprotection by...
Authors:André Heinen, Friederike Behmenburg, Aykut Aytulun, Maximilian Dierkes, Lea Zerbin, Wolfgang Kaisers, Maximilian Schaefer, Tanja Meyer-Treschan, Susanne Feit, Inge Bauer, Markus W. Hollmann and Ragnar Huhn
Citation:Journal of Translational Medicine 2018 16:112
Published on: 27 April 2018
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Content Type:Research
Cardiopulmonary bypass reduces myocardial oxidative stress, inflammation and increases c-kit+CD45− cell population in newborns
The aim of this study was to characterize the influence of cardiopulmonary bypass (CPB) on myocardial remodeling in newborns and children.
Authors:Johannes Petersen, Andrey Kazakov, Michael Böhm, Hans-Joachim Schäfers, Ulrich Laufs and Hashim Abdul-Khaliq
Citation:Journal of Translational Medicine 2018 16:111
Published on: 27 April 2018
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Content Type:Research
Contribution of TLR4 signaling in intermittent hypoxia-mediated atherosclerosis progression
Intermittent hypoxia (IH), a typical character of obstructive sleep apnea (OSA), is related to atherogenesis. However, the role of IH on atherosclerosis (AS) progression and the mechanisms involved remains poo...
Authors:Xianqin Zeng, Rong Guo, Mei Dong, Julia Zheng, Huili Lin and Huixia Lu
Citation:Journal of Translational Medicine 2018 16:106
Published on: 19 April 2018
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Content Type:Research
Endoplasmic reticulum stress in perivascular adipose tissue promotes destabilization of atherosclerotic plaque by regulating GM-CSF paracrine
Perivascular adipose tissue (PVAT) accelerates plaque progression and increases cardiovascular risk. We tested the hypothesis that PVAT contributed to plaque vulnerability and investigated whether endoplasmic ...
Authors:Ru Ying, Sheng-Wei Li, Jia-Yuan Chen, Hai-Feng Zhang, Ying Yang, Zhen-Jie Gu, Yang-Xin Chen and Jing-Feng Wang
Citation:Journal of Translational Medicine 2018 16:105
Published on: 18 April 2018
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Content Type:Research
Plasma proteomic analysis reveals altered protein abundances in cardiovascular disease
Cardiovascular disease (CVD) describes the pathological conditions of the heart and blood vessels. Despite the large number of studies on CVD and its etiology, its key modulators remain largely unknown. To thi...
Authors:Vasiliki Lygirou, Agnieszka Latosinska, Manousos Makridakis, William Mullen, Christian Delles, Joost P. Schanstra, Jerome Zoidakis, Burkert Pieske, Harald Mischak and Antonia Vlahou
Citation:Journal of Translational Medicine 2018 16:104
Published on: 17 April 2018
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Content Type:Research
Deregulated microRNA and mRNA expression profiles in the peripheral blood of patients with Marfan syndrome
MicroRNAs (miRNAs) are small RNAs regulating gene expression post-transcriptionally. While acquired changes of miRNA and mRNA profiles in cancer have been extensively studied, little is known about expression ...
Authors:Masood Abu-Halima, Mustafa Kahraman, Dominic Henn, Tanja Rädle-Hurst, Andreas Keller, Hashim Abdul-Khaliq and Eckart Meese
Citation:Journal of Translational Medicine 2018 16:60
Published on: 12 March 2018
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Content Type:Research
Alloxan-induced diabetes exacerbates coronary atherosclerosis and calcification in Ossabaw miniature swine with metabolic syndrome
There is a preponderance of evidence implicating diabetes with increased coronary artery disease (CAD) and calcification (CAC) in human patients with metabolic syndrome (MetS), but the effect of diabetes on CA...
Authors:Jill K. Badin, Ayeeshik Kole, Benjamin Stivers, Victor Progar, Anisha Pareddy, Mouhamad Alloosh and Michael Sturek
Citation:Journal of Translational Medicine 2018 16:58
Published on: 9 March 2018
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Content Type:Research
Association between non-cholesterol sterol concentrations and Achilles tendon thickness in patients with genetic familial hypercholesterolemia
Familial hypercholesterolemia (FH) is a genetic disorder that result in abnormally high low-density lipoprotein cholesterol levels, markedly increased risk of coronary heart disease (CHD) and tendon xanthomas ...
Authors:Lucía Baila-Rueda, Itziar Lamiquiz-Moneo, Estíbaliz Jarauta, Rocío Mateo-Gallego, Sofía Perez-Calahorra, Victoria Marco-Benedí, Ana M. Bea, Ana Cenarro and Fernando Civeira
Citation:Journal of Translational Medicine 2018 16:6
Published on: 15 January 2018
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Content Type:Research
Water T2 as an early, global and practical biomarker for metabolic syndrome: an observational cross-sectional study
Metabolic syndrome (MetS) is a highly prevalent condition that identifies individuals at risk for type 2 diabetes mellitus and atherosclerotic cardiovascular disease. Prevention of these diseases relies on ear...
Authors:Michelle D. Robinson, Ina Mishra, Sneha Deodhar, Vipulkumar Patel, Katrina V. Gordon, Raul Vintimilla, Kim Brown, Leigh Johnson, Sid O’Bryant and David P. Cistola
Citation:Journal of Translational Medicine 2017 15:258
Published on: 19 December 2017
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Content Type:Review
The use of the tyrosine kinase inhibitor Nilotinib in Spondyloarthritis: does targeting inflammatory pathways with a treatment lead to vascular toxicity?
Spondylarthritis (SpA) is an inflammatory rheumatic disease associated with increased incidence of major adverse cardiovascular events (MACEs). Recently, Paramarta et al. proposed the use of the tyrosine kinas...
Authors:Loukman Omarjee, Vincent Jaquinandi and Guillaume Mahe
Citation:Journal of Translational Medicine 2017 15:255
Published on: 15 December 2017
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Content Type:Research
Molecular and histological effects of MR-guided pulsed focused ultrasound to the rat heart
Image-guided high intensity focused ultrasound has been used as an extracorporeal cardiac pacing tool and to enhance homing of stem cells to targeted tissues. However, molecular changes in the myocardium after...
Authors:Kee W. Jang, Tsang-Wei Tu, Matthew E. Nagle, Bobbi K. Lewis, Scott R. Burks and Joseph A. Frank
Citation:Journal of Translational Medicine 2017 15:252
Published on: 13 December 2017
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Content Type:Review
GlycA, a novel biomarker of systemic inflammation and cardiovascular disease risk
GlycA is a novel spectroscopic marker of systemic inflammation with low intra-individual variability and other attributes favoring its clinical use in patients with chronic inflammatory and autoimmune diseases...
Authors:Margery A. Connelly, James D. Otvos, Irina Shalaurova, Martin P. Playford and Nehal N. Mehta
Citation:Journal of Translational Medicine 2017 15:219
Published on: 27 October 2017
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Content Type:Research
Haemoadsorption reduces the inflammatory response and improves blood flow during ex vivo renal perfusion in an experimental model
Ex-vivo normothermic perfusion strategies are a promising new instrument in organ transplantation. The perfusion conditions are designed to be protective however the artificial environment can induce a local i...
Authors:Sarah A. Hosgood, Tom Moore, Theresa Kleverlaan, Tom Adams and Michael L. Nicholson
Citation:Journal of Translational Medicine 2017 15:216
Published on: 25 October 2017
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Content Type:Research
The effect of renal denervation in an experimental model of chronic renal insufficiency, The REmnant kidney Denervation In Pigs study (REDIP study)
Renal denervation (RDN) is a promising therapeutic method in cardiology. Its currently most investigated indication is resistant hypertension. Other potential indications are atrial fibrillation, type 2 diabet...
Authors:Jean-Claude Lubanda, Miroslav Chochola, Mikuláš Mlček, Petr Neužil, Josef Marek, Štěpán Havránek, Sylvie Kuchynková, Zdeňka Fingrová, Kao-Hsuan Aimee Huang and Aleš Linhart
Citation:Journal of Translational Medicine 2017 15:215
Published on: 25 October 2017
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Content Type:Research
Porcine model of progressive cardiac hypertrophy and fibrosis with secondary postcapillary pulmonary hypertension
Meaningful translational large animal models for cardiac diseases are indispensable for studying disease mechanisms, development of novel therapeutic strategies, and evaluation of potential drugs.
Authors:Mariann Gyöngyösi, Noemi Pavo, Dominika Lukovic, Katrin Zlabinger, Andreas Spannbauer, Denise Traxler, Georg Goliasch, Ljubica Mandic, Jutta Bergler-Klein, Alfred Gugerell, Andras Jakab, Zsuzsanna Szankai, Levente Toth, Rita Garamvölgyi, Gerald Maurer, Frederic Jaisser…
Citation:Journal of Translational Medicine 2017 15:202
Published on: 6 October 2017
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Content Type:Research
Analysis of circulating microRNAs in patients with repaired Tetralogy of Fallot with and without heart failure
MicroRNAs (miRNAs) are a class of regulatory RNAs that regulate gene expression post-transcriptionally. Little, however, is known on the expression profile of circulating miRNAs in Tetralogy of Fallot (TOF) pa...
Authors:Masood Abu-Halima, Eckart Meese, Andreas Keller, Hashim Abdul-Khaliq and Tanja Rädle-Hurst
Citation:Journal of Translational Medicine 2017 15:156
Published on: 10 July 2017
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Content Type:Protocol
Effect of a 6-month pedometer-based walking intervention on functional capacity in patients with chronic heart failure with reduced (HFrEF) and with preserved (HFpEF) ejection fraction: study protocol for two multicenter randomized controlled trials
Regular physical activity is recommended for patients with chronic heart failure to improve their functional capacity, and walking is a popular, effective, and safe form of physical activity. Pedometers have s...
Authors:Tomas Vetrovsky, Michal Siranec, Jiri Parenica, Martin Griva, Jiri Stastny, Jan Precek, Radek Pelouch, Vaclav Bunc, Ales Linhart and Jan Belohlavek
Citation:Journal of Translational Medicine 2017 15:153
Published on: 3 July 2017
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Content Type:Research
Transplantation of human fetal pancreatic progenitor cells ameliorates renal injury in streptozotocin-induced diabetic nephropathy
Diabetic nephropathy (DN) is a severe complication of diabetes mellitus (DM). Pancreas or islet transplantation has been reported to prevent the development of DN lesions and ameliorate or reverse existing glo...
Authors:Yongwei Jiang, Wenjian Zhang, Shiqing Xu, Hua Lin, Weiguo Sui, Honglin Liu, Liang Peng, Qing Fang, Li Chen and Jinning Lou
Citation:Journal of Translational Medicine 2017 15:147
Published on: 27 June 2017
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Content Type:Research
Imaging of αvβ3 integrin expression in experimental myocardial ischemia with [68Ga]NODAGA-RGD positron emission tomography
Radiolabeled RGD peptides detect αvβ3 integrin expression associated with angiogenesis and extracellular matrix remodeling after myocardial infarction. We studied whether cardiac positron emission tomography (PET...
Authors:Maria Grönman, Miikka Tarkia, Tuomas Kiviniemi, Paavo Halonen, Antti Kuivanen, Timo Savunen, Tuula Tolvanen, Jarmo Teuho, Meeri Käkelä, Olli Metsälä, Mikko Pietilä, Pekka Saukko, Seppo Ylä-Herttuala, Juhani Knuuti, Anne Roivainen and Antti Saraste
Citation:Journal of Translational Medicine 2017 15:144
Published on: 19 June 2017
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Content Type:Research
Blood metabolomic fingerprint is distinct in healthy coronary and in stenosing or microvascular ischemic heart disease
The endothelium is a key variable in the pathogenesis of atherosclerosis and its complications, particularly coronary artery disease (CAD). Current evidence suggests that the endothelial status can be regarded...
Authors:Martino Deidda, Cristina Piras, Christian Cadeddu Dessalvi, Damiana Congia, Emanuela Locci, Federica Ascedu, Gianfranco De Candia, Mauro Cadeddu, Giorgio Lai, Raimondo Pirisi, Luigi Atzori and Giuseppe Mercuro
Citation:Journal of Translational Medicine 2017 15:112
Published on: 23 May 2017
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Content Type:Research
Distinct gene expression profiles associated with Notch ligands Delta-like 4 and Jagged1 in plaque material from peripheral artery disease patients: a pilot study
The lack of early diagnosis, progression markers and effective pharmacological treatment has dramatic unfavourable effects on clinical outcomes in patients with peripheral artery disease (PAD). Addressing thes...
Authors:Giorgio Aquila, Cinzia Fortini, Antonio Pannuti, Serena Delbue, Micaela Pannella, Marco Bruno Morelli, Cristiana Caliceti, Fausto Castriota, Monica de Mattei, Alessia Ongaro, Agnese Pellati, Pasquale Ferrante, Lucio Miele, Luigi Tavazzi, Roberto Ferrari, Paola Rizzo…
Citation:Journal of Translational Medicine 2017 15:98
Published on: 4 May 2017
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