Coronavirus [NEW TOPIC PAGE]

Hot Topics of the Day|PHGKB

 Coronavirus

APOE E4 genotype predicts severe COVID-19 in the UK biobank community cohort
CL Kuo et al, MEDRXIV May 15, 2020

CRISPR-Cas Systems Based Molecular Diagnostic Tool for Infectious Diseases and Emerging 2019 Novel Coronavirus (COVID-19) Pneumonia.
Xiang Xiaohong et al. Journal of drug targeting 2020 May 1-10

Reopening Society and the Need for Real-Time Assessment of COVID-19 at the Community Level
FJ Angulo et al, JAMA< May 15, 2020

Accurate assessment of COVID-19 at the community level requires reliable evidence about the proportion of symptomatic persons tested for COVID-19, the proportion of cases that are asymptomatic, COVID-19 cumulative incidence, the proportion of persons who are hospitalized, and the proportion who die.

A global effort to define the human genetics of protective immunity to SARS-CoV-2 infection
JL Casanova et al, Cell, May 13, 2020

The role of human genetics in determining clinical response to the virus remains unclear. Studies of outliers – individuals remaining uninfected despite viral exposure and healthy young patients with life-threatening disease – presents a unique opportunity to reveal human genetic determinants of infection and disease.

Whole genome sequencing and phylogenetic analysis of SARS-CoV-2 strains from the index and early patients with COVID-19 in Dubai, United Arab Emirates, 29 January to 18 March 2020
AA Tayoun et al, BIORXIV, May 14, 2020

Patient DNA cross-reactivity of CDC SARS-nCoV2 extraction control leads to potential false negative results
AP Rosebrock, BIORXIV, May 14, 2020

ACE2 interaction networks in COVID-19: a physiological framework for prediction of outcome in patients with cardiovascular risk factors
Z Wicick et al, BIORXIV, May 14, 2020

Triage tool for suspected COVID-19 patients in the emergency room: AIFELL score
I Levenfus et al, MEDRXIV, May 15, 2020

Strong Social Distancing Measures In The United States Reduced The COVID-19 Growth Rate
C Courtemanche et al, Health Affairs, May 14, 2020

NIH begins clinical trial of hydroxychloroquine and azithromycin to treat COVID-19- Study enrolling adults with mild to moderate COVID-19 in the United States.
NIH, May 14, 2020

Rapid implementation of real-time SARS-CoV-2 sequencing to investigate healthcare-associated COVID-19 infections
LW Meredith et al, MEDRXIV, May 14, 2020