BMC Neuroscience | Cognition and behavior: in vitro or in vivo brain repair

BMC Neuroscience | Cognition and behavior: in vitro or in vivo brain repair

Cognition and behavior: in vitro or in vivo brain repair

Section edited by Anthony Kline

This section covers topics in the field of brain repair in both human and animal models. Topics of interest include, but are not limited to, neurotrauma and repair, neuropharmacology, pathophysiology, and rehabilitation.

1. Content Type:Research Article

   The role of PI3K-mediated AMPA receptor changes in post-conditioning of propofol in brain protection

   We aimed to study the role of amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptor (AMPAR) glutamate receptor 2 (GluR2) subunit trafficking, and activity changes in short-term neuroprotection provided b...

   Authors:Chenxu Wang, Ying Wei, Yuan Yuan, Yonghao Yu, Keliang Xie, Beibei Dong, Yuan Shi and Guolin Wang

   Citation:BMC Neuroscience 2019 20:51

   Published on: 1 October 2019

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2. Content Type:Research Article

   Isoliquiritigenin attenuates lipopolysaccharide-induced cognitive impairment through antioxidant and anti-inflammatory activity

   Oxidative stress and neuroinflammation are central pathogenic mechanisms common to many neurological diseases. Isoliquiritigenin (ISL) is a flavonoid in licorice with multiple pharmacological properties, inclu...

   Authors:Xiaobo Zhu, Jiankun Liu, Shaojie Chen, Jiang Xue, Shanying Huang, Yibiao Wang and Ou Chen

   Citation:BMC Neuroscience 2019 20:41

   Published on: 6 August 2019

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3. Content Type:Research Article

   A safety study of 500 μA cathodal transcranial direct current stimulation in rat

   Transcranial direct current stimulation (tDCS) is a noninvasive neural control technology that has become a research hotspot. To facilitate further research of tDCS, the biosafety of 500 μA cathodal tDCS, a co...

   Authors:Keying Zhang, Ling Guo, Junping Zhang, Guangzhou An, Yan Zhou, Jiajin Lin, Junling Xing, Mai Lu and Guirong Ding

   Citation:BMC Neuroscience 2019 20:40

   Published on: 6 August 2019

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4. Content Type:Research Article

   Gastrodin protects dopaminergic neurons via insulin-like pathway in a Parkinson’s disease model

   Recently, the use of traditional Chinese medicine (TCM) has become more generally accepted, including by the Food and Drug Administration. To expand the use of TCM worldwide, it is important to study the molec...

   Authors:Jinyuan Yan, Zhongshan Yang, Ninghui Zhao, Zhiwei Li and Xia Cao

   Citation:BMC Neuroscience 2019 20:31

   Published on: 17 June 2019

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5. Content Type:Methodology Article

   Enhanced setup for wired continuous long-term EEG monitoring in juvenile and adult rats: application for epilepsy and other disorders

   The electroencephalogram (EEG) is a widely used laboratory technique in rodent models of epilepsy, traumatic brain injury (TBI), and other neurological diseases accompanied by seizures. Obtaining prolonged con...

   Authors:Yasser Medlej, Rita Asdikian, Lara Wadi, Houssein Salah, Laura Dosh, Rabih Hashash, Nabil Karnib, Mohammad Medlej, Hala Darwish, Firas Kobeissy and Makram Obeid

   Citation:BMC Neuroscience 2019 20:8

   Published on: 4 March 2019

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6. Content Type:Research Article

   Involvement of Akt/CREB signaling pathways in the protective effect of EPA against interleukin-1β-induced cytotoxicity and BDNF down-regulation in cultured rat hippocampal neurons

   Our published data have indicated that the omega-3 polyunsaturated fatty acid eicosapentaenoic acid (EPA) provides beneficial effects by attenuating neuronal damage induced by interleukin-1β (IL-1β), and up-re...

   Authors:YiLong Dong, KangJing Pu, WenJing Duan, HuiCheng Chen, LiXing Chen and YanMei Wang

   Citation:BMC Neuroscience 2018 19:52

   Published on: 6 September 2018

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7. Content Type:Research Article

   Normobaric hypoxia overnight impairs cognitive reaction time

   Impaired reaction time in patients suffering from hypoxia during sleep, caused by sleep breathing disorders, is a well-described phenomenon. High altitude sleep is known to induce periodic breathing with centr...

   Authors:Stephan Pramsohler, Stefan Wimmer, Martin Kopp, Hannes Gatterer, Martin Faulhaber, Martin Burtscher and Nikolaus Cristoph Netzer

   Citation:BMC Neuroscience 2017 18:43

   Published on: 15 May 2017

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8. Content Type:Research Article

   The GLP-1 receptor agonists exendin-4 and liraglutide alleviate oxidative stress and cognitive and micturition deficits induced by middle cerebral artery occlusion in diabetic mice

   Glucagon-like peptide 1 (GLP-1) analogs protect a variety of cell types against oxidative damage and vascular and neuronal injury via binding to GLP-1 receptors. This study aimed to investigate the effects of ...

   Authors:Ping-Chia Li, Li-Fen Liu, Ming-Jia Jou and Hao-Kuang Wang

   Citation:BMC Neuroscience 2016 17:37

   Published on: 13 June 2016

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9. Content Type:Research Article

   Reduced task-related functional connectivity during a set-shifting task in unmedicated early-stage Parkinson’s disease patients

   Patients with Parkinson’s disease (PD) often suffer from cognitive impairments, including set-shifting deficits, in addition to the characteristic motor symptoms. It is hypothesized that the striatal dopamine ...

   Authors:Corine C. de Bondt, Niels J. H. M. Gerrits, Dick J. Veltman, Henk W. Berendse, Odile A. van den Heuvel and Ysbrand D. van der Werf

   Citation:BMC Neuroscience 2016 17:20

   Published on: 18 May 2016

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10. Content Type:Research Article

    Astaxanthin ameliorates prenatal LPS-exposed behavioral deficits and oxidative stress in adult offspring

    Prenatal maternal lipopolysaccharide (LPS) exposure leads to behavioral deficits such as depression, anxiety, and schizophrenia in the adult lives. LPS-exposure resulted in the production of cytokines and oxid...

    Authors:Md. Mamun Al-Amin, Rabeya Sultana, Sharmin Sultana, Md. Mahbubur Rahman and Hasan Mahmud Reza

    Citation:BMC Neuroscience 2016 17:11

    Published on: 8 February 2016

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11. Content Type:Research Article

    Re-engineering a neuroprotective, clinical drug as a procognitive agent with high in vivo potency and with GABAA potentiating activity for use in dementia

    Synaptic dysfunction is a key event in pathogenesis of neurodegenerative diseases such as Alzheimer’s disease (AD) where synapse loss pathologically correlates with cognitive decline and dementia. Although evi...

    Authors:Jia Luo, Sue H. Lee, Lawren VandeVrede, Zhihui Qin, Sujeewa Piyankarage, Ehsan Tavassoli, Rezene T. Asghodom, Manel Ben Aissa, Mauro Fà, Ottavio Arancio, Lan Yue, David R. Pepperberg and Gregory R. J. Thatcher

    Citation:BMC Neuroscience 2015 16:67

    Published on: 19 October 2015

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12. Content Type:Research Article

    Impaired trial-by-trial adjustment of cognitive control in obsessive compulsive disorder improves after deep repetitive transcranial magnetic stimulation

    Adaptive decision making requires the adjustment of behaviour following an error. Some theories suggest that repetitive thoughts and behaviours in obsessive compulsive disorder (OCD) are driven by malfunctioni...

    Authors:Mandana Modirrousta, Benjamin P. Meek, Jitender Sareen and Murray W. Enns

    Citation:BMC Neuroscience 2015 16:63

    Published on: 9 October 2015

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13. Content Type:Research Article

    Effects of eslicarbazepine acetate on acute and chronic latrunculin A-induced seizures and extracellular amino acid levels in the mouse hippocampus

    Latrunculin A microperfusion of the hippocampus induces acute epileptic seizures and long-term biochemical changes leading to spontaneous seizures. This study tested the effect of eslicarbazepine acetate (ESL)...

    Authors:Germán Sierra-Paredes, Ana I Loureiro, Lyndon C Wright, Germán Sierra-Marcuño and Patrício Soares-da-Silva

    Citation:BMC Neuroscience 2014 15:134

    Published on: 20 December 2014

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14. Content Type:Research Article

    Evaluating the translational potential of progesterone treatment following transient cerebral ischaemia in male mice

    Progesterone is neuroprotective in numerous preclinical CNS injury models including cerebral ischaemia. The aim of this study was two-fold; firstly, we aimed to determine whether progesterone delivery via osmo...

    Authors:Raymond Wong, Claire L Gibson, David A Kendall and Philip MW Bath

    Citation:BMC Neuroscience 2014 15:131

    Published on: 29 November 2014

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15. Content Type:Research Article

    Long-lasting anxiolytic effect of neural precursor cells freshly prepared but not neurosphere-derived cell transplantation in newborn rats

    The GABAergic system plays an important role in modulating levels of anxiety. When transplanted into the brain, precursor cells from the medial ganglionic eminence (MGE) have the ability to differentiate into ...

    Authors:Simone Amaro Alves Romariz, Daisyléa de Souza Paiva, Maria Fernanda Valente, Gabriela Filoso Barnabé, Roberto Frussa-Filho, Regina Cláudia Barbosa-Silva, Maria Elisa Calcagnotto and Beatriz Monteiro Longo

    Citation:BMC Neuroscience 2014 15:94

    Published on: 2 August 2014

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16. Content Type:Research Article

    Melatonin facilitates extinction, but not acquisition or expression, of conditional cued fear in rats

    Previous studies have shown that melatonin is involved in the processes that contribute to learning and memory. At present study, we tested the effects of exogenous melatonin (2.5 mg/kg) on the acquisition, ex...

    Authors:Fulian Huang, Zehua Yang, Xiaoyan Liu and Chang-Qi Li

    Citation:BMC Neuroscience 2014 15:86

    Published on: 15 July 2014

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17. Content Type:Research Article

    Expression of amygdala mineralocorticoid receptor and glucocorticoid receptor in the single-prolonged stress rats

    Post-traumatic stress disorder (PTSD) is an anxious disorder associated with low levels of corticosterone and enhanced negative feedback of the hypothalamic–pituitary–adrenal (HPA) axis. Previous studies showe...

    Authors:Fang Han, Jinlan Ding and Yuxiu Shi

    Citation:BMC Neuroscience 2014 15:77

    Published on: 19 June 2014

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18. Content Type:Research Article

    Changes in motor cortex excitability associated with temporal repetitive transcranial magnetic stimulation in tinnitus: hints for cross-modal plasticity?

    Motor cortex excitability was found to be changed after repetitive transcranial magnetic stimulation (rTMS) of the temporal cortex highlighting the occurrence of cross-modal plasticity in non-invasive brain st...

    Authors:Martin Schecklmann, Michael Landgrebe, Tobias Kleinjung, Elmar Frank, Philipp G Sand, Rainer Rupprecht, Peter Eichhammer, Göran Hajak and Berthold Langguth

    Citation:BMC Neuroscience 2014 15:71

    Published on: 4 June 2014

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19. Content Type:Research Article

    The effects of different doses of estradiol (E2) on cerebral ischemia in an in vitro model of oxygen and glucose deprivation and reperfusion and in a rat model of middle carotid artery occlusion

    Because neuroprotective effects of estrogen remain controversial, we aimed to investigate the effect of different doses of estradiol (E2) on cerebral ischemia using both in vivo and in vitro experiments.

    Authors:Yu-Long Ma, Pei Qin, Yan Li, Lan Shen, Shi-Quan Wang, Hai-Long Dong, Wu-Gang Hou and Li-Ze Xiong

    Citation:BMC Neuroscience 2013 14:118

    Published on: 9 October 2013

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20. Content Type:Research Article

    Estradiol prevents olfactory dysfunction induced by A-β 25–35 injection in hippocampus

    Some neurodegenerative diseases, such as Alzheimer and Parkinson, present an olfactory impairment in early stages, and sometimes even before the clinical symptoms begin. In this study, we assess the role of CA...

    Authors:Carlos Bernal-Mondragón, Selva Rivas-Arancibia, Keith M Kendrick and Rosalinda Guevara-Guzmán

    Citation:BMC Neuroscience 2013 14:104

    Published on: 24 September 2013

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21. Content Type:Research Article

    Evidence for inflammation-mediated memory dysfunction in gastropods: putative PLA2and COX inhibitors abolish long-term memory failure induced by systemic immune challenges

    Previous studies associate lipid peroxidation with long-term memory (LTM) failure in a gastropod model (Lymnaea stagnalis) of associative learning and memory. This process involves activation of Phospholipase A2 ...

    Authors:Petra M Hermann, Deborah Park, Emily Beaulieu and Willem C Wildering

    Citation:BMC Neuroscience 2013 14:83

    Published on: 6 August 2013

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22. Content Type:Research Article

    Enriched environment and masticatory activity rehabilitation recover spatial memory decline in aged mice

    To measure the impact of masticatory reduction on learning and memory, previous studies have produced experimental masticatory reduction by modified diet or molar removal. Here we induced spatial learning impa...

    Authors:Fabíola de Carvalho Chaves de Siqueira Mendes, Marina Negrão Frota de Almeida, André Pinheiro Gurgel Felício, Ana Carla Fadel, Diego de Jesus Silva, Thaíssa Gomes Borralho, Rodrigo Perez da Silva, João Bento-Torres, Pedro Fernando da Costa Vasconcelos, Victor Hugh Perry, Edson Marcos Leal Soares Ramos, Cristovam Wanderley Picanço-Diniz and Marcia Consentino Kronka Sosthenes

    Citation:BMC Neuroscience 2013 14:63

    Published on: 28 June 2013

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23. Content Type:Research Article

    Cortical mapping of the infraspinatus muscle in healthy individuals

    While cortical representations of intrinsic hand muscles have been extensively studied in healthy individuals, little is known about the representation of proximal upper limb muscles. Improving our understandi...

    Authors:Suzy Ngomo, Catherine Mercier and Jean-Sébastien Roy

    Citation:BMC Neuroscience 2013 14:52

    Published on: 24 April 2013

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24. Content Type:Research Article

    Etanercept attenuates traumatic brain injury in rats by reducing early microglial expression of tumor necrosis factor-α

    Tumor necrosis factor-alpha (TNF-α) is elevated early in injured brain after traumatic brain injury (TBI), in humans and in animals. Etanercept (a TNF-α antagonist with anti-inflammatory effects) attenuates TB...

    Authors:Chung-Ching Chio, Chin-Hong Chang, Che-Chuan Wang, Chong-Un Cheong, Chien-Ming Chao, Bor-Chih Cheng, Chung-Zhing Yang and Ching-Ping Chang

    Citation:BMC Neuroscience 2013 14:33

    Published on: 15 March 2013

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25. Content Type:Research Article

    Working memory- and anxiety-related behavioral effects of repeated nicotine as a stressor: the role of cannabinoid receptors

    Like emotional symptoms such as anxiety, modulations in working memory are among the frequently-reported but controversial psychiatric symptoms associated with nicotine (NC) administration. In the present stud...

    Authors:Tamaki Hayase

    Citation:BMC Neuroscience 2013 14:20

    Published on: 9 February 2013

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26. Content Type:Research Article

    Acupuncture regulates the glucose metabolism in cerebral functional regions in chronic stage ischemic stroke patients—a PET-CT cerebral functional imaging study

    Acupuncture has been applied to aid in the recovery of post-stroke patients, but its mechanism is unclear. This study aims to analyze the relationship between acupuncture and glucose metabolism in cerebral fun...

    Authors:Yong Huang, Chunzhi Tang, Shuxia Wang, Yangjia Lu, Wei Shen, Junjun Yang, Junqi Chen, Renyong Lin, Shaoyang Cui, Huiling Xiao, Shanshan Qu, Xinsheng Lai and Baoci Shan

    Citation:BMC Neuroscience 2012 13:75

    Published on: 27 June 2012

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