Hypertension, preeclampsia, renal and cardiovascular disease in pregnancy

Hypertension, preeclampsia, renal and cardiovascular disease in pregnancy

This collection in Biology of Sex Differences, featuring original research and short review articles, focuses on associative, mechanistic, and translational studies linking pregnancy, pregnancy hypertension, preeclampsia, renal and cardiovascular diseases as they relate to pregnancy outcomes, placental factors, development of hypertension, congenital diseases and adverse fetal outcomes. The editors encourage submission of both basic science research using animal models and clinically relevant translational studies involving human subjects.

1. Cardiac hypertrophy with obesity is augmented after pregnancy in C57BL/6 mice

   Over a third of reproductive-age women in the USA are obese, and the prevalence of cardiovascular disease (CVD) is rising in premenopausal women. Cardiac hypertrophy is an independent predictor of CVD. In cont...

   Authors:Chen Che, Kayla Dudick and Robin Shoemaker

   Citation:Biology of Sex Differences 2019 10:59

   Content type:Research

   Published on: 16 December 2019

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2. The angiotensin II type I receptor contributes to impaired cerebral blood flow autoregulation caused by placental ischemia in pregnant rats

   Placental ischemia and hypertension, characteristic features of preeclampsia, are associated with impaired cerebral blood flow (CBF) autoregulation and cerebral edema. However, the factors that contribute to t...

   Authors:Junie P. Warrington, Fan Fan, Jeremy Duncan, Mark W. Cunningham, Babette B. LaMarca, Ralf Dechend, Gerd Wallukat, Richard J. Roman, Heather A. Drummond, Joey P. Granger and Michael J. Ryan

   Citation:Biology of Sex Differences 2019 10:58

   Content type:Research

   Published on: 11 December 2019

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3. Fetal growth outcomes following peri-implantation exposure of Long-Evans rats to noise and ozone differ by sex

   Exposure to air pollution and high levels of noise have both been independently associated with the development of adverse pregnancy outcomes including low birth weight. However, exposure to such environmental...

   Authors:Colette N. Miller, Urmila P. Kodavanti, Erica J. Stewart, Mette C. Schladweiler, Judy H. Richards, Samantha J. Snow, Andres R. Henriquez, Wendy M. Oshiro, Aimen K. Farraj, Mehdi S. Hazari and Janice A. Dye

   Citation:Biology of Sex Differences 2019 10:54

   Content type:Research

   Published on: 2 December 2019

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4. Targeting senescence improves angiogenic potential of adipose-derived mesenchymal stem cells in patients with preeclampsia

   Preeclampsia is a pregnancy-specific hypertensive disorder characterized by impaired angiogenesis. We postulate that senescence of mesenchymal stem cells (MSC), multipotent cells with pro-angiogenic activities...

   Authors:Sonja Suvakov, Hajrunisa Cubro, Wendy M. White, Yvonne S. Butler Tobah, Tracey L. Weissgerber, Kyra L. Jordan, Xiang Y. Zhu, John R. Woollard, Fouad T. Chebib, Natasa M. Milic, Joseph P. Grande, Ming Xu, Tamara Tchkonia, James L. Kirkland, Lilach O. Lerman and Vesna D. Garovic

   Citation:Biology of Sex Differences 2019 10:49

   Content type:Research

   Published on: 14 September 2019

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