Cognition and behavior: behavioral neurogenetics
Page 1 of 2
Proteomic analyses of limbic regions in neonatal male, female and androgen receptor knockout mice
It is well-established that organizational effects of sex steroids during early development are fundamental for sex-typical displays of, for example, mating and aggressive behaviors in rodents and other specie...BMC Neuroscience 2017 18:9Epigenetic evidence for involvement of the oxytocin receptor gene in obsessive–compulsive disorder
Obsessive–compulsive disorder (OCD) is a chronic neurodevelopmental disorder that affects up to 3% of the general population. Although epigenetic mechanisms play a role in neurodevelopment disorders, epigenet...BMC Neuroscience 2016 17:79Genotypic differences in intruder-evoked immediate early gene activation in male, but not female, vasopressin 1b receptor knockout mice
The neuropeptide arginine vasopressin (Avp) modulates social behaviors via its two centrally expressed receptors, the Avp 1a receptor and the Avp 1b receptor (Avpr1b). Recent work suggests that, at least in mi...BMC Neuroscience 2016 17:75Social behavioral testing and brain magnetic resonance imaging in chicks exposed to mobile phone radiation during development
The potential adverse effect of mobile phone radiation is currently an area of great concern in the field of public health. In the present study, we aimed to investigate the effect of mobile phone radiation (9...BMC Neuroscience 2016 17:36Absence of M-Ras modulates social behavior in mice
The molecular mechanisms that determine social behavior are poorly understood. Pheromones play a critical role in social recognition in most animals, including mice, but how these are converted into behavioral...BMC Neuroscience 2015 16:68Genetic contributions to attentional response time slopes across repeated trials
Attention provides vital contribution to everyday functioning, and deficits in attention feature in many psychological disorders. Improved understanding of attention may eventually be critical to early identif...BMC Neuroscience 2015 16:66A 72-hour high fat diet increases transcript levels of the neuropeptide galanin in the dorsal hippocampus of the rat
Recent evidence identifies the hippocampus, a brain structure commonly associated with learning and memory, as key to the regulation of food intake and the development and consequences of obesity. Intake of a ...BMC Neuroscience 2015 16:51mRNA and microRNA analysis reveals modulation of biochemical pathways related to addiction in the ventral tegmental area of methamphetamine self-administering rats
Methamphetamine is a highly addictive central nervous system stimulant with increasing levels of abuse worldwide. Alterations to mRNA and miRNA expression within the mesolimbic system can affect addiction-like...BMC Neuroscience 2015 16:43Cognitive-behavioral phenotypes of Williams syndrome are associated with genetic variation in the GTF2I gene, in a healthy population
Individuals with Williams syndrome, a neurogenetic condition caused by deletion of a set of genes at chromosomal location 7q11.23, exhibit a remarkable suite of traits including hypersociality with high, nonse...BMC Neuroscience 2014 15:127Common genetic variation of the APOE gene and personality
A recent study yielded first evidence that personality plays an important role in explaining the influence of a prominent APOE polymorphism on cognitive decline and Alzheimer’s disease (AD) in elderly humans. Add...BMC Neuroscience 2014 15:64A two years longitudinal study of a transgenic Huntington disease monkey
A two-year longitudinal study composed of morphometric MRI measures and cognitive behavioral evaluation was performed on a transgenic Huntington’s disease (HD) monkey. rHD1, a transgenic HD monkey expressing e...BMC Neuroscience 2014 15:36Ultra-fast speech comprehension in blind subjects engages primary visual cortex, fusiform gyrus, and pulvinar – a functional magnetic resonance imaging (fMRI) study
Individuals suffering from vision loss of a peripheral origin may learn to understand spoken language at a rate of up to about 22 syllables (syl) per second - exceeding by far the maximum performance level of ...BMC Neuroscience 2013 14:74A small cohort of FRUM and Engrailed-expressing neurons mediate successful copulation in Drosophila melanogaster
In Drosophila, male flies require the expression of the male-specific Fruitless protein (FRUM) within the developing pupal and adult nervous system in order to produce male courtship and copulation behaviors. Rec...BMC Neuroscience 2013 14:57Differential involvement of the gamma-synuclein in cognitive abilities on the model of knockout mice
Gamma-synuclein is a member of the synuclein family of cytoplasmic, predominantly neuron-specific proteins. Despite numerous evidences for the importance of gamma-synuclein in the control of monoamine homeosta...BMC Neuroscience 2013 14:53Chronic self-administration of alcohol results in elevated ΔFosB: comparison of hybrid mice with distinct drinking patterns
The inability to reduce or regulate alcohol intake is a hallmark symptom for alcohol use disorders. Research on novel behavioral and genetic models of experience-induced changes in drinking will further our kn...BMC Neuroscience 2012 13:130High throughput analysis reveals dissociable gene expression profiles in two independent neural systems involved in the regulation of social behavior
Production of contextually appropriate social behaviors involves integrated activity across many brain regions. Many songbird species produce complex vocalizations called ‘songs’ that serve to attract potentia...BMC Neuroscience 2012 13:126Omega 3 polyunsaturated fatty acid improves spatial learning and hippocampal Peroxisome Proliferator Activated Receptors (PPARα and PPARγ) gene expression in rats
This study examined the effects of dietary polyunsaturated fatty acids (PUFA) as different n-6: n-3 ratios on spatial learning and gene expression of peroxisome- proliferator-activated receptors (PPARs) in the...BMC Neuroscience 2012 13:109Common brain activations for painful and non-painful aversive stimuli
Identification of potentially harmful stimuli is necessary for the well-being and self-preservation of all organisms. However, the neural substrates involved in the processing of aversive stimuli are not well ...BMC Neuroscience 2012 13:60Spatial memory decline after masticatory deprivation and aging is associated with altered laminar distribution of CA1 astrocytes
Chewing imbalances are associated with neurodegeneration and are risk factors for senile dementia in humans and memory deficits in experimental animals. We investigated the impact of long-term reduced masticat...BMC Neuroscience 2012 13:23The neural correlates of picture naming facilitated by auditory repetition
Overt repetition of auditorily presented words can facilitate picture naming performance in both unimpaired speakers and individuals with word retrieval difficulties, but the underlying neurocognitive mechanis...BMC Neuroscience 2012 13:21Online detection of error-related potentials boosts the performance of mental typewriters
Increasing the communication speed of brain-computer interfaces (BCIs) is a major aim of current BCI-research. The idea to automatically detect error-related potentials (ErrPs) in order to veto erroneous decis...BMC Neuroscience 2012 13:19Lateral frontal cortex volume reduction in Tourette syndrome revealed by VBM
Structural changes have been found predominantly in the frontal cortex and in the striatum in children and adolescents with Gilles de la Tourette syndrome (GTS). The influence of comorbid symptomatology is unc...BMC Neuroscience 2012 13:17Age-related changes in neural functional connectivity and its behavioral relevance
Resting-state recordings are characterized by widely distributed networks of coherent brain activations. Disturbances of the default network - a set of regions that are deactivated by cognitive tasks and activ...BMC Neuroscience 2012 13:16The effect of water immersion on short-latency somatosensory evoked potentials in human
Water immersion therapy is used to treat a variety of cardiovascular, respiratory, and orthopedic conditions. It can also benefit some neurological patients, although little is known about the effects of water...BMC Neuroscience 2012 13:13Visual laterality in dolphins: importance of the familiarity of stimuli
Many studies of cerebral asymmetries in different species lead, on the one hand, to a better understanding of the functions of each cerebral hemisphere and, on the other hand, to develop an evolutionary histor...BMC Neuroscience 2012 13:9Electrophysiological correlates of associative learning in smokers: a higher-order conditioning experiment
Classical conditioning has been suggested to play an important role in the development, maintenance, and relapse of tobacco smoking. Several studies have shown that initially neutral stimuli that are directly ...BMC Neuroscience 2012 13:8Auditory sustained field responses to periodic noise
Auditory sustained responses have been recently suggested to reflect neural processing of speech sounds in the auditory cortex. As periodic fluctuations below the pitch range are important for speech perceptio...BMC Neuroscience 2012 13:7Volumetric associations between uncinate fasciculus, amygdala, and trait anxiety
Recent investigations of white matter (WM) connectivity suggest an important role of the uncinate fasciculus (UF), connecting anterior temporal areas including the amygdala with prefrontal-/orbitofrontal corti...BMC Neuroscience 2012 13:4It's not what you say but the way that you say it: an fMRI study of differential lexical and non-lexical prosodic pitch processing
This study aims to identify the neural substrate involved in prosodic pitch processing. Functional magnetic resonance imaging was used to test the premise that prosody pitch processing is primarily subserved b...BMC Neuroscience 2011 12:128Narrative exposure therapy for PTSD increases top-down processing of aversive stimuli - evidence from a randomized controlled treatment trial
Little is known about the neurobiological foundations of psychotherapy for Posttraumatic Stress Disorder (PTSD). Prior studies have shown that PTSD is associated with altered processing of threatening and aver...BMC Neuroscience 2011 12:127Chemotherapy-induced cognitive impairment is associated with decreases in cell proliferation and histone modifications
In this study, we examined the effects of cyclophosphamide, methothrexate, and 5-Fluorouracil (CMF) drug combination on various aspects of learning and memory. We also examined the effects of CMF on cell proli...BMC Neuroscience 2011 12:124Heightened inflammasome activation is linked to age-related cognitive impairment in Fischer 344 rats
Members of the mammalian nucleotide binding domain, leucine-rich repeat (LRR)-containing receptor (NLR) family of proteins are key modulators of innate immunity regulating inflammation. Our previous work has s...BMC Neuroscience 2011 12:123Effects of vocoding and intelligibility on the cerebral response to speech
Degrading speech through an electronic synthesis technique called vocoding has been shown to affect cerebral processing of speech in several cortical areas. However, it is not clear whether the effects of spee...BMC Neuroscience 2011 12:122Do resting brain dynamics predict oddball evoked-potential?
The oddball paradigm is widely applied to the investigation of cognitive function in neuroscience and in neuropsychiatry. Whether cortical oscillation in the resting state can predict the elicited oddball even...BMC Neuroscience 2011 12:121Rapid eye movements during sleep in mice: High trait-like stability qualifies rapid eye movement density for characterization of phenotypic variation in sleep patterns of rodents
In humans, rapid eye movements (REM) density during REM sleep plays a prominent role in psychiatric diseases. Especially in depression, an increased REM density is a vulnerability marker for depression. In cli...BMC Neuroscience 2011 12:110Characteristics of the aberrant pyramidal tract in comparison with the pyramidal tract in the human brain
The aberrant pyramidal tract (APT) refers to the collateral pathway of the pyramidal tract (PT) through the medial lemniscus in the midbrain and pons. Using diffusion tensor tractography (DTT), we investigated...BMC Neuroscience 2011 12:108Inhibition of cerebrovascular raf activation attenuates cerebral blood flow and prevents upregulation of contractile receptors after subarachnoid hemorrhage
Late cerebral ischemia carries high morbidity and mortality after subarachnoid hemorrhage (SAH) due to reduced cerebral blood flow (CBF) and the subsequent cerebral ischemia which is associated with upregulati...BMC Neuroscience 2011 12:107Two genetic loci control syllable sequences of ultrasonic courtship vocalizations in inbred mice
The ultrasonic vocalizations (USV) of courting male mice are known to possess a phonetic structure with a complex combination of several syllables. The genetic mechanisms underlying the syllable sequence organ...BMC Neuroscience 2011 12:104Inner ear dysfunction in caspase-3 deficient mice
Caspase-3 is one of the most downstream enzymes activated in the apoptotic pathway. In caspase-3 deficient mice, loss of cochlear hair cells and spiral ganglion cells coincide closely with hearing loss. In con...BMC Neuroscience 2011 12:102Practice effects on the modified Concept Shifting Task (mCST): A convenient assessment for treatment effects on prefrontal cognitive function
Trail-making tests, such as the Concept Shifting Task (CST), can be used to test the effects of treatment on cognitive performance over time in various neuropsychological disorders. However, cognitive performa...BMC Neuroscience 2011 12:101Pattern of BOLD signal in auditory cortex relates acoustic response to perceptual streaming
Segregating auditory scenes into distinct objects or streams is one of our brain's greatest perceptual challenges. Streaming has classically been studied with bistable sound stimuli, perceived alternately as a...BMC Neuroscience 2011 12:85Topographical aspects in the dynamics of sleep homeostasis in young men: individual patterns
Sleep homeostasis refers to the increase of sleep pressure during waking and the decrease of sleep intensity during sleep. Electroencephalography (EEG) slow-wave activity (SWA; EEG power in the 0.75-4.5 Hz range)...BMC Neuroscience 2011 12:84Arithmetic mismatch negativity and numerical magnitude processing in number matching
This study examined the relationship of the arithmetic mismatch negativity (AMN) and the semantic evaluation of numerical magnitude. The first question was whether the AMN was sensitive to the incongruity in n...BMC Neuroscience 2011 12:83Everyday episodic memory in amnestic mild cognitive impairment: a preliminary investigation
Decline in episodic memory is one of the hallmark features of Alzheimer's disease (AD) and is also a defining feature of amnestic Mild Cognitive Impairment (MCI), which is posited as a potential prodrome of AD...BMC Neuroscience 2011 12:80Combinatorial administration of insulin and vitamin C alleviates the cerebral vasospasm after experimental subarachnoid hemorrhage in rabbit
Cerebral vasospasm (CVS) is a common serious complication after the spontaneous subarachnoid hemorrhage (SAH). Despite recent advances in medical and surgical treatments, the 30-day mortality rate of SAH remai...BMC Neuroscience 2011 12:77Cathepsin K deficiency in mice induces structural and metabolic changes in the central nervous system that are associated with learning and memory deficits
Cathepsin K is a cysteine peptidase known for its importance in osteoclast-mediated bone resorption. Inhibitors of cathepsin K are in clinical trials for treatment of osteoporosis. However, side effects of fir...BMC Neuroscience 2011 12:74Differences in cortical response to acupressure and electroacupuncture stimuli
FMRI studies focus on sub-cortical effects of acupuncture stimuli. The purpose of this study was to assess changes in primary somatosensory (S1) activity over the course of different types of acupuncture stimu...BMC Neuroscience 2011 12:73Reward system and temporal pole contributions to affective evaluation during a first person shooter video game
Violent content in video games evokes many concerns but there is little research concerning its rewarding aspects. It was demonstrated that playing a video game leads to striatal dopamine release. It is unclea...BMC Neuroscience 2011 12:66Granulocyte colony-stimulating factor increases the therapeutic efficacy of bone marrow mononuclear cell transplantation in cerebral ischemia in mice
Bone marrow mononuclear cell (BMMC) transplantation is a promising therapy for cerebral ischemia; however, little is known if its therapeutic efficacy may be improved by co-administration of potential modulato...BMC Neuroscience 2011 12:61Investigation of fMRI activation in the internal capsule
Functional magnetic resonance imaging (fMRI) in white matter has long been considered controversial. Recently, this viewpoint has been challenged by an emerging body of evidence demonstrating white matter acti...BMC Neuroscience 2011 12:56
.png)
No hay comentarios:
Publicar un comentario