From CDC Information Database
This database includes general CDC public health information on specific diseases and health related topics. When available, the database displays genomic information from various CDC web pages. Users are also encouraged to conduct searches of CDC website for additional information.
- Have You or a Family Member Had Colorectal (Colon) Cancer?
- U.S. healthcare facilities have capacity to meet colorectal cancer screening goals
News Release, June 22, 2016 - How much do you know about colorectal cancer?
Take the CDC quiz - What Are the Risk Factors for Colorectal Cancer?
- Colorectal cancer screening saves lives. Talk to your doctor about getting screened.
- Colorectal cancer screening saves lives. Talk to your doctor about getting screened.
From NIH National Cancer Institute Web Sites
From CDC-Authored Genomics Publication Database
This database contains CDC-authored publications in public health genomics including infectious diseases, newborn screening, reproductive health, genetic testing, cancer, chronic diseases, birth defects and developmental disabilities, environmental and occupational health as well as laboratory, bioinformatics and statistical methods.
- The gut microbiota in conventional and serrated precursors of colorectal cancer.
Peters Brandilyn A et al. Microbiome 2016 Dec (1) 69 - Implementing screening for Lynch syndrome among patients with newly diagnosed colorectal cancer: summary of a public health/clinical collaborative meeting.
Bellcross Cecelia A et al. Genetics in medicine : official journal of the American College of Medical Genetics 2012 Jan 14(1) 152-62 - When is genomic testing cost-effective? Testing for Lynch syndrome in patients with newly-diagnosed colorectal cancer and their relatives
Grosse, SC Healthcare 2015, 3(4), 860-878 - The cost-effectiveness of routine testing for Lynch syndrome in newly diagnosed patients with colorectal cancer in the United States: corrected estimates.
Grosse Scott D et al. Genet. Med. 2015 Jun 17(6) 510-1 - Effective communication of molecular genetic test results to primary care providers.
Scheuner Maren T et al. Genet. Med. 2013 Jun 15(6) 444-9
From Implementation Database
This database focuses on state and national activities that integrate genomics into public health programs and clinical practice
- Lynch syndrome educational video (Spanish)
[Disease: Lynch syndrome; Type: Education; State: Multiple States] - Lynch Video English August 2016
[Disease: Lynch syndrome; Type: Education; State: Multiple States] - Implementing Public Health Genomics in Your State: Resources from the CDC Office of Public Health Genomics
[Disease: Lynch syndrome|Breast Cancer|Ovarian Cancer; Type: Education; State: Multiple States] - JAX Genomic Education: Genetic Testing for Colorectal Cancer Risk
[Disease: Lynch syndrome; Type: Education; State: Multiple States] - JAX Genomic Education: Categorizing Cancer Risk
[Disease: Lynch syndrome|Ovarian Cancer|Breast Cancer; Type: Education; State: Multiple States]
From Guideline Database
This database contains updated guidelines, policies and recommendations on genomic research and practice, as provided by professional organizations, federal advisory groups, expert panels and policy groups.
- Guidelines for surveillance of individuals with constitutional mismatch repair-deficiency proposed by the European Consortium "Care for CMMR-D" (C4CMMR-D).
Published 2014 (EU-Consortium Care for CMMR-D (C4CMMR-D)) - Guidelines on genetic evaluation and management of Lynch syndrome: a consensus statement by the U.S. Multi-Society Task Force on Colorectal Cancer.
Published 2014 (U.S. Multi-Society Task Force on Colorectal Cancer) - Japanese Society of Medical Oncology Clinical Guidelines: RAS (KRAS/NRAS) mutation testing in colorectal cancer patients.
Published 2015 (Japanese Society of Medical Oncology) - Recommendations from the EGAPP Working Group: can UGT1A1 genotyping reduce morbidity and mortality in patients with metastatic colorectal cancer treated with irinotecan?
Published 2009 (Evaluation of Genomic Applications in Practice and Prevention) - Recommendations from the EGAPP Working Group: genetic testing strategies in newly diagnosed individuals with colorectal cancer aimed at reducing morbidity and mortality from Lynch syndrome in relatives.
Published 2009 (Evaluation of Genomic Applications in Practice and Prevention)
From Tier Table Database
CDC Office of Public Health Genomics (OPHG) conducts horizon scanning (a systematic research method to find and follow novel technologies appearing in the literature) to identify and track the progress of genomic tests as they move from research into clinical and public health practice. As an aid in organizing horizon scanning results, OPHG ranks genomic tests, and family health history applications, by levels of evidence. See detail.
| Disease/Disorder | Test to be Assessed | Intended Use | Tier Classified | Detail |
|---|---|---|---|---|
| Metastatic colorectal cancer | NRAS or PIK3CA mutation analysis and/or testing for loss of PTEN or AKT protein expression | Pharmacogenomic for anti-EGFR therapy | Tier 3  | |
| Dukes’ C colon cancer, metastatic colorectal cancer, metastatic breast cancer | DPD testing | Pharmacogenomic for 5-FU (capecitabine) | Tier 2 | |
| Colorectal cancer in patient with relatives (two or more first- or second-degree) with Lynch syndrome related cancer at any age | Testing for Lynch syndrome | Diagnostic, screening | Tier 2 | |
| Colorectal cancer in patient with relative (one or more first-degree) with Lynch syndrome related cancer that was diagnosed under age 50 years | Testing for Lynch syndrome | Diagnostic, screening | Tier 2 | |
| MSI-H histology in colorectal cancer patients younger than 60 years | Testing for Lynch syndrome | Diagnostic, screening | Tier 2 |
From HuGE Literature Finder Database
This database contains published literature on genetic associations and other human genome epidemiology
- Clinicopathological Associations of K-RAS and N-RAS Mutations in Indonesian Colorectal Cancer Cohort.
Journal of gastrointestinal cancer 2017 Jan .
Levi Michael, Prayogi Gintang, Sastranagara Farid, Sudianto Edi, Widjajahakim Grace, Gani Winiarti, Mahanadi Albert, Agnes Jocelyn, Khairunisa Bela Haifa, Utomo Ahmad - Cost evaluation of irinotecan-related toxicities associated with the UGT1A1*28 patient genotype.
Clinical pharmacology and therapeutics 2017 Jan .
Roncato R, Cecchin E, Montico M, De Mattia E, Giodini L, Buonadonna A, Solfrini V, Innocenti F, Toffoli - Detection of KRAS Mutations in Plasma DNA Using a fully Automated Rapid Detection System in Colorectal Cancer Patients.
Pathology oncology research : POR 2017 Jan .
Hosoya Kazuhisa, Matsusaka Satoshi, Kashiwada Tomomi, Suzuki Koichi, Ureshino Norio, Sato Akemi, Miki Yoshio, Kitera Kazuki, Hirai Mitsuharu, Hatake Kiyohiko, Kimura Shinya, Sueoka-Aragane Nao - KRAS and TP53 mutations in inflammatory bowel disease-associated colorectal cancer: a meta-analysis.
Oncotarget 2017 Jan .
Du Lijun, Kim John J, Shen Jinhua, Chen Binrui, Dai Ni - Polymorphisms of MTHFR C677T and A1298C associated with survival in patients with colorectal cancer treated with 5-fluorouracil-based chemotherapy.
International journal of clinical oncology 2017 Jan .
Yeh Chih-Ching, Lai Ching-Yu, Chang Shih-Ni, Hsieh Ling-Ling, Tang Reiping, Sung Fung-Chang, Lin Yi-Ku
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