Coronavirus [NEW TOPIC PAGE]

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 Coronavirus

Doctors Investigate Link Between Rare Childhood Disease and Covid-19 -Italian and British doctors urge colleagues to look out for symptoms associated with Kawasaki disease, an inflammatory condition affecting blood vessels
WSJ, April 29, 2020

Hopes rise on coronavirus drug remdesivir
H Ledford, Nature News, April 30, 2020

Despite conflicting data, results from largest trial that show the antiviral speeds up recovery will make the treatment a standard of care in the United States.

A SARS-CoV-2 protein interaction map reveals targets for drug repurposing
DE Gordon et al, Nature, April 30, 2020

We identify 66 druggable human proteins or host factors targeted by 69 compounds (29 FDA-approved drugs, 12 drugs in clinical trials, and 28 compounds). Screening a subset of these in multiple viral assays identified 2 sets of agents that displayed antiviral activity: inhibitors of mRNA translation and regulators of Sigma1 and Sigma2 receptors.

Why Are More Men Than Women Dying Of COVID-19?
M Koerth, FiveThirtyEight, April 30, 2020

Show evidence that apps for COVID-19 contact-tracing are secure and effective
Nature editorial, April 29, 2020

Key questions need answers: One serious concern is accuracy. If incorrect information has been sent to a large group of contacts, it will have caused unnecessary alarm. An equally important concern is privacy. It is becoming easier to identify individuals from anonymized data sets.

The natural history and transmission potential of asymptomatic SARS-CoV-2 infection
NVV Chau et al, MEDRXIV, April 29, 2020

A gene locus that controls expression of ACE2 in virus infection
MA Ansari et al, MEDRXIV, April 29, 2020

Integrated analysis of bulk multi omic and single-cell sequencing data confirms the molecular origin of hemodynamic changes in Covid-19 infection explaining coagulopathy and higher geriatric mortality
S Johri et al, MEDRXIV, April 29, 2020

Key predictors of attending hospital with COVID19: An association study from the COVID Symptom Tracker App in 2,618,948 individuals
MN Lochlain et al, MEDRXIV, April 29, 2020

We aimed to identify key demographic risk factors for hospital attendance with COVID-19 infection. Design: Community survey Setting: The COVID Symptom Tracker mobile application. Being older, obese, diabetic or suffering from pre-existing lung, heart or renal disease placed participants at increased risk of visiting hospital with COVID-19.

Clinical Laboratory Parameters Associated with Severe or Critical Novel Coronavirus Disease 2019 (COVID-19): A Systematic Review and Meta-analysis
J Moutchia et al, MEDRXIV, April 29, 2020

Relative to non-severe COVID-19, severe or critical COVID-19 is characterized by increased markers of innate immune response, decreased markers of adaptive immune response, and increased markers of tissue damage and major organ failure. These markers could be used to recognize severe or critical disease and to monitor clinical course of COVID-19.

First round of meta analysis results
COVID-19 Host Genomics Consortium, April 30, 2020

Why the Coronavirus Is So Confusing- A guide to making sense of a problem that is now too big for any one person to fully comprehend
Ed Yong, the Atlantic, April 2020