domingo, 10 de mayo de 2020

Coronavirus [NEW TOPIC PAGE]

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Coronavirus

Modeling shield immunity to reduce COVID-19 epidemic spread
JS Weitz et al, Nature Medicine, May 7, 2020
We have developed and analyzed an epidemiological intervention model that leverages serological tests6,7 to identify and deploy recovered individuals8 as focal points for sustaining safer interactions via interaction substitution, developing what we term ‘shield immunity’ at the population scale.
We used transgenic mice bearing human ACE2 and infected with SARS-CoV-2 to study and confirmed the pathogenicity of the virus. The mouse model with SARS-CoV-2 infection will be valuable for evaluating antiviral therapeutics and vaccines as well as understanding the pathogenesis of COVID-19.
We confirmed that the increase of genome units in raw wastewaters followed the increase of human COVID-19 cases. Viral genomes could be detected before the exponential growth of the epidemic. A marked decrease in the quantities of genome units was observed with the reduction in the number of new cases which was an expected consequence of the lockdown.

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