Journal of Translational Medicine | Medical bioinformatics

Medical bioinformatics

Section edited by Michele Ceccarelli

The explosion of genome sequencing data along with genotype to phenotype correlation studies has created data deluge in the area of biomedical sciences. The aim of the Medical bioinformatics section is to aid the development and maturation of the field by providing a platform for the translation of these datasets into useful clinical applications. The increase in computing capabilities and availability of different data from advanced technologies will allow researchers to build System Biology models of various diseases in order to efficiently develop new therapeutic interventions and reduce the current prohibitively large costs of drug discovery.

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Content Type:Research
AntAngioCOOL: computational detection of anti-angiogenic peptides
Angiogenesis inhibition research is a cutting edge area in angiogenesis-dependent disease therapy, especially in cancer therapy. Recently, studies on anti-angiogenic peptides have provided promising results in...
Authors:Javad Zahiri, Babak Khorsand, Ali Akbar Yousefi, Mohammadjavad Kargar, Ramin Shirali Hossein Zade and Ghasem Mahdevar
Citation:Journal of Translational Medicine 2019 17:71
Published on: 4 March 2019
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Content Type:Research
Identification of an immune signature predicting prognosis risk of patients in lung adenocarcinoma
Lung cancer has become the most common cancer type and caused the most cancer deaths. Lung adenocarcinoma (LUAD) is one of the major type of lung cancer. This study aimed to establish a signature based on immu...
Authors:Qian Song, Jun Shang, Zuyi Yang, Lanlin Zhang, Chufan Zhang, Jianing Chen and Xianghua Wu
Citation:Journal of Translational Medicine 2019 17:70
Published on: 4 March 2019
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Content Type:Research
Comprehensive bioinformatics analysis of acquired progesterone resistance in endometrial cancer cell line
Progesterone resistance is a problem in endometrial carcinoma, and its underlying molecular mechanisms remain poorly understood. The aim of this study was to elucidate the molecular mechanisms of progesterone ...
Authors:Wenzhi Li, Shufen Wang, Chunping Qiu, Zhiming Liu, Qing Zhou, Deshui Kong, Xiaohong Ma and Jie Jiang
Citation:Journal of Translational Medicine 2019 17:58
Published on: 27 February 2019
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Content Type:Research
Bioinformatic gene analysis for potential biomarkers and therapeutic targets of atrial fibrillation-related stroke
Atrial fibrillation (AF) is one of the most prevalent sustained arrhythmias, however, epidemiological data may understate its actual prevalence. Meanwhile, AF is considered to be a major cause of ischemic stro...
Authors:Rongjun Zou, Dingwen Zhang, Lei Lv, Wanting Shi, Zijiao Song, Bin Yi, Bingjia Lai, Qian Chen, Songran Yang and Ping Hua
Citation:Journal of Translational Medicine 2019 17:45
Published on: 13 February 2019
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Content Type:Methodology
DRAP: a toolbox for drug response analysis and visualization tailored for preclinical drug testing on patient-derived xenograft models
One of the key reasons for the high failure rate of new agents and low therapeutic benefit of approved treatments is the lack of preclinical models that mirror the biology of human tumors. At present, the opti...
Authors:Quanxue Li, Wentao Dai, Jixiang Liu, Yi-Xue Li and Yuan-Yuan Li
Citation:Journal of Translational Medicine 2019 17:39
Published on: 29 January 2019
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Content Type:Research
An integrative genomic analysis of transcriptional profiles identifies characteristic genes and patterns in HIV-infected long-term non-progressors and elite controllers
Despite that most HIV-infected individuals experience progressive CD4+ T cell loss and develop AIDS, a minority of HIV-infected individuals remain asymptomatic and maintain high level CD4+ T cell counts severa...
Authors:Jiwei Ding, Ling Ma, Jianyuan Zhao, Yongli Xie, Jinming Zhou, Xiaoyu Li and Shan Cen
Citation:Journal of Translational Medicine 2019 17:35
Published on: 21 January 2019
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Content Type:Research
Prediction of postoperative complications of pediatric cataract patients using data mining
The common treatment for pediatric cataracts is to replace the cloudy lens with an artificial one. However, patients may suffer complications (severe lens proliferation into the visual axis and abnormal high i...
Authors:Kai Zhang, Xiyang Liu, Jiewei Jiang, Wangting Li, Shuai Wang, Lin Liu, Xiaojing Zhou and Liming Wang
Citation:Journal of Translational Medicine 2019 17:2
Published on: 3 January 2019
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Content Type:Research
Prediction and prognostic significance of BCAR3 expression in patients with multiple myeloma
Multiple myeloma (MM) is the plasma cell tumor, which is characterized by clonal proliferation of tumor cells, with high risk of progression to renal impairment, bone damage and amyloidosis. Although the survi...
Authors:Weilong Zhang, Yuansheng Lin, Xiaoni Liu, Xue He, Ye Zhang, Wei Fu, Zuozhen Yang, Ping Yang, Jing Wang, Kai Hu, Xiuru Zhang, Weiyou Liu, Xiaoliang Yuan and Hongmei Jing
Citation:Journal of Translational Medicine 2018 16:363
Published on: 18 December 2018
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Content Type:Research
A novel semi-supervised model for miRNA-disease association prediction based on $ℓ_{1}$ -norm graph
Identification of miRNA-disease associations has attracted much attention recently due to the functional roles of miRNAs implicated in various biological and pathological processes. Great efforts have been mad...
Authors:Cheng Liang, Shengpeng Yu, Ka-Chun Wong and Jiawei Luo
Citation:Journal of Translational Medicine 2018 16:357
Published on: 14 December 2018
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Content Type:Research
A heterogeneous label propagation approach to explore the potential associations between miRNA and disease
Research on microRNAs (miRNAs) has attracted increasingly worldwide attention over recent years as growing experimental results have made clear that miRNA correlates with masses of critical biological processe...
Authors:Xing Chen, De-Hong Zhang and Zhu-Hong You
Citation:Journal of Translational Medicine 2018 16:348
Published on: 11 December 2018
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Content Type:Research
Crosstalk in competing endogenous RNA networks reveals new circular RNAs involved in the pathogenesis of early HIV infection
The events in early HIV infection (EHI) are important determinants of disease severity and progression rate to AIDS, but the mechanisms of pathogenesis in EHI have not been fully understood. Circular RNAs (cir...
Authors:Yue Zhang, Hui Zhang, Minghui An, Bin Zhao, Haibo Ding, Zining Zhang, Youwen He, Hong Shang and Xiaoxu Han
Citation:Journal of Translational Medicine 2018 16:332
Published on: 29 November 2018
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Content Type:Research
Molecular network-based identification of competing endogenous RNAs and mRNA signatures that predict survival in prostate cancer
The aim of the study is described the regulatory mechanisms and prognostic values of differentially expressed RNAs in prostate cancer and construct an mRNA signature that predicts survival.
Authors:Ning Xu, Yu-Peng Wu, Hu-Bin Yin, Xue-Yi Xue and Xin Gou
Citation:Journal of Translational Medicine 2018 16:274
Published on: 4 October 2018
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Content Type:Research
Identification of invasion-metastasis-associated microRNAs in hepatocellular carcinoma based on bioinformatic analysis and experimental validation
Hepatocellular carcinoma (HCC) is one of the most lethal cancer, mainly attributing to its high tendency to metastasis. Vascular invasion provides a direct path for solid tumor metastasis. Mounting evidence ha...
Authors:Weiyang Lou, Jing Chen, Bisha Ding, Danni Chen, Huilin Zheng, Donghai Jiang, Liang Xu, Chang Bao, Guoqiang Cao and Weimin Fan
Citation:Journal of Translational Medicine 2018 16:266
Published on: 29 September 2018
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Content Type:Methodology
MAGIC: once upon a time in consent management—a FHIR® tale
The use of medical data for research purposes requires an informed consent of the patient that is compliant with the EU General Data Protection Regulation. In the context of multi-centre research initiatives a...
Authors:Martin Bialke, Thomas Bahls, Lars Geidel, Henriette Rau, Arne Blumentritt, Sandra Pasewald, Robert Wolff, Jonas Steinmann, Tobias Bronsch, Björn Bergh, Galina Tremper, Martin Lablans, Frank Ückert, Stefan Lang, Tarik Idris and Wolfgang Hoffmann
Citation:Journal of Translational Medicine 2018 16:256
Published on: 14 September 2018
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Content Type:Research
Large-scale in silico identification of drugs exerting sex-specific effects in the heart
Major differences exist between men and women in both physiology and pathophysiology. Dissecting the underlying processes and contributing mechanisms of sex differences in health and disease represents a cruci...
Authors:Changting Cui, Chuanbo Huang, Kejia Liu, Guoheng Xu, Jichun Yang, Yong Zhou, Yingmei Feng, Georgios Kararigas, Bin Geng and Qinghua Cui
Citation:Journal of Translational Medicine 2018 16:236
Published on: 29 August 2018
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Content Type:Research
HBV infection increases the risk of macular degeneration: the roles of HBx-mediated sensitization of retinal pigment epithelial cells to UV and blue light irradiation
Hepatitis B virus (HBV) infection is strongly associated with hepatocellular carcinoma due to the main pathogenic X protein of HBV (HBx). Whether HBV infection and the HBx protein could result in macular degen...
Authors:Ruey-Hwang Chou, Chang-Yin Lee, Lee-Won Chong, Kuang-Hsi Chang, Cheng-Li Lin, Ke-Sin Yan, Chingfu Tsou and Yi-Chao Hsu
Citation:Journal of Translational Medicine 2018 16:221
Published on: 10 August 2018
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Content Type:Research
Identification of an early diagnostic biomarker of lung adenocarcinoma based on co-expression similarity and construction of a diagnostic model
The purpose of this study was to achieve early and accurate diagnosis of lung cancer and long-term monitoring of the therapeutic response.
Authors:Zhirui Fan, Wenhua Xue, Lifeng Li, Chaoqi Zhang, Jingli Lu, Yunkai Zhai, Zhenhe Suo and Jie Zhao
Citation:Journal of Translational Medicine 2018 16:205
Published on: 20 July 2018
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Content Type:Research
GC/MS-based urine metabolomics analysis of renal allograft recipients with acute rejection
Acute renal allograft rejection is a common complication after renal transplantation that often leads to chronic rejection and ultimate graft loss. While renal allograft biopsy remains the gold standard for di...
Authors:Long Zheng, Jina Wang, Wenjun Gao, Chao Hu, Shuo Wang, Ruiming Rong, Yinlong Guo, Tongyu Zhu and Dong Zhu
Citation:Journal of Translational Medicine 2018 16:202
Published on: 20 July 2018
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Content Type:Research
Computer-aided prediction of antigen presenting cell modulators for designing peptide-based vaccine adjuvants
Evidences in literature strongly advocate the potential of immunomodulatory peptides for use as vaccine adjuvants. All the mechanisms of vaccine adjuvants ensuing immunostimulatory effects directly or indirect...
Authors:Gandharva Nagpal, Kumardeep Chaudhary, Piyush Agrawal and Gajendra P. S. Raghava
Citation:Journal of Translational Medicine 2018 16:181
Published on: 3 July 2018
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Content Type:Research
Association of viral hepatitis and bipolar disorder: a nationwide population-based study
Bipolar disorder (BD), a type of psychiatric mood disorder, is manifested by chronic and recurrent mood fluctuations. This study aims to determine whether hepatitis B virus (HBV) or hepatitis C virus (HCV) inf...
Authors:Lee-Won Chong, Chih-Chao Hsu, Chang-Yin Lee, Ruey-Hwang Chou, Cheng-Li Lin, Kuang-Hsi Chang and Yi-Chao Hsu
Citation:Journal of Translational Medicine 2018 16:173
Published on: 22 June 2018
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Content Type:Research
In silico identification of drug target pathways in breast cancer subtypes using pathway cross-talk inhibition
Despite great development in genome and proteome high-throughput methods, treatment failure is a critical point in the management of most solid cancers, including breast cancer (BC). Multiple alternative mecha...
Authors:Claudia Cava, Gloria Bertoli and Isabella Castiglioni
Citation:Journal of Translational Medicine 2018 16:154
Published on: 5 June 2018
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Content Type:Research
Network modules uncover mechanisms of skeletal muscle dysfunction in COPD patients
Chronic obstructive pulmonary disease (COPD) patients often show skeletal muscle dysfunction that has a prominent negative impact on prognosis. The study aims to further explore underlying mechanisms of skelet...
Authors:Ákos Tényi, Isaac Cano, Francesco Marabita, Narsis Kiani, Susana G. Kalko, Esther Barreiro, Pedro de Atauri, Marta Cascante, David Gomez-Cabrero and Josep Roca
Citation:Journal of Translational Medicine 2018 16:34
Published on: 20 February 2018
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Content Type:Methodology
Toolbox for Research, or how to facilitate a central data management in small-scale research projects
In most research projects budget, staff and IT infrastructures are limiting resources. Especially for small-scale registries and cohort studies professional IT support and commercial electronic data capture sy...
Authors:Martin Bialke, Henriette Rau, Oliver C. Thamm, Ronny Schuldt, Peter Penndorf, Arne Blumentritt, Robert Gött, Jens Piegsa, Thomas Bahls and Wolfgang Hoffmann
Citation:Journal of Translational Medicine 2018 16:16
Published on: 25 January 2018
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Content Type:Research
Exhaled breath condensate metabolome clusters for endotype discovery in asthma
Asthma is a complex, heterogeneous disorder with similar presenting symptoms but with varying underlying pathologies. Exhaled breath condensate (EBC) is a relatively unexplored matrix which reflects the signat...
Authors:Anirban Sinha, Koundinya Desiraju, Kunal Aggarwal, Rintu Kutum, Siddhartha Roy, Rakesh Lodha, S. K. Kabra, Balaram Ghosh, Tavpritesh Sethi and Anurag Agrawal
Citation:Journal of Translational Medicine 2017 15:262
Published on: 22 December 2017
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Content Type:Research
Structure based drug discovery for designing leads for the non-toxic metabolic targets in multi drug resistant Mycobacterium tuberculosis
The problem of drug resistance and bacterial persistence in tuberculosis is a cause of global alarm. Although, the UN’s Sustainable Development Goals for 2030 has targeted a Tb free world, the treatment gap ex...
Authors:Divneet Kaur, Shalu Mathew, Chinchu G. S. Nair, Azitha Begum, Ashwin K. Jainanarayan, Mukta Sharma and Samir K. Brahmachari
Citation:Journal of Translational Medicine 2017 15:261
Published on: 21 December 2017
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Content Type:Research
MKRMDA: multiple kernel learning-based Kronecker regularized least squares for MiRNA–disease association prediction
Recently, as the research of microRNA (miRNA) continues, there are plenty of experimental evidences indicating that miRNA could be associated with various human complex diseases development and progression. He...
Authors:Xing Chen, Ya-Wei Niu, Guang-Hui Wang and Gui-Ying Yan
Citation:Journal of Translational Medicine 2017 15:251
Published on: 12 December 2017
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Content Type:Research
Detecting the tipping points in a three-state model of complex diseases by temporal differential networks
The progression of complex diseases, such as diabetes and cancer, is generally a nonlinear process with three stages, i.e., normal state, pre-disease state, and disease state, where the pre-disease state is a ...
Authors:Pei Chen, Yongjun Li, Xiaoping Liu, Rui Liu and Luonan Chen
Citation:Journal of Translational Medicine 2017 15:217
Published on: 26 October 2017
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Content Type:Research
Statistically controlled identification of differentially expressed genes in one-to-one cell line comparisons of the CMAP database for drug repositioning
The Connectivity Map (CMAP) database, an important public data source for drug repositioning, archives gene expression profiles from cancer cell lines treated with and without bioactive small molecules. Howeve...
Authors:Jun He, Haidan Yan, Hao Cai, Xiangyu Li, Qingzhou Guan, Weicheng Zheng, Rou Chen, Huaping Liu, Kai Song, Zheng Guo and Xianlong Wang
Citation:Journal of Translational Medicine 2017 15:198
Published on: 29 September 2017
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Content Type:Research
Genome-wide computational analysis of potential long noncoding RNA mediated DNA:DNA:RNA triplexes in the human genome
Only a handful of long noncoding RNAs have been functionally characterized. They are known to modulate regulation through interacting with other biomolecules in the cell: DNA, RNA and protein. Though there hav...
Authors:Saakshi Jalali, Amrita Singh, Souvik Maiti and Vinod Scaria
Citation:Journal of Translational Medicine 2017 15:186
Published on: 2 September 2017
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Content Type:Research
In silico prediction of novel therapeutic targets using gene–disease association data
Target identification and validation is a pressing challenge in the pharmaceutical industry, with many of the programmes that fail for efficacy reasons showing poor association between the drug target and the ...
Authors:Enrico Ferrero, Ian Dunham and Philippe Sanseau
Citation:Journal of Translational Medicine 2017 15:182
Published on: 29 August 2017
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Content Type:Research
Identification of miRNA-mRNA crosstalk in CD4+ T cells during HIV-1 infection by integrating transcriptome analyses
HIV-1-infected long-term nonprogressors (LTNPs) are characterized by infection with HIV-1 more than 7–10 years, but keeping high CD4+ T cell counts and low viral load in the absence of antiretroviral treatment, w...
Authors:Qibin Liao, Jin Wang, Zenglin Pei, Jianqing Xu and Xiaoyan Zhang
Citation:Journal of Translational Medicine 2017 15:41
Published on: 21 February 2017
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Content Type:Research
Antibiotics-induced depletion of mice microbiota induces changes in host serotonin biosynthesis and intestinal motility
The gastrointestinal motility is affected by gut microbiota and the relationship between them has become a hot topic. However, mechanisms of microbiota in regulating motility have not been well defined. We thu...
Authors:Xiaolong Ge, Chao Ding, Wei Zhao, Lizhi Xu, Hongliang Tian, Jianfeng Gong, Minsheng Zhu, Jieshou Li and Ning Li
Citation:Journal of Translational Medicine 2017 15:13
Published on: 13 January 2017
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Content Type:Research
Prediction of anti-inflammatory proteins/peptides: an insilico approach
The current therapy for inflammatory and autoimmune disorders involves the use of nonspecific anti-inflammatory drugs and other immunosuppressant, which are often accompanied with potential side effects. As an...
Authors:Sudheer Gupta, Ashok K. Sharma, Vibhuti Shastri, Midhun K. Madhu and Vineet K. Sharma
Citation:Journal of Translational Medicine 2017 15:7
Published on: 6 January 2017
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Content Type:Research
Guizhi-Shaoyao-Zhimu decoction attenuates rheumatoid arthritis partially by reversing inflammation-immune system imbalance
Guizhi-Shaoyao-Zhimu decoction (GSZD) has been extensively used for rheumatoid arthritis (RA) therapy. Marked therapeutic efficacy of GSZD acting on RA has been demonstrated in several long-term clinical trial...
Authors:Qiuyan Guo, Xia Mao, Yanqiong Zhang, Shuqin Meng, Yue Xi, Yi Ding, Xiaocun Zhang, Yuntao Dai, Xia Liu, Chao Wang, Yuting Li and Na Lin
Citation:Journal of Translational Medicine 2016 14:165
Published on: 8 June 2016
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Content Type:Review
Regulatory mechanisms of microRNA expression
MicroRNAs (miRs, miRNAs) are small molecules of 18–22 nucleotides that serve as important regulators of gene expression at the post-transcriptional level. One of the mechanisms through which miRNAs regulate ge...
Authors:Lyudmila F. Gulyaeva and Nicolay E. Kushlinskiy
Citation:Journal of Translational Medicine 2016 14:143
Published on: 20 May 2016
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Content Type:Research
Elevated urinary urea by high-protein diet could be one of the inducements of bladder disorders
Previous work found that urea accumulation in urothelial cells caused by urea transporter B knockout led to DNA damage and apoptosis that contributed to the carcinogenesis. The purpose of this study is to expl...
Authors:Ming Liu, Min Li, Jiangfeng Liu, Hongkai Wang, Dandan Zhong, Hong Zhou and Baoxue Yang
Citation:Journal of Translational Medicine 2016 14:53
Published on: 16 February 2016
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Content Type:Research
Development and validation of new glomerular filtration rate predicting models for Chinese patients with type 2 diabetes
Previous researches has depicted that the performance of the recommended glomerular filtration rate (GFR)-estimating equations in the type 2 diabetic population is inferior to that in the non-diabetic populati...
Authors:Jinxia Chen, Hua Tang, Hui Huang, Linsheng Lv, Yanni Wang, Xun Liu and Tanqi Lou
Citation:Journal of Translational Medicine 2015 13:317
Published on: 28 September 2015
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Content Type:Research
Comparative study of anti-angiogenic activities of luteolin, lectin and lupeol biomolecules
Angiogenesis is a hallmark feature in the initiation, progression and growth of tumour. There are various factors for promotion of angiogenesis on one hand and on the other hand, biomolecules have been report...
Authors:Rashmi K. Ambasta, Saurabh Kumar Jha, Dhiraj Kumar, Renu Sharma, Niraj Kumar Jha and Pravir Kumar
Citation:Journal of Translational Medicine 2015 13:307
Published on: 18 September 2015
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Content Type:Research
Integrated analysis of miRNA, gene, and pathway regulatory networks in hepatic cancer stem cells
Hepatocellular carcinoma (HCC) is one of the most common malignancies worldwide. HCC has a poor prognosis associated with tumor recurrence and drug resistance, which has been attributed to the existence of hep...
Authors:Min Ding, Jiang Li, Yong Yu, Hui Liu, Zi Yan, Jinghan Wang and Qijun Qian
Citation:Journal of Translational Medicine 2015 13:259
Published on: 11 August 2015
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Content Type:Research
miFRame: analysis and visualization of miRNA sequencing data in neurological disorders
While in the past decades nucleic acid analysis has been predominantly carried out using quantitative low- and high-throughput approaches such as qRT-PCR and microarray technology, next-generation sequencing (...
Authors:Christina Backes, Jan Haas, Petra Leidinger, Karen Frese, Thomas Großmann, Klemens Ruprecht, Benjamin Meder, Eckart Meese and Andreas Keller
Citation:Journal of Translational Medicine 2015 13:224
Published on: 14 July 2015
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Content Type:Methodology
Empirical study using network of semantically related associations in bridging the knowledge gap
The data overload has created a new set of challenges in finding meaningful and relevant information with minimal cognitive effort. However designing robust and scalable knowledge discovery systems remains a c...
Authors:Vida Abedi, Mohammed Yeasin and Ramin Zand
Citation:Journal of Translational Medicine 2014 12:324
Published on: 27 November 2014
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Content Type:Research
Systems level mapping of metabolic complexity in Mycobacterium tuberculosis to identify high-value drug targets
The effectiveness of current therapeutic regimens for Mycobacterium tuberculosis (Mtb) is diminished by the need for prolonged therapy and the rise of drug resistant/tolerant strains. This global health threat, d...
Authors:Rohit Vashisht, Ashwini G Bhat, Shreeram Kushwaha, Anshu Bhardwaj, OSDD Consortium and Samir K Brahmachari
Citation:Journal of Translational Medicine 2014 12:263
Published on: 11 October 2014
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Content Type:Research
Drug-repurposing identified the combination of Trolox C and Cytisine for the treatment of type 2 diabetes
Drug-induced gene expression dataset (for example Connectivity Map, CMap) represent a valuable resource for drug-repurposing, a class of methods for identifying novel indications for approved drugs. Recently, ...
Authors:Ling Jin, Jian Tu, Jianwei Jia, Wenbin An, Huanran Tan, Qinghua Cui and Zhixin Li
Citation:Journal of Translational Medicine 2014 12:153
Published on: 31 May 2014
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Content Type:Research
Identification of candidate miRNA biomarkers from miRNA regulatory network with application to prostate cancer
MicroRNAs (miRNAs) are a class of non-coding regulatory RNAs approximately 22 nucleotides in length that play a role in a wide range of biological processes. Abnormal miRNA function has been implicated in vari...
Authors:Wenyu Zhang, Jin Zang, Xinhua Jing, Zhandong Sun, Wenying Yan, Dongrong Yang, Feng Guo and Bairong Shen
Citation:Journal of Translational Medicine 2014 12:66
Published on: 11 March 2014
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Content Type:Meeting Report
Dry computational approaches for wet medical problems
This is a report on the 4th international conference in ‘Quantitative Biology and Bioinformatics in Modern Medicine’ held in Belfast (UK), 19–20 September 2013. The aim of the conference was to bring together ...
Authors:Frank Emmert-Streib, Shu-Dong Zhang and Peter Hamilton
Citation:Journal of Translational Medicine 2014 12:26
Published on: 25 January 2014
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Content Type:Research
VIRsiRNApred: a web server for predicting inhibition efficacy of siRNAs targeting human viruses
Selection of effective viral siRNA is an indispensable step in the development of siRNA based antiviral therapeutics. Despite immense potential, a viral siRNA efficacy prediction algorithm is still not availab...
Authors:Abid Qureshi, Nishant Thakur and Manoj Kumar
Citation:Journal of Translational Medicine 2013 11:305
Published on: 11 December 2013
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Content Type:Research
A network model of genomic hormone interactions underlying dementia and its translational validation through serendipitous off-target effect
While the majority of studies have focused on the association between sex hormones and dementia, emerging evidence supports the role of other hormone signals in increasing dementia risk. However, due to the la...
Authors:Erfan Younesi and Martin Hofmann-Apitius
Citation:Journal of Translational Medicine 2013 11:177
Published on: 26 July 2013
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Content Type:Research
Clear cell renal cell carcinoma associated microRNA expression signatures identified by an integrated bioinformatics analysis
Clear cell renal cell carcinoma (ccRCC) represents the most invasive and common adult kidney neoplasm. Mounting evidence suggests that microRNAs (miRNAs) are important regulators of gene expression. But their ...
Authors:Jiajia Chen, Daqing Zhang, Wenyu Zhang, Yifei Tang, Wenying Yan, Lingchuan Guo and Bairong Shen
Citation:Journal of Translational Medicine 2013 11:169
Published on: 10 July 2013
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Content Type:Methodology
Implementation of the CDC translational informatics platform - from genetic variants to the national Swedish Rheumatology Quality Register
Sequencing of the human genome and the subsequent analyses have produced immense volumes of data. The technological advances have opened new windows into genomics beyond the DNA sequence. In parallel, clinical...
Authors:Imad Abugessaisa, David Gomez-Cabrero, Omri Snir, Staffan Lindblad, Lars Klareskog, Vivianne Malmström and Jesper Tegnér
Citation:Journal of Translational Medicine 2013 11:85
Published on: 2 April 2013
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Content Type:Research
In silico approaches for designing highly effective cell penetrating peptides
Cell penetrating peptides have gained much recognition as a versatile transport vehicle for the intracellular delivery of wide range of cargoes (i.e. oligonucelotides, small molecules, proteins, etc.), that other...
Authors:Ankur Gautam, Kumardeep Chaudhary, Rahul Kumar, Arun Sharma, Pallavi Kapoor, Atul Tyagi and Gajendra P S Raghava
Citation:Journal of Translational Medicine 2013 11:74
Published on: 22 March 2013
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