Last Posted: Jan 05, 2017
- ‘Heart-In-A-Dish’ Sheds Light on Genetics of Heart Disease,
Science Blog, January 3, 2017 - Old challenges and new opportunities in the clinical management of heterozygous familial hypercholesterolemia (HeFH): The promises of PCSK9 inhibitors.
Arca Marcello et al. Atherosclerosis 2016 Sep - Point-of-care genetic profiling and/or platelet function testing in acute coronary syndrome.
Collet Jean-Philippe et al. Thrombosis and haemostasis 2016 Jan 115(2) 382-91 - Shared decision-making following disclosure of coronary heart disease genetic risk: results from a randomized clinical trial.
Jouni Hayan et al. Journal of investigative medicine : the official publication of the American Federation for Clinical Research 2016 Dec - The Power of Simple Life Changes to Prevent Heart Disease
E Carroll, New York Times, December 12, 2016 - Genomic prediction of coronary heart disease.
Abraham Gad et al. European heart journal 2016 Sep - The response to receiving phenotypic and genetic coronary heart disease risk scores and lifestyle advice - a qualitative study.
Shefer Guy et al. BMC public health 2016 Dec 16(1) 1221 - Variation in PCSK9 and HMGCR and Risk of Cardiovascular Disease and Diabetes
BA Ference et al, NEJM, November 30, 2016 - Announcement: National Family History Day - November 24, 2016.
et al. MMWR. Morbidity and mortality weekly report 2016 Nov 65(46) 1305 - Genetic Heart Disease Risk Eased by Healthy Habits, Study Finds
G Kolata, New York Times, November 11, 2016 - Precision Public Health in Action: How to Prevent Heart Disease and Cancer Associated with Inherited Mutations
NCI Webinar, December 14, 2-3 pm, - DNA Is Not Destiny When It Comes To Heart Risk
R Harris, NPR News, November 13, 2016 - Genetic Risk, Adherence to a Healthy Lifestyle, and Coronary Disease
AV Khera et al, NEJM< November 12, 2016 - How Suitable Are Registry Data for Recurrence Risk Calculations? Validation of Diagnoses on 1,593 Families With Congenital Heart Disease.
Ellesøe Sabrina Gade et al. World journal for pediatric & congenital heart surgery 2016 Mar 7(2) 169-77 - Implementing evidence-driven individualized treatment plans within Morquio A Syndrome.
Clarke Lorne A et al. Molecular genetics and metabolism 2016 Feb 117(2) 217 - Testing toddlers for inherited heart disease
Genomics Education UK, October 31, 2016
From CDC Information Database
This database includes general CDC public health information on specific diseases and health related topics. When available, the database displays genomic information from various CDC web pages. Users are also encouraged to conduct searches of CDC website for additional information.
- New Global Initiative Has the Power to Shake Up Cardiovascular Health
- Beyond the Blood Spot: Newborn Screening for Hearing Loss and Critical Congenital Heart Disease
CDC Public Health Grand Rounds, Septemeber 20, 2016 - This Father's Day, Up Your Health Game
- Does Heart Disease Run in Your Family?
Rhiannon's Story - Strong Men Put Their Heart Health First
- Strong Men Put Their Heart Health First
From CDC-Authored Genomics Publication Database
This database contains CDC-authored publications in public health genomics including infectious diseases, newborn screening, reproductive health, genetic testing, cancer, chronic diseases, birth defects and developmental disabilities, environmental and occupational health as well as laboratory, bioinformatics and statistical methods.
- A public health economic assessment of hospitals' cost to screen newborns for critical congenital heart disease.
Peterson Cora et al. Public Health Rep 129(1) 86-93 - Reducing the burden of disease and death from familial hypercholesterolemia: a call to action.
Knowles Joshua W et al. Am. Heart J. 2014 Dec 168(6) 807-11 - Association between alcohol and cardiovascular disease: Mendelian randomisation analysis based on individual participant data.
Holmes Michael V et al. BMJ 2014 349g4164 - Universal state newborn screening programs can reduce health disparities.
Brosco Jeffrey P et al. JAMA Pediatr 2015 Jan 169(1) 7-8 - Survival among people with Down syndrome: a nationwide population-based study in Denmark.
Zhu Jin Liang et al. Genet. Med. 2013 Jan 15(1) 64-9
From Implementation Database
This database focuses on state and national activities that integrate genomics into public health programs and clinical practice
- Screening for Familial Hypercholesterolemia in Children: What Can We Learn From Adult Screening Programs?
[Disease: Familial Hypercholesterolemia; Type: Data|Program; State: Multiple States] - Prevention Status Reports (PSR)
[Disease: Heart Disease; Type: General Info; State: Multiple States] - WISEWOMAN
[Disease: Stroke|Familial Hypercholesterolemia|Heart Disease; Type: Program; State: Multiple States] - Statewide Screening of Fifth Graders Leads to Identification and Treatment of Those With Genetic Predisposition to Early-Onset Heart Disease
[Disease: Heart Disease|Familial Hypercholesterolemia|Stroke; Type: Data|Program; State: West Virginia] - Addressing Familial Hypercholesterolemia
[Disease: Familial Hypercholesterolemia|Heart Disease|Stroke; Type: Education; State: West Virginia]
From Guideline Database
This database contains updated guidelines, policies and recommendations on genomic research and practice, as provided by professional organizations, federal advisory groups, expert panels and policy groups.
- Eligibility and Disqualification Recommendations for Competitive Athletes With Cardiovascular Abnormalities: Task Force 4: Congenital Heart Disease: A Scientific Statement From the American Heart Association and American College of Cardiology.
Published 2015 (American College of Cardiology) (American Heart Association) - Recommendations for initiation and cessation of enzyme replacement therapy in patients with Fabry disease: the European Fabry Working Group consensus document.
Published 2015 (European Fabry Working Group) - [Diagnosis and treatment of familial hypercholesterolemia in Spain: Consensus document.]
Published 2015 (Expert panel) - Integrated guidance on the care of familial hypercholesterolaemia from the International FH Foundation.
Published 2014 (International FH Foundation) - Integrated guidance on the care of familial hypercholesterolaemia from the International FH Foundation.
Published 2015 (International FH Foundation)
From Tier Table Database
CDC Office of Public Health Genomics (OPHG) conducts horizon scanning (a systematic research method to find and follow novel technologies appearing in the literature) to identify and track the progress of genomic tests as they move from research into clinical and public health practice. As an aid in organizing horizon scanning results, OPHG ranks genomic tests, and family health history applications, by levels of evidence. See detail.
| Disease/Disorder | Test to be Assessed | Intended Use | Tier Classified | Detail |
|---|---|---|---|---|
| Acute coronary syndrome | CYP2C19 | Pharmacogenomic for ticagrelor | Tier 2  | |
| Acute coronary syndrome managed with percutaneous coronary intervention | CYP2C19 | Pharmacogenomic for prasugrel | Tier 2 | |
| Non-ST-segment elevation acute coronary syndrome, ST-elevation myocardial infarction, myocardial infarction, stroke, peripheral arterial disease | CYP2C19 | Pharmacogenomic for clopidogrel | Tier 2 | |
| Atrial fibrillation | CYP2D6 | Pharmacogenomic for propafenone | Tier 2 | |
| Chronic heart failure, left ventricular dysfunction following myocardial infarction, hypertension | CYP2D6 | Pharmacogenomic for carvedilol | Tier 2 |
From HuGE Literature Finder Database
This database contains published literature on genetic associations and other human genome epidemiology
- A genome-wide association study identifies novel genetic loci that modify antiplatelet effects and pharmacokinetics of clopidogrel.
Clinical pharmacology and therapeutics 2016 Dec .
Zhong Wan-Ping, Wu Hong, Chen Ji-Yan, Li Xin-Xin, Lin Hao-Ming, Zhang Bin, Zhang Zhi-Wei, Ma Dun-Liang, Sun Shuo, Li Han-Ping, Mai Li-Ping, He Guo-Dong, Wang Xi-Pei, Lei He-Ping, Zhou Huang-Kai, Tang Lan, Liu Shu-Wen, Zhong Shi-Lo - Coffee intake, cardiovascular disease and all-cause mortality: observational and Mendelian randomization analyses in 95?000-223?000 individuals.
International journal of epidemiology 2016 Dec .
Nordestgaard Ask Tybjærg, Nordestgaard Børge Grøn - Mannose-binding lectin 2 (Mbl2) gene polymorphisms are related to protein plasma levels, but not to heart disease and infection by Chlamydia.
Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas 2016 Dec 49 (12): e5519.
Queiroz M A F, Gomes S T M, Almeida N C C, Souza M I M, Costa S R C F, Hermes R B, Lima S S, Zaninotto M M, Fossa M A A, Maneschy M A, Martins-Feitosa R N, Azevedo V N, Machado L F A, Ishak M O G, Ishak R, Vallinoto A C - Significant association between functional microRNA polymorphisms and coronary heart disease susceptibility: a comprehensive meta-analysis involving 16484 subjects.
Oncotarget 2016 Dec .
Liu Xu, You Lianghao, Zhou Ruizhi, Zhang Ji - ZNF208 polymorphisms associate with ischemic stroke in southern Chinese Han population.
The journal of gene medicine 2016 Dec .
Yu Jianzhong, Zhou Feng, Luo Dong, Wang Nianzhen, Zhang Chong, Jin Tianbo, Liang Xiongfei, Yu D
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