Journal of Translational Medicine | Translational imaging

Journal of Translational Medicine | Translational imaging

Translational imaging

Section edited by Ravinder Reddy

The Translational Imaging section provides a platform for rapid dissemination of the advances in medical imaging research emphasizing clinical translation. The topics covered in this section will include methodological innovations in early diagnoses of human diseases and monitoring of therapeutic responses from all the major imaging modalities (MRI, PET, US etc.,). Articles considered for publication include studies in human subjects, pre-clinical models and ex vivo systems dealing with imaging of human pathophysiologies.

1. Content Type:Research

   Microbubble-mediated delivery of human adenoviruses does not elicit innate and adaptive immunity response in an immunocompetent mouse model of prostate cancer

   Gene transfer to malignant sites using human adenoviruses (hAds) has been limited because of their immunogenic nature and host specificity. Murine cells often lack some of the receptors needed for hAds attachm...

   Authors:Flavia De Carlo, Litty Thomas, Bell Brooke, Elliot T. Varney, Rounak Nande, Olivia Boskovic, Gailen D. Marshall, Pier Paolo Claudio and Candace M. Howard

   Citation:Journal of Translational Medicine 2019 17:19

   Published on: 11 January 2019

   • ViewFull Text
    
   • ViewPDF
2. Content Type:Research

   Towards the use of diffuse reflectance spectroscopy for real-time in vivo detection of breast cancer during surgery

   Breast cancer surgeons struggle with differentiating healthy tissue from cancer at the resection margin during surgery. We report on the feasibility of using diffuse reflectance spectroscopy (DRS) for real-tim...

   Authors:Lisanne L. de Boer, Torre M. Bydlon, Frederieke van Duijnhoven, Marie-Jeanne T. F. D. Vranken Peeters, Claudette E. Loo, Gonneke A. O. Winter-Warnars, Joyce Sanders, Henricus J. C. M. Sterenborg, Benno H. W. Hendriks and Theo J. M. Ruers

   Citation:Journal of Translational Medicine 2018 16:367

   Published on: 19 December 2018

   • ViewFull Text
    
   • ViewPDF
3. Content Type:Research

   Feasibility study of dual parametric 2D histogram analysis of breast lesions with dynamic contrast-enhanced and diffusion-weighted MRI

   This study aimed to investigate the diagnostic value of a dual-parametric 2D histogram classification method for breast lesions.

   Authors:Yanqiong Chen, Bin Wu, Hui Liu, Dan Wang and Yajia Gu

   Citation:Journal of Translational Medicine 2018 16:325

   Published on: 23 November 2018

   • ViewFull Text
    
   • ViewPDF
4. Content Type:Research

   Polyethylene glycol-conjugated HER2-targeted peptides as a nuclear imaging probe for HER2-overexpressed gastric cancer detection in vivo

   The human epidermal growth factor receptor 2 (HER2) involved proliferation, angiogenesis, and reduced apoptosis in gastric cancer (GC), which is a common target for tumor therapy. HER2 is usually overexpressed...

   Authors:Siao-Syun Guan, Cheng-Tien Wu, Chen-Yuan Chiu, Tsai-Yueh Luo, Jeng-Yih Wu, Tse-Zung Liao and Shing-Hwa Liu

   Citation:Journal of Translational Medicine 2018 16:168

   Published on: 19 June 2018

   • ViewFull Text
    
   • ViewPDF
5. Content Type:Research

   Preoperative metabolic tumor volume of intrahepatic cholangiocarcinoma measured by 18F-FDG-PET is associated with the KRAS mutation status and prognosis

   Surgical resection remains the mainstay of curative treatment for intrahepatic cholangiocarcinoma (ICC). Prognosis after surgery is unsatisfactory despite improvements in treatment and post-operative clinical ...

   Authors:Yoshinobu Ikeno, Satoru Seo, Keiko Iwaisako, Tomoaki Yoh, Yuji Nakamoto, Hiroaki Fuji, Kojiro Taura, Hideaki Okajima, Toshimi Kaido, Shimon Sakaguchi and Shinji Uemoto

   Citation:Journal of Translational Medicine 2018 16:95

   Published on: 11 April 2018

   • ViewFull Text
    
   • ViewPDF
6. Content Type:Methodology

   9.4 T small animal MRI using clinical components for direct translational studies

   Magnetic resonance is a major preclinical and clinical imaging modality ideally suited for longitudinal studies, e.g. in pharmacological developments. The lack of a proven platform that maintains an identical ...

   Authors:Jörg Felder, A. Avdo Celik, Chang-Hoon Choi, Stefan Schwan and N. Jon Shah

   Citation:Journal of Translational Medicine 2017 15:264

   Published on: 28 December 2017

   • ViewFull Text
    
   • ViewPDF
7. Content Type:Research

   Evaluation of the effect of d-amino acid incorporation into amyloid-reactive peptides

   Systemic amyloidoses comprise diseases characterized by the deposition of proteinaceous material known as amyloid. Currently, without performing multiple biopsies, there is no way to ascertain the extent of am...

   Authors:Emily B. Martin, Angela Williams, Tina Richey, Craig Wooliver, Alan Stuckey, James S. Foster, Stephen J. Kennel and Jonathan S. Wall

   Citation:Journal of Translational Medicine 2017 15:247

   Published on: 11 December 2017

   • ViewFull Text
    
   • ViewPDF
8. Content Type:Research

   Evaluation of B1 inhomogeneity effect on DCE-MRI data analysis of brain tumor patients at 3T

   Dynamic-contrast-enhanced (DCE) MRI data acquired using gradient echo based sequences is affected by errors in flip angle (FA) due to transmit B1 inhomogeneity (B1inh). The purpose of the study was to evaluate th...

   Authors:Anirban Sengupta, Rakesh Kumar Gupta and Anup Singh

   Citation:Journal of Translational Medicine 2017 15:242

   Published on: 2 December 2017

   • ViewFull Text
    
   • ViewPDF
9. Content Type:Research

   Monitoring inflammation and airway remodeling by fluorescence molecular tomography in a chronic asthma model

   Asthma is a multifactorial disease for which a variety of mouse models have been developed. A major drawback of these models is represented by the transient nature of the airway pathology peaking 24–72 h after...

   Authors:Fabio Stellari, Angelo Sala, Francesca Ruscitti, Chiara Carnini, Prisco Mirandola, Marco Vitale, Maurizio Civelli and Gino Villetti

   Citation:Journal of Translational Medicine 2015 13:336

   Published on: 24 October 2015

   • ViewFull Text
    
   • ViewPDF
10. Content Type:Research

    Reduced cortical thickness in patients with acute-on-chronic liver failure due to non-alcoholic etiology

    Acute-on-chronic liver failure (ACLF) is a form of liver disease with high short-term mortality. ACLF offers considerable potential to affect the cortical areas by significant tissue injury due to loss of neur...

    Authors:Santosh K. Yadav, Rakesh K. Gupta, Vivek A. Saraswat, Murali Rangan, Michael A. Thomas, Sergio Rutella, Silvio Danese, Ena Wang, Francesco M. Marincola and Mohammad Haris

    Citation:Journal of Translational Medicine 2015 13:322

    Published on: 6 October 2015

    • ViewFull Text
     
    • ViewPDF
11. Content Type:Research

    Diffuse reflectance spectroscopy accurately quantifies various degrees of liver steatosis in murine models of fatty liver disease

    A real-time objective evaluation for the extent of liver steatosis during liver transplantation is currently not available. Diffuse reflectance spectroscopy (DRS) rapidly and accurately assesses the extent of...

    Authors:Andrie C. Westerkamp, Vishnu V. Pully, Golnar Karimian, Fernanda Bomfati, Zwanida J. Veldhuis, Janneke Wiersema-Buist, Benno H. W. Hendriks, Ton Lisman and Robert J. Porte

    Citation:Journal of Translational Medicine 2015 13:309

    Published on: 21 September 2015

    • ViewFull Text
     
    • ViewPDF
12. Content Type:Research

    T1ρ MRI of healthy and fibrotic human livers at 1.5 T

    Liver fibrosis is a public health problem worldwide. There is a need of noninvasive imaging based methods for better diagnosis of this disease. In the current study, we aim to evaluate the potential of T1ρ MRI...

    Authors:Anup Singh, Damodar Reddy, Mohammad Haris, Kejia Cai, K. Rajender Reddy, Hari Hariharan and Ravinder Reddy

    Citation:Journal of Translational Medicine 2015 13:292

    Published on: 8 September 2015

    • ViewFull Text
     
    • ViewPDF
13. Content Type:Methodology

    Correlation between μCT imaging, histology and functional capacity of the osteoarthritic knee in the rat model of osteoarthritis

    To acquire the most meaningful understanding of human arthritis, it is essential to select the disease model and methodology translatable to human conditions. The primary objective of this study was to evaluat...

    Authors:Cedo M. Bagi, David E. Zakur, Edwin Berryman, Catharine J. Andresen and Dean Wilkie

    Citation:Journal of Translational Medicine 2015 13:276

    Published on: 25 August 2015

    • ViewFull Text
     
    • ViewPDF
14. Content Type:Research

    In vivo imaging of the lung inflammatory response to Pseudomonas aeruginosa and its modulation by azithromycin

    Chronic inflammation of the airways is a central component in lung diseases and is frequently associated with bacterial infections. Monitoring the pro-inflammatory capability of bacterial virulence factors in ...

    Authors:Fabio Stellari, Gabriella Bergamini, Angela Sandri, Gaetano Donofrio, Claudio Sorio, Francesca Ruscitti, Gino Villetti, Barouk M Assael, Paola Melotti and Maria M Lleo

    Citation:Journal of Translational Medicine 2015 13:251

    Published on: 4 August 2015

    • ViewFull Text
     
    • ViewPDF