Coronavirus [NEW TOPIC PAGE]

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 Coronavirus

The COVID-19 Host Genetics Initiative, a global initiative to elucidate the role of host genetic factors in susceptibility and severity of the SARS-CoV-2 virus pandemic
The COVID-19 Host Genetics Initiative, EJHG, May 13, 2020

The initiative has 3 goals: Provide an environment to foster sharing of resources to facilitate host genetics research; Organize analytical activities across studies to identify genetic determinants of susceptibility and severity; Provide a platform to share results, as well as the individual-level data where possible, to benefit the broader scientific community.

Single-cell landscape of bronchoalveolar immune cells in patients with COVID-19
M Liao et al, Nature Medicine, May 12, 2020

Development and Validation of a Clinical Risk Score to Predict the Occurrence of Critical Illness in Hospitalized Patients With COVID-19
W Liang et al, JAMA Internal Medicine, May 12, 2020

In this study with a development cohort of 1590 patients and a validation cohort of 710 patients, a risk score was developed and validated to predict development of critical illness. We identified 10 independent predictors and developed a risk score (COVID-GRAM) that predicts development of critical illness

Exploring diseases/traits and blood proteins causally related to expression of ACE2, the putative receptor of SARS-CoV-2: A Mendelian Randomization analysis highlights tentative relevance of diabetes-related traits
S Rao et al, MEDRXIV, May 12, 2020

Serum protein profiling reveals a landscape of inflammation and immune signaling in early-stage COVID-19 infection
X Hou et al, MEDRXIV, May 13, 2020

Defining the Pandemic at the State Level: Sequence-Based Epidemiology of the SARS-CoV-2 virus by the Arizona COVID-19 Genomics Union (ACGU)
JD Ladner et al, MEDRXIV, May 13, 2020

Phylogenetic analysis of 79 genomes we generated from across Arizona revealed a minimum of 9 distinct introductions throughout February and March. We show that >80% of our sequences descend from clades that were initially circulating widely in Europe but have since dominated the outbreak in the United States.

Saliva as a non-invasive sample for the detection of SARS-CoV-2: a systematic review
Z Khurshid et al, MEDRXIV, May 13, 2020

Epidemic Models for Personalised COVID-19 Isolation and Exit Policies Using Clinical Risk Predictions
T Evgeniou et al, MEDRXIV, May 12, 2020

Predicting the Growth and Trend of COVID-19 Pandemic using Machine Learning and Cloud Computing
S Tuli, et al, MEDRXIV, May 11, 2020

Genome-wide data inferring the evolution and population demography of the novel pneumonia coronavirus (SARS-CoV-2)
B Fang et al, BIORXIV, May 11, 2020

Nearly 40% of Icelanders are using a covid app—and it hasn’t helped much- The country has the highest penetration of any automated contact tracing app in the world, but one senior figure says it “wasn’t a game changer.”
M Johnson, MIT Tech Review, May 11, 2020

COVID-19 outcomes and the human genome
MF Murray et al, Genetics in Medicine, May 13, 2020

Human infection is a complex interaction between microbe, environment, and human host. Host genomic variability has been linked to complications associated with infections. The ability to identify host factors that increase susceptibility or resistance to complications of COVID-19 and to translate findings to improved patient care should be the goal.