jueves, 17 de octubre de 2019

Journal of Experimental & Clinical Cancer Research | Articles

Journal of Experimental & Clinical Cancer Research | Articles

  • New Content Item
  • Owned by the Association for International Promotion & Study in Tumors (APSIT)
  • Regina Elena NCI
  • Official journal of the Regina Elena National Cancer Institute, Scientific Director Gennaro Ciliberto, Rome, Italy
  1. Research

    The transcription factor HOXD9 is one of the members of the HOX family, which plays an important role in neoplastic processes. However, the role of HOXD9 in the growth and metastasis of gastric cancer (GC) rem...
    Authors:Huiqiong Zhu, Weiyu Dai, Jiaying Li, Li Xiang, Xiaosheng Wu, Weimei Tang, Yaying Chen, Qiong Yang, Mengwei Liu, Yizhi Xiao, Wenjing Zhang, Jianjiao Lin, Jing Wang, Guangnan Liu, Yong Sun, Ping Jiang…
    Citation:Journal of Experimental & Clinical Cancer Research 2019 38:412
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  2. Content Type:Research

    Long non-coding RNA (lncRNA) HOXA transcript at the distal tip (HOTTIP), has been demonstrated to be a vital biomarker when evaluating the prognosis of multiple cancers. Nevertheless, the potential function of...
    Authors:Anquan Shang, Weiwei Wang, Chenzheng Gu, Chen Chen, Bingjie Zeng, Yibao Yang, Ping Ji, Junjun Sun, Junlu Wu, Wenying Lu, Zujun Sun and Dong Li
    Citation:Journal of Experimental & Clinical Cancer Research 2019 38:411
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  3. Content Type:Research

    UFM1 has been found to be involved in the regulation of tumor development. This study aims to clarify the role and potential molecular mechanisms of UFM1 in the invasion and metastasis of gastric cancer.
    Authors:Jian-Xian Lin, Xin-Sheng Xie, Xiong-Feng Weng, Sheng-Liang Qiu, Changhwan Yoon, Ning-Zi Lian, Jian-Wei Xie, Jia-Bin Wang, Jun Lu, Qi-Yue Chen, Long-Long Cao, Mi Lin, Ru-Hong Tu, Ying-Hong Yang, Chang-Ming Huang, Chao-Hui Zheng…
    Citation:Journal of Experimental & Clinical Cancer Research 2019 38:410
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  4. Content Type:Research

    ATPase associated with a variety of cellular activities (AAA ATPase) family members are closely linked to tumor formation and progression. However, their roles in hepatocellular carcinoma (HCC) largely remain ...
    Authors:Meng-Xuan Zhu, Chuan-Yuan Wei, Peng-Fei Zhang, Dong-Mei Gao, Jie Chen, Yan Zhao, Shuang-Shuang Dong and Bin-Bin Liu
    Citation:Journal of Experimental & Clinical Cancer Research 2019 38:409
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  5. Content Type:Research

    Replication-competent oncolytic viruses (OVs) have been proven to be a potent anticancer weapon for clinical therapy. The preexisting neutralizing antibody in patients is a big challenge for oncolytic efficacy...
    Authors:Mao Xia, Dongjun Luo, Jie Dong, Meihong Zheng, Gang Meng, Junhua Wu and Jiwu Wei
    Citation:Journal of Experimental & Clinical Cancer Research 2019 38:408
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  6. Content Type:Correction

    In the publication of this article [1], there are two corrections.
    Authors:Ming Tan, Qian Zhang, Xiaohong Yuan, Yuanzhong Chen and Yong Wu
    Citation:Journal of Experimental & Clinical Cancer Research 2019 38:407
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    The original article was published in Journal of Experimental & Clinical Cancer Research 2019 38:308
  7. Content Type:Review

    Iron, an indispensable element for life, is involved in all kinds of important physiological activities. Iron promotes cell growth and proliferation, but it also causes oxidative stress damage. The body has a ...
    Authors:Fang Wang, Huanhuan Lv, Bin Zhao, Liangfu Zhou, Shenghang Wang, Jie Luo, Junyu Liu and Peng Shang
    Citation:Journal of Experimental & Clinical Cancer Research 2019 38:406
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  8. Content Type:Research

    Skin cutaneous melanoma (SKCM) is the most lethal form of skin cancer and while incidence rates are declining for most cancers, they have been steadily rising for SKCM. Serine protease inhibitor, kunitz-type, ...
    Authors:Elena Gómez-Abenza, Sofía Ibáñez-Molero, Diana García-Moreno, Inmaculada Fuentes, Leonard I. Zon, Maria C. Mione, María L. Cayuela, Chiara Gabellini and Victoriano Mulero
    Citation:Journal of Experimental & Clinical Cancer Research 2019 38:405
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  9. Content Type:Research

    Metabolic reprogramming is an important characteristic of tumors. In the progression of pituitary adenomas (PA), abnormal glucose metabolism has been confirmed by us before. However, whether cholesterol metabo...
    Authors:Xiao Ding, Kexia Fan, Jintao Hu, Zhenle Zang, Shunli Zhang, Yin Zhang, Zhichao Lin, Xiangdong Pei, Xin Zheng, Feng Zhu, Hui Yang and Song Li
    Citation:Journal of Experimental & Clinical Cancer Research 2019 38:404
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  10. Content Type:Review

    T cells play important roles in anti-tumor immunity. Emerging evidence has revealed that distinct metabolic changes impact the activation and differentiation of T cells. Tailoring immune responses by manipulat...
    Authors:Zhongping Yin, Ling Bai, Wei Li, Tanlun Zeng, Huimin Tian and Jiuwei Cui
    Citation:Journal of Experimental & Clinical Cancer Research 2019 38:403
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  11. Content Type:Research

    Dihydroartemisinin (DHA) has been shown to exert anticancer activity through iron-dependent reactive oxygen species (ROS) generation, which is similar to ferroptosis, a novel form of cell death. However, wheth...
    Authors:Yibing Chen, Yanjun Mi, Xiaofei Zhang, Qian Ma, Yucen Song, Liwei Zhang, Dandan Wang, Jinliang Xing, Benxin Hou, Haolong Li, Huan Jin, Wei Du and Zhengzhi Zou
    Citation:Journal of Experimental & Clinical Cancer Research 2019 38:402
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  12. Content Type:Research

    Colon cancer is the second leading cancer worldwide. Recurrent disease and chemotherapeutic drug resistance are very common in the advanced stage of colon cancer. ATP-citrate lyase (ACLY), the first-step rate-...
    Authors:Jun Wen, Xuejie Min, Mengqin Shen, Qian Hua, Yuan Han, Li Zhao, Liu Liu, Gang Huang, Jianjun Liu and Xiaoping Zhao
    Citation:Journal of Experimental & Clinical Cancer Research 2019 38:401
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  13. Content Type:Research

    Neuroblastoma (NB) is one of the deadliest paediatric solid tumours due to its rapid proliferative characteristics. Amplified copies of MYCN are considered the most important marker for the prediction of tumou...
    Authors:Ping Jiang, Mao Huang, Weiwei Qi, Fenghua Wang, Tianyou Yang, Tianxiao Gao, Chuanghua Luo, Jing Deng, Zhonghan Yang, Ti Zhou, Yan Zou, Guoquan Gao and Xia Yang
    Citation:Journal of Experimental & Clinical Cancer Research 2019 38:400
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  14. Content Type:Research

    Radiotherapy (RT) is a highly effective multimodal nonsurgical treatment that is essential for patients with advanced colorectal cancer (CRC). Nevertheless, cell subpopulations displaying intrinsic radioresist...
    Authors:So-Yeon Park, Choong-Jae Lee, Jang-Hyun Choi, Jee-Heun Kim, Ji-Won Kim, Ji-Young Kim and Jeong-Seok Nam
    Citation:Journal of Experimental & Clinical Cancer Research 2019 38:399
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  15. Content Type:Research

    Growing evidences indicate that circular RNAs (circRNAs) play an important role in the regulation of biological behavior of tumor. We aim to explore the role of circRNA in glioma and elucidate how circRNA acts.
    Authors:Jiansheng Chen, Taoliang Chen, Yubo Zhu, Yan Li, Yuxuan Zhang, Yun Wang, Xiao Li, Xiaomi Xie, Jihui Wang, Min Huang, Xinlin Sun and Yiquan Ke
    Citation:Journal of Experimental & Clinical Cancer Research 2019 38:398
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  16. Content Type:Research

    Immune checkpoint inhibition and in particular anti-PD-1 immunotherapy have revolutionized the treatment of advanced melanoma. In this regard, higher tumoral PD-L1 protein (gene name: CD274) expression is associa...
    Authors:Alexander Thiem, Sonja Hesbacher, Hermann Kneitz, Teresa di Primio, Markus V. Heppt, Heike M. Hermanns, Matthias Goebeler, Svenja Meierjohann, Roland Houben and David Schrama
    Citation:Journal of Experimental & Clinical Cancer Research 2019 38:397
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  17. Content Type:Review

    Hepatocellular carcinoma (HCC) ranks the most common primary liver malignancy and the third leading cause of tumor-related mortality worldwide. Unfortunately, despite advances in HCC treatment, less than 40% o...
    Authors:Yaojie Fu, Shanshan Liu, Shan Zeng and Hong Shen
    Citation:Journal of Experimental & Clinical Cancer Research 2019 38:396
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  18. Content Type:Research

    Long non-coding RNA plays a crucial role in the occurrence and progression of glioma. We aimed to explore the function of LINC00174 in cell proliferation, apoptosis, migration, invasion and glycolysis of gliom...
    Authors:Jian Shi, Yang Zhang, Bing Qin, Yongjie Wang and Xiangdong Zhu
    Citation:Journal of Experimental & Clinical Cancer Research 2019 38:395
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  19. Content Type:Research

    FAM92A1–289(abbreviated FAM289) is recognized as one of the newly-discovered putative oncogenes. However, its role and molecular mechanisms in promoting cancer progression has not yet been elucidated. This stu...
    Authors:Xing Rong Guo, Mu Yu Wu, Long Jun Dai, Yu Huang, Meng Ye Shan, Shi Nan Ma, Jue Wang, Hao Peng, Yan Ding, Qiu Fang Zhang, Jun Ming Tang, Xu Zhi Ruan and Dong Sheng Li
    Citation:Journal of Experimental & Clinical Cancer Research 2019 38:394
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  20. Content Type:Research

    m6A modification has been proved to play an important role in many biological processes. METTL3 as the main methyltransferase for methylation process has been found to be upregulated in many cancers, including...
    Authors:Wen Peng, Jie Li, Ranran Chen, Qiou Gu, Peng Yang, Wenwei Qian, Dongjian Ji, Qingyuan Wang, Zhiyuan Zhang, Junwei Tang and Yueming Sun
    Citation:Journal of Experimental & Clinical Cancer Research 2019 38:393
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  21. Content Type:Research

    Radioresistance remains a challenge to the successful treatment of various tumors. Intrinsic factors like alterations in signaling pathways regulate response to radiation. RhoC, which has been shown to modulat...
    Authors:Annapurna Pranatharthi, Pavana Thomas, Avinash H. Udayashankar, Chandra Bhavani, Srinag Bangalore Suresh, Sudhir Krishna, Jayashree Thatte, Nirmala Srikantia, Cecil R. Ross and Sweta Srivastava
    Citation:Journal of Experimental & Clinical Cancer Research 2019 38:392
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  22. Content Type:Research

    Clinically, prostate cancer (PCa) exhibits a high avidity to metastasize to bone. Myc-associated zinc-finger protein (MAZ) is a well-documented oncogene involved in the progression and metastasis of multiple c...
    Authors:Qing Yang, Chuandong Lang, Zhengquan Wu, Yuhu Dai, Shaofu He, Wei Guo, Shuai Huang, Hong Du, Dong Ren and Xinsheng Peng
    Citation:Journal of Experimental & Clinical Cancer Research 2019 38:391
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  23. Content Type:Research

    Dysregulation of microRNAs (miRNAs) play critical roles in cancerous processes. Although miR-3064 was reported to be an important tumor suppressor in ovarian cancer, the cellular impact of miR-3064 on pancreat...
    Authors:Jiayan Yan, Yunxi Jia, Han Chen, Wei Chen and Xiaoying Zhou
    Citation:Journal of Experimental & Clinical Cancer Research 2019 38:390
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  24. Content Type:Research

    In cancer progression, hypoxia, or low oxygen tension, is a major regulator of tumor aggressiveness and metastasis. However, how cancer cells adapt to the hypoxia and communicate with other mesenchymal cells i...
    Authors:Yu Mao, Yimin Wang, Lixin Dong, Yunjie Zhang, Yanqiu Zhang, Chao Wang, Qiang Zhang, Sen Yang, Liyan Cao, Xinyuan Zhang, Xin Li and Zhanzhao Fu
    Citation:Journal of Experimental & Clinical Cancer Research 2019 38:389
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  25. Content Type:Research

    Hypoxia is a key feature of breast cancer, which affects cancer development, metastasis and metabolism. Previous studies suggested that circular RNAs (circRNAs) could participate in cancer progression and hypo...
    Authors:Shasha Ren, Jiuzhou Liu, Yun Feng, Zhenyu Li, Liang He, Leilei Li, Xiaozhong Cao, Zhenghua Wang and Yanwu Zhang
    Citation:Journal of Experimental & Clinical Cancer Research 2019 38:388
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  26. Content Type:Correction

    In the original publication of this article [1], the Fig. 7 is wrong, but does not affect discussions and conclusions drawn in the article.
    Authors:Qing Yang, Binhui Xie, Hui Tang, Wei Meng, Changchang Jia, Xiaomei Zhang, Yi Zhang, Jianwen Zhang, Heping Li and Binsheng Fu
    Citation:Journal of Experimental & Clinical Cancer Research 2019 38:387
    Published on: 
    The original article was published in Journal of Experimental & Clinical Cancer Research 2019 38:263
  27. Content Type:Research

    Renal cell carcinoma (RCC) is a deadly urological tumor that remains largely incurable. Our limited understanding of key molecular mechanisms underlying RCC invasion and metastasis has hampered efforts to iden...
    Authors:Yong Wang, Jing Su, Yiting Wang, Donghe Fu, Justin E. Ideozu, Hua Geng, Qiqi Cui, Chao Wang, Ruibing Chen, Yixi Yu, Yuanjie Niu and Dan Yue
    Citation:Journal of Experimental & Clinical Cancer Research 2019 38:386
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  28. Content Type:Correction

    In the original publication of this article [1], there are mistakes in Fig. 3A and Fig. 3D.
    Authors:Fei Zhang, Qiang Ma, Zihang Xu, Haibin Liang, Huaifeng Li, Yuanyuan Ye, Shanshan Xiang, Yijian Zhang, Lin Jiang, Yunping Hu, Zheng Wang, Xuefeng Wang, Yong Zhang, Wei Gong and Yingbin Liu
    Citation:Journal of Experimental & Clinical Cancer Research 2019 38:385
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    The original article was published in Journal of Experimental & Clinical Cancer Research 2017 36:68
  29. Content Type:Research

    Aberrant activation of Notch signaling has been causally linked to the metastasis of hepatocellular carcinoma (HCC), however the underlying molecular mechanisms are still poorly understood. RING finger protein...
    Authors:Lei Zhang, Jiewei Chen, Juanjuan Yong, Liang Qiao, Leibo Xu and Chao Liu
    Citation:Journal of Experimental & Clinical Cancer Research 2019 38:384
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  30. Content Type:Research

    Triple negative breast cancer (TNBC) is an incurable disease where novel therapeutic strategies are needed. Proteolysis targeting chimeric (PROTAC) are novel compounds that promote protein degradation by bindi...
    Authors:María del Mar Noblejas-López, Cristina Nieto-Jimenez, Miguel Burgos, Mónica Gómez-Juárez, Juan Carlos Montero, Azucena Esparís-Ogando, Atanasio Pandiella, Eva M. Galán-Moya and Alberto Ocaña
    Citation:Journal of Experimental & Clinical Cancer Research 2019 38:383
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  31. Content Type:Research

    Ovarian carcinomas are the deadliest gynecological malignancies owing to their high rate of recurrence and high resistance to platinum-based chemotherapy. Recent studies have shown platinum-dependent enrichmen...
    Authors:Syed S. Islam and Abdelilah Aboussekhra
    Citation:Journal of Experimental & Clinical Cancer Research 2019 38:382
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  32. Content Type:Research

    High rates of recurrence and metastasis are the major cause of the poor outcomes for patients with lung cancer. In previous research, we have demonstrated that Tac2-N promotes tumor growth by suppressing p53 s...
    Authors:Xianglin Hao, Li-yun Gao, Ning Zhang, Hongqiang Chen, Xiao Jiang, Wenbin Liu, Lin Ao, Jia Cao, Fei Han and Jinyi Liu
    Citation:Journal of Experimental & Clinical Cancer Research 2019 38:319
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  33. Content Type:Research

    Anti-angiogenesis remains an attractive strategy for cancer therapy. Some anti-angiogenic reagents have bell-shape dose-response curves with higher than the effective doses yielding lower anti-angiogenic effec...
    Authors:Jialiang Hu, Wenjing Wang, Chen Liu, Mengwei Li, Edouard Nice and Hanmei Xu
    Citation:Journal of Experimental & Clinical Cancer Research 2019 38:381
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  34. Content Type:Research

    Accumulating evidence demonstrates the oncogenic roles of lncRNA (long non-coding RNA) molecules in a wide variety of cancer types including glioma. Equally important, However, tumorigenic functions of lncRNA ...
    Authors:Zhenzhe Li, Jixing Zhang, Hongshan Zheng, Chenlong Li, Jinsheng Xiong, Weiliang Wang, Hongbo Bao, Hua Jin and Peng Liang
    Citation:Journal of Experimental & Clinical Cancer Research 2019 38:380
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  35. Content Type:Research

    TP53 is one of the most frequently mutated genes among all cancer types, and TP53 mutants occur more than 60% in colorectal cancer (CRC). Among all mutants, there are three hot spots, including p53-R175H, p53-...
    Authors:Yuechao Zhao, Yiran Li, Jie Sheng, Fan Wu, Kai Li, Rong Huang, Xiaojuan Wang, Tao Jiao, Xin Guan, Yan Lu, Xiao Chen, Zhiwen Luo, Yanchi Zhou, Hanjie Hu, Wenjie Liu, Boyu Du…
    Citation:Journal of Experimental & Clinical Cancer Research 2019 38:379
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  36. Content Type:Research

    Cripto-1 (CR-1) has been reported to be involved in the development of several human cancers. The potential role of CR-1 in clear cell renal cell carcinoma (ccRCC) is still not clear.
    Authors:Yi-Jun Xue, Song-Ning Chen, Wei-Guang Chen, Geng-Qing Wu, Yun-Feng Liao, Jian-Bin Xu, Hao Tang, Shui-Hua Yang, Shui-Yong He, Yun-Fei Luo, Zhi-Hui Wu and Hai-Wen Huang
    Citation:Journal of Experimental & Clinical Cancer Research 2019 38:378
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  37. Content Type:Research

    Cardamonin, a chalcone isolated from Alpiniae katsumadai, has anti-inflammatory and anti-tumor activities. However, the molecular mechanism by which cardamonin inhibits breast cancer progression largely remains t...
    Authors:Jinmei Jin, Shuiping Qiu, Ping Wang, Xiaohui Liang, Fei Huang, Hui Wu, Beibei Zhang, Weidong Zhang, Xinhui Tian, Ren Xu, Hailian Shi and Xiaojun Wu
    Citation:Journal of Experimental & Clinical Cancer Research 2019 38:377
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  38. Content Type:Research

    Metformin has been reported to function as the anti-tumor inhibiting the growth of different types of cancers, including bladder cancer. But there are few reports on the roles of Yap1, the key molecule of Hipp...
    Authors:Yanju Wu, Qianqian Zheng, Yan Li, Guang Wang, Shuting Gao, Xiaodong Zhang, Xu Yan, Xinwen Zhang, Jisheng Xie, Yuanyuan Wang, Xun Sun, Xin Meng, Bo Yin and Biao Wang
    Citation:Journal of Experimental & Clinical Cancer Research 2019 38:376
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  39. Content Type:Research

    An increasing number of studies have demonstrated that long non-coding RNAs (lncRNAs) play pivotal roles in cancer onset and development. LncRNA AFAP1-AS1 has been validated to be abnormally upregulated and pl...
    Authors:Deyao Shi, Fashuai Wu, Shidai Mu, Binwu Hu, Binlong Zhong, Feng Gao, Xiangcheng Qing, Jianxiang Liu, Zhicai Zhang and Zengwu Shao
    Citation:Journal of Experimental & Clinical Cancer Research 2019 38:375
    Published on: 
  40. Content Type:Correction

    In the original publication of this article [1], there is an error in Fig. 4A.
    Authors:Jia Wei, Ling Ma, Yi-Hui Lai, Ruijie Zhang, Huameng Li, Chenglong Li and Jiayuh Lin
    Citation:Journal of Experimental & Clinical Cancer Research 2019 38:374
    Published on: 
    The original article was published in Journal of Experimental & Clinical Cancer Research 2019 38:63
  41. Content Type:Research

    An increasing number of anticancer agents has been proposed in recent years with the attempt to overcome treatment-resistant cancer cells and particularly cancer stem cells (CSC), the major culprits for tumour...
    Authors:Isabella Orienti, Valentina Salvati, Giovanni Sette, Massimo Zucchetti, Lucilla Bongiorno-Borbone, Angelo Peschiaroli, Lello Zolla, Federica Francescangeli, Mariella Ferrari, Cristina Matteo, Ezia Bello, Antonio Di Virgilio, Mario Falchi, Maria Laura De Angelis, Marta Baiocchi, Gerry Melino…
    Citation:Journal of Experimental & Clinical Cancer Research 2019 38:373
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  42. Content Type:Research

    Topoisomerase inhibitors (TI) can inhibit cell proliferation by preventing DNA replication, stimulating DNA damage and inducing cell cycle arrest. Although these agents have been commonly used in the chemother...
    Authors:Jiafei Liu, Like Qu, Lin Meng and Chengchao Shou
    Citation:Journal of Experimental & Clinical Cancer Research 2019 38:370
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  43. Content Type:Research

    Esophageal squamous cell carcinoma (ESCC) is one of the most common cancers worldwide, which lacks effective biomarkers for prognosis. Therefore, it is urgent to explore new potential molecular markers to disc...
    Authors:Yan Liu, Yingru Zhi, Haizhu Song, Mingzhu Zong, Jun Yi, Guoxin Mao, Longbang Chen and Guichun Huang
    Citation:Journal of Experimental & Clinical Cancer Research 2019 38:369
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  44. Content Type:Review

    Survivin (also named BIRC5) is a well-known cancer therapeutic target. Since its discovery more than two decades ago, the use of survivin as a target for cancer therapeutics has remained a central goal of surv...
    Authors:Fengzhi Li, Ieman Aljahdali and Xiang Ling
    Citation:Journal of Experimental & Clinical Cancer Research 2019 38:368
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