DNA methylation changes in Down syndrome derived neural iPSCs uncover co-dysregulation of ZNF and HOX3 families of transcription factors | Clinical Epigenetics | Full Text

DNA methylation changes in Down syndrome derived neural iPSCs uncover co-dysregulation of ZNF and HOX3 families of transcription factors | Clinical Epigenetics | Full Text

DNA methylation changes in Down syndrome derived neural iPSCs uncover co-dysregulation of ZNF and HOX3 families of transcription factors

Down syndrome (DS) is characterized by neurodevelopmental abnormalities caused by partial or complete trisomy of human chromosome 21 (T21). Analysis of Down syndrome brain specimens has shown global epigenetic...

Authors:Loora Laan, Joakim Klar, Maria Sobol, Jan Hoeber, Mansoureh Shahsavani, Malin Kele, Ambrin Fatima, Muhammad Zakaria, Göran Annerén, Anna Falk, Jens Schuster and Niklas Dahl

Citation:Clinical Epigenetics 2020 12:9

Content type:Research

Published on: 8 January 2020

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