Melanoma
Melanoma: Public Health and Genomic Insights - August 20, 2015
CDC and Related Info
- Vital Signs: Melanoma incidence and mortality trends and projections - United States, 1982-2030MMWR, June 2 2015
- Skin cancer is the most common cancer in the United States. Most cases of melanoma, the deadliest kind of skin cancer, are caused by exposure to ultraviolet light
- Genes reported in relation to melanoma, including genomewide association studies via theHuGE Navigator
Jimmy Carter says he has melanoma that has spread to his brain,
by Sam Levine, Huffington Post, August 20, 2015
Update on melanoma epigenetics.![External Web Site Icon External Web Site Icon](https://lh3.googleusercontent.com/blogger_img_proxy/AEn0k_tDi6j3k1p9CW3fwK58dJOPh4DhoUIQdEpD6QLKRpbGfeyOoCdYuNJ4Q3hIkmLykwG84cPR6CyxqinRxLL1zVRDPslVF8hxbk6iIx_2XaNoKxQ_Hl9wC8zI=s0-d)
de Unamuno Blanca et al. Curr Opin Oncol 2015 Sep (5) 420-6
de Unamuno Blanca et al. Curr Opin Oncol 2015 Sep (5) 420-6
Clinical utility of a blood-based BRAF(V600E) mutation assay in melanoma.![External Web Site Icon External Web Site Icon](https://lh3.googleusercontent.com/blogger_img_proxy/AEn0k_tDi6j3k1p9CW3fwK58dJOPh4DhoUIQdEpD6QLKRpbGfeyOoCdYuNJ4Q3hIkmLykwG84cPR6CyxqinRxLL1zVRDPslVF8hxbk6iIx_2XaNoKxQ_Hl9wC8zI=s0-d)
Panka DJ et al. Mol. Cancer Ther. 2014 Dec 13(12) 3210-8
Panka DJ et al. Mol. Cancer Ther. 2014 Dec 13(12) 3210-8
Meta-analysis uncovers five additional susceptibility loci for cutaneous malignant melanoma,![External Web Site Icon External Web Site Icon](https://lh3.googleusercontent.com/blogger_img_proxy/AEn0k_tDi6j3k1p9CW3fwK58dJOPh4DhoUIQdEpD6QLKRpbGfeyOoCdYuNJ4Q3hIkmLykwG84cPR6CyxqinRxLL1zVRDPslVF8hxbk6iIx_2XaNoKxQ_Hl9wC8zI=s0-d)
Genome Web, Aug 3 [by free subscription only]
Genome Web, Aug 3 [by free subscription only]
Genome-wide meta-analysis identifies five new susceptibility loci for cutaneous malignant melanoma![External Web Site Icon External Web Site Icon](https://lh3.googleusercontent.com/blogger_img_proxy/AEn0k_tDi6j3k1p9CW3fwK58dJOPh4DhoUIQdEpD6QLKRpbGfeyOoCdYuNJ4Q3hIkmLykwG84cPR6CyxqinRxLL1zVRDPslVF8hxbk6iIx_2XaNoKxQ_Hl9wC8zI=s0-d)
Law ML et al, Nature Genetics, August 3, 2015
Law ML et al, Nature Genetics, August 3, 2015
Precision oncology: Creating a genomic guide for melanoma therapy,
NIH, Director's Blog, June 23, 2015
Vital Signs: Melanoma incidence and mortality trends and projections - United States, 1982-2030
MMWR, June 2 2015
MMWR, June 2 2015
Melanoma![External Web Site Icon External Web Site Icon](https://lh3.googleusercontent.com/blogger_img_proxy/AEn0k_tDi6j3k1p9CW3fwK58dJOPh4DhoUIQdEpD6QLKRpbGfeyOoCdYuNJ4Q3hIkmLykwG84cPR6CyxqinRxLL1zVRDPslVF8hxbk6iIx_2XaNoKxQ_Hl9wC8zI=s0-d)
Schadendorf D et al. Nature Reviews Disease Primers, April 23, 2015
Schadendorf D et al. Nature Reviews Disease Primers, April 23, 2015
Therapeutic advances and treatment options in metastatic melanoma![External Web Site Icon External Web Site Icon](https://lh3.googleusercontent.com/blogger_img_proxy/AEn0k_tDi6j3k1p9CW3fwK58dJOPh4DhoUIQdEpD6QLKRpbGfeyOoCdYuNJ4Q3hIkmLykwG84cPR6CyxqinRxLL1zVRDPslVF8hxbk6iIx_2XaNoKxQ_Hl9wC8zI=s0-d)
Johnson DB et al. JAMA Oncology, April 23, 2015
Johnson DB et al. JAMA Oncology, April 23, 2015
NRAS and BRAF mutational status and melanoma-specific survival ![External Web Site Icon External Web Site Icon](https://lh3.googleusercontent.com/blogger_img_proxy/AEn0k_tDi6j3k1p9CW3fwK58dJOPh4DhoUIQdEpD6QLKRpbGfeyOoCdYuNJ4Q3hIkmLykwG84cPR6CyxqinRxLL1zVRDPslVF8hxbk6iIx_2XaNoKxQ_Hl9wC8zI=s0-d)
Thomas N et al. JAMA Oncology, April 9, 2015
Thomas N et al. JAMA Oncology, April 9, 2015
Towards predicting metastatic progression of melanoma based on gene expression data.![External Web Site Icon External Web Site Icon](https://lh3.googleusercontent.com/blogger_img_proxy/AEn0k_tDi6j3k1p9CW3fwK58dJOPh4DhoUIQdEpD6QLKRpbGfeyOoCdYuNJ4Q3hIkmLykwG84cPR6CyxqinRxLL1zVRDPslVF8hxbk6iIx_2XaNoKxQ_Hl9wC8zI=s0-d)
Li Y et al. Pigment Cell Melanoma Res 2015 Apr 3.
Li Y et al. Pigment Cell Melanoma Res 2015 Apr 3.
Inherited genetic variants associated with occurrence of multiple primary melanoma.![External Web Site Icon External Web Site Icon](https://lh3.googleusercontent.com/blogger_img_proxy/AEn0k_tDi6j3k1p9CW3fwK58dJOPh4DhoUIQdEpD6QLKRpbGfeyOoCdYuNJ4Q3hIkmLykwG84cPR6CyxqinRxLL1zVRDPslVF8hxbk6iIx_2XaNoKxQ_Hl9wC8zI=s0-d)
Gibbs DC et al. Cancer Epidemiol. Biomarkers Prev. 2015 Apr 2.
Gibbs DC et al. Cancer Epidemiol. Biomarkers Prev. 2015 Apr 2.
Molecular characterization of melanoma cases in Denmark suspected of genetic predisposition.![External Web Site Icon External Web Site Icon](https://lh3.googleusercontent.com/blogger_img_proxy/AEn0k_tDi6j3k1p9CW3fwK58dJOPh4DhoUIQdEpD6QLKRpbGfeyOoCdYuNJ4Q3hIkmLykwG84cPR6CyxqinRxLL1zVRDPslVF8hxbk6iIx_2XaNoKxQ_Hl9wC8zI=s0-d)
Wadt KA et al. PLoS ONE 2015 (3) e0122662
Wadt KA et al. PLoS ONE 2015 (3) e0122662
Unique genomic profile associated with pediatric uveal melanoma.![External Web Site Icon External Web Site Icon](https://lh3.googleusercontent.com/blogger_img_proxy/AEn0k_tDi6j3k1p9CW3fwK58dJOPh4DhoUIQdEpD6QLKRpbGfeyOoCdYuNJ4Q3hIkmLykwG84cPR6CyxqinRxLL1zVRDPslVF8hxbk6iIx_2XaNoKxQ_Hl9wC8zI=s0-d)
Blasi MA et al. Eur J Ophthalmol 2015 Mar 16. 0
Blasi MA et al. Eur J Ophthalmol 2015 Mar 16. 0
Pleiotropic and sex-specific effects of cancer GWAS SNPs on melanoma risk in the population architecture using genomics and epidemiology (PAGE) study.![External Web Site Icon External Web Site Icon](https://lh3.googleusercontent.com/blogger_img_proxy/AEn0k_tDi6j3k1p9CW3fwK58dJOPh4DhoUIQdEpD6QLKRpbGfeyOoCdYuNJ4Q3hIkmLykwG84cPR6CyxqinRxLL1zVRDPslVF8hxbk6iIx_2XaNoKxQ_Hl9wC8zI=s0-d)
Kocarnik JM et al. PLoS ONE 2015 (3) e0120491
Kocarnik JM et al. PLoS ONE 2015 (3) e0120491
Targeted therapies in melanoma.![External Web Site Icon External Web Site Icon](https://lh3.googleusercontent.com/blogger_img_proxy/AEn0k_tDi6j3k1p9CW3fwK58dJOPh4DhoUIQdEpD6QLKRpbGfeyOoCdYuNJ4Q3hIkmLykwG84cPR6CyxqinRxLL1zVRDPslVF8hxbk6iIx_2XaNoKxQ_Hl9wC8zI=s0-d)
Moschos Stergios J et al. Surg. Oncol. Clin. N. Am. 2015 Apr (2) 347-358
Moschos Stergios J et al. Surg. Oncol. Clin. N. Am. 2015 Apr (2) 347-358
Loss of CITED1, an MITF regulator, drives a phenotype switch in vitro and can predict clinical outcome in primary melanoma tumours.![External Web Site Icon External Web Site Icon](https://lh3.googleusercontent.com/blogger_img_proxy/AEn0k_tDi6j3k1p9CW3fwK58dJOPh4DhoUIQdEpD6QLKRpbGfeyOoCdYuNJ4Q3hIkmLykwG84cPR6CyxqinRxLL1zVRDPslVF8hxbk6iIx_2XaNoKxQ_Hl9wC8zI=s0-d)
Howlin J et al. PeerJ 2015 e788
Howlin J et al. PeerJ 2015 e788
A melanoma subtype with intrinsic resistance to BRAF inhibition identified by receptor tyrosine kinases gene-driven classification.![External Web Site Icon External Web Site Icon](https://lh3.googleusercontent.com/blogger_img_proxy/AEn0k_tDi6j3k1p9CW3fwK58dJOPh4DhoUIQdEpD6QLKRpbGfeyOoCdYuNJ4Q3hIkmLykwG84cPR6CyxqinRxLL1zVRDPslVF8hxbk6iIx_2XaNoKxQ_Hl9wC8zI=s0-d)
Dugo M et al. Oncotarget 2015 Mar 10. (7) 5118-33
Dugo M et al. Oncotarget 2015 Mar 10. (7) 5118-33
Genome-wide DNA methylation analysis in melanoma reveals the importance of CpG methylation in MITF regulation.![External Web Site Icon External Web Site Icon](https://lh3.googleusercontent.com/blogger_img_proxy/AEn0k_tDi6j3k1p9CW3fwK58dJOPh4DhoUIQdEpD6QLKRpbGfeyOoCdYuNJ4Q3hIkmLykwG84cPR6CyxqinRxLL1zVRDPslVF8hxbk6iIx_2XaNoKxQ_Hl9wC8zI=s0-d)
Lauss M et al. J. Invest. Dermatol. 2015 Feb 23.
Lauss M et al. J. Invest. Dermatol. 2015 Feb 23.
Melanoma: Recent Genomic Insights - January 23, 2015
Development of a prognostic genetic signature to predict the metastatic risk associated with cutaneous melanoma.![External Web Site Icon External Web Site Icon](https://lh3.googleusercontent.com/blogger_img_proxy/AEn0k_tDi6j3k1p9CW3fwK58dJOPh4DhoUIQdEpD6QLKRpbGfeyOoCdYuNJ4Q3hIkmLykwG84cPR6CyxqinRxLL1zVRDPslVF8hxbk6iIx_2XaNoKxQ_Hl9wC8zI=s0-d)
Gerami P, et al. Clin Cancer Res. 2015 Jan 1;21(1):175-83.
Gerami P, et al. Clin Cancer Res. 2015 Jan 1;21(1):175-83.
New test identifies early-stage melanoma with metastatic risk,
Medscape, Jan 15 [by free subscription only]
Epigenetic regulation in human melanoma: Past and future.![External Web Site Icon External Web Site Icon](https://lh3.googleusercontent.com/blogger_img_proxy/AEn0k_tDi6j3k1p9CW3fwK58dJOPh4DhoUIQdEpD6QLKRpbGfeyOoCdYuNJ4Q3hIkmLykwG84cPR6CyxqinRxLL1zVRDPslVF8hxbk6iIx_2XaNoKxQ_Hl9wC8zI=s0-d)
Sarkar D, et al. Epigenetics. 2015 Jan 14:0.
Sarkar D, et al. Epigenetics. 2015 Jan 14:0.
TRIB2 as a biomarker for diagnosis and progression of melanoma.![External Web Site Icon External Web Site Icon](https://lh3.googleusercontent.com/blogger_img_proxy/AEn0k_tDi6j3k1p9CW3fwK58dJOPh4DhoUIQdEpD6QLKRpbGfeyOoCdYuNJ4Q3hIkmLykwG84cPR6CyxqinRxLL1zVRDPslVF8hxbk6iIx_2XaNoKxQ_Hl9wC8zI=s0-d)
Hill R, et al. Carcinogenesis. 2015 Jan 13.
Hill R, et al. Carcinogenesis. 2015 Jan 13.
Limited genomic heterogeneity of circulating melanoma cells in advanced stage patients.![External Web Site Icon External Web Site Icon](https://lh3.googleusercontent.com/blogger_img_proxy/AEn0k_tDi6j3k1p9CW3fwK58dJOPh4DhoUIQdEpD6QLKRpbGfeyOoCdYuNJ4Q3hIkmLykwG84cPR6CyxqinRxLL1zVRDPslVF8hxbk6iIx_2XaNoKxQ_Hl9wC8zI=s0-d)
Ruiz C, et al. Phys Biol. 2015 Jan 9;12(1):016008
Ruiz C, et al. Phys Biol. 2015 Jan 9;12(1):016008
Current therapeutic leads for the treatment of melanoma: Targeted Immunotherapy in the post-genomic era.![External Web Site Icon External Web Site Icon](https://lh3.googleusercontent.com/blogger_img_proxy/AEn0k_tDi6j3k1p9CW3fwK58dJOPh4DhoUIQdEpD6QLKRpbGfeyOoCdYuNJ4Q3hIkmLykwG84cPR6CyxqinRxLL1zVRDPslVF8hxbk6iIx_2XaNoKxQ_Hl9wC8zI=s0-d)
Papanastasiou AD, et al. Curr Mol Pharmacol. 2014;7(1):33-43.
Papanastasiou AD, et al. Curr Mol Pharmacol. 2014;7(1):33-43.
Clinically relevant genes and regulatory pathways associated with NRASQ61 mutations in melanoma through an integrative genomics approach.![External Web Site Icon External Web Site Icon](https://lh3.googleusercontent.com/blogger_img_proxy/AEn0k_tDi6j3k1p9CW3fwK58dJOPh4DhoUIQdEpD6QLKRpbGfeyOoCdYuNJ4Q3hIkmLykwG84cPR6CyxqinRxLL1zVRDPslVF8hxbk6iIx_2XaNoKxQ_Hl9wC8zI=s0-d)
Jiang W, et al. Oncotarget. 2014 Dec 10
Jiang W, et al. Oncotarget. 2014 Dec 10
Nonsense mutations in the shelterin complex genes ACD and TERF2IP in familial melanoma.![External Web Site Icon External Web Site Icon](https://lh3.googleusercontent.com/blogger_img_proxy/AEn0k_tDi6j3k1p9CW3fwK58dJOPh4DhoUIQdEpD6QLKRpbGfeyOoCdYuNJ4Q3hIkmLykwG84cPR6CyxqinRxLL1zVRDPslVF8hxbk6iIx_2XaNoKxQ_Hl9wC8zI=s0-d)
Aoude LG, et al. J Natl Cancer Inst. 2014 Dec 13
Aoude LG, et al. J Natl Cancer Inst. 2014 Dec 13
Melanoma genome sequencing reveals frequent PREX2 mutations.![External Web Site Icon External Web Site Icon](https://lh3.googleusercontent.com/blogger_img_proxy/AEn0k_tDi6j3k1p9CW3fwK58dJOPh4DhoUIQdEpD6QLKRpbGfeyOoCdYuNJ4Q3hIkmLykwG84cPR6CyxqinRxLL1zVRDPslVF8hxbk6iIx_2XaNoKxQ_Hl9wC8zI=s0-d)
Chroscinski D,et al. Elife. 2014 Dec 10;3.
Chroscinski D,et al. Elife. 2014 Dec 10;3.
Implementation of a companion diagnostic in the clinical laboratory: the BRAF example in melanoma.![External Web Site Icon External Web Site Icon](https://lh3.googleusercontent.com/blogger_img_proxy/AEn0k_tDi6j3k1p9CW3fwK58dJOPh4DhoUIQdEpD6QLKRpbGfeyOoCdYuNJ4Q3hIkmLykwG84cPR6CyxqinRxLL1zVRDPslVF8hxbk6iIx_2XaNoKxQ_Hl9wC8zI=s0-d)
Mancini I, et al. Clin Chim Acta. 2015 Jan 15;439:128-36
Mancini I, et al. Clin Chim Acta. 2015 Jan 15;439:128-36
Genomic microarray analysis on formalin-fixed paraffin-embedded material for uveal melanoma prognostication.![External Web Site Icon External Web Site Icon](https://lh3.googleusercontent.com/blogger_img_proxy/AEn0k_tDi6j3k1p9CW3fwK58dJOPh4DhoUIQdEpD6QLKRpbGfeyOoCdYuNJ4Q3hIkmLykwG84cPR6CyxqinRxLL1zVRDPslVF8hxbk6iIx_2XaNoKxQ_Hl9wC8zI=s0-d)
Minca EC et al. Cancer Genet. 2014 Jul-Aug;207(7-8):306-15
Minca EC et al. Cancer Genet. 2014 Jul-Aug;207(7-8):306-15
Melanomagenesis; multifaceted attacks on the genome.![External Web Site Icon External Web Site Icon](https://lh3.googleusercontent.com/blogger_img_proxy/AEn0k_tDi6j3k1p9CW3fwK58dJOPh4DhoUIQdEpD6QLKRpbGfeyOoCdYuNJ4Q3hIkmLykwG84cPR6CyxqinRxLL1zVRDPslVF8hxbk6iIx_2XaNoKxQ_Hl9wC8zI=s0-d)
Bordelon JR, et al. Exp Dermatol. 2014 Nov 24.
Bordelon JR, et al. Exp Dermatol. 2014 Nov 24.
The melanoma revolution: from UV carcinogenesis to a new era in therapeutics.![External Web Site Icon External Web Site Icon](https://lh3.googleusercontent.com/blogger_img_proxy/AEn0k_tDi6j3k1p9CW3fwK58dJOPh4DhoUIQdEpD6QLKRpbGfeyOoCdYuNJ4Q3hIkmLykwG84cPR6CyxqinRxLL1zVRDPslVF8hxbk6iIx_2XaNoKxQ_Hl9wC8zI=s0-d)
Lo JA, Fisher DE. Science. 2014 Nov 21;346(6212):945-9.
Lo JA, Fisher DE. Science. 2014 Nov 21;346(6212):945-9.
Genetic basis for clinical response to CTLA-4 blockade in melanoma.![External Web Site Icon External Web Site Icon](https://lh3.googleusercontent.com/blogger_img_proxy/AEn0k_tDi6j3k1p9CW3fwK58dJOPh4DhoUIQdEpD6QLKRpbGfeyOoCdYuNJ4Q3hIkmLykwG84cPR6CyxqinRxLL1zVRDPslVF8hxbk6iIx_2XaNoKxQ_Hl9wC8zI=s0-d)
Snyder A, et al. N Engl J Med. 2014 Dec 4;371(23):2189-99.
Snyder A, et al. N Engl J Med. 2014 Dec 4;371(23):2189-99.
Updated field synopsis and systematic meta-analyses of genetic association studies in cutaneous melanoma: The MelGene database.![External Web Site Icon External Web Site Icon](https://lh3.googleusercontent.com/blogger_img_proxy/AEn0k_tDi6j3k1p9CW3fwK58dJOPh4DhoUIQdEpD6QLKRpbGfeyOoCdYuNJ4Q3hIkmLykwG84cPR6CyxqinRxLL1zVRDPslVF8hxbk6iIx_2XaNoKxQ_Hl9wC8zI=s0-d)
Antonopoulou K,et al. J Invest Dermatol. 2014 Nov 19.
Antonopoulou K,et al. J Invest Dermatol. 2014 Nov 19.
IL28B polymorphism cannot predict response to interferon alpha treatment in patients with melanoma.![External Web Site Icon External Web Site Icon](https://lh3.googleusercontent.com/blogger_img_proxy/AEn0k_tDi6j3k1p9CW3fwK58dJOPh4DhoUIQdEpD6QLKRpbGfeyOoCdYuNJ4Q3hIkmLykwG84cPR6CyxqinRxLL1zVRDPslVF8hxbk6iIx_2XaNoKxQ_Hl9wC8zI=s0-d)
Probst M, et al. PLoS One. 2014 Nov 12;9(11):e112613
Probst M, et al. PLoS One. 2014 Nov 12;9(11):e112613
Melanoma Genomics: Sun Exposure and New Therapies - November 26, 2014
Risk factors for melanoma include genes and family health history,
from the National Cancer Institute
A special supplement from Nature Outlook: Melanoma — the deadliest form of skin cancer
is on the rise in many parts of the world. But new treatments, and efforts to tell people how to prevent it, could mean we will soon gain the upper hand on the disease. November, 2014
The cancer that rises with the sun.![External Web Site Icon External Web Site Icon](https://lh3.googleusercontent.com/blogger_img_proxy/AEn0k_tDi6j3k1p9CW3fwK58dJOPh4DhoUIQdEpD6QLKRpbGfeyOoCdYuNJ4Q3hIkmLykwG84cPR6CyxqinRxLL1zVRDPslVF8hxbk6iIx_2XaNoKxQ_Hl9wC8zI=s0-d)
David Holmes Nature, 515, S110–S111, 20 November 2014
David Holmes Nature, 515, S110–S111, 20 November 2014
Risk factors: Riddle of the rays![External Web Site Icon External Web Site Icon](https://lh3.googleusercontent.com/blogger_img_proxy/AEn0k_tDi6j3k1p9CW3fwK58dJOPh4DhoUIQdEpD6QLKRpbGfeyOoCdYuNJ4Q3hIkmLykwG84cPR6CyxqinRxLL1zVRDPslVF8hxbk6iIx_2XaNoKxQ_Hl9wC8zI=s0-d)
Cassandra Willyard, Nature 515, S112–S113 (20 November 2014)
Cassandra Willyard, Nature 515, S112–S113 (20 November 2014)
Epidemiology, risk factors, prevention, and early detection of melanoma.![External Web Site Icon External Web Site Icon](https://lh3.googleusercontent.com/blogger_img_proxy/AEn0k_tDi6j3k1p9CW3fwK58dJOPh4DhoUIQdEpD6QLKRpbGfeyOoCdYuNJ4Q3hIkmLykwG84cPR6CyxqinRxLL1zVRDPslVF8hxbk6iIx_2XaNoKxQ_Hl9wC8zI=s0-d)
Azoury SC, Lange JR. Surg Clin North Am. 2014 Oct;94(5):945-62
Azoury SC, Lange JR. Surg Clin North Am. 2014 Oct;94(5):945-62
Did you know? 389 genes have been reported in relation to melanoma risk and outcomes, including 33 genomewide association studies. To find out more, check out the HuGE Navigator![External Web Site Icon External Web Site Icon](https://lh3.googleusercontent.com/blogger_img_proxy/AEn0k_tDi6j3k1p9CW3fwK58dJOPh4DhoUIQdEpD6QLKRpbGfeyOoCdYuNJ4Q3hIkmLykwG84cPR6CyxqinRxLL1zVRDPslVF8hxbk6iIx_2XaNoKxQ_Hl9wC8zI=s0-d)
Recent Genomic Insights
Interactions between ultraviolet light and MC1R and OCA2 variants are determinants of childhood nevus and freckle phenotypes.![External Web Site Icon External Web Site Icon](https://lh3.googleusercontent.com/blogger_img_proxy/AEn0k_tDi6j3k1p9CW3fwK58dJOPh4DhoUIQdEpD6QLKRpbGfeyOoCdYuNJ4Q3hIkmLykwG84cPR6CyxqinRxLL1zVRDPslVF8hxbk6iIx_2XaNoKxQ_Hl9wC8zI=s0-d)
Anna E. Barón et al. CEBP, November 18, 2014
Anna E. Barón et al. CEBP, November 18, 2014
Genes and sun behaviors during childhood may play large role in future melanoma risk,
American Association for Cancer Research, November 19, 2014
Editorial: Somatic mutations and immunotherapy outcome with CTLA-4 blockade in melanoma.![External Web Site Icon External Web Site Icon](https://lh3.googleusercontent.com/blogger_img_proxy/AEn0k_tDi6j3k1p9CW3fwK58dJOPh4DhoUIQdEpD6QLKRpbGfeyOoCdYuNJ4Q3hIkmLykwG84cPR6CyxqinRxLL1zVRDPslVF8hxbk6iIx_2XaNoKxQ_Hl9wC8zI=s0-d)
NEJM, November 19, 2014.
NEJM, November 19, 2014.
Genetic basis for clinical response to CTLA-4 blockade in melanoma.![External Web Site Icon External Web Site Icon](https://lh3.googleusercontent.com/blogger_img_proxy/AEn0k_tDi6j3k1p9CW3fwK58dJOPh4DhoUIQdEpD6QLKRpbGfeyOoCdYuNJ4Q3hIkmLykwG84cPR6CyxqinRxLL1zVRDPslVF8hxbk6iIx_2XaNoKxQ_Hl9wC8zI=s0-d)
NEJM, November 19, 2014
NEJM, November 19, 2014
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