herenciageneticayenfermedad: Drug Discovery and Production | Medical News | Medical Articles

viernes, 8 de mayo de 2020

Drug Discovery and Production | Medical News | Medical Articles | Drug Discovery and Production |

	Drug Discovery and Production
	The latest drug discovery news from News Medical

Removing Evaporation Bottlenecks in PROTAC Drug Discovery Workflow

PROTACs could enable the design of drugs to target "undruggable" proteins, which equate to 85% of the proteome, but PROTAC synthesis requires numerous evaporation steps and which produce evaporation bottlenecks in production.

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Improving Automated NMR Integration Through Deep Learning

With NMR, it is important to detect and integrate each signal region. You can then use this information to quantify your compounds, for example, or to do relaxation measurements. There are currently several ways to do this using TopSpin.

In this interview, Data Scientist Federico Paruzzo discusses how Bruker has used deep learning to develop the new command, and how it compares to other approaches available. Federico will also introduce the Sigreg, the first machine-learning—based automatic signal region detection for 1H NMR spectra which is the latest edition of Bruker’s TopSpin software.

Project Expands Use Of Metal Catalysts For Drug Discovery

The use of metals in drug delivery could offer major benefits, including allowing for lower dosages of a medication to achieve therapeutic effects. These small-molecule intracellular metal catalysts work differently than typical organic molecules, offering potentially powerful new ways to deliver medications and other treatments. Despite that, Do said both scientific barriers and concerns about toxicity have limited their use.

	What Role Does Epigenetics Play in Drug Discovery? Epigenetics is being used to help identify DNA modifications that are implicated in disease.

	Exploiting A Chink In The Armor Of Bacteria Could Result In New Drug Therapies Scientists have identified a key process in the way bacteria protect themselves from attack, and it heralds a new strategy in the hunt for antibiotics.

	How toxic are chloroquine and hydroxychloroquine to cells? The spread of the pandemic disease COVID-19 caused by the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) has now reached almost every country of the world, with over 3.11 million cases and over 217,000 deaths as of April 29, 2020.

	Optimizing DLS Measurements for Protein Drugs and Biotherapeutics Testa Analytical has published a study that investigates parameters that can be tweaked to improve Dynamic Light Scattering (DLS) measurement quality when analyzing monomeric and aggregated monoclonal antibodies.