Journal of Translational Medicine | Neuroscience

Journal of Translational Medicine | Neuroscience

Neuroscience

Section edited by Luis F. Alguacil

The Neuroscience section aims to encourage publications that help to reduce the gap between basic preclinical science and medical applications for the patients in the neuroscience field.

Featured articles

Betel quid dependence is associated with functional connectivity changes of the anterior cingulate cortex: a resting-state fMRI study
Tao Liu, et al


NGF eye-drops topical administration in patients with retinitis pigmentosa, a pilot study
Benedetto Falsini, et al


Development of patient-derived xenograft models from a spontaneously immortal low-grade meningioma cell line, KCI-MENG1
Sharon K Michelhaugh, et al

1. Content Type:Research

   Chronic abdominal vagus stimulation increased brain metabolic connectivity, reduced striatal dopamine transporter and increased mid-brain serotonin transporter in obese miniature pigs

   Changes in brain metabolism has been investigated thoroughly during unilateral cervical chronic vagal stimulation in epileptic or depressive patients. Bilateral stimulation of the abdominal vagus (aVNS) has recei...

   Authors:Charles-Henri Malbert, Mickael Genissel, Jean-Louis Divoux and Christine Henry

   Citation:Journal of Translational Medicine 2019 17:78

   Published on: 12 March 2019

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2. Content Type:Review

   Pediatric sleep disturbances and treatment with melatonin

   There are no guidelines concerning the best approach to improving sleep, but it has been shown that it can benefit the affected children and their entire families. The aim of this review is to analyse the effi...

   Authors:Susanna Esposito, Daniela Laino, Renato D’Alonzo, Annalisa Mencarelli, Lorenza Di Genova, Antonella Fattorusso, Alberto Argentiero and Elisabetta Mencaroni

   Citation:Journal of Translational Medicine 2019 17:77

   Published on: 12 March 2019

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3. Content Type:Research

   Identification of a multidimensional transcriptome signature for survival prediction of postoperative glioblastoma multiforme patients

   Glioblastoma multiform (GBM) is a devastating brain tumor with maximum surgical resection, radiotherapy plus concomitant and adjuvant temozolomide (TMZ) as the standard treatment. Diverse clinicopathological a...

   Authors:Wei-Zhen Gao, Lie-Mei Guo, Tian-Qi Xu, Yu-Hua Yin and Feng Jia

   Citation:Journal of Translational Medicine 2018 16:368

   Published on: 20 December 2018

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4. Content Type:Research

   Gut microbiota dysbiosis in male patients with chronic traumatic complete spinal cord injury

   Neurogenic bowel dysfunction (NBD) is a major physical and psychological problem in patients with spinal cord injury (SCI), and gut dysbiosis is commonly occurs in SCI. Here, we document neurogenic bowel manag...

   Authors:Chao Zhang, Wenhao Zhang, Jie Zhang, Yingli Jing, Mingliang Yang, Liangjie Du, Feng Gao, Huiming Gong, Liang Chen, Jun Li, Hongwei Liu, Chuan Qin, Yanmei Jia, Jiali Qiao, Bo Wei, Yan Yu…

   Citation:Journal of Translational Medicine 2018 16:353

   Published on: 13 December 2018

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5. Content Type:Research

   Increased circulating endothelial progenitor cells and improved short-term outcomes in acute non-cardioembolic stroke after hyperbaric oxygen therapy

   Acute ischemic stroke is a leading cause of mortality and long-term disability, and profiles of endothelial progenitor cells (EPCs) reflect the degree of endothelial impairment. This study tested the hypothesi...

   Authors:Chen-Yu Chen, Re-Wen Wu, Nai-Wen Tsai, Mel S. Lee, Wei-Che Lin, Mei-Chi Hsu, Chih-Cheng Huang, Yun-Ru Lai, Chia-Te Kung, Hung-Chen Wang, Yu-Jih Su, Chih-Min Su, Sheng-Yuan Hsiao, Ben-Chung Cheng, Yi-Fang Chiang and Cheng-Hsien Lu

   Citation:Journal of Translational Medicine 2018 16:255

   Published on: 12 September 2018

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6. Content Type:Research

   The dimensionality of fatigue in Parkinson’s disease

   Fatigue is a common problem among individuals with Parkinson’s disease (PD). It may occur before the overt symptoms of bradykinesia, rigidity and tremor. Little is understood about how to measure fatigue in PD...

   Authors:Raymond Chong, Lauren Albor, Chandramohan Wakade and John Morgan

   Citation:Journal of Translational Medicine 2018 16:192

   Published on: 11 July 2018

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7. Content Type:Research

   Multimodal characterization of the semantic N400 response within a rapid evaluation brain vital sign framework

   For nearly four decades, the N400 has been an important brainwave marker of semantic processing. It can be recorded non-invasively from the scalp using electrical and/or magnetic sensors, but largely within th...

   Authors:Sujoy Ghosh Hajra, Careesa C. Liu, Xiaowei Song, Shaun D. Fickling, Teresa P. L. Cheung and Ryan C. N. D’Arcy

   Citation:Journal of Translational Medicine 2018 16:151

   Published on: 4 June 2018

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8. Content Type:Research

   Adolescent mental health education InSciEd Out: a case study of an alternative middle school population

   Mental illness contributes substantially to global disease burden, particularly when illness onset occurs during youth and help-seeking is delayed and/or limited. Yet, few mental health promotion interventions...

   Authors:Joanna Yang, Roberto Lopez Cervera, Susannah J. Tye, Stephen C. Ekker and Chris Pierret

   Citation:Journal of Translational Medicine 2018 16:84

   Published on: 3 April 2018

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9. Content Type:Research

   Facial nerve stimulation in normal pigs and healthy human volunteers: transitional development of a medical device for the emergency treatment of ischemic stroke

   Magnetic stimulation of the facial nerve has been tested in preclinical studies as a new, non-invasive emergency treatment of ischemic stroke that acts by increasing cerebral blood flow (CBF). The objective of...

   Authors:Olivia Sanchez, Andrea García, Fernando Castro-Prado, Miriam Perez, Rafael Lara-Estrada, Martin Ramirez-Meza, Montserrat Godinez, Michael L. Coco, Joaquín Azpiroz, Mark K. Borsody and Emilio Sacristán

   Citation:Journal of Translational Medicine 2018 16:27

   Published on: 15 February 2018

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10. Content Type:Review

    Hepcidin, an emerging and important player in brain iron homeostasis

    Hepcidin is emerging as a new important factor in brain iron homeostasis. Studies suggest that there are two sources of hepcidin in the brain; one is local and the other comes from the circulation. Little is k...

    Authors:Driton Vela

    Citation:Journal of Translational Medicine 2018 16:25

    Published on: 7 February 2018

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11. Content Type:Research

    Novel neuro-audiological findings and further evidence for TWNK involvement in Perrault syndrome

    Hearing loss and ovarian dysfunction are key features of Perrault syndrome (PRLTS) but the clinical and pathophysiological features of hearing impairment in PRLTS individuals have not been addressed. Mutations...

    Authors:Monika Ołdak, Dominika Oziębło, Agnieszka Pollak, Iwona Stępniak, Michal Lazniewski, Urszula Lechowicz, Krzysztof Kochanek, Mariusz Furmanek, Grażyna Tacikowska, Dariusz Plewczynski, Tomasz Wolak, Rafał Płoski and Henryk Skarżyński

    Citation:Journal of Translational Medicine 2017 15:25

    Published on: 8 February 2017

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12. Content Type:Research

    Sodium ferulate and n-butylidenephthalate combined with bone marrow stromal cells (BMSCs) improve the therapeutic effects of angiogenesis and neurogenesis after rat focal cerebral ischemia

    Studies have indicated that bone marrow stromal cell (BMSC) administration is a promising approach for stroke treatment. For our study, we chose sodium ferulate (SF) and n-butylidenephthalide (BP) combined with B...

    Authors:Qian Zhang, Yonghua Zhao, Youhua Xu, Zhenwei Chen, Naiwei Liu, Chienchih Ke, Bowen Liu and Weikang Wu

    Citation:Journal of Translational Medicine 2016 14:223

    Published on: 28 July 2016

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13. Content Type:Research

    Longitudinal brain structural alterations and systemic inflammation in obstructive sleep apnea before and after surgical treatment

    Systemic inflammation, neurocognitive impairments, and morphologic brain changes are associated with obstructive sleep apnea (OSA). Understanding their longitudinal evolution and interactions after surgical tr...

    Authors:Wei-Che Lin, Chih-Cheng Huang, Hsiu-Ling Chen, Kun-Hsien Chou, Pei-Chin Chen, Nai-Wen Tsai, Meng-Hsiang Chen, Michael Friedman, Hsin-Ching Lin and Cheng-Hsien Lu

    Citation:Journal of Translational Medicine 2016 14:139

    Published on: 17 May 2016

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14. Content Type:Research

    Effects of vagus nerve stimulation on cognitive functioning in rats with cerebral ischemia reperfusion

    Vagus nerve stimulation (VNS) has become the most common non-pharmacological treatment for intractable drug-resistant epilepsy. However, the contribution of VNS to neurological rehabilitation following stroke ...

    Authors:Ai-fen Liu, Feng-bo Zhao, Jing Wang, Yi-Fan Lu, Jian Tian, Yin Zhao, Yan Gao, Xia-jun Hu, Xiao-yan Liu, Jie Tan, Yun-li Tian and Jing Shi

    Citation:Journal of Translational Medicine 2016 14:101

    Published on: 27 April 2016

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15. Content Type:Research

    Betel quid dependence is associated with functional connectivity changes of the anterior cingulate cortex: a resting-state fMRI study

    It is generally acknowledged that drug dependence is connected with abnormal functional organization in the individual’s brain. The present study aimed to identify the anterior cingulate cortex (ACC) abnormali...

    Authors:Tao Liu, Jianjun Li, Zhongyan Zhao, Yuan Zhong, Zhiqiang Zhang, Qiang Xu, Guoshuai Yang, Guangming Lu, Suyue Pan and Feng Chen

    Citation:Journal of Translational Medicine 2016 14:33

    Published on: 2 February 2016

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16. Content Type:Research

    Exome sequencing identifies a mutation in TMC1 as a novel cause of autosomal recessive nonsyndromic hearing loss

    Autosomal recessive non-syndromic hearing loss (ARNSHL) is highly heterogeneous, and mutations in the gene encoding transmembrane channel-like 1 (TMC1) have been implicated in its development. To date, 35 homo...

    Authors:Jiongjiong Hu, Fei Liu, Wenjun Xia, Lili Hao, Jun Lan, Zhenghua Zhu, Jing Ye, Duan Ma and Zhaoxin Ma

    Citation:Journal of Translational Medicine 2016 14:29

    Published on: 28 January 2016

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17. Content Type:Research

    NGF eye-drops topical administration in patients with retinitis pigmentosa, a pilot study

    Preclinical trials have shown beneficial effects of nerve growth factor (NGF) administration on visual function in animal models of retinitis pigmentosa (RP). The aim of this pilot study was to explore the po...

    Authors:Benedetto Falsini, Giancarlo Iarossi, Antonio Chiaretti, Antonio Ruggiero, Luigi Manni, Lucia Galli-Resta, Giovanni Corbo and Edoardo Abed

    Citation:Journal of Translational Medicine 2016 14:8

    Published on: 9 January 2016

    The Erratum to this article has been published in Journal of Translational Medicine 2016 14:43

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18. Content Type:Research

    Brain mediators of systemic oxidative stress on perceptual impairments in Parkinson’s disease

    Parkinson’s disease (PD) is well documented to be associated with elevated systemic oxidative stress and perceptual impairments. Furthermore, the striatum and extrastriatal cortical areas, which are involved i...

    Authors:Wei-Che Lin, Kun-Hsien Chou, Pei-Lin Lee, Yung-Cheng Huang, Nai-Wen Tsai, Hsiu-Ling Chen, Kuei-Yueh Cheng, Hung-Chen Wang, Tsu-Kung Lin, Shau-Hsuan Li, Meng-Hsiang Chen, Cheng-Hsien Lu and Ching-Po Lin

    Citation:Journal of Translational Medicine 2015 13:386

    Published on: 21 December 2015

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19. Content Type:Research

    Autophagy biomarkers in CSF correlates with infarct size, clinical severity and neurological outcome in AIS patients

    Autophagy is demonstrated to be involved in acute ischemic stroke(AIS), which, however, is confined to cells and/or animals levels. The aim of this study was to determine two autophagy biomarkers, Beclin1 and ...

    Authors:Honghong Li, Shuwei Qiu, Xiangpen Li, Mei Li and Ying Peng

    Citation:Journal of Translational Medicine 2015 13:359

    Published on: 14 November 2015

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20. Content Type:Research

    Development of patient-derived xenograft models from a spontaneously immortal low-grade meningioma cell line, KCI-MENG1

    There is a paucity of effective therapies for recurrent/aggressive meningiomas. Establishment of improved in vitro and in vivo meningioma models will facilitate development and testing of novel therapeutic app...

    Authors:Sharon K Michelhaugh, Anthony R Guastella, Kaushik Varadarajan, Neil V Klinger, Prahlad Parajuli, Aamir Ahmad, Seema Sethi, Amro Aboukameel, Sam Kiousis, Ian M Zitron, Salah A Ebrahim, Lisa A Polin, Fazlul H Sarkar, Aliccia Bollig-Fischer and Sandeep Mittal

    Citation:Journal of Translational Medicine 2015 13:227

    Published on: 15 July 2015

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21. Content Type:Research

    Severe disturbance of glucose metabolism in peripheral blood mononuclear cells of schizophrenia patients: a targeted metabolomic study

    Schizophrenia is a widespread and debilitating mental disorder. However, the underlying molecular mechanism of schizophrenia remains largely unknown and no objective laboratory tests are available to diagnose ...

    Authors:Mei-Ling Liu, Xiao-Tong Zhang, Xiang-Yu Du, Zheng Fang, Zhao Liu, Yi Xu, Peng Zheng, Xue-Jiao Xu, Peng-Fei Cheng, Ting Huang, Shun-Jie Bai, Li-Bo Zhao, Zhi-Guo Qi, Wei-Hua Shao and Peng Xie

    Citation:Journal of Translational Medicine 2015 13:226

    Published on: 14 July 2015

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22. Content Type:Research

    Differential hypoglycaemic, anorectic, autonomic and emetic effects of the glucagon-like peptide receptor agonist, exendin-4, in the conscious telemetered ferret

    Rodents are incapable of emesis and consequently the emetic potential of glucagon-like peptide-1 receptor (GLP-1R) agonists in studies designed to assess a potential blood glucose lowering action of the compou...

    Authors:Zengbing Lu, Nathalie Percie Du Sert, Sze Wa Chan, Chi-Kong Yeung, Ge Lin, David TW Yew, Paul LR Andrews and John A Rudd

    Citation:Journal of Translational Medicine 2014 12:327

    Published on: 10 December 2014

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23. Content Type:Research

    Growth factor-eluting cochlear implant electrode: impact on residual auditory function, insertional trauma, and fibrosis

    A cochlear implant (CI) is an artificial hearing device that can replace a damaged cochlea. The present study examined the use of growth factor-eluting gelatin hydrogel coatings on the electrodes to minimize i...

    Authors:Yayoi S Kikkawa, Takayuki Nakagawa, Lin Ying, Yasuhiko Tabata, Hirohito Tsubouchi, Akio Ido and Juichi Ito

    Citation:Journal of Translational Medicine 2014 12:280

    Published on: 4 October 2014

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24. Content Type:Research

    Biochemical and inflammatory biomarkers in ischemic stroke: translational study between humans and two experimental rat models

    our objective was to examine the plasma levels of three biological markers involved in cerebral ischemia (IL-6, glutamate and TNF-alpha) in stroke patients and compare them with two different rat models of foc...

    Authors:Patricia Martínez-Sánchez, María Gutiérrez-Fernández, Blanca Fuentes, Jaime Masjuán, María Alonso de Leciñana Cases, Maria Elena Novillo-López and Exuperio Díez-Tejedor

    Citation:Journal of Translational Medicine 2014 12:220

    Published on: 3 August 2014

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25. Content Type:Research

    Existence of a potential neurogenic system in the adult human brain

    Prevailingly, adult mammalian neurogenesis is thought to occur in discrete, separate locations known as neurogenic niches that are best characterized in the subgranular zone (SGZ) of the dentate gyrus and in t...

    Authors:Adriano Barreto Nogueira, Mari Cleide Sogayar, Alison Colquhoun, Sheila Aparecida Siqueira, Ariel Barreto Nogueira, Paulo Eurípedes Marchiori and Manoel Jacobsen Teixeira

    Citation:Journal of Translational Medicine 2014 12:75

    Published on: 22 March 2014

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26. Content Type:Research

    Developing regional genetic counseling for southern Chinese with nonsyndromic hearing impairment: a unique mutational spectrum

    Racial and regional factors are important for the clinical diagnosis of non-syndromic hearing impairment. Comprehensive genetic analysis of deaf patients in different regions of China must be performed to prov...

    Authors:Kaitian Chen, Ling Zong, Min Liu, Xianren Wang, Wei Zhou, Yuan Zhan, Hui Cao, Chang Dong, Haocheng Tang and Hongyan Jiang

    Citation:Journal of Translational Medicine 2014 12:64

    Published on: 11 March 2014

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27. Content Type:Research

    Novel compound heterozygous mutations in the MYO15A gene in autosomal recessive hearing loss identified by whole-exome sequencing

    Inherited genetic defects play an important role in congenital hearing loss, contributing to about 60% of deafness occurring in infants. Hereditary nonsyndromic hearing loss is highly heterogeneous, and most p...

    Authors:Xue Gao, Qing-yan Zhu, Yue-Shuai Song, Guo-Jian Wang, Yong-Yi Yuan, Feng Xin, Sha-Sha Huang, Dong-Yang Kang, Ming-Yu Han, Li-ping Guan, Jian-guo Zhang and Pu Dai

    Citation:Journal of Translational Medicine 2013 11:284

    Published on: 9 November 2013

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28. Content Type:Research

    MiRNA-329 targeting E2F1 inhibits cell proliferation in glioma cells

    MicroRNAs have recently emerged as key regulators of cancers, miR-329 located on 14q32.31 is one of down-regulated miRNAs in glioma, but the function and molecular mechanisms of miR-329 in determining the mali...

    Authors:Bingxiang Xiao, Li Tan, Benfu He, Zhiliang Liu and Ruxiang Xu

    Citation:Journal of Translational Medicine 2013 11:172

    Published on: 17 July 2013

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29. Content Type:Research

    Neuromimetic model of saccades for localizing deficits in an atypical eye-movement pathology

    When patients with ocular motor deficits come to the clinic, in numerous situations it is hard to relate their behavior to one or several deficient neural structures. We sought to demonstrate that neuromimetic...

    Authors:Pierre M Daye, Lance M Optican, Emmanuel Roze, Bertrand Gaymard and Pierre Pouget

    Citation:Journal of Translational Medicine 2013 11:125

    Published on: 22 May 2013

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30. Content Type:Methodology

    Evaluating glymphatic pathway function utilizing clinically relevant intrathecal infusion of CSF tracer

    Neurodegenerative diseases such as Alzheimer’s are associated with the aggregation of endogenous peptides and proteins that contribute to neuronal dysfunction and loss. The glymphatic system, a brain-wide peri...

    Authors:Lijun Yang, Benjamin T Kress, Harris J Weber, Meenakshisundaram Thiyagarajan, Baozhi Wang, Rashid Deane, Helene Benveniste, Jeffrey J Iliff and Maiken Nedergaard

    Citation:Journal of Translational Medicine 2013 11:107

    Published on: 1 May 2013

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31. Content Type:Research

    Activation of axonal Kv7 channels in human peripheral nerve by flupirtine but not placebo - therapeutic potential for peripheral neuropathies: results of a randomised controlled trial

    Flupirtine is an analgesic with muscle-relaxing properties that activates Kv7 potassium channels. Kv7 channels are expressed along myelinated and unmyelinated peripheral axons where their activation is expecte...

    Authors:Johannes Fleckenstein, Ruth Sittl, Beate Averbeck, Philip M Lang, Dominik Irnich and Richard W Carr

    Citation:Journal of Translational Medicine 2013 11:34

    Published on: 8 February 2013

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32. Content Type:Review

    Nerve growth factor: from the early discoveries to the potential clinical use

    The physiological role of the neurotrophin nerve growth factor (NGF) has been characterized, since its discovery in the 1950s, first in the sensory and autonomic nervous system, then in central nervous, endocr...

    Authors:Luigi Aloe, Maria Luisa Rocco, Patrizia Bianchi and Luigi Manni

    Citation:Journal of Translational Medicine 2012 10:239

    Published on: 29 November 2012

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33. Content Type:Research

    Alzheimer's disease biomarker discovery using in silico literature mining and clinical validation

    Alzheimer’s Disease (AD) is the most widespread form of dementia in the elderly but despite progress made in recent years towards a mechanistic understanding, there is still an urgent need for disease modifica...

    Authors:Ines Greco, Nicola Day, Joanna Riddoch-Contreras, Jane Reed, Hilkka Soininen, Iwona Kłoszewska, Magda Tsolaki, Bruno Vellas, Christian Spenger, Patrizia Mecocci, Lars-Olof Wahlund, Andrew Simmons, Julie Barnes and Simon Lovestone

    Citation:Journal of Translational Medicine 2012 10:217

    Published on: 31 October 2012

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34. Content Type:Review

    Standards and pitfalls of focal ischemia models in spontaneously hypertensive rats: With a systematic review of recent articles

    We reviewed the early development of various focal ischemia models in spontaneously hypertensive rats (SHR), and summarized recent reports on this topic. Among 6 focal ischemia models established in divergent ...

    Authors:Hiroshi Yao and Toru Nabika

    Citation:Journal of Translational Medicine 2012 10:139

    Published on: 6 July 2012

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35. Content Type:Research

    Mitochondrial DNA mutation m.10680G > A is associated with Leber hereditary optic neuropathy in Chinese patients

    Leber hereditary optic neuropathy (LHON) is a mitochondrial disorder with gender biased and incomplete penetrance. The majority of LHON patients are caused by one of the three primary mutations (m.3460G > A, m...

    Authors:A-Mei Zhang, Xiaoyun Jia, Xiangming Guo, Qingjiong Zhang and Yong-Gang Yao

    Citation:Journal of Translational Medicine 2012 10:43

    Published on: 9 March 2012

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36. Content Type:Review

    Cellular therapies for treating pain associated with spinal cord injury

    Spinal cord injury leads to immense disability and loss of quality of life in human with no satisfactory clinical cure. Cell-based or cell-related therapies have emerged as promising therapeutic potentials bot...

    Authors:Lawrence Leung

    Citation:Journal of Translational Medicine 2012 10:37

    Published on: 6 March 2012

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37. Content Type:Research

    MGMT promoter methylation in gliomas-assessment by pyrosequencing and quantitative methylation-specific PCR

    Methylation of the O6-methylguanine-DNA methyltransferase (MGMT) gene promoter is a favorable prognostic factor in glioblastoma patients. However, reported methylation frequencies vary significantly partly due to...

    Authors:Annette Bentsen Håvik, Petter Brandal, Hilde Honne, Hanne-Sofie Spenning Dahlback, David Scheie, Merete Hektoen, Torstein Ragnar Meling, Eirik Helseth, Sverre Heim, Ragnhild A Lothe and Guro Elisabeth Lind

    Citation:Journal of Translational Medicine 2012 10:36

    Published on: 6 March 2012

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38. Content Type:Research

    Identification and proteomic profiling of exosomes in human cerebrospinal fluid

    Exosomes are released from multiple cell types, contain protein and RNA species, and have been exploited as a novel reservoir for disease biomarker discovery. They can transfer information between cells and ma...

    Authors:Jonathan M Street, Perdita E Barran, C Logan Mackay, Stefan Weidt, Craig Balmforth, Tim S Walsh, Rod TA Chalmers, David J Webb and James W Dear

    Citation:Journal of Translational Medicine 2012 10:5

    Published on: 5 January 2012

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39. Content Type:Research

    MicroRNA modulation in complex regional pain syndrome

    Aberrant expression of small noncoding RNAs called microRNAs (miRNAs) is a common feature of several human diseases. The objective of the study was to identify miRNA modulation in patients with complex regiona...

    Authors:Irina A Orlova, Guillermo M Alexander, Rehman A Qureshi, Ahmet Sacan, Alessandro Graziano, James E Barrett, Robert J Schwartzman and Seena K Ajit

    Citation:Journal of Translational Medicine 2011 9:195

    Published on: 10 November 2011

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40. Content Type:Editorial

    Introducing the neurosciences section of the journal of translational medicine

    Authors:Luis F Alguacil

    Citation:Journal of Translational Medicine 2011 9:117

    Published on: 21 July 2011

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