Double lung, unlike single lung transplantation might provide a protective effect on mortality and bronchiolitis obliterans syndrome

Mohammed FakhroEmail author,
Ellen Broberg,
Lars Algotsson,
Lennart Hansson,
Bansi Koul,
Ronny Gustafsson,
Per Wierup,
Richard Ingemansson and
Sandra Lindstedt

Journal of Cardiothoracic Surgery201712:100

https://doi.org/10.1186/s13019-017-0666-5

Received: 28 June 2017
Accepted: 16 November 2017
Published: 25 November 2017

Open Peer Review reports

Abstract

Background

Survival after lung transplantation (LTx) is often limited by bronchiolitis obliterans syndrome (BOS).

Method

Survey of 278 recipients who underwent LTx. The endpoint used was BOS (BOS grade ≥ 2), death or Re-lung transplantation (Re-LTx) assessed by competing risk regression analyses.

Results

The incidence of BOS grade ≥ 2 among double LTx (DLTx) recipients was 16 ± 3% at 5 years, 30 ± 4% at 10 years, and 37 ± 5% at 20 years, compared to single LTx (SLTx) recipients whose corresponding incidence of BOS grade ≥ 2 was 11 ± 3%, 20 ± 4%, and 24 ± 5% at 5, 10, and 20 years, respectively (p > 0. 05). The incidence of BOS grade ≥ 2 by major indications ranked in descending order: other, PF, CF, COPD, PH and AAT1 (p < 0. 05). The mortality rate by major indication ranked in descending order: COPD, PH, AAT1, PF, Other and CF (p < 0. 05).

Conclusion

No differences were seen in the incidence of BOS grade ≥ 2 regarding type of transplant, however, DLTx recipients showed a better chance of survival despite developing BOS compared to SLTx recipients. The highest incidence of BOS was seen among CF, PF, COPD, PH, and AAT1 recipients in descending order, however, CF and PF recipients showed a better chance of survival despite developing BOS compared to COPD, PH, and AAT1 recipients.