Coronavirus [NEW TOPIC PAGE]

Hot Topics of the Day|PHGKB

 Coronavirus

Rapid and Inexpensive Whole-Genome Sequencing of SARS-CoV2 using 1200 bp Tiled Amplicons and Oxford Nanopore Rapid Barcoding
NE Freed et al, BIORXIV, May 29, 2020

Rapid and cost-efficient whole-genome sequencing of SARS-CoV-2, the virus that causes COVID-19, is critical for understanding viral transmission dynamics. Here we show that using a new multiplexed set of primers in conjunction with the Oxford Nanopore Rapid Barcode library kit allows for faster, simpler, and less expensive SARS-CoV-2 genome sequencing.

SARS-CoV-2 transmission chains from genetic data: a Danish case study
A Bluhm et al, BIORXIV, May 29, 2020

Genomic analysis of early SARS-CoV-2 strains introduced in Mexico
B Taboada et al, BIORXIV, May 30, 2020

Seek COVER: Development and validation of a personalized risk calculator for COVID-19 outcomes in an international network
RD Williams et al, MEDRXIV, May 29, 2020

The study sought to develop and externally validate COVID-19 Estimated Risk (COVER) scores that quantify a patient's risk of hospital admission, requiring intensive services, or fatality in the 30-days following diagnosis. The design was a multinational, distributed network cohorts from 13 data sources and 6 countries, mapped to a common data model.

Combining PCR and CT testing for COVID
C Shen et al, MEDRXIV, May 29, 2020

Evaluation of commercial qPCR kits for detection of SARS-CoV-2 in pooled samples
V Petrovan et al, BIORXIV, May 28, 2020

COVID-19 Data Dives: Why Don't We Have a Vaccine for SARS or MERS?
NE Dean, Medscape, May 28, 2020

Serum proteomics in COVID-19 patients: Altered coagulation and complement status as a function of IL-6 level
A D'Alessandro et al, MEDRXIV, May 29, 2020

ACE2 variants underlie interindividual variability and susceptibility to COVID-19 in Italian population
A Renieri et al, MEDRXIV, May 29, 2020