Environmental Epidemiology
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Low concentrations of fine particle air pollution and mortality in the Canadian Community Health Survey cohort
Approximately 2.9 million deaths are attributed to ambient fine particle air pollution around the world each year (PM2.5). In general, cohort studies of mortality and outdoor PM2.5 concentrations have limited inf...Environmental Health 2019 18:84Published on: 10 October 2019Geomagnetic disturbances driven by solar activity enhance total and cardiovascular mortality risk in 263 U.S. cities
Short-term geomagnetic disturbances (GMD) driven by the quasi-periodic 11-year cycle of solar activity have been linked to a broad range of adverse health effects, including cardiovascular diseases (CVD) and t...Environmental Health 2019 18:83Published on: 11 September 2019Changes in triggering of ST-elevation myocardial infarction by particulate air pollution in Monroe County, New York over time: a case-crossover study
Previous studies have reported that fine particle (PM2.5) concentrations triggered ST elevation myocardial infarctions (STEMI). In Rochester, NY, multiple air quality policies and economic changes/influences from...Environmental Health 2019 18:82Published on: 6 September 2019Association of urinary concentrations of early pregnancy phthalate metabolites and bisphenol A with length of gestation
Environmental exposure to phthalates and bisphenol A (BPA) may have endocrine disrupting effects that alter length of gestation. We assessed the association between the urinary concentrations of 11 phthalate m...Environmental Health 2019 18:80Published on: 30 August 2019Making the invisible visible: results of a community-led health survey following PFAS contamination of drinking water in Merrimack, New Hampshire
In March 2016, citizens of Merrimack, New Hampshire, learned that their public water supply was contaminated with perfluorooctanoic acid (PFOA). A subsequent state-led investigation revealed widespread contami...Environmental Health 2019 18:79Published on: 30 August 2019Asbestos exposure and malignant mesothelioma of the tunica vaginalis testis: a systematic review and the experience of the Apulia (southern Italy) mesothelioma register
Malignant mesothelioma of the tunica vaginalis testis (MMTVT) is a rare disease with a poor prognosis. The diagnosis and management of these lesions are often difficult for pathologists, surgeons, oncologists ...Environmental Health 2019 18:78Published on: 30 August 2019An overview of methods to address distinct research questions on environmental mixtures: an application to persistent organic pollutants and leukocyte telomere length
Numerous methods exist to analyze complex environmental mixtures in health studies. As an illustration of the different uses of mixture methods, we employed methods geared toward distinct research questions co...Environmental Health 2019 18:76Published on: 28 August 2019Thyroid hormone levels associate with exposure to polychlorinated biphenyls and polybrominated biphenyls in adults exposed as children
Michigan residents were directly exposed to endocrine-disrupting compounds, polybrominated biphenyl (PBB) and polychlorinated biphenyl (PCB). A growing body of evidence suggests that exposure to certain endocr...Environmental Health 2019 18:75Published on: 23 August 2019Potential role of polycyclic aromatic hydrocarbons as mediators of cardiovascular effects from combustion particles
Air pollution is the most important environmental risk factor for disease and premature death, and exposure to combustion particles from vehicles is a major contributor. Human epidemiological studies combined ...Environmental Health 2019 18:74Published on: 22 August 2019Impact of the warm summer 2015 on emergency hospital admissions in Switzerland
Only a few studies have examined the impact of a particular heat event on morbidity. The aim of this study was to evaluate the impact of the warm summer 2015 on emergency hospital admissions (EHA) in Switzerla...Environmental Health 2019 18:66Published on: 15 August 2019Long-term exposure to air pollution and hospitalization for dementia in the Rome longitudinal study
Few studies have explored the role of air pollution in neurodegenerative processes, especially various types of dementia. Our aim was to evaluate the association between long-term exposure to air pollution and...Environmental Health 2019 18:72Published on: 9 August 2019Cumulative asbestos exposure and mortality from asbestos related diseases in a pooled analysis of 21 asbestos cement cohorts in Italy
Despite the available information on cancer risk, asbestos is used in large areas in the world, mostly in the production of asbestos cement. Moreover, questions are raised regarding the shape of the dose respo...Environmental Health 2019 18:71Published on: 7 August 2019Acute effects of fine particulate matter (PM2.5) on hospital admissions for cardiovascular disease in Beijing, China: a time-series study
Air pollution and cardiovascular disease are increasing problems in China. However, the short-term association between fine particulate matter (PM2.5) and cardiovascular disease (CVD) is not well documented. The ...Environmental Health 2019 18:70Published on: 1 August 2019CYP1A1 methylation mediates the effect of smoking and occupational polycyclic aromatic hydrocarbons co-exposure on oxidative DNA damage among Chinese coke-oven workers
Multiple factors, including co-exposure between lifestyle and environmental risks, are important in susceptibility to oxidative DNA damage. However, the underlying mechanism is not fully understood. This study...Environmental Health 2019 18:69Published on: 29 July 2019Susceptibility of prediabetes to the health effect of air pollution: a community-based panel study with a nested case-control design
Recent studies suggest that people with diabetes or who are at risk of developing diabetes, i.e. prediabetic (preDM), are potentially susceptible to air pollution, but the underlying mechanisms remain unclear ...Environmental Health 2019 18:65Published on: 15 July 2019Associations between short-term exposure to gaseous pollutants and pulmonary heart disease-related mortality among elderly people in Chengdu, China
Pulmonary heart disease (PHD) has become a global burden, especially in low- and middle-income countries. However, very few studies have assessed the influence of air pollution on PHD. This is the first study ...Environmental Health 2019 18:64Published on: 15 July 2019Urinary trace metals, maternal circulating angiogenic biomarkers, and preeclampsia: a single-contaminant and mixture-based approach
Exposures to toxic metals and deficiencies in essential metals disrupt placentation and may contribute to preeclampsia. However, effects of exposure to combinations of metals remain unknown.Environmental Health 2019 18:63Published on: 12 July 2019Using web data to improve surveillance for heat sensitive health outcomes
Elevated and prolonged exposure to extreme heat is an important cause of excess summertime mortality and morbidity. To protect people from health threats, some governments are currently operating syndromic sur...Environmental Health 2019 18:59Published on: 9 July 2019Exposure to polychlorinated biphenyls and organochlorine pesticides and risk of dementia, Alzheimer’s disease and cognitive decline in an older population: a prospective analysis from the Canadian Study of Health and Aging
Little attention has been paid to neurotoxicants on the risk of dementia. Exposure to known neurotoxicants such as polychlorinated biphenyls (PCBs) and organochlorine (OC) pesticides is suspected to have adver...Environmental Health 2019 18:57Published on: 14 June 2019Smoking-induced risk of future cardiovascular disease is partly mediated by cadmium in tobacco: Malmö Diet and Cancer Cohort Study
Smoking is a strong risk factor for cardiovascular disease (CVD) and causes exposure to cadmium, which is a pro-atherosclerotic metal. Cadmium exposure has also been shown to increase the risk of CVD, even aft...Environmental Health 2019 18:56Published on: 14 June 2019Temperature as a risk factor of emergency department visits for acute kidney injury: a case-crossover study in Seoul, South Korea
Previous studies show that escalations in ambient temperature are among the risk factors for acute kidney injury (AKI). However, it has not been adequately studied in our location, Seoul, South Korea. In this ...Environmental Health 2019 18:55Published on: 14 June 2019Issues with incorrect computing of population attributable fraction (PAF) in a global perspective on coal-fired power plants and burden of lung cancer
All observational studies are liable to confounding and Levin’s formula becomes useless in practice for unbiasedly estimating PAF. With respect to causal interpretation of PAF in public health setting, unbiase...Environmental Health 2019 18:54Published on: 13 June 2019The original article was published in Environmental Health 2019 18:9The Letter to the Editor Response to this article has been published in Environmental Health 2019 18:52Hospital, health, and community burden after oil refinery fires, Richmond, California 2007 and 2012
Emergency Departments experience a significant census burst after disasters. The aim of this study is to describe patient presentations at Emergency Departments in Contra Costa County, California following che...Environmental Health 2019 18:48Published on: 16 May 2019Two-step approach for assessing the health effects of environmental chemical mixtures: application to simulated datasets and real data from the Navajo Birth Cohort Study
There is increasing interest in examining the consequences of simultaneous exposures to chemical mixtures. However, a consensus or recommendations on how to appropriately select the statistical approach analyz...Environmental Health 2019 18:46Published on: 9 May 2019Fetal growth in environmental epidemiology: mechanisms, limitations, and a review of associations with biomarkers of non-persistent chemical exposures during pregnancy
Non-persistent chemicals, such as phthalates, environmental phenols, organophosphate pesticides, and others, are challenging to study because of their ubiquity in the environment, diverse exposure routes, and ...Environmental Health 2019 18:43Published on: 8 May 2019Historical evidence of glyphosate exposure from a US agricultural cohort
In response to the recent review by Gillezeau et al., The evidence of human exposure to glyphosate: A review, Environmental Health 1/19/19, here we report additional glyphosate biomonitoring data from a repositor...Environmental Health 2019 18:42Published on: 7 May 2019The Review to this article has been published in Environmental Health 2019 18:2Assessing the magnitude and uncertainties of the burden of selected diseases attributable to extreme heat and extreme precipitation under a climate change scenario in Michigan for the period 2041–2070
Extreme heat (EH) and extreme precipitation (EP) events are expected to increase with climate change in many parts of the world. Characterizing the potential future morbidity and mortality burden of EH and EP ...Environmental Health 2019 18:40Published on: 27 April 2019Considerations in the use of different spirometers in epidemiological studies
Spirometric lung function measurements have been proven to be excellent objective markers of respiratory morbidity. The use of different types of spirometers in epidemiological and clinical studies may present...Environmental Health 2019 18:39Published on: 25 April 2019A tensor product quasi-Poisson model for estimating health effects of multiple ambient pollutants on mortality
People are exposed to mixtures of highly correlated gaseous, liquid and solid pollutants. However, in previous studies, the assessment of air pollution effects was mainly based on single-pollutant models or wa...Environmental Health 2019 18:38Published on: 24 April 2019Estimating policy-relevant health effects of ambient heat exposures using spatially contiguous reanalysis data
Regional National Weather Service (NWS) heat advisory criteria in New York State (NYS) were based on frequency of heat events estimated by sparse monitoring data. These may not accurately reflect temperatures ...Environmental Health 2019 18:35Published on: 18 April 2019Para-occupational exposure to pesticides, PON1 polymorphisms and hypothyroxinemia during the first half of pregnancy in women living in a Mexican floricultural area
Adequate maternal thyroxine (T4) concentrations during the first half of pregnancy are fundamental to the embryo’s or fetus’ neural development. Organophosphate pesticides (OP) can act as thyroid disruptors an...Environmental Health 2019 18:33Published on: 11 April 2019Methods to account for uncertainties in exposure assessment in studies of environmental exposures
Accurate exposure estimation in environmental epidemiological studies is crucial for health risk assessment. Failure to account for uncertainties in exposure estimation could lead to biased results in exposure...Environmental Health 2019 18:31Published on: 8 April 2019Screening of noise-induced hearing loss (NIHL)-associated SNPs and the assessment of its genetic susceptibility
The aim of this study was to screen for noise-induced hearing loss (NIHL)-associated single nucleotide polymorphisms (SNPs) and to construct genetic risk prediction models for NIHL in a Chinese population.Environmental Health 2019 18:30Published on: 4 April 2019A repeated measures study of phenol, paraben and Triclocarban urinary biomarkers and circulating maternal hormones during gestation in the Puerto Rico PROTECT cohort
Prenatal exposure to some phenols and parabens has been associated with adverse birth outcomes. Hormones may play an intermediate role between phenols and adverse outcomes. We examined the associations of phen...Environmental Health 2019 18:28Published on: 2 April 2019Head and neck cancer and occupational exposure to leather dust: results from the ICARE study, a French case-control study
Leather dust is an established carcinogen of the sinonasal cavities; however, evidence is lacking regarding its association with other head and neck cancers (HNC). To date, few studies have been conducted on t...Environmental Health 2019 18:27Published on: 29 March 2019Bootstrap approach to validate the performance of models for predicting mortality risk temperature in Portuguese Metropolitan Areas
There has been increasing interest in assessing the impacts of extreme temperatures on mortality due to diseases of the circulatory system. This is further relevant for future climate scenarios where marked ch...Environmental Health 2019 18:25Published on: 29 March 2019Urinary concentrations of phthalate biomarkers and weight change among postmenopausal women: a prospective cohort study
Some phthalates are endocrine disrupting chemicals used as plasticizers in consumer products, and have been associated with obesity in cross-sectional studies, yet prospective evaluations of weight change are ...Environmental Health 2019 18:20Published on: 12 March 2019Thyroid cancer risks among medical radiation workers in South Korea, 1996–2015
Thyroid cancer rates, especially among children, are known to be increased by radiation exposure. However, little is known about the impact of chronic low-dose radiation exposure on thyroid cancer risk in adul...Environmental Health 2019 18:19Published on: 11 March 2019A hybrid expert approach for retrospective assessment of occupational exposures in a population-based case-control study of cancer
While the expert-based occupational exposure assessment approach has been considered the reference method for retrospective population-based studies, its implementation in large study samples has become prohib...Environmental Health 2019 18:14Published on: 15 February 2019Measurement error in a multi-level analysis of air pollution and health: a simulation study
Spatio-temporal models are increasingly being used to predict exposure to ambient outdoor air pollution at high spatial resolution for inclusion in epidemiological analyses of air pollution and health. Measure...Environmental Health 2019 18:13Published on: 14 February 2019Persistent mental and physical health impact of exposure to the September 11, 2001 World Trade Center terrorist attacks
Asthma, gastroesophageal reflux disease (GERD), posttraumatic stress disorder (PTSD) and depression have each been linked to exposure to the September 11, 2001 World Trade Center (WTC) terrorist attacks (9/11)...Environmental Health 2019 18:12Published on: 12 February 2019Tampon use, environmental chemicals and oxidative stress in the BioCycle study
Tampons are used by up to 86% of US women and are a rarely considered potential source of pesticide and metal exposure. Tampons may be of particular concern given the likely higher absorption that occurs in th...Environmental Health 2019 18:11Published on: 11 February 2019Mediating role of arsenic in the relationship between diet and pregnancy outcomes: prospective birth cohort in Bangladesh
Epidemiological evidence suggests that arsenic (As) exposure during pregnancy may reduce infant birth weight. One significant source of As exposure is diet; thus, As may indirectly affect infant growth by medi...Environmental Health 2019 18:10Published on: 6 February 2019Development and performance evaluation of a GIS-based metric to assess exposure to airborne pollutant emissions from industrial sources
Dioxins are environmental and persistent organic carcinogens with endocrine disrupting properties. A positive association with several cancers, including risk of breast cancer has been suggested.Environmental Health 2019 18:8Published on: 25 January 2019Prenatal exposure to perfluoroalkyl and polyfluoroalkyl substances and the risk of hypertensive disorders of pregnancy
Perfluoroalkyl and polyfluoroalkyl substances (PFAS) have been reported to disrupt endocrine system and reproduction. However, epidemiological evidence on the association between PFAS and preeclampsia is incon...Environmental Health 2019 18:5Published on: 9 January 2019The evidence of human exposure to glyphosate: a review
Despite the growing and widespread use of glyphosate, a broad-spectrum herbicide and desiccant, very few studies have evaluated the extent and amount of human exposure.Environmental Health 2019 18:2Published on: 7 January 2019The Letter to the Editor to this article has been published in Environmental Health 2019 18:42Mortality among workers exposed to asbestos at the shipyard of Genoa, Italy: a 55 years follow-up
Exposure to asbestos remains a global issue due to its massive use in the twentieth century and its long environmental persistence. Exposure to asbestos still occurs during dismantling of ships and vessels, bu...Environmental Health 2018 17:94Published on: 29 December 2018Association between mesothelioma and non-occupational asbestos exposure: systematic review and meta-analysis
The risk of mesothelioma has been shown to be associated with exposure to asbestos fibers. Most of the existing literature focuses on occupational exposure; however, non-occupational asbestos exposure has also...Environmental Health 2018 17:90Published on: 19 December 2018Epidemiological association between multiple chemical sensitivity and birth by caesarean section: a nationwide case-control study
Multiple chemical sensitivity (MCS) is characterized by recurrent nonspecific symptoms that are attributed to exposure to trace levels of environmental agents. Although the clinical symptoms of MCS have been d...Environmental Health 2018 17:89Published on: 14 December 2018Responses of healthy young males to fine-particle exposure are modified by exercise habits: a panel study
Aerobic exercise benefits health but increases inhalation of fine particles (PM2.5) in ambient air. Acute cardiopulmonary responses to PM2.5 exposure in individuals with different exercise habits, especially in a...Environmental Health 2018 17:88Published on: 13 December 2018
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